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1. 发明申请

US20100179146A1 Indolinone Compounds as Kinase Inhibitors 有权
标题翻译：吲哚酮化合物作为激酶抑制剂
公开(公告)号：US20100179146A1
公开(公告)日：2010-07-15
申请号：US12492281
申请日：2009-06-26
申请人： Jiann-Jyh Huang , Chao-Cheng Chiang , Chiawei Liu , Chun-Liang Lai , Shu Fu Lin , Yu-Hsiang Lin , Ru-Wen Wang , Sheng-Chuan Yang , Jia-Ming Chang , Shih-Hsien Chuang , Paonien Chen
发明人： Jiann-Jyh Huang , Chao-Cheng Chiang , Chiawei Liu , Chun-Liang Lai , Shu Fu Lin , Yu-Hsiang Lin , Ru-Wen Wang , Sheng-Chuan Yang , Jia-Ming Chang , Shih-Hsien Chuang , Paonien Chen
IPC分类号： A61K31/404 , C07D403/06 , C07D409/14 , C07D403/14 , C07D401/14 , C07D413/14 , A61K31/454 , A61K31/4439 , A61K31/5377 , A61K31/496 , A61P35/00 , A61P3/10 , A61P19/02 , A61P37/00
CPC分类号： C07D401/14 , A61K31/404 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5377 , C07D403/06 , C07D403/14 , C07D409/14
摘要： Indolinone compounds of formula (I) or (II): wherein A, R1, R2, R3, R4, R5, R6, R7, and n are defined herein. Also disclosed are methods for decreasing the activity of a protein kinase and for treating a protein kinase-related disease, such as cancer, with these compounds.
摘要翻译：式（I）或（II）的吲哚啉酮化合物：其中A，R1，R2，R3，R4，R5，R6，R7和n如本文所定义。还公开了用这些化合物降低蛋白激酶的活性和用于治疗蛋白激酶相关疾病如癌症的方法。

2. 发明授权

US07897602B2 Indolinone compounds as kinase inhibitors 有权
标题翻译：吲哚酮化合物作为激酶抑制剂
公开(公告)号：US07897602B2
公开(公告)日：2011-03-01
申请号：US12492281
申请日：2009-06-26
申请人： Jiann-Jyh Huang , Chao-Cheng Chiang , Chiawei Liu , Chun-Liang Lai , Shu Fu Lin , Yu-Hsiang Lin , Ru-Wen Wang , Sheng-Chuan Yang , Jia-Ming Chang , Shih-Hsien Chuang , Paonien Chen
发明人： Jiann-Jyh Huang , Chao-Cheng Chiang , Chiawei Liu , Chun-Liang Lai , Shu Fu Lin , Yu-Hsiang Lin , Ru-Wen Wang , Sheng-Chuan Yang , Jia-Ming Chang , Shih-Hsien Chuang , Paonien Chen
IPC分类号： A61K31/5377 , A61K31/496 , A61K31/454 , A61K31/404 , C07D413/14 , C07D403/14 , C07D401/14 , C07D403/06
CPC分类号： C07D401/14 , A61K31/404 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5377 , C07D403/06 , C07D403/14 , C07D409/14
摘要： Indolinone compounds of formula (I) or (II): wherein A, R1, R2, R3, R4, R5, R6, R7, and n are defined herein. Also disclosed are methods for decreasing the activity of a protein kinase and for treating a protein kinase-related disease, such as cancer, with these compounds.
摘要翻译：式（I）或（II）的吲哚啉酮化合物：其中A，R1，R2，R3，R4，R5，R6，R7和n如本文所定义。还公开了用这些化合物降低蛋白激酶的活性和用于治疗蛋白激酶相关疾病如癌症的方法。

3. 发明申请

US20120309821A1 Use of epigallocatechin-3-gallate for immune regulation 审中-公开
标题翻译：表没食子儿茶素-3-没食子酸酯用于免疫调节
公开(公告)号：US20120309821A1
公开(公告)日：2012-12-06
申请号：US13153088
申请日：2011-06-03
申请人： Ann Chen , Shuk-Man Ka , Jia-Ming Chang , Jiann-Jyh Huang
发明人： Ann Chen , Shuk-Man Ka , Jia-Ming Chang , Jiann-Jyh Huang
IPC分类号： A61K31/353 , A61P13/12 , A61P19/04
CPC分类号： A61K31/353
摘要： The preset invention relates to a method for treating lupus erythematosus, particularly lupus nephritis, comprising administering a subject in need thereof a therapeutically effective amount of epigallocatechin-3-gallate (EGCG) or a pharmaceutically acceptable salt or a physiologically functional derivative, together with one or more pharmaceutically acceptable carriers, diluents or excipients.
摘要翻译：本发明涉及一种治疗红斑狼疮，特别是狼疮肾炎的方法，其包括给予有需要的受试者治疗有效量的表没食子儿茶素-3-没食子酸酯（EGCG）或其药学上可接受的盐或生理功能衍生物，以及一种或更多的药学上可接受的载体，稀释剂或赋形剂。

4. 发明授权

US09150482B2 GLP-1 potentiators from hedychium coronarium and their applications 有权
标题翻译：来自hedychium coronarium的GLP-1增效剂及其应用
公开(公告)号：US09150482B2
公开(公告)日：2015-10-06
申请号：US13912102
申请日：2013-06-06
申请人： Rey-Yuh Wu , Hui-Ling Chen , Yu-Yuan Wu , Jiann-Jyh Huang , Shoei-Sheng Lee , K-Lim King
发明人： Rey-Yuh Wu , Hui-Ling Chen , Yu-Yuan Wu , Jiann-Jyh Huang , Shoei-Sheng Lee , K-Lim King
IPC分类号： A61K38/26 , A61K31/397 , A61K31/335 , C07C321/00 , C07C45/00 , C07C47/225 , C07D309/30 , C07D321/04 , C07C47/267 , C07D205/12 , C07D305/14 , A61K31/11 , A61K31/351 , A61K31/357 , C07C47/46 , A61K36/9068 , A61K45/06 , A61K31/365 , C07C47/277 , A61K31/337
CPC分类号： C07C47/225 , A61K31/11 , A61K31/337 , A61K31/351 , A61K31/357 , A61K31/365 , A61K31/397 , A61K36/9068 , A61K38/26 , A61K45/06 , C07C47/267 , C07C47/277 , C07C47/46 , C07C2602/26 , C07C2603/30 , C07D205/12 , C07D305/14 , C07D309/30 , C07D321/04 , A61K2300/00
摘要： A compound for controlling blood glucose level has a structure shown in Formula I: wherein R5-R8 are as defined herein. A method for controlling blood glucose level includes administering to a subject in need thereof a compound of Formula I. The method further includes administering to the subject a GLP-1 receptor ligand. The compound and the GLP-1 receptor ligand may be administered together. The compound may be Galanal A or Galanal B. The GLP-1 receptor ligand may be GLP-1 or exendin-4.
摘要翻译：用于控制血糖水平的化合物具有式I所示的结构：其中R5-R8如本文所定义。用于控制血糖水平的方法包括向有需要的受试者施用式I的化合物。该方法还包括向受试者施用GLP-1受体配体。化合物和GLP-1受体配体可以一起施用。该化合物可以是Galanal A或Galanal B. GLP-1受体配体可以是GLP-1或毒蜥外泌肽-4。

5. 发明授权

US06812247B2 Organometallic complex 失效
标题翻译：有机金属络合物
公开(公告)号：US06812247B2
公开(公告)日：2004-11-02
申请号：US10261130
申请日：2002-09-30
申请人： Kuang-Lieh Lu , Jih-Ru Hwu , Shwu-Chen Tsay , Sheng-Fa Yu , Jui-Te Hung , Jiann-Jyh Huang
发明人： Kuang-Lieh Lu , Jih-Ru Hwu , Shwu-Chen Tsay , Sheng-Fa Yu , Jui-Te Hung , Jiann-Jyh Huang
IPC分类号： A61K3324
CPC分类号： A61K31/282 , A61K31/555
摘要： A metal complex and its use for binding or cleaving a nucleic acid. The metal complex has the formula: M is Pt, Pd, Ni, Co, or Cu; X is aryl, heteroaryl, cyclyl, or heterocyclyl; Y is halogen, tosylate, mesylate, triflate, pyrophosphate, or carboxylate; each of A1 and A2, independently, is N or C; each of A3 and A4, independently, is N, S, or O, wherein A1, A2, A3, and A4 taken together have one positive charge; and each of R1 and R2, independently, is alkyl, aryl, heteroaryl, alkoxyl, aryloxyl, heteroaryloxyl, alkoxylcarbonyl, aryloxylcarbonyl, or heteroaryloxylcarbonyl.
摘要翻译：金属络合物及其用于结合或切割核酸的用途。金属络合物具有下式：M是Pt，Pd，Ni，Co或Cu; X是芳基，杂芳基，环基或杂环基; Y是卤素，甲苯磺酸酯，甲磺酸酯，三氟甲磺酸酯，焦磷酸酯或羧酸酯; A1和A2各自独立地为N或C; A3和A4各自独立地为N，S或O，其中A1，A2，A3和A4一起具有一个正电荷; R 1和R 2各自独立地是烷基，芳基，杂芳基，烷氧基，芳氧基，杂芳氧基，烷氧基羰基，芳氧基羰基或杂芳氧基羰基。

6. 发明授权

US06458833B1 Organometallic complex 失效
标题翻译：有机金属络合物
公开(公告)号：US06458833B1
公开(公告)日：2002-10-01
申请号：US09989768
申请日：2001-11-20
申请人： Kuang-Lieh Lu , Jih-Ru Hwu , Shwu-Chen Tsay , Sheng-Fa Yu , Jui-Te Hung , Jiann-Jyh Huang
发明人： Kuang-Lieh Lu , Jih-Ru Hwu , Shwu-Chen Tsay , Sheng-Fa Yu , Jui-Te Hung , Jiann-Jyh Huang
IPC分类号： A61K3324
CPC分类号： A61K31/282 , A61K31/555
摘要： A metal complex and its use for binding or cleaving a nucleic acid. The metal complex has the formula: M is Pt, Pd, Ni, Co, or Cu; X is aryl, heteroaryl, cyclyl, or heterocyclyl; Y is halogen, tosylate, mesylate, triflate, pyrophosphate, or carboxylate; each of A1 and A2, independently, is N or C; each of A3 and A4, independently, is N, S, or 0, wherein A1, A2, A3, and A4 taken together have one positive charge; and each of R1 and R2, independently, is alkyl, aryl, heteroaryl, alkoxyl, aryloxyl, heteroaryloxyl, alkoxylcarbonyl, aryloxylcarbonyl, or heteroaryloxylcarbonyl.
摘要翻译：金属络合物及其用于结合或切割核酸的用途。金属络合物具有下式：M是Pt，Pd，Ni，Co或Cu; X是芳基，杂芳基，环基或杂环基; Y是卤素，甲苯磺酸酯，甲磺酸酯，三氟甲磺酸酯，焦磷酸酯或羧酸酯; A1和A2各自独立地为N或C; A3和A4各自独立地为N，S或0，其中A1，A2，A3和A4一起具有一个正电荷; R 1和R 2各自独立地是烷基，芳基，杂芳基，烷氧基，芳氧基，杂芳氧基，烷氧基羰基，芳氧基羰基或杂芳氧基羰基。

7. 发明申请

US20130331323A1 GLP-1 POTENTIATORS FROM HEDYCHIUM CORONARIUM AND THEIR APPLICATIONS 有权
标题翻译：来自枸杞子的GLP-1电位及其应用
公开(公告)号：US20130331323A1
公开(公告)日：2013-12-12
申请号：US13912102
申请日：2013-06-06
申请人： Rey-Yuh Wu , Hui-Ling Chen , Yu-Yuan Wu , Jiann-Jyh Huang , Shoei-Sheng Lee , K-Lim King
发明人： Rey-Yuh Wu , Hui-Ling Chen , Yu-Yuan Wu , Jiann-Jyh Huang , Shoei-Sheng Lee , K-Lim King
IPC分类号： C07C47/225 , C07D321/04 , C07C47/267 , C07D205/12 , A61K38/26 , A61K31/11 , A61K31/351 , A61K31/357 , A61K31/337 , A61K31/397 , C07D309/30 , C07D305/14
CPC分类号： C07C47/225 , A61K31/11 , A61K31/337 , A61K31/351 , A61K31/357 , A61K31/365 , A61K31/397 , A61K36/9068 , A61K38/26 , A61K45/06 , C07C47/267 , C07C47/277 , C07C47/46 , C07C2602/26 , C07C2603/30 , C07D205/12 , C07D305/14 , C07D309/30 , C07D321/04 , A61K2300/00
摘要： A compound for controlling blood glucose level has a structure shown in Formula I: wherein R5-R8 are as defined herein. A method for controlling blood glucose level includes administering to a subject in need thereof a compound of Formula I. The method further includes administering to the subject a GLP-1 receptor ligand. The compound and the GLP-1 receptor ligand may be administered together. The compound may be Galanal A or Galanal B. The GLP-1 receptor ligand may be GLP-1 or exendin-4.
摘要翻译：用于控制血糖水平的化合物具有式I所示的结构：其中R5-R8如本文所定义。用于控制血糖水平的方法包括向有需要的受试者施用式I的化合物。该方法还包括向受试者施用GLP-1受体配体。化合物和GLP-1受体配体可以一起施用。该化合物可以是Galanal A或Galanal B. GLP-1受体配体可以是GLP-1或毒蜥外泌肽-4。

8. 发明申请

US20110230486A1 Modulators Of HEC1 Activity And Methods Therefor 有权
标题翻译： HEC1活性调节剂及其方法
公开(公告)号：US20110230486A1
公开(公告)日：2011-09-22
申请号：US13048709
申请日：2011-03-15
申请人： Johnson Lau , Jiann-Jyh Huang
发明人： Johnson Lau , Jiann-Jyh Huang
IPC分类号： A61K31/5377 , C07D417/12 , A61K31/4439 , A61K31/427 , C07D403/14 , A61K31/496 , C07D413/14 , A61K31/506 , A61K31/501 , A61P35/00
CPC分类号： C07D417/14 , A61K31/426 , A61K31/427 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/501 , A61K31/506 , A61K31/5377 , C07D277/44 , C07D417/12
摘要： Compounds, compositions, and methods for modulation of Hec1/Nek2 interaction are provided. Especially preferred compounds disrupt Nek2/Hec1 binding and are therefore useful as chemotherapeutic agent for neoplastic diseases.
摘要翻译：提供了用于调节Hec1 / Nek2相互作用的化合物，组合物和方法。特别优选的化合物破坏Nek2 / Hec1结合，因此可用作肿瘤性疾病的化学治疗剂。

9. 发明授权

US08785459B2 Quinazoline compounds as kinase inhibitors 有权
标题翻译：喹唑啉化合物作为激酶抑制剂
公开(公告)号：US08785459B2
公开(公告)日：2014-07-22
申请号：US13337863
申请日：2011-12-27
申请人： Jiann-Jyh Huang , Chu-Bin Liao , Pao-Nien Chen
发明人： Jiann-Jyh Huang , Chu-Bin Liao , Pao-Nien Chen
IPC分类号： A01N43/54 , A61K31/517 , C07D239/02 , C07D401/00 , C07D403/00 , C07D413/00 , C07D417/00 , C07D419/00
CPC分类号： C12N9/99 , C07D239/94 , C12Y207/00
摘要： A compound for treating protein kinase-related disease or disorder having a structure of formula (A): wherein X is N or CH; Y is NH, O, or CH2; Z is an aryl or a heteroaryl; and R1, R2, R3, and R4 are independently H, halo, nitro, cyano, aryl, heteroaryl, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, cycloalkenyl, heterocycloalkenyl, —ORa, —C(O)Ra, —C(O)NRaRb, —NRaC(O)Rb, —NRaRb, —S(O)2Ra, —S(O)2NRaRb, —NRaS(O)2Rb, —N═CRaRb, or —NRaC(O)NHRb, wherein each of Ra and Rb, independently, is H, alkyl, alkenyl, alkynyl, aryl, aryloxy, alkoxy, hydroxy, heteroaryl, cycloalkyl, heterocycloalkyl, cycloalkenyl, or heterocycloalkenyl, or Ra and Rb, together with the nitrogen atom to which they are bonded, form heteroaryl, heterocycloalkyl, or heterocycloalkenyl; or R3 and R4 are as defined above, and R1 and R2 together with the carbons, to which they are attached, form a heterocycloalkenyl or heteroaryl.
摘要翻译：一种用于治疗具有式（A）结构的蛋白激酶相关疾病或病症的化合物：其中X是N或CH; Y是NH，O或CH 2; Z是芳基或杂芳基; 并且R 1，R 2，R 3和R 4独立地是H，卤素，硝基，氰基，芳基，杂芳基，烷基，烯基，炔基，环烷基，杂环烷基，环烯基，杂环烯基，-OR a，-C（O） O）NR a R b，-NR a C（O）R b，-NR a R b，-S（O）2 R a，-S（O）2 NR a R b，-NR a（O）2 R b，-N = CR a R b或-NR a C（O）NHR b，的R a和R b独立地是H，烷基，烯基，炔基，芳基，芳氧基，烷氧基，羟基，杂芳基，环烷基，杂环烷基，环烯基或杂环烯基，或者R a和R b与它们所键合的氮原子一起，形成杂芳基，杂环烷基或杂环烯基; 或R 3和R 4如上所定义，并且R 1和R 2与它们所连接的碳一起形成杂环烯基或杂芳基。

10. 发明申请

US20130165458A1 QUINAZOLINE COMPOUNDS AS KINASE INHIBITORS 有权
标题翻译：喹唑啉化合物作为激酶抑制剂
公开(公告)号：US20130165458A1
公开(公告)日：2013-06-27
申请号：US13337863
申请日：2011-12-27
申请人： Jiann-Jyh Huang , Chu-Bin Liao , Pao-Nien Chen
发明人： Jiann-Jyh Huang , Chu-Bin Liao , Pao-Nien Chen
IPC分类号： A61K31/517 , C07D401/12 , C07D215/44 , A61K31/4706 , A61K31/4709 , C12N9/99 , A61P3/10 , A61P13/12 , A61P19/02 , A61P37/00 , A61P35/02 , C07D239/94 , A61P35/00
CPC分类号： C12N9/99 , C07D239/94 , C12Y207/00
摘要： A compound for treating protein kinase-related disease or disorder having a structure of formula (A): wherein X is N or CH; Y is NH, O, or CH2; Z is an aryl or a heteroaryl; and R1, R2, R3, and R4 are independently H, halo, nitro, cyano, aryl, heteroaryl, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, cycloalkenyl, heterocycloalkenyl, —ORa, —C(O)Ra, —C(O)NRaRb, —NRaC(O)Rb, —NRaRb, —S(O)2Ra, —S(O)2NRa Rb, —NRaS(O)2Rb, —N═CRaRb, or —NRaC(O)NHRb, wherein each of Ra and Rb, independently, is H, alkyl, alkenyl, alkynyl, aryl, aryloxy, alkoxy, hydroxy, heteroaryl, cycloalkyl, heterocycloalkyl, cycloalkenyl, or heterocycloalkenyl, or Ra and Rb, together with the nitrogen atom to which they are bonded, form heteroaryl, heterocycloalkyl, or heterocycloalkenyl; or R3 and R4 are as defined above, and R1 and R2 together with the carbons, to which they are attached, form a heterocycloalkenyl or heteroaryl.
摘要翻译：一种用于治疗具有式（A）结构的蛋白激酶相关疾病或病症的化合物：其中X是N或CH; Y是NH，O或CH 2; Z是芳基或杂芳基; 并且R 1，R 2，R 3和R 4独立地是H，卤素，硝基，氰基，芳基，杂芳基，烷基，烯基，炔基，环烷基，杂环烷基，环烯基，杂环烯基，-OR a，-C（O） O）NR a R b，-NR a C（O）R b，-NR a R b，-S（O）2 R a，-S（O）2 NR a R b，-NR a（O）2 R b，-N = CR a R b或-NR a C（O） R a和R b各自独立地是H，烷基，烯基，炔基，芳基，芳氧基，烷氧基，羟基，杂芳基，环烷基，杂环烷基，环烯基或杂环烯基，或者R a和R b与它们所在的氮原子一起杂芳基，杂环烷基或杂环烯基; 或R 3和R 4如上所定义，并且R 1和R 2与它们所连接的碳一起形成杂环烯基或杂芳基。

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