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1. 发明授权

US5638820A Ultrasound system for estimating the speed of sound in body tissue 失效
标题翻译：用于估计身体组织中声音速度的超声系统
公开(公告)号：US5638820A
公开(公告)日：1997-06-17
申请号：US674652
申请日：1996-06-25
申请人： Jian-Feng Chen , Lin-Xin Yao , Patrick L. Von Behren
发明人： Jian-Feng Chen , Lin-Xin Yao , Patrick L. Von Behren
IPC分类号： G01H5/00 , G01N29/07 , G01N29/44 , G01N29/50 , G01S7/52 , A61B8/00
CPC分类号： G01N29/4427 , G01H5/00 , G01N29/07 , G01N29/50 , G01S7/52049 , G01N2291/011 , G01N2291/02475 , G01S7/5205 , G01S7/52071
摘要： An ultrasound system (50) estimates the speed of sound in the tissue (60) under examination. The ultrasound system obtains a series of test images (150) using different estimates of the speed of sound in the body tissue. For each image produced, the ultrasound system computes a function that is indicative of image quality for one or more regions of interest (152) in the test image. The image quality function exhibits a minimum or maximum when computed for a region of interest obtained at a speed of sound substantially equal to a true speed of sound in the tissue. The ultrasound system selects the test image having the minimum or maximum function value and obtains subsequent images of the tissue using the speed of sound used to obtain the test image selected.
摘要翻译：超声系统（50）估计检查中的组织（60）中的声音速度。超声系统使用不同的身体组织中声速的估计来获得一系列测试图像（150）。对于所产生的每个图像，超声系统计算在测试图像中指示一个或多个感兴趣区域（152）的图像质量的函数。当以基本上等于组织中的真实速度的声音的速度获得的感兴趣区域计算时，图像质量函数表现出最小或最大值。超声系统选择具有最小或最大功能值的测试图像，并使用用于获得所选择的测试图像的声速来获得组织的后续图像。

2. 发明授权

US06558324B1 System and method for strain image display 有权
标题翻译：应变图像显示系统和方法
公开(公告)号：US06558324B1
公开(公告)日：2003-05-06
申请号：US09994589
申请日：2001-11-20
申请人： Patrick L. Von Behren , Dong-Cyuan Liu , Jian-Feng Chen
发明人： Patrick L. Von Behren , Dong-Cyuan Liu , Jian-Feng Chen
IPC分类号： A61B800
CPC分类号： A61B8/485 , A61B8/08 , A61B8/0825 , A61B8/463 , A61B8/5276 , G01S7/52034 , G01S7/52042 , G01S7/52069 , G01S7/52071 , G01S7/52074 , G01S15/8993
摘要： A region of interest (ROI) of a patient's body is repeatedly scanned using an ultrasound transducer array. Data sets representing an image property, such as intensity, from portions of the ROI are used to calculate a representation of the displacement profile within the ROI at different stress levels. From the displacement profile, a function of strain is also preferably calculated. According to one aspect of the invention, a data set representing an estimate of the elasticity profile within the ROI is color-coded and is displayed along with a B-mode display in a single, overlaid display. According to another aspect of the preferred embodiment of the invention, the display of elasticity is adaptively persisted as a function of, for example, a measure of image quality. The invention also provides an on-screen guide that indicates to a user a measure of quality of each of a series of estimated displacement data sets.
摘要翻译：使用超声波换能器阵列重复扫描患者身体的感兴趣区域（ROI）。使用表示来自ROI部分的图像属性（例如强度）的数据集来计算在不同应力水平下ROI内的位移曲线的表示。从位移分布中，也优选计算应变的函数。根据本发明的一个方面，表示ROI内的弹性分布的估计的数据集是彩色编码的，并且在单个重叠显示中与B模式显示一起显示。根据本发明的优选实施例的另一方面，作为例如图像质量的度量的函数，弹性显示被自适应地持续。本发明还提供一种屏幕指南，其向用户指示一系列估计位移数据集中的每一个的质量的量度。

3. 发明授权

US07050610B2 Method and system for improving the spatial resolution for strain imaging 有权
公开(公告)号：US07050610B2
公开(公告)日：2006-05-23
申请号：US09825783
申请日：2001-04-04
申请人： Jian-Feng Chen , Patrick L. Von Behren
发明人： Jian-Feng Chen , Patrick L. Von Behren
IPC分类号： G06K9/00
CPC分类号： A61B8/485 , A61B8/0825 , A61B8/0833 , G01S7/52036 , G01S7/52042 , G01S7/5206 , G01S15/8981
摘要： A method and system for quantification of strain imaging is disclosed. The method and system comprises performing a motion analysis on the at least two regions of interest. The method and system further includes providing a strain estimate for each of the at least two regions of interest and comparing the strain estimates of each of the at least two regions to quantify the strain for the at least two regions of interest. A system and method in accordance with the present invention provides for strain quantification based on conventional B-mode images. Using this technique, the strain of regions of interest (ROI) defined by users can be determined and quantitative comparisons can be effectively made in real time. The strain quantification can be used to determine tissue's properties and can potentially be applied in breast imaging as well as cardiac imaging.

4. 发明授权

US07033320B2 Extended volume ultrasound data acquisition 有权
标题翻译：扩展体积超声数据采集
公开(公告)号：US07033320B2
公开(公告)日：2006-04-25
申请号：US10635193
申请日：2003-08-05
申请人： Patrick L. Von Behren , Jian-Feng Chen
发明人： Patrick L. Von Behren , Jian-Feng Chen
IPC分类号： A61B8/00
CPC分类号： G01S7/52065 , A61B8/00 , A61B8/4254 , A61B8/483 , G01S15/66 , G01S15/8993 , Y10S128/916
摘要： Three or four-dimensional ultrasound data acquisition for extended field of view imaging is provided. Multiple volumes are registered with respect to each other and spliced together to form an extended volume. The extended volume is a contiguous volume larger than a volumetric region that a multi-dimensional or wobbler transducer array is capable of imaging without movement. Information representing different volumes is registered with respect to each other by sensing the transducer position associated with each of the different volumes. The position is sensed using a position sensing mechanism, such as magnetic optical or gyroscope measurements. Acoustic data may be used to determine decorrelation of speckle or correlation of features to sense position. After the volumes are registered, any overlapping regions are compounded. The resulting extended field of view volume is displayed and manipulated for viewing by the user. A large volume or extended volume of the patient is used for assessing an organ, such as an entire fetus in OB applications.
摘要翻译：提供用于扩展视野成像的三维或四维超声数据采集。将多个卷相对于彼此登记并拼接在一起以形成扩展卷。扩展体积是大于容积区域的连续体积，多维或摇摆换能器阵列能够在无移动的情况下成像。通过感测与每个不同体积相关联的换能器位置，相对于彼此登记表示不同体积的信息。使用诸如磁光学或陀螺仪测量的位置感测机构感测位置。声学数据可用于确定斑点的去相关或特征的相关性以感测位置。卷注册后，任何重叠区域都会复合。显示和操作所产生的扩展视野音量以供用户查看。大量或扩大体积的患者用于评估器官，例如OB应用中的整个胎儿。

5. 发明授权

US5619999A Body surface position locator for ultrasound transducer 失效
标题翻译：超声波换能器的体表位置定位器
公开(公告)号：US5619999A
公开(公告)日：1997-04-15
申请号：US580147
申请日：1995-12-28
申请人： Patrick L. Von Behren , David J. Thomas
发明人： Patrick L. Von Behren , David J. Thomas
IPC分类号： A61B8/08 , G03B42/00
CPC分类号： A61B8/08
摘要： An ultrasound imaging system comprises a position location array adapted to be affixed to a surface layer of an imaging subject. The position location array comprises a plurality of electrodes disposed in a grid pattern within a flexible substrate. An imaging transducer having at least one element is operable to provide an acoustic pulse through the position location array and the surface layer in response to a driving signal and to provide a corresponding return signal in response thereto. A receiver is coupled to the imaging transducer to receive the return signal from the at least one element and provide a beamformed signal. A processor coupled to the receiver and the position location array forms an image from the beamformed signal that includes position coordinates that correspond to an intersection between the acoustic pulse and associated ones of the plurality of electrodes.
摘要翻译：超声成像系统包括适于固定到成像对象的表面层的位置阵列。位置阵列包括以柔性基底内的网格图案设置的多个电极。具有至少一个元件的成像传感器可操作以响应于驱动信号而通过位置阵列和表面层提供声脉冲，并响应于此产生相应的返回信号。接收器耦合到成像换能器以接收来自至少一个元件的返回信号并且提供波束形成的信号。耦合到接收器和位置阵列的处理器形成来自波束形成信号的图像，该波束形成信号包括对应于声脉冲和多个电极中的相关联电极之间的交点的位置坐标。

6. 发明授权

US07356172B2 Methods and systems for motion tracking 有权
标题翻译：运动跟踪的方法和系统
公开(公告)号：US07356172B2
公开(公告)日：2008-04-08
申请号：US10259350
申请日：2002-09-26
申请人： Liexiang Fan , Patrick L. Von Behren , Arun P. Tirumalai , Zuhua Mao
发明人： Liexiang Fan , Patrick L. Von Behren , Arun P. Tirumalai , Zuhua Mao
IPC分类号： G06K9/00 , G06K9/36 , A61B5/00
CPC分类号： G06T7/251 , G06T7/246 , G06T2207/30004 , G06T2207/30204
摘要： Systems and methods are described for tracking motion in a medical imaging system. The methods use landmark sets including hard landmarks and soft landmarks. The systems can include means for generating a landmark set, means for constructing a landmark set spatial relationship, means for computing a context similarity measurement, means for cost function construction, and means for cost function minimization and motion estimation. The invention provides advantages because, among other reasons, the use of a cost function of two or more variables, where the cost function is defined over members of the landmark set collection, and the cost function subject to at least two constraints and the landmark set stability in terms of context similarity measurements and spatial relationship provide effective and robust motion tracking.
摘要翻译：描述了用于在医学成像系统中跟踪运动的系统和方法。这些方法使用地标集，包括硬地标和软地标。该系统可以包括用于生成地标集的装置，用于构建地标集合空间关系的装置，用于计算上下文相关度测量的装置，用于成本函数构造的装置，以及用于成本函数最小化和运动估计的装置。本发明提供了优点，因为除了其他原因之外，使用两个或多个变量的成本函数，其中成本函数被定义在地标集合集合的成员上，并且成本函数受到至少两个约束和地标集合在上下文相似度测量和空间关系方面的稳定性提供有效和鲁棒的运动跟踪。

7. 发明授权

US06824518B2 High transmit power diagnostic ultrasound imaging 有权
标题翻译：高传输功率诊断超声成像
公开(公告)号：US06824518B2
公开(公告)日：2004-11-30
申请号：US10304350
申请日：2002-11-26
申请人： Patrick L. Von Behren , Alampallam R. Ramachandran , Zoran B. Banjanin , Wayne J. Gueck
发明人： Patrick L. Von Behren , Alampallam R. Ramachandran , Zoran B. Banjanin , Wayne J. Gueck
IPC分类号： A61B800
CPC分类号： A61B8/00 , A61B8/467 , A61B8/543 , A61B8/546 , G01S7/52019 , G01S15/895
摘要： Methods and systems for improving an ultrasound image quality are provided. On demand transmission of unsustainably high power ultrasonic pulses are temporary or spatially interleaved with low power, zero power, or standard ultrasonic pulses. In response to a user initiated trigger, a physiological trigger, a system trigger, or external equipment trigger, the unsustainably high power pulses provide better signal-to-noise ratio and/or allow increased imaging frequencies for difficult to image patients in any of various modes, such as B-modes, harmonic B-mode responsive to tissue or contrast agent, or color flow modes. Unsustainably high power ultrasonic pulses cause an increase in the tissue temperature within the body and at the interface between the transducer and the skin. Standard imagining or standard high power pulses may increase either temperature by around 6° C., such as from a body normal 37° C. to an average of 43° C. over time. The unsustainably high power ultrasonic pulses may cause the temperature to exceed 43° C. for a limited time period. For example, the in-situ temperature may be increased to 50° C. for one second, but the temperature is not sustained at this level. Tissue damage may occur for increased temperature over a long period of time, unlike the standard 43° C. for ultrasound imaging. A thermocouple or/and software for temperature and procedure monitoring prevent operator errors in causing harm to patient and/or transducer.
摘要翻译：提供了改善超声图像质量的方法和系统。按需传输不可持续的高功率超声波脉冲是在低功率，零功率或标准超声波脉冲下进行临时或空间交错的。响应于用户发起的触发，生理触发，系统触发或外部设备触发，不可持续的高功率脉冲提供更好的信噪比和/或允许增加的成像频率，用于难以映像的患者中的任何一种模式，例如B模式，响应于组织或造影剂的谐波B模式或颜色流动模式。不可持续的高功率超声脉冲导致体内组织温度和换能器与皮肤之间的界面增加。标准想象或标准高功率脉冲可以将温度升高约6℃，例如从正常37℃至平均43℃随时间增加。不可持续的高功率超声波脉冲可能导致温度超过43°C在有限的时间段内。例如，原位温度可以增加到50℃一秒钟，但温度不能维持在该水平。组织损伤可能发生在长时间内升高的温度，与标准43°C超声成像不同。用于温度和程序监控的热电偶或/和软件可防止操作员对患者和/或换能器造成伤害的错误。

8. 发明授权

US06626836B2 Adaptive signal processing scheme for contrast agent imaging 有权
公开(公告)号：US06626836B2
公开(公告)日：2003-09-30
申请号：US09825814
申请日：2001-04-04
申请人： Zuhua Mao , Hui Jiang , Patrick L. Von Behren
发明人： Zuhua Mao , Hui Jiang , Patrick L. Von Behren
IPC分类号： A61B800
CPC分类号： A61B8/481
摘要： An ultrasound system includes a transmit/receive switch (502), at least one frequency band selection circuit (512), and a selection unit (511). The selection unit (511) is used to determine if the data being received are from tissue or contrast agent regions. Depending on which type of region the data are from, different signal processing techniques are applied to the data. For example for tissue regions, a harmonic filter can be applied to the signal. If the signals are from contrast agent flow regions, both the harmonic filter and a fundamental filter can be used.

9. 发明授权

US4458688A Method and apparatus for cardiac nuclear imaging 失效
标题翻译：心脏核成像的方法和装置
公开(公告)号：US4458688A
公开(公告)日：1984-07-10
申请号：US395735
申请日：1982-07-06
申请人： Patrick L. Von Behren
发明人： Patrick L. Von Behren
IPC分类号： G01T1/164 , G06F17/00 , G06F15/42 , A61B6/00 , G01N23/04
CPC分类号： G01T1/1648 , A61B6/4258 , Y10S378/901
摘要： Counts of a gamma camera, acquired during a nuclear cardiac structure examination, which represent time-activity curves at different locations of a pixel matrix of the cardiac structure are fitted to a cosine wave function. From said fitted function the wave amplitude, phase, and an error value (representing the reliability of the acquired time-activity curve) are extracted. Finally, for each location in the pixel matrix said extracted values are simultaneously displayed as they are acquired.
摘要翻译：在核心结构检查期间获取的表示心脏结构的像素矩阵的不同位置处的时间 - 活动曲线的伽马相机的计数被拟合到余弦波函数。从所述拟合函数中提取波幅，相位和误差值（表示所获得的时间 - 活动曲线的可靠性）。最后，对于像素矩阵中的每个位置，所提取的值在被获取时同时显示。

10. 发明授权

US07097619B2 Elevation beam pattern variation for ultrasound imaging 有权
标题翻译：用于超声成像的仰角波束模式变化
公开(公告)号：US07097619B2
公开(公告)日：2006-08-29
申请号：US10403259
申请日：2003-03-31
申请人： Patrick L. Von Behren , Paul D. Freiburger
发明人： Patrick L. Von Behren , Paul D. Freiburger
IPC分类号： A61B8/00
CPC分类号： G01S7/52046 , A61B8/00 , G01S7/52077 , G01S15/8925 , G01S15/8995
摘要： Methods and systems vary the elevation beam pattern during an imaging session. A user based or automatic search mode is provided where one or more elevation beam thicknesses are used, and then a diagnosis mode is provided where an optimal or narrow elevation beam thickness is used for continued imaging. 1.25, 1.5, 1.75 and 2D arrays are used to obtain frames of data responsive to the varied elevation beam pattern.
摘要翻译：方法和系统在成像会话期间改变仰角波束图案。提供基于用户的或自动搜索模式，其中使用一个或多个仰角光束厚度，然后提供诊断模式，其中使用最佳或窄的仰角光束厚度进行连续成像。 1.25,1.5,1.75和2D阵列用于响应于不同的仰角波束图案来获得数据帧。

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