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1. 发明授权

US08380307B2 Switch polarity pacing to improve cardiac resynchronization therapy 有权
标题翻译：切换极性起搏以改善心脏再同步治疗
公开(公告)号：US08380307B2
公开(公告)日：2013-02-19
申请号：US12255516
申请日：2008-10-21
申请人： Jie Lian , Garth Garner , Dirk Muessig , Volker Lang
发明人： Jie Lian , Garth Garner , Dirk Muessig , Volker Lang
IPC分类号： A61N1/00
CPC分类号： A61N1/3627 , A61N1/3688
摘要： The invention is directed to a heart stimulator for left-ventricular pacing comprising a left ventricular stimulation pulse generator connected or connectable to a single electrode lead for left ventricular stimulation having one or more electrodes for delivery of stimulation pulses to left ventricular myocardial heart tissue, said stimulation pulse generator being adapted to generate and deliver stimulation pulses of switchable polarity. The heart stimulator further comprises a control unit connected to the stimulation pulse generator for controlling the stimulation pulse generator and to trigger generation and delivery of stimulation pulses having a polarity controlled by said control unit, wherein the control unit is adapted to control said left ventricular stimulation pulse generator so as to deliver at least a pair of suprathreshold stimulation pulses of opposite polarity.
摘要翻译：本发明涉及用于左心室起搏的心脏刺激器，其包括连接或可连接到用于左心室刺激的单个电极引线的左心室刺激脉冲发生器，其具有用于将刺激脉冲递送至左心室心肌心脏组织的一个或多个电极，所述左心室起搏器刺激脉冲发生器适于产生和递送可切换极性的刺激脉冲。心脏刺激器还包括连接到刺激脉冲发生器的控制单元，用于控制刺激脉冲发生器并触发具有由所述控制单元控制的极性的刺激脉冲的产生和传递，其中控制单元适于控制所述左心室刺激以产生相反极性的至少一对超阈值刺激脉冲。

2. 发明授权

US07899520B2 Medical device for monitoring biological signals 有权
标题翻译：用于监测生物信号的医疗设备
公开(公告)号：US07899520B2
公开(公告)日：2011-03-01
申请号：US12124499
申请日：2008-05-21
申请人： Jie Lian , Garth Garner , Dirk Muessig , Volker Lang
发明人： Jie Lian , Garth Garner , Dirk Muessig , Volker Lang
IPC分类号： A61B5/04
CPC分类号： G06K9/00496 , A61N1/3684 , A61N1/3712 , G06K9/00536
摘要： A medical device having a sensor for sampling a biological signal, the biological signal representing a signal waveform and forming a waveform vector composed of the biological signal samples, and a memory for storing a least two threshold vectors composed of boundary samples representing at least two boundaries related to the biological signal defining subspaces for the biological signal samples. One threshold vector is an upper threshold vector composed of upper boundary samples and the other threshold vector is a lower threshold vector composed of lower boundary samples. An evaluation unit connected to the sensor determines a similarity index (ASCI) by comparing each of the biological signal samples of the waveform vector to corresponding boundary samples of the threshold vectors, thus determining to which subspace each biological signal sample belongs to and creating a trichotomized signal vector, and calculating the signed correlation product of two trichotomized signal vectors.
摘要翻译：一种具有用于对生物体信号进行采样的传感器的医疗装置，生物信号表示信号波形并形成由生物信号样本构成的波形矢量，以及存储器，用于存储由表示至少两个边界的边界样本组成的至少两个阈值向量与生物信号样品的生物信号定义子空间有关。一个阈值向量是由上边界样本组成的上阈值向量，另一阈值向量是由下边界样本组成的下阈值向量。连接到传感器的评估单元通过将波形向量的生物信号样本与阈值向量的相应边界样本进行比较来确定相似性指数（ASCI），从而确定每个生物信号样本属于哪个子空间并创建三分法信号向量，并计算两个三分信号向量的有符号相关乘积。

3. 发明申请

US20080294217A1 MEDICAL DEVICE FOR MONITORING BIOLOGICAL SIGNALS 有权
标题翻译：用于监测生物信号的医疗设备
公开(公告)号：US20080294217A1
公开(公告)日：2008-11-27
申请号：US12124499
申请日：2008-05-21
申请人： Jie Lian , Garth Garner , Dirk Muessig , Volker Lang
发明人： Jie Lian , Garth Garner , Dirk Muessig , Volker Lang
IPC分类号： A61N1/368 , A61B5/00
CPC分类号： G06K9/00496 , A61N1/3684 , A61N1/3712 , G06K9/00536
摘要： A medical device having a sensor for sampling a biological signal, the biological signal representing a signal waveform and forming a waveform vector composed of the biological signal samples, and a memory for storing a least two threshold vectors composed of boundary samples representing at least two boundaries related to the biological signal defining subspaces for the biological signal samples. One threshold vector is an upper threshold vector composed of upper boundary samples and the other threshold vector is a lower threshold vector composed of lower boundary samples. An evaluation unit connected to the sensor determines a similarity index (ASCI) by comparing each of the biological signal samples of the waveform vector to corresponding boundary samples of the threshold vectors, thus determining to which subspace each biological signal sample belongs to and creating a trichotomized signal vector, and calculating the signed correlation product of two trichotomized signal vectors.
摘要翻译：一种具有用于对生物体信号进行采样的传感器的医疗装置，生物信号表示信号波形并形成由生物信号样本构成的波形矢量，以及存储器，用于存储由表示至少两个边界的边界样本组成的至少两个阈值向量与生物信号样品的生物信号定义子空间有关。一个阈值向量是由上边界样本组成的上阈值向量，另一个阈值向量是由下边界样本组成的下阈值向量。连接到传感器的评估单元通过将波形向量的生物信号样本与阈值向量的相应边界样本进行比较来确定相似性指数（ASCI），从而确定每个生物信号样本属于哪个子空间并创建三分法信号矢量，并计算两个三分信号矢量的有符号相关乘积。

4. 发明申请

US20090240298A1 SWITCH POLARITY PACING TO IMPROVE CARDIAC RESYNCHRONIZATION THERAPY 有权
标题翻译：开展极地改善心脏康复治疗
公开(公告)号：US20090240298A1
公开(公告)日：2009-09-24
申请号：US12255516
申请日：2008-10-21
申请人： Jie LIAN , Garth Garner , Dirk Muessig , Volker Lang
发明人： Jie LIAN , Garth Garner , Dirk Muessig , Volker Lang
IPC分类号： A61N1/39 , A61N1/362
CPC分类号： A61N1/3627 , A61N1/3688
摘要： The invention is directed to a heart stimulator for left-ventricular pacing comprising a left ventricular stimulation pulse generator connected or connectable to a single electrode lead for left ventricular stimulation having one or more electrodes for delivery of stimulation pulses to left ventricular myocardial heart tissue, said stimulation pulse generator being adapted to generate and deliver stimulation pulses of switchable polarity. The heart stimulator further comprises a control unit connected to the stimulation pulse generator for controlling the stimulation pulse generator and to trigger generation and delivery of stimulation pulses having a polarity controlled by said control unit, wherein the control unit is adapted to control said left ventricular stimulation pulse generator so as to deliver at least a pair of suprathreshold stimulation pulses of opposite polarity.
摘要翻译：本发明涉及用于左心室起搏的心脏刺激器，其包括连接或可连接到用于左心室刺激的单个电极引线的左心室刺激脉冲发生器，其具有用于将刺激脉冲递送至左心室心肌心脏组织的一个或多个电极，所述左心室起搏器刺激脉冲发生器适于产生和递送可切换极性的刺激脉冲。心脏刺激器还包括连接到刺激脉冲发生器的控制单元，用于控制刺激脉冲发生器并触发具有由所述控制单元控制的极性的刺激脉冲的产生和传递，其中控制单元适于控制所述左心室刺激以产生相反极性的至少一对超阈值刺激脉冲。

5. 发明申请

US20110130669A1 Method and apparatus for improving signal to noise ratio of ECG signals to facilitate cardiac beat detection 有权
标题翻译：用于提高ECG信号的信噪比以便于心跳检测的方法和装置
公开(公告)号：US20110130669A1
公开(公告)日：2011-06-02
申请号：US12954418
申请日：2010-11-24
申请人： Garth Garner , Jie Lian , Dirk Muessig
发明人： Garth Garner , Jie Lian , Dirk Muessig
IPC分类号： A61B5/0402
CPC分类号： A61B5/04012 , A61B5/04288
摘要： Improving the signal-to-noise ratio of electrocardiogram (ECG) measurements facilitates cardiac beat detection in a human or animal patient. ECG signals measured either on the surface of the skin or subcutaneously from pairs of leads may be combined to calculate a differential signal. The measured signal may also be averaged to produce a second estimate. A point-by-point product of the differential signal and the averaged signal is generated if the sample pair has the same polarity. The product signals feature enhanced signal components and reduced noise components, thus improving the signal-to-noise ratio of the to respective input channels. Product signals are then subjected to peak detection through a conventional auto-sensing approach. Preliminary event detection results from the conditional product signals may then be aggregated, and final sense markers for ECG beat detection may be generated by means of a voting algorithm.
摘要翻译：提高心电图（ECG）测量的信噪比有助于人或动物患者的心跳检测。可以组合在皮肤表面或皮下从引线对测量的ECG信号以计算差分信号。测量的信号也可以被平均以产生第二估计。如果采样对具有相同的极性，则产生差分信号和平均信号的逐点乘积。产品信号具有增强的信号分量和降低的噪声分量，从而提高相应输入通道的信噪比。然后通过传统的自动感测方法对产品信号进行峰值检测。然后可以聚合来自条件产品信号的初步事件检测结果，并且可以通过投票算法产生用于ECG拍摄检测的最终感测标记。

6. 发明申请

US20090240300A1 DEVICE, METHOD AND COMPUTER-READABLE STORAGE MEDIUM FOR SVT AND VT CLASSIFICATION 有权
标题翻译：用于SVT和VT分类的设备，方法和计算机可读存储介质
公开(公告)号：US20090240300A1
公开(公告)日：2009-09-24
申请号：US12210381
申请日：2008-09-15
申请人： Jie Lian , Garth Garner , Dirk Muessig
发明人： Jie Lian , Garth Garner , Dirk Muessig
IPC分类号： A61N1/365
CPC分类号： A61B5/04525 , A61B5/0464 , A61B5/7264
摘要： A device for classifying of supraventricular tachyarrhythmia (SVT) from ventricular tachyarrhythmia (VT) comprising means for providing a template signal and a test signal originated from an electrogram, the template signal and the test signal comprising samples, means for transforming at least the test signal resulting in a representation of the test signal where the sample values of the signal take integers, means for determining a correlation between the template signal and the test signal and means for classifying of SVT from ventricular VT based on the correlation.
摘要翻译：用于从室性快速性心律失常（VT）分类室上性快速性心律失常（SVT）的装置，包括用于提供源自电描记图的模板信号和测试信号的装置，模板信号和包括样本的测试信号，用于至少转换测试信号的装置导致测试信号的表示，其中信号的采样值采用整数，用于确定模板信号和测试信号之间的相关性的装置以及用于基于相关性从心室VT分类SVT的装置。

7. 发明申请

US20090240157A1 DEVICE, METHOD AND COMPUTER-READABLE STORAGE MEDIUM FOR ENHANCED SENSE EVENT CLASSIFICATION IN IMPLANTABLE DEVICES BY MEANS OF MORPHOLOGY ANALYSIS 有权
标题翻译：通过形态学分析方法，在可移植设备中增强感知事件分类的设备，方法和计算机可读存储介质
公开(公告)号：US20090240157A1
公开(公告)日：2009-09-24
申请号：US12368328
申请日：2009-02-10
申请人： Jie Lian , Garth Garner , Dirk Muessig
发明人： Jie Lian , Garth Garner , Dirk Muessig
IPC分类号： A61B5/0402
CPC分类号： A61B5/04525 , A61B5/7203 , A61B5/7264
摘要： An implantable cardiac device, e.g., a pacemaker, defibrillator, cardioverter or biventricular pacing device, that can sense cardiac electrical signals and accurately classify the sensed events. The device provides a template signal and a test signal originated from an electrogram. The device further transforms at least the test signal into a representation of the test signal for example in numerical format where the sample values of the test signal take the form of integers. The device further determines a correlation between the template and test signals, and classifies the sense events based on the correlation. The electrogram may be an intracardiac electrogram (IEGM), atrial electrogram (AEGM), ventricular electrogram (VEGM), surface electrocardiogram (ECG) or subcutaneous electrogram.
摘要翻译：可植入的心脏装置，例如起搏器，除颤器，心律转复器或双心室起搏装置，其可以感测心脏电信号并且精确地分类所感测到的事件。该装置提供模板信号和源自电描记图的测试信号。该装置至少将测试信号转换为测试信号的表示，例如以测试信号的采样值采取整数形式的数字格式。该装置还确定模板和测试信号之间的相关性，并且基于相关性对感测事件进行分类。电描记图可以是心内电描记图（IEGM），心房电图（AEGM），心室电图（VEGM），表面心电图（ECG）或皮下电图。

8. 发明授权

US08396538B2 Method and apparatus for improving signal to noise ratio of ECG signals to facilitate cardiac beat detection 有权
标题翻译：用于提高ECG信号的信噪比以便于心跳检测的方法和装置
公开(公告)号：US08396538B2
公开(公告)日：2013-03-12
申请号：US12954418
申请日：2010-11-24
申请人： Garth Garner , Jie Lian , Dirk Muessig
发明人： Garth Garner , Jie Lian , Dirk Muessig
IPC分类号： A61B5/04
CPC分类号： A61B5/04012 , A61B5/04288
摘要： Improving the signal-to-noise ratio of electrocardiogram (ECG) measurements facilitates cardiac beat detection in a human or animal patient. ECG signals measured either on the surface of the skin or subcutaneously from pairs of leads may be combined to calculate a differential signal. The measured signal may also be averaged to produce a second estimate. A point-by-point product of the differential signal and the averaged signal is generated if the sample pair has the same polarity. The product signals feature enhanced signal components and reduced noise components, thus improving the signal-to-noise ratio of the to respective input channels. Product signals are then subjected to peak detection through a conventional auto-sensing approach. Preliminary event detection results from the conditional product signals may then be aggregated, and final sense markers for ECG beat detection may be generated by means of a voting algorithm.
摘要翻译：提高心电图（ECG）测量的信噪比有助于人或动物患者的心跳检测。可以组合在皮肤表面或皮下从引线对测量的ECG信号以计算差分信号。测量的信号也可以被平均以产生第二估计。如果采样对具有相同的极性，则产生差分信号和平均信号的逐点乘积。产品信号具有增强的信号分量和降低的噪声分量，从而提高相应输入通道的信噪比。然后通过传统的自动感测方法对产品信号进行峰值检测。然后可以聚合来自条件产品信号的初步事件检测结果，并且可以通过投票算法产生用于ECG拍摄检测的最终感测标记。

9. 发明授权

US08090434B2 Device, method and computer-readable storage medium for enhanced sense event classification in implantable devices by means of morphology analysis 有权
标题翻译：用于通过形态学分析在植入式装置中增强感觉事件分类的装置，方法和计算机可读存储介质
公开(公告)号：US08090434B2
公开(公告)日：2012-01-03
申请号：US12368328
申请日：2009-02-10
申请人： Jie Lian , Garth Garner , Dirk Muessig
发明人： Jie Lian , Garth Garner , Dirk Muessig
IPC分类号： A61B5/04
CPC分类号： A61B5/04525 , A61B5/7203 , A61B5/7264
摘要： An implantable cardiac device, e.g., a pacemaker, defibrillator, cardioverter or biventricular pacing device, that can sense cardiac electrical signals and accurately classify the sensed events. The device provides a template signal and a test signal originated from an electrogram. The device further transforms at least the test signal into a representation of the test signal for example in numerical format where the sample values of the test signal take the form of integers. The device further determines a correlation between the template and test signals, and classifies the sense events based on the correlation. The electrogram may be an intracardiac electrogram (IEGM), atrial electrogram (AEGM), ventricular electrogram (VEGM), surface electrocardiogram (ECG) or subcutaneous electrogram.
摘要翻译：可植入的心脏装置，例如起搏器，除颤器，心律转复器或双心室起搏装置，其可以感测心脏电信号并且精确地分类所感测到的事件。该装置提供模板信号和源自电描记图的测试信号。该装置至少将测试信号转换为测试信号的表示，例如以测试信号的采样值采取整数形式的数字格式。该装置还确定模板和测试信号之间的相关性，并且基于相关性对感测事件进行分类。电描记图可以是心内电描记图（IEGM），心房电图（AEGM），心室电图（VEGM），表面心电图（ECG）或皮下电图。

10. 发明授权

US08082028B2 Device, method and computer-readable storage medium for SVT and VT classification 有权
标题翻译：用于SVT和VT分类的设备，方法和计算机可读存储介质
公开(公告)号：US08082028B2
公开(公告)日：2011-12-20
申请号：US12210381
申请日：2008-09-15
申请人： Jie Lian , Garth Garner , Dirk Muessig
发明人： Jie Lian , Garth Garner , Dirk Muessig
IPC分类号： A61B5/04
CPC分类号： A61B5/04525 , A61B5/0464 , A61B5/7264
摘要： A device for classifying of supraventricular tachyarrhythmia (SVT) from ventricular tachyarrhythmia (VT) comprising means for providing a template signal and a test signal originated from an electrogram, the template signal and the test signal comprising samples, means for transforming at least the test signal resulting in a representation of the test signal where the sample values of the signal take integers, means for determining a correlation between the template signal and the test signal and means for classifying of SVT from ventricular VT based on the correlation.
摘要翻译：用于从室性快速性心律失常（VT）分类室上性快速性心律失常（SVT）的装置，包括用于提供源自电描记图的模板信号和测试信号的装置，模板信号和包括样本的测试信号，用于至少转换测试信号的装置导致测试信号的表示，其中信号的采样值采用整数，用于确定模板信号和测试信号之间的相关性的装置以及用于基于相关性从心室VT分类SVT的装置。

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