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1. 发明申请

US20110064721A1 CATHEPSIN-D NEUROPROTECTION 审中-公开
标题翻译： CATHEPSIN-D神经保护
公开(公告)号：US20110064721A1
公开(公告)日：2011-03-17
申请号：US12667832
申请日：2008-07-02
申请人： Jianhua Zhang , Guy Caldwell , Kevin Roth , David Standaert , Kim Cladwell , Shusei Hamamichi
发明人： Jianhua Zhang , Guy Caldwell , Kevin Roth , David Standaert , Kim Cladwell , Shusei Hamamichi
IPC分类号： A61K39/395 , C12Q1/37 , A61K38/02 , A61P25/28 , A61P25/16 , A61K31/7088 , C12Q1/68 , A61K38/48
CPC分类号： A61K31/47 , A61K38/488 , G01N33/5023 , G01N33/5088
摘要： Provided herein are methods and compositions for promoting neuroprotection in a subject and for treating a neural disorder associated with protein aggregation comprising administering to the subject an agent that increases expression or activity of cathepsin-D. Also provided are methods of screening for agents that increase expression or activity of cathepsin-D and methods of screening for neuroprotective agents.
摘要翻译：本文提供用于促进受试者中神经保护作用并用于治疗与蛋白质聚集相关的神经障碍的方法和组合物，包括向受试者施用增加组织蛋白酶D的表达或活性的试剂。还提供了筛选增加组织蛋白酶-D的表达或活性的试剂的方法和筛选神经保护剂的方法。

2. 发明授权

US10270282B2 Solar charger comprising a charging unit for charging a power battery to a high voltage, a photo-sensitive unit for detecting light intensity, a switch unit for regulating connection between the charging unit and the power battery, and a control unit for regulating the charging of the power battery based on a saturation level and the light intensity 有权
公开(公告)号：US10270282B2
公开(公告)日：2019-04-23
申请号：US13538016
申请日：2012-06-29
申请人： Guangxi Guo , Yang Xu , Shulin Liang , Jianhua Zhang
发明人： Guangxi Guo , Yang Xu , Shulin Liang , Jianhua Zhang
IPC分类号： H02J7/35 , H01L31/042 , H01M10/46
摘要： A solar charger for charging a power battery is provided, comprising: a photo-sensitive unit configured to detect light intensity; a charging unit configured to receive a voltage transformed from solar energy and to boost the voltage for charging the power battery; a switch unit coupled between the charging unit and the power battery and configured to disconnect the charging unit from the power battery or connect the charging unit with the power battery; and a control unit coupled to each of the photo-sensitive unit, the switch unit, and the charging unit, and configured to switch on the charging unit and the switch unit when the light intensity is higher than a first predetermined value to charge the power battery.

3. 发明授权

US09153794B2 Thin film encapsulation of organic light emitting diodes 有权
标题翻译：有机发光二极管的薄膜封装
公开(公告)号：US09153794B2
公开(公告)日：2015-10-06
申请号：US14003373
申请日：2011-05-11
申请人： Edward Feng , Jianhua Zhang
发明人： Edward Feng , Jianhua Zhang
IPC分类号： H01L51/44 , H01L51/56 , H01L51/52 , H01L51/00
CPC分类号： H01L51/56 , H01L51/0021 , H01L51/5206 , H01L51/5221 , H01L51/5231 , H01L51/5237 , H01L51/5253
摘要： A low temperature, low cost method of encapsulating organic light emitting diodes (OLED) that avoids damage to the OLED device. A metal passivation layer is formed using a plasma, UV-ozone, or wet chemical treatment, wherein the metal passivation layer serves to encapsulate and protect the OLED from moisture and oxygen. Alternatively, a buffer layer and a metal layer are formed onto the OLED and the metal layer is treated using a plasma, UV-ozone, or wet chemical treatment, to form a metal passivation layer that serves to encapsulate and protect the OLED from moisture and oxygen.
摘要翻译：封装有机发光二极管（OLED）的低温，低成本方法，其避免对OLED器件的损坏。使用等离子体，UV-臭氧或湿化学处理形成金属钝化层，其中金属钝化层用于将OLED封装并保护OLED免受湿气和氧气的侵害。或者，在OLED上形成缓冲层和金属层，并且使用等离子体，UV-臭氧或湿化学处理来处理金属层，以形成用于将OLED封装并保护OLED的金属钝化层，氧。

4. 发明授权

US08956867B2 Method for culturing stem cells 有权
标题翻译：培养干细胞的方法
公开(公告)号：US08956867B2
公开(公告)日：2015-02-17
申请号：US12615044
申请日：2009-11-09
申请人： Timothy J. Kamp , Jianhua Zhang , Jeffrey C. Mohr , Juan J. Depablo , Sean P. Palecek
发明人： Timothy J. Kamp , Jianhua Zhang , Jeffrey C. Mohr , Juan J. Depablo , Sean P. Palecek
IPC分类号： C12N5/00 , C12N5/02 , C12N5/071 , C07K16/18 , C12N5/073
CPC分类号： C07K16/18 , C12N5/0603 , C12N2533/90
摘要： A three-dimensional microwell system that supports long term pluripotent cell culture and formation of homogeneous embryoid bodies (EBs) is described. Microwell-cultured pluripotent cells remain viable and undifferentiated for several weeks in culture and maintain undifferentiated replication when passaged to Matrigel®-coated, tissue culture-treated polystyrene dishes. Microwell-cultured pluripotent cells maintain pluripotency, differentiating to each of the three embryonic germ layers. Pluripotent cell aggregates released from microwells can be passaged for undifferentiated replication or differentiated to monodisperse EBs. The ability to constrain pluripotent cell growth in three dimensions advantageously provides for more efficient, reproducible culture of undifferentiated cells, high-throughput screening, and the ability to direct pluripotent cell differentiation by generating monodisperse EBs of a desired size and shape. Cardiomyocyte-rich EBs are obtained from pluripotent cells cultured in microwells of defined size and shape.
摘要翻译：描述了支持长期多能细胞培养和形成均质胚状体（EB）的三维微孔系统。微培养的多能细胞在培养物中保持存活和未分化数周，并在传播至经Matrigel®涂覆的组织培养处理的聚苯乙烯培养皿时保持未分化的复制。微孔培养的多能细胞保持多能性，与三个胚胎胚层分化。可以将从微孔释放的多能细胞聚集体传代为未分化复制或分化为单分散EB。在三维中约束多能细胞生长的能力有利地提供了更有效，可重复的未分化细胞的培养，高通量筛选，以及通过产生所需大小和形状的单分散EB来引导多能细胞分化的能力。富含心肌细胞的EB是从在规定尺寸和形状的微孔中培养的多能细胞获得的。

5. 发明申请

US20110142935A1 CARDIAC DIFFERENTIATION OF HUMAN PLURIPOTENT STEM CELLS UNDER DEFINED CONDITIONS USING MATRIX OVERLAY METHODS 有权
标题翻译：使用矩阵覆盖方法定义的条件下人类间质干细胞的心脏分化
公开(公告)号：US20110142935A1
公开(公告)日：2011-06-16
申请号：US12946019
申请日：2010-11-15
申请人： Timothy J. Kamp , Sean Palecek , Jianhua Zhang , Samira Azarin , Xiaojun Lian
发明人： Timothy J. Kamp , Sean Palecek , Jianhua Zhang , Samira Azarin , Xiaojun Lian
IPC分类号： A61K9/00 , C12N5/077 , A61K35/34 , A61P9/00
CPC分类号： C12N5/0657 , C12N2501/155 , C12N2501/16 , C12N2501/727 , C12N2506/02 , C12N2506/45
摘要： Methods for culturing the pluripotent stem cells to undergo epithelial-to-mesenchymal transition and for generating high-yield, high-purity cardiomyocyte cultures from pluripotent stem cells are described. Pluripotent stem cells are cultured on a support with an overlaid matrix and, optionally, exposed to one or more factors to induce epithelial-to-mesenchymal transition and cardiogenesis.
摘要翻译：描述了培养多能干细胞进行上皮 - 间质转化和从多能干细胞产生高产量，高纯度心肌细胞培养物的方法。多能干细胞在具有重叠基质的载体上培养，并且任选地暴露于一种或多种因子以诱导上皮 - 间质转化和心脏发生。

6. 发明授权

US07690353B2 Synchronizing common rail pumping events with engine operation 失效
标题翻译：将共轨泵送事件与发动机运行同步
公开(公告)号：US07690353B2
公开(公告)日：2010-04-06
申请号：US11998652
申请日：2007-11-30
申请人： Scott Shafer , Jianhua Zhang , Daniel Ibrahim
发明人： Scott Shafer , Jianhua Zhang , Daniel Ibrahim
IPC分类号： F02M37/04
CPC分类号： F02M63/0225 , F02M39/00
摘要： Noise and vibrations associated with a common rail fuel system drive linkage are reduced by synchronizing a high pressure common rail supply pump with engine operation. This may be accomplished by selecting a linkage associated with a desired ratio of engine speed to pump speed along with selecting a number of pump plungers and cam lobes that results in synchronizing action of the pump with engine combustion events. In particular, a pattern of pumping events per engine cycle repeats during each engine cycle. In a more sophisticated version, the pattern of pumping events per engine cycle includes a sub-pattern of pumping events that repeats an integer number of times each engine cycle, where the integer number equals the number of engine cylinders.
摘要翻译：通过使高压共轨供油泵与发动机运转同步，减少与共轨燃油系统驱动联动系统相关的噪音和振动。这可以通过选择与期望的发动机转速与泵速的比例相关联的连杆来实现，同时选择一些泵柱塞和凸轮凸角，这导致泵与发动机燃烧事件的同步动作。特别地，每个发动机循环中的泵送事件的模式在每个发动机循环期间重复。在更复杂的版本中，每个发动机循环的泵送事件的模式包括泵送事件的子模式，其重复每个发动机循环的整数倍，其中整数等于发动机气缸的数量。

7. 发明申请

US20100005735A1 TELESCOPING SHORING POST WITH GROSS ADJUSTMENT CAPACITY 审中-公开
标题翻译：用调整能力调整短裤
公开(公告)号：US20100005735A1
公开(公告)日：2010-01-14
申请号：US12498643
申请日：2009-07-07
申请人： Paul Gillespie , Jianhua Zhang
发明人： Paul Gillespie , Jianhua Zhang
IPC分类号： E04C3/30
CPC分类号： E04G25/04 , E04G25/06
摘要： A telescoping shoring post having an inner tube having a plurality of projections spaced longitudinally thereon, longitudinally adjacent projections forming a groove there between to create a plurality of grooves on the inner tube; a hollow outer tube, the outer tube dimensions to allow the inner tube to slide therein; a load plate, the load plate having a collar adapted to affix the load plate to the outer tube and tongues projecting from the load plate, the tongues adapted to project over a hollow portion of the outer tube when the load plate is affixed to the outer tube, wherein the inner tube can slide within the outer tube to a gross adjustment extension length and wherein the tongues on the load plate are adapted to engage the grooves on the inner tube.
摘要翻译：一种伸缩式支柱，其具有内管，所述内管具有在其上纵向隔开的多个突起，纵向相邻的突起在其间形成凹槽，以在内管上形成多个凹槽; 一个中空的外管，外管尺寸允许内管在其中滑动; 负载板，该负载板具有适于将负载板固定到外管的凸缘和从负载板突出的舌片，所述舌片适于在所述负载板固定到所述外壳上时突出到所述外管的中空部分上管，其中内管可以在外管内滑动到大的调整延伸长度，并且其中装载板上的舌片适于接合内管上的凹槽。

8. 发明授权

US07444989B2 Opposed pumping load high pressure common rail fuel pump 有权
公开(公告)号：US07444989B2
公开(公告)日：2008-11-04
申请号：US11604579
申请日：2006-11-27
申请人： Scott F. Shafer , Timur Trubnikov , William John Love V , Heather Rebholz , Jianhua Zhang
发明人： Scott F. Shafer , Timur Trubnikov , William John Love V , Heather Rebholz , Jianhua Zhang
IPC分类号： F02M57/02 , F02M37/04 , F04B1/04
CPC分类号： F04B1/0413 , F02M59/06 , F02M59/366 , F02M63/0295 , F02M2200/03 , F04B1/02 , F04B1/0538 , F04B9/042 , F04B49/24 , F04B2201/1202 , F04B2201/1207
摘要： A high volume high pressure common rail pump for a fuel system includes pairs of pump head assemblies in phase with each other but oriented in opposition to one another about a rotating cam shaft. Pump pistons in the pump head assemblies simultaneously undergo pumping strokes via a shared two lobe cam of the rotating cam shaft. The pump may include two pairs of pump head assemblies, and each head assembly may include two pump pistons. The cam shaft includes two cams sufficiently out of phase with one another that the cam shaft always has a positive torque even when the cam lobes are symmetrical. In addition, because the pumping is done simultaneously on opposite sides of the cam shaft, the forces on the cam shaft are balanced and its support bearings experience less wear and tear.

9. 发明申请

US20050287021A1 Variable discharge fuel pump 有权
标题翻译：可变排放燃油泵
公开(公告)号：US20050287021A1
公开(公告)日：2005-12-29
申请号：US10874210
申请日：2004-06-24
申请人： Mandi Ferleyko , Scott Chockley , Ronald Shinogle , Scott Shafer , Jianhua Zhang
发明人： Mandi Ferleyko , Scott Chockley , Ronald Shinogle , Scott Shafer , Jianhua Zhang
IPC分类号： F04B17/00 , F04B35/04 , F04B49/24
CPC分类号： F04B49/24
摘要： A pump has a housing defining at least one pumping chamber, and a plunger slidably disposed within the at least one pumping chamber. The plunger is movable between a first and second spaced apart end positions to pressurize a fluid. The pump also has a driver operatively engaged with the plunger to move the plunger between the first end position and the second end position. The pump further has a high-pressure outlet in fluid communication with the at least one pumping chamber. The high pressure outlet passes pressurized fluid during movement of the plunger between the first end position and the second end position. The passing of pressurized fluid through the high-pressure outlet terminates before the plunger completes movement from the first end position to the second end position.
摘要翻译：泵具有限定至少一个泵送室的壳体和可滑动地设置在所述至少一个泵送室内的柱塞。柱塞可以在第一和第二间隔开的端部位置之间移动以对流体加压。泵还具有与柱塞可操作地接合的驱动器，以在第一端部位置和第二端部位置之间移动柱塞。泵还具有与至少一个泵送室流体连通的高压出口。高压出口在柱塞在第一端位置和第二端位置之间运动期间通过加压流体。加压流体通过高压出口的通过在柱塞从第一端部位置移动到第二端部位置之前终止。

10. 发明申请

US20150125975A1 THIN FILM ENCAPSULATION OF ORGANIC LIGHT EMITTING DIODES 审中-公开
标题翻译：有机发光二极管的薄膜封装
公开(公告)号：US20150125975A1
公开(公告)日：2015-05-07
申请号：US14003373
申请日：2011-05-11
申请人： Edward Feng , Jianhua Zhang
发明人： Edward Feng , Jianhua Zhang
IPC分类号： H01L51/56 , H01L51/00 , H01L51/52
CPC分类号： H01L51/56 , H01L51/0021 , H01L51/5206 , H01L51/5221 , H01L51/5231 , H01L51/5237 , H01L51/5253
摘要： A low temperature, low cost method of encapsulating organic light emitting diodes (OLED) that avoids damage to the OLED device. One method comprises forming a metal passivation layer using a plasma, UV-ozone, or wet chemical treatment, wherein the metal passivation layer serves to encapsulate and protect the OLED from moisture and oxygen. Another method comprises forming a buffer layer and a metal layer onto the OLED and then treating the metal layer using a plasma, UV-ozone, or wet chemical treatment, to form a metal passivation layer that serves to encapsulate and protect the OLED from moisture and oxygen.
摘要翻译：封装有机发光二极管（OLED）的低温，低成本方法，其避免对OLED器件的损坏。一种方法包括使用等离子体，UV-臭氧或湿化学处理形成金属钝化层，其中金属钝化层用于将OLED封装并保护OLED免受湿气和氧气的侵害。另一种方法包括在OLED上形成缓冲层和金属层，然后使用等离子体，UV-臭氧或湿化学处理来处理金属层，以形成用于封装和保护OLED免受湿气影响的金属钝化层，以及氧。

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