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1. 发明授权

US5415864A Colonic-targeted oral drug-dosage forms based on crosslinked hydrogels containing azobonds and exhibiting PH-dependent swelling 失效
标题翻译：基于含有偶联物的交联水凝胶并显示出PH依赖性肿胀的结肠靶向口服药物剂型
公开(公告)号：US5415864A
公开(公告)日：1995-05-16
申请号：US932914
申请日：1992-08-20
申请人： Jindrich Kopecek , Sung W. Kim , Helle Brondsted , Pavla Kopeckova
发明人： Jindrich Kopecek , Sung W. Kim , Helle Brondsted , Pavla Kopeckova
IPC分类号： A61K9/20 , A61K47/32 , A61K47/48 , C08F20/02 , C08F20/26 , C08F20/34 , C08F20/42 , C08F20/52 , C08F26/10 , C08F212/00 , C08F212/12 , C08F218/02 , C08F218/08 , C08F220/04 , C08F220/06 , C08F220/28 , C08F220/36 , C08F220/46 , C08F220/58 , C08F220/60 , C08F222/06 , C08F226/10 , C08F246/00 , C08L31/04 , C08L33/00 , C08L33/04 , A61K9/48 , A61F9/02
CPC分类号： C08F246/00 , A61K47/32 , A61K47/48176 , A61K9/2027
摘要： Colonic-targeted oral drug dosage forms composed of a drug confined within a crosslinked hydrogel that exhibits pH-dependent swelling and is composed of an ionizable comonomer such as acrylic acid, a nonionizable comonomer such as an acrylamide, and a crosslinking agent that contains an aromatic azobond. Selective drug release in the colon occurs by a combination of pH-dependent swelling of the hydrogel and degradation of the hydrogel by enzymatic cleavage of the azobonds by azoreductases.
摘要翻译：由限制在交联水凝胶内的药物组成的结肠靶向口服药物剂型，其表现出pH依赖性溶胀并且由可离子化的共聚单体如丙烯酸，不可分解的共聚单体如丙烯酰胺和含有芳族化合物的交联剂组成偶氮结肠中的选择性药物释放通过水凝胶的pH依赖性溶胀和水解凝胶的降解的组合发生，通过偶氮氧化酶的酶切割。

2. 发明授权

US09207989B2 System and method for providing virtual device 有权
标题翻译：提供虚拟设备的系统和方法
公开(公告)号：US09207989B2
公开(公告)日：2015-12-08
申请号：US13592133
申请日：2012-08-22
申请人： Eui N. Huh , Sang H. Na , Sung W. Kim , Jun H. Lee
发明人： Eui N. Huh , Sang H. Na , Sung W. Kim , Jun H. Lee
IPC分类号： G06F15/16 , G06F9/50
CPC分类号： G06F9/5072
摘要： Disclosed is a system and method for providing a virtual terminal. A virtual cloud server may configure a plurality of virtual terminals by employing a virtual machine in a cloud environment. The virtual cloud server may provide an application of a heterogeneous platform to a terminal that accesses the virtual cloud server. A cooperative middleware apparatus may determine a cloud server suitable for a mobile terminal among a plurality of cloud servers, based on content information of content and virtual terminal information stored in the plurality of cloud servers.
摘要翻译：公开了一种用于提供虚拟终端的系统和方法。虚拟云服务器可以通过在云环境中采用虚拟机来配置多个虚拟终端。虚拟云服务器可以向访问虚拟云服务器的终端提供异构平台的应用。合作中间件装置可以基于存储在多个云服务器中的内容的内容信息和虚拟终端信息来确定适合于多个云服务器中的移动终端的云服务器。

3. 发明授权

US5223262A Transdermal delivery system utilizing one way membranes 失效
标题翻译：使用单向膜的透皮递送系统
公开(公告)号：US5223262A
公开(公告)日：1993-06-29
申请号：US565479
申请日：1990-08-10
申请人： Sung W. Kim , Teruo Okano , Soon H. Yuk
发明人： Sung W. Kim , Teruo Okano , Soon H. Yuk
IPC分类号： A61K9/70
CPC分类号： A61K9/7084 , A61K9/7092 , Y10T428/31511 , Y10T428/31663
摘要： A system for transdermally delivering a hydrophobic alkanol soluble active agent to the skin at a constant rate utilizing a lower alkanol penetration enhancer. The system comprises an overlying solvent reservoir containing a lower alkanol solvent and a drug compartment containing an active agent in aqueous alkanol. A one-way membrane is sandwiched between and divides the solvent reservoir from the drum compartment. The one-way membrane is permeable to the alkanol solvent and substantially impermeable to back flux of drug and water into the reservoir. An outer membrane permeable to the alkanol solvent and drug is attached to the outer surface of the drug compartment. Adhesive means is contained on the outer surface of this membrane for attaching the delivery system to the skin of a wearer. Alkanol from the reservoir permeates into the drug compartment and drug and alkanol pass through the outer membrane to the skin of the wearer for transdermal absorption. The rate of alkanol permeation from the reservoir to the drug compartment and from the drug compartment to the skin is substantially constant. The membrane is made up of an epoxidized silicone rubber to which is preferably laminated a layer of a dense hydrophobic copolymer of vinyl-terminated polydimethyl siloxane with methylhydro-dimethyl siloxane. If desired, to prevent any back flux of hydrophobic drugs, and additional layer of cellulose acetate may be sandwiched between the epoxidized silicone rubber and dense hydrophobic membrane.
摘要翻译：一种利用低级烷醇渗透增强剂以一定速率将疏水性链烷醇可溶性活性剂透皮递送至皮肤的系统。该系统包括含有低级链烷醇溶剂的上层溶剂储存器和在链烷醇水溶液中含有活性剂的药物隔室。单向膜夹在溶剂容器和鼓室之间。单向膜对于链烷醇溶剂是可渗透的，并且基本上不可渗透地将药物和水的通量回流到储存器中。可通过链烷醇溶剂和药物的外膜附着到药物隔室的外表面。粘合剂装在该膜的外表面上，用于将输送系统附着到穿着者的皮肤上。来自储存器的烷醇渗透到药物隔室中，药物和链烷醇通过外膜到穿着者的皮肤以经皮吸收。从储存器到药物隔室以及从药物室到皮肤的链烷醇渗透速率基本上是恒定的。膜由环氧化的硅橡胶组成，其优选层压有乙烯基封端的聚二甲基硅氧烷与甲基氢二甲基硅氧烷的致密疏水性共聚物层。如果需要，为了防止疏水性药物的任何回流，并且附加的乙酸纤维素层可夹在环氧化硅橡胶和致密疏水膜之间。

4. 发明授权

US4931287A Heterogeneous interpenetrating polymer networks for the controlled release of drugs 失效
标题翻译：用于控释药物的非均相互穿聚合物网络
公开(公告)号：US4931287A
公开(公告)日：1990-06-05
申请号：US206593
申请日：1988-06-14
申请人： You H. Bae , Teruo Okano , Sung W. Kim
发明人： You H. Bae , Teruo Okano , Sung W. Kim
IPC分类号： A61K9/20
CPC分类号： A61K9/2031 , A61K9/2027
摘要： A heterogeneous interpenetrating polymer network is provided for use in the controlled release of drugs. The network is a heterogeneous matrix that is formed from a hydrophilic component such as polyethylene oxide or poly(N,N'-dimethyl acrylamide-co-styrene) and a hydrophobic component such as styrene, an alkyl methacrylate, or polytetramethylene ether glycol. The relative amounts of the two components, or "domains", can be varied, as can the diffusivities and solubilities of the drug combinations to be loaded therein, to control and change as desired the timed release profile of incorporated drug. Prolonged pseudo-zero order release can be obtained where one domain acts as a diffusion barrier layer to the release of drug from the other domain.
摘要翻译：提供异构互穿聚合物网络用于药物的控制释放。该网络是由亲水组分如聚环氧乙烷或聚（N，N'-二甲基丙烯酰胺 - 共 - 苯乙烯）和疏水组分如苯乙烯，甲基丙烯酸烷基酯或聚四亚甲基醚二醇形成的非均相基体。可以改变两种组分或“结构域”的相对量，以及待加载的药物组合的扩散性和溶解度，以控制并根据需要改变并入药物的定时释放曲线。可以获得延长的伪零次释放，其中一个结构域充当从另一个域释放药物的扩散阻挡层。

5. 发明申请

US20130159392A1 SYSTEM AND METHOD FOR PROVIDING VIRTUAL DEVICE 有权
标题翻译：用于提供虚拟设备的系统和方法
公开(公告)号：US20130159392A1
公开(公告)日：2013-06-20
申请号：US13592133
申请日：2012-08-22
申请人： Eui N. HUH , Sang H. Na , Sung W. Kim , Jun H. Lee
发明人： Eui N. HUH , Sang H. Na , Sung W. Kim , Jun H. Lee
IPC分类号： G06F15/16
CPC分类号： G06F9/5072
摘要： Disclosed is a system and method for providing a virtual terminal. A virtual cloud server may configure a plurality of virtual terminals by employing a virtual machine in a cloud environment. The virtual cloud server may provide an application of a heterogeneous platform to a terminal that accesses the virtual cloud server. A cooperative middleware apparatus may determine a cloud server suitable for a mobile terminal among a plurality of cloud servers, based on content information of content and virtual terminal information stored in the plurality of cloud servers.
摘要翻译：公开了一种用于提供虚拟终端的系统和方法。虚拟云服务器可以通过在云环境中采用虚拟机来配置多个虚拟终端。虚拟云服务器可以向访问虚拟云服务器的终端提供异构平台的应用。合作中间件装置可以基于存储在多个云服务器中的内容的内容信息和虚拟终端信息来确定适合于多个云服务器中的移动终端的云服务器。

6. 外观设计

USD378830S Process cartridge 失效
公开(公告)号：USD378830S
公开(公告)日：1997-04-15
申请号：US49640
申请日：1996-01-16
申请人： Sung W. Kim
设计人： Sung W. Kim

7. 发明授权

US5346141A Method for pulverizing silicon particles by fluid jet energy 失效
标题翻译：流体喷射能粉碎硅粒子的方法
公开(公告)号：US5346141A
公开(公告)日：1994-09-13
申请号：US1094
申请日：1993-01-06
申请人： Hee Y. Kim , Dae H. Kwon , Yong M. Song , Sung W. Kim , Jong Y. Jeon , Kang M. Lee , Jae S. Lee
发明人： Hee Y. Kim , Dae H. Kwon , Yong M. Song , Sung W. Kim , Jong Y. Jeon , Kang M. Lee , Jae S. Lee
IPC分类号： B02C19/06 , B01J2/16 , B01J8/24 , C01B33/027 , C01B33/18 , F27B15/00 , B02C19/12 , B02C23/00
CPC分类号： B01J8/245 , B01J2/16 , C01B33/027 , F27B15/006
摘要： A jet pulverizing method is described for preparing silicon seed particles from silicon feed particles without contamination. The method comprises accelerating silicon feed particles by fluid jet energy and colliding them with each other within a pulverizing chamber to fracture or split them into small particles which are recovered for use as seed particles. The method is characterized by the technique that silicon particles fluidized within the pulverizing chamber are formed into a dilute-phase fluidized bed with low particle density. Thus, the generation of fine powders may be suppressed and additional sieving to separate larger particles is not required.
摘要翻译：描述了用于从硅进料颗粒制备硅种子颗粒而不污染的射流粉碎方法。该方法包括通过流体喷射能量加速硅进料颗粒并在粉碎室内将它们彼此碰撞以将其分解或分离成小颗粒，该颗粒被回收以用作种子颗粒。该方法的特征在于将在粉碎室内流化的硅颗粒形成为具有低颗粒密度的稀相流化床。因此，可以抑制细粉的产生并且不需要额外的筛分以分离更大的颗粒。

8. 发明授权

US5226902A Pulsatile drug delivery device using stimuli sensitive hydrogel 失效
标题翻译：使用刺激敏感水凝胶的脉冲药物递送装置
公开(公告)号：US5226902A
公开(公告)日：1993-07-13
申请号：US737675
申请日：1991-07-30
申请人： You H. Bae , Sung W. Kim , Lev I. Valuev
发明人： You H. Bae , Sung W. Kim , Lev I. Valuev
IPC分类号： A61K9/00 , A61K9/22
CPC分类号： A61K9/0004 , Y10S514/965
摘要： A device for the dispensing of a biologically active material into the surrounding environment is disclosed which consists of at least one wall enclosing a compartment which contains a swollen stimuli sensitive hydrogel in which the biologically active material is entrained in solution. The hydrogel deswells or shrinks in response to contact by external physical or chemical stimuli releasing the biologically active material into the portion of the compartment previously occupied by the swollen hydrogel. The wall enclosing the compartment is rigid and contains means allowing the passage of the biologically active material from the compartment to the surrounding environment and also for transmitting the external stimuli to the swollen hydrogel in said compartment. The wall may contain orifices or be permeable to the active material and external stimuli depending upon the drug and the stimuli to be used. The hydrogel reversibly deswells, shrinks or contracts in response to stimuli, such as temperature, pH, ionic strength, glucose concentration or metabolites in the body and then reswells and reentrains active material not diffused from the compartment when the stimuli is removed. The wall may consist of one or more layers which, in combination, provide for the expeditious delivery of the active substance either through permeation through the wall or through orifices in the wall and also for the conducting of the external stimuli through the wall into the compartment to trigger the deswelling of the hydrogel.
摘要翻译：公开了一种用于将生物活性物质分配到周围环境中的装置，其由至少一个包围腔室的壁组成，所述隔室包含溶胀的刺激性敏感水凝胶，其中生物活性物质被夹带在溶液中。水凝胶响应于外部物理或化学刺激的接触而溶解或收缩，将生物活性物质释放到先前由膨胀的水凝胶占据的隔室部分。包围隔室的壁是刚性的并且包含允许生物活性材料从隔室通过到周围环境的装置，并且还用于将外部刺激传递到所述隔室中的溶胀水凝胶。根据药物和使用的刺激，该壁可能含有孔口或对活性物质可渗透和外部刺激。水凝胶可以响应于身体中的温度，pH，离子强度，葡萄糖浓度或代谢物等刺激而可逆地解冻，收缩或收缩，然后在去除刺激物时，将不会从隔室扩散的活性物质重新流通并重新吸入。该壁可以由一个或多个层组成，其组合地提供活性物质的快速递送，所述活性物质通过壁穿过壁或通过壁中的孔，并且还用于通过壁进入外部刺激进入隔室触发水凝胶的溶解。

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