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1. 发明申请

US20080166706A1 Novel gold nanoparticle aggregates and their applications 审中-公开
标题翻译：新型金纳米颗粒聚集体及其应用
公开(公告)号：US20080166706A1
公开(公告)日：2008-07-10
申请号：US11396098
申请日：2006-03-30
申请人： Jin Zhang , Adam Schwartzberg , Thaddeus Norman , Tammy Y. Oshiro , Christian D. Grant , Rebecca Sutphen , Leo Seballos , Yi Zhang , Claire Gu
发明人： Jin Zhang , Adam Schwartzberg , Thaddeus Norman , Tammy Y. Oshiro , Christian D. Grant , Rebecca Sutphen , Leo Seballos , Yi Zhang , Claire Gu
IPC分类号： C12Q1/68 , C12M1/34 , G01N33/551
CPC分类号： G01N33/54346 , G01N21/658 , G01N33/54313 , G01N33/553 , G01N33/585 , G01N33/587 , G01N33/6854
摘要： The invention is drawn to novel gold nanoparticles that are used in a dual optical method for sensitive and selective detection of antigens. The gold nanoparticle aggregates are synthesized from gold hydrochloride and sulfur salts in an aqueous solution. The aggregates can be selectively sized using a spectral notch filter that results in an improved product with versatile uses. The gold nanoparticles can also be used in improved optical communications devices.
摘要翻译：本发明涉及用于双光学方法中用于敏感和选择性检测抗原的新型金纳米颗粒。金纳米颗粒聚集体由金盐酸盐和硫盐在水溶液中合成。聚集体可以使用频谱陷波滤波器选择性地定尺寸，其产生具有通用用途的改进的产品。金纳米颗粒也可用于改进的光通信设备中。

2. 发明申请

US20120142119A1 Novel gold nanoparticle aggregates and their applications 有权
标题翻译：新型金纳米颗粒聚集体及其应用
公开(公告)号：US20120142119A1
公开(公告)日：2012-06-07
申请号：US13199563
申请日：2011-09-03
申请人： Jin Zhang , Adam Schwartzberg , Thaddeus Norman , Tammy Y. Oshiro , Christian D. Grant , Rebecca Sutphen , Leo Seballos , Yi Zhang , Claire Gu
发明人： Jin Zhang , Adam Schwartzberg , Thaddeus Norman , Tammy Y. Oshiro , Christian D. Grant , Rebecca Sutphen , Leo Seballos , Yi Zhang , Claire Gu
IPC分类号： G01N21/65 , B82Y15/00
CPC分类号： G01N33/54346 , G01N21/658 , G01N33/54313 , G01N33/553 , G01N33/585 , G01N33/587 , G01N33/6854
摘要： The invention is drawn to a method of using nanoparticle aggregates to form sensors and optical filters. Properly sized (60 and 200 nm) nanoparticle aggregates with cores having a sulfur-oxygen molecular species and a shell with a surface in contact with the core are obtained. Those nanoparticle aggregates have a first resonance profile to wavelengths between 350 nm and 1075 nm. A modified resonance profile for those nanoparticle aggregates is determined. The nanoparticle aggregates are then selectively sized by irradiating them with electromagnetic energy at sufficient intensity and spectral content to modify the first resonance profile towards the modified resonance profile. The resulting nanoparticle aggregates can be used as sensors or optical filters at a selected wavelength.
摘要翻译：本发明涉及使用纳米颗粒聚集体形成传感器和滤光器的方法。获得具有硫 - 氧分子种类的芯和具有与芯接触的表面的壳的适当尺寸（60和200nm）纳米颗粒聚集体。那些纳米颗粒聚集体具有在350nm和1075nm之间的波长的第一共振分布。确定这些纳米颗粒聚集体的改性共振谱。然后通过以足够的强度和光谱含量的电磁能照射纳米颗粒聚集体来选择性地调整纳米颗粒聚集体，以改变朝向修饰的共振分布的第一共振分布。所得到的纳米颗粒聚集体可以用作选定波长的传感器或光学滤光器。

3. 发明授权

US09297801B2 Gold nanoparticle aggregates and their applications 有权
标题翻译：金纳米颗粒聚集体及其应用
公开(公告)号：US09297801B2
公开(公告)日：2016-03-29
申请号：US13199563
申请日：2011-09-03
申请人： Jin Zhang , Adam Schwartzberg , Thaddeus Norman , Tammy Y. Oshiro , Christian D. Grant , Rebecca Sutphen , Leo Seballos , Yi Zhang , Claire Gu
发明人： Jin Zhang , Adam Schwartzberg , Thaddeus Norman , Tammy Y. Oshiro , Christian D. Grant , Rebecca Sutphen , Leo Seballos , Yi Zhang , Claire Gu
IPC分类号： G01N33/553 , G01N33/543 , G01N33/58
CPC分类号： G01N33/54346 , G01N21/658 , G01N33/54313 , G01N33/553 , G01N33/585 , G01N33/587 , G01N33/6854
摘要： The invention is drawn to a method of using nanoparticle aggregates to form sensors and optical filters. Properly sized (60 and 200 nm) nanoparticle aggregates with cores having a sulfur-oxygen molecular species and a shell with a surface in contact with the core are obtained. Those nanoparticle aggregates have a first resonance profile to wavelengths between 350 nm and 1075 nm. A modified resonance profile for those nanoparticle aggregates is determined. The nanoparticle aggregates are then selectively sized by irradiating them with electromagnetic energy at sufficient intensity and spectral content to modify the first resonance profile towards the modified resonance profile. The resulting nanoparticle aggregates can be used as sensors or optical filters at a selected wavelength.
摘要翻译：本发明涉及使用纳米颗粒聚集体形成传感器和滤光器的方法。获得具有硫 - 氧分子种类的芯和具有与芯接触的表面的壳的适当尺寸（60和200nm）纳米颗粒聚集体。那些纳米颗粒聚集体具有在350nm和1075nm之间的波长的第一共振分布。确定这些纳米颗粒聚集体的改性共振谱。然后通过以足够的强度和光谱含量的电磁能照射纳米颗粒聚集体来选择性地调整纳米颗粒聚集体，以改变朝向修饰的共振分布的第一共振分布。所得到的纳米颗粒聚集体可以用作选定波长的传感器或光学滤光器。

4. 发明申请

US20160153977A1 NOVEL GOLD NANOPARTICLE AGGREGATES AND THEIR APPLICATIONS 审中-公开
标题翻译：新型金纳米颗粒聚集体及其应用
公开(公告)号：US20160153977A1
公开(公告)日：2016-06-02
申请号：US15018761
申请日：2016-02-08
申请人： Jin Zhang , Adam Scheartzberg , Thaddeus Norman , Tammy Oshiro , Christian D. Grant , Rebecca Sutphen , Leo Seballos , Yi Zhang
发明人： Jin Zhang , Adam Scheartzberg , Thaddeus Norman , Tammy Oshiro , Christian D. Grant , Rebecca Sutphen , Leo Seballos , Yi Zhang
IPC分类号： G01N33/543 , G01N21/65 , G01N33/58 , G01N33/553 , G01N33/68
CPC分类号： G01N33/54346 , G01N21/658 , G01N33/54313 , G01N33/553 , G01N33/585 , G01N33/587 , G01N33/6854
摘要： The invention is drawn to a method of using nanoparticle aggregates to form sensors and optical filters. Properly sized (60 and 200 nm) nanoparticle aggregates with cores having a sulfur-oxygen molecular species and a shell with a surface in contact with the core are obtained. Those nanoparticle aggregates have a first resonance profile to wavelengths between 350 nm and 1075 nm. A modified resonance profile for those nanoparticle aggregates is determined. The nanoparticle aggregates are then selectively sized by irradiating them with electromagnetic energy at sufficient intensity and spectral content to modify the first resonance profile towards the modified resonance profile. The resulting nanoparticle aggregates can be used as sensors or optical filters at a selected wavelength.
摘要翻译：本发明涉及使用纳米颗粒聚集体形成传感器和滤光器的方法。获得具有硫 - 氧分子种类的芯和具有与芯接触的表面的壳的适当尺寸（60和200nm）纳米颗粒聚集体。那些纳米颗粒聚集体具有在350nm和1075nm之间的波长的第一共振分布。确定这些纳米颗粒聚集体的改性共振谱。然后通过以足够的强度和光谱含量的电磁能照射纳米颗粒聚集体来选择性地调整纳米颗粒聚集体，以改变朝向修饰的共振分布的第一共振分布。所得到的纳米颗粒聚集体可以用作选定波长的传感器或光学滤光器。

5. 发明申请

US20060003465A1 Luminescence Characterization of Quantum Dots Conjugated with Biomarkers for Early Cancer Detection 有权
标题翻译：用于早期癌症检测的生物标志物缀合的量子点的发光表征
公开(公告)号：US20060003465A1
公开(公告)日：2006-01-05
申请号：US11160617
申请日：2005-06-30
申请人： Tatyana Zhukov , Sergei Ostapenko , Rebecca Sutphen , Johnathan Lancaster , Thomas Sellers , Jin Zhang
发明人： Tatyana Zhukov , Sergei Ostapenko , Rebecca Sutphen , Johnathan Lancaster , Thomas Sellers , Jin Zhang
IPC分类号： G01N33/551
CPC分类号： B82Y15/00 , B82Y5/00 , B82Y10/00 , G01N33/57423 , G01N33/57449 , G01N33/588
摘要： Luminescent semiconductor quantum dots (QDs) conjugated with biomolecules to serve as sensitive probes for early detection of the cancer cells, specifically for ovarian cancer and lung cancer, which represents the most lethal malignancies. The luminescence characterization of the bin-conjugated QDs with cancer specific antigens using linkage molecules. Photo-enhancement is measured at various laser density power, temperatures and laser wavelengths.
摘要翻译：与生物分子结合的发光半导体量子点（QDs）用作早期检测癌细胞的敏感探针，特别是代表最致命的恶性肿瘤的卵巢癌和肺癌。使用连锁分子的具有癌症特异性抗原的bin结合的QD的发光表征。在各种激光密度功率，温度和激光波长下测量光增强。

6. 发明授权

US08197789B2 Method of selectively eliminating metallic carbon nanotubes, semiconducting carbon nanotubes and preparation method thereof using the same 有权
标题翻译：选择性去除金属碳纳米管，半导体碳纳米管的方法及其制备方法
公开(公告)号：US08197789B2
公开(公告)日：2012-06-12
申请号：US12277688
申请日：2008-11-25
申请人： Jin Zhang , Yi Zhang , Yongyi Zhang , Zhongfan Liu
发明人： Jin Zhang , Yi Zhang , Yongyi Zhang , Zhongfan Liu
IPC分类号： D01F9/12 , C01B31/02
CPC分类号： B82B3/00 , B82Y30/00 , B82Y40/00 , C01B32/172 , C01B32/18 , C01B2202/02 , C01B2202/22 , Y10S977/734 , Y10S977/845
摘要： Metallic carbon nanotubes (“CNTs”) may be selectively eliminated and semiconducting CNTs may be prepared using light-irradiation. The light provided by the light-irradiation may have a wavelength of about 180 nm to about 11 μm. Further, the light may have an intensity of about 30 mW/cm2 to about 300 mW/cm2. The light-irradiation may be simple and controllable, and may not require any special instruments except a light source.
摘要翻译：可以选择性地除去金属碳纳米管（“CNT”），并且可以使用光照射来制备半导体CNT。通过光照射提供的光可以具有约180nm至约11μm的波长。此外，光可以具有约30mW / cm 2至约300mW / cm 2的强度。光照射可以是简单和可控的，除了光源之外，可能不需要任何特殊的仪器。

7. 发明公开

US20240124610A1 METHODS FOR TREATING HER2-NEGATIVE OR HER2-LOW CANCER 审中-公开
公开(公告)号：US20240124610A1
公开(公告)日：2024-04-18
申请号：US18318232
申请日：2023-05-16
申请人： Nicole Maher , Christopher Maher , Andrew Nickless , Jin Zhang , Amy Ly , Jace Webster
发明人： Nicole Maher , Christopher Maher , Andrew Nickless , Jin Zhang , Amy Ly , Jace Webster
IPC分类号： C07K16/32 , A61K31/506 , A61P35/00 , C12Q1/6886
CPC分类号： C07K16/32 , A61K31/506 , A61P35/00 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158
摘要： The present disclosure provides methods for treating a subject having a HER2 non-amplified (HER2-negative) cancer or low HER2 expressing (HER2-low) cancer, comprising detecting expression of a BCAR4 gene fusion in a biological sample from the subject. If expression of the BCAR4 gene fusion is detected, a HER2-targeted cancer treatment is administered to the subject; if expression of the BCAR4 gene fusion is not detected, a cancer treatment that is not HER2-targeted is administered to the subject. Methods of predicting response to a HER2-targeted cancer treatment and detecting BCAR4 or BCAR4 gene fusion activation are also provided.

8. 发明公开

US20240044907A1 LUMINESCENT RESONANCE ENERGY TRANSFER SENSORS FOR NON-INVASELY AND CONTINUOUSLY MONITORING GLUCOSE FOR DIABETES 审中-公开
公开(公告)号：US20240044907A1
公开(公告)日：2024-02-08
申请号：US17988832
申请日：2022-11-17
申请人： JIN ZHANG
发明人： Jin Zhang , Xianbin Wang
IPC分类号： G01N33/66
CPC分类号： G01N33/66
摘要： The present disclosure discloses a non-invasive wireless glucose level monitoring device. The device is fitted into a contact lens and can analyze glucose levels in tear fluid. The results of the analysis can be continuously transmitted to a nearby receiver and uploaded to a computer, mobile device or server.

9. 发明授权

US11215355B2 Air energy boiler 有权
公开(公告)号：US11215355B2
公开(公告)日：2022-01-04
申请号：US16607872
申请日：2018-03-30
申请人： Jin Zhang
发明人： Jin Zhang
IPC分类号： F22B3/06 , F24V40/00
摘要： The present invention discloses an air energy boiler and belongs to the technical field of energy conversion. A crankshaft of the boiler is fixed at the output end of a rotating unit. The crankshaft is provided with at least one bulge. A driving piston of each conversion assembly is arranged in an air cavity in a reciprocating motion. The driving piston divides the air cavity into a first cavity and a second cavity. A wrist pin is arranged in the second cavity, and the wrist pin is fixed and connected with the driving piston. Both ends of a piston rod is rotatably connected with the wrist pin and the corresponding bulge respectively. The first cavity is provided with an air intake. Multiple heating pipes are in communication with the first cavity at one end and stretch into the boiler body at the other end. The boiler body is sealed and stores water, and the boiler body is provided with a steam outlet, wherein the steam outlet of the boiler body is connected to various terminals through the use of pipelines. Since air is used as the heat source, no conditional limitations exist for installation, and it is safe to use and saves energy and electricity.

10. 发明授权

US11150349B2 Multi-line, high-definition LiDAR device and method with integrated direct spatial reference 有权
公开(公告)号：US11150349B2
公开(公告)日：2021-10-19
申请号：US16104129
申请日：2018-08-16
申请人： Wei Chen , Shan Zhong , Jin Zhang , Zhonghua Zhu , Lei Wu
发明人： Wei Chen , Shan Zhong , Jin Zhang , Zhonghua Zhu , Lei Wu
IPC分类号： G01S17/00 , G01S17/36 , G01S17/58 , G01S7/4911 , G01S7/4912
摘要： The present disclosure relates to a FMCW Light Detection and Ranging system, a wave train of carrier frequency is modulated in narrow-band sequence, an delay interferometer with in-phase and quadrature outputs extracts the phase of this frequency modulation, and a coherent receiver with in-phase and quadrature outputs detects the phase of reflected light from a remote object, the ratio between two phases determines the distance of the remote object.

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