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1. 发明申请

US20210047329A1 SUBSTITUTED 4,6-DIHYDROSPIRO[[1,2,3]TRIAZOLO[4,5-B]PYRIDINE-7,3'-INDOLINE]-2',5(3H)-DIONE ANALOGUES 有权
公开(公告)号：US20210047329A1
公开(公告)日：2021-02-18
申请号：US16938886
申请日：2020-07-24
申请人： Jia Zhou , Pei-Yong Shi , Jimin Xu , Xuping Xie
发明人： Jia Zhou , Pei-Yong Shi , Jimin Xu , Xuping Xie
IPC分类号： C07D471/20 , A61P31/14
摘要： A series of substituted 4,6-dihydrospiro[[1,2,3]triazolo[4,5-b]pyridine-7,3′-indoline]-2′,5(3H)-dione analogues, the use thereof and the preparation thereof.

2. 发明授权

US11407752B2 Substituted 4,6-dihydrospiro[[1,2,3]triazolo[4,5-b]pyridine-7,3′-indoline]-2′,5(3H)-dione analogues 有权
公开(公告)号：US11407752B2
公开(公告)日：2022-08-09
申请号：US16938886
申请日：2020-07-24
申请人： Jia Zhou , Pei-Yong Shi , Jimin Xu , Xuping Xie
发明人： Jia Zhou , Pei-Yong Shi , Jimin Xu , Xuping Xie
IPC分类号： C07D471/20 , C07D495/04 , A61P31/14
摘要： A series of substituted 4,6-dihydrospiro[[1,2,3]triazolo[4,5-b]pyridine-7,3′-indoline]-2′,5(3H)-dione analogues, the use thereof and the preparation thereof.

3. 发明授权

US11117865B2 Inhibitors of bromodomain-containing protein 4 (BRD4) 有权
公开(公告)号：US11117865B2
公开(公告)日：2021-09-14
申请号：US16442526
申请日：2019-06-16
申请人： Jia Zhou , Allan R. Brasier , Bing Tian , Zhiqing Liu , Haiying Chen , Erik Rytting
发明人： Jia Zhou , Allan R. Brasier , Bing Tian , Zhiqing Liu , Haiying Chen , Erik Rytting
IPC分类号： A61K9/14 , A61P29/00 , C07D311/00 , C07D215/38 , C07D207/48 , C07D241/04 , C07D311/30 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D413/04 , C07D413/06 , C07D413/14 , C07D471/04
摘要： Certain embodiments are directed to small molecule selective inhibitors of the BRD4 bromodomain. Compounds described herein can be used to modulate the bronchiolar NFkB-BRD4 axis, which plays a role in acute neutrophilic response to viral molecular patterns. Compounds described herein can be developed as preventive and therapeutic agents for various human diseases and conditions.

4. 发明申请

US20190292168A1 NOVEL SMALL MOLECULE BRD4 MODULATORS FOR HIV EPIGENETIC REGULATION 审中-公开
公开(公告)号：US20190292168A1
公开(公告)日：2019-09-26
申请号：US16441748
申请日：2019-06-14
申请人： Haitao Hu , Jia Zhou , Zhiqing Liu
发明人： Haitao Hu , Jia Zhou , Zhiqing Liu
IPC分类号： C07D403/06 , C07D401/06 , C07D207/48 , A61P31/18
摘要： The invention relates generally to novel small molecule BRD4 modulators for HIV, the preparation thereof as well as the use thereof.

5. 发明授权

US10161223B2 Use of superabsorbent polymers for pressure control and diversion applications 有权
公开(公告)号：US10161223B2
公开(公告)日：2018-12-25
申请号：US15084598
申请日：2016-03-30
申请人： Jia Zhou , Harold Dean Brannon , Paul S. Carman , Leiming Li , Thomas Ray Starks , D. V. Satyanarayana Gupta , Harold G. Hudson , Scott G. Nelson
发明人： Jia Zhou , Harold Dean Brannon , Paul S. Carman , Leiming Li , Thomas Ray Starks , D. V. Satyanarayana Gupta , Harold G. Hudson , Scott G. Nelson
IPC分类号： E21B37/06 , C09K8/52 , E21B33/134 , C09K8/62 , C09K8/70 , C09K8/80 , E21B43/26 , E21B43/267 , C09K8/76 , E21B33/138 , C09K8/575 , C09K8/68 , E21B43/04 , C09K8/035 , C09K8/12 , C09K8/34 , E21B21/00
摘要： A method of hydraulically fracturing a subterranean formation penetrated by a wellbore comprises: providing a diverting fluid comprising a carrier fluid, a first superabsorbent polymer and a second superabsorbent polymer, the second superabsorbent polymer having a shape, or a composition, or a combination thereof different from that of the first superabsorbent polymer; injecting the diverting fluid into the subterranean formation; and injecting a fracturing fluid into the formation after injecting the diverting fluid. A viscosity modifying agent can be present in the diverting fluid. Superabsorbent polymers can also be used to develop a temporary filter cake at the formation face to reduce or eliminate the fluid leakoff out of the wellbore.

6. 发明授权

US10113396B2 Fracturing fluids and methods of treating hydrocarbon formations 有权
公开(公告)号：US10113396B2
公开(公告)日：2018-10-30
申请号：US15084833
申请日：2016-03-30
申请人： Scott Gregory Nelson , Hong Sun , Jia Zhou , Leiming Li , Xiaolan Wang , Qi Qu
发明人： Scott Gregory Nelson , Hong Sun , Jia Zhou , Leiming Li , Xiaolan Wang , Qi Qu
IPC分类号： E21B43/267 , E21B37/06 , C09K8/52 , E21B33/134 , C09K8/62 , C09K8/70 , C09K8/80 , E21B43/26 , C09K8/76 , E21B33/138 , C09K8/575 , C09K8/68 , E21B43/04 , C09K8/035 , C09K8/12 , C09K8/34 , E21B21/00
摘要： A method of fracturing a subterranean formation penetrated by a well comprises: forming a fracturing composition comprising a carrier fluid; and a superabsorbent polymer component comprising one or more of the following: a first composite of a proppant and a first superabsorbent polymer in an unhydrated form, the first superabsorbent polymer being at least partially embedded in a void area of the proppant; a coated superabsorbent polymer; a superabsorbent material having a three-dimensional network; or a second composite of a second superabsorbent polymer and a slow-release breaker; and pumping the hydraulic fracturing composition into the subterranean formation to create or enlarge a fracture.

7. 发明授权

US09828844B2 Hydraulic fracturing composition, method for making and use of same 有权
$Hydraulic fracturing composition, method for making and use of same$
公开(公告)号：US09828844B2
公开(公告)日：2017-11-28
申请号：US14169698
申请日：2014-01-31
申请人： Jia Zhou , Qi Qu , Scott G. Nelson , Hong Sun , Leiming Li
发明人： Jia Zhou , Qi Qu , Scott G. Nelson , Hong Sun , Leiming Li
IPC分类号： E21B43/267 , C09K8/68
CPC分类号： E21B43/267 , C09K8/685 , C09K2208/26
摘要： A hydraulic fracturing composition includes: a superabsorbent polymer in an expanded state; a plurality of proppant particles disposed in the superabsorbent polymer; an additive comprising a surfactant, a viscose polymer, or a combination thereof, and a fluid to expand the superabsorbent polymer into the expanded state. A process for disposing a plurality of proppant particles in a fracture comprises: disposing a hydraulic fracturing composition in a downhole environment; forming a fracture; disposing the hydraulic fracturing composition in the fracture; breaking the superabsorbent polymer after forming the fracture; and releasing the plurality of proppant particles from superabsorbent polymer. The process also comprises injecting a proppant-free fluid and a proppant-containing fluid in an alternating order into a subterranean formation.

8. 发明申请

US20170239346A1 NOVEL COCAINE HAPTENS AND NANOFIBER-BASED COCAINE VACCINES 审中-公开
公开(公告)号：US20170239346A1
公开(公告)日：2017-08-24
申请号：US15441474
申请日：2017-02-24
申请人： Jia Zhou , Jai S. Rudra , Kathryn A. Cunningham
发明人： Jia Zhou , Jai S. Rudra , Kathryn A. Cunningham
IPC分类号： A61K39/385 , A61K39/00
CPC分类号： A61K39/385 , A61K39/0013 , A61K2039/6012 , A61K2039/6031 , A61K2039/627
摘要： Certain embodiments are directed to chemically defined self-adjuvanting cocaine vaccines composed of novel cocaine haptens and self-assembling peptide domains.

9. 发明申请

US20160347985A1 FLUIDS AND METHODS FOR TREATING HYDROCARBON-BEARING FORMATIONS 审中-公开
标题翻译：用于处理碳氢化合物轴承的流体和方法
公开(公告)号：US20160347985A1
公开(公告)日：2016-12-01
申请号：US15153870
申请日：2016-05-13
申请人： Leiming Li , Jia Zhou , Hong Sun , Harold D. Brannon , Magnus Legemah
发明人： Leiming Li , Jia Zhou , Hong Sun , Harold D. Brannon , Magnus Legemah
IPC分类号： C09K8/512 , E21B43/26 , E21B33/138 , C09K8/502
CPC分类号： E21B43/267 , C09K8/508 , C09K8/605 , C09K8/80 , C09K2208/08 , C09K2208/20 , C09K2208/24 , C09K2208/26
摘要： A fluid for temporarily plugging a hydrocarbon-bearing formation is disclosed. The fluid includes a carrier fluid and a crosslinked synthetic polymer, wherein the polymer comprises a labile group to degrade the polymer when exposed to a change in a condition of the fluid.
摘要翻译：公开了一种用于暂时堵塞含烃地层的流体。流体包括载体流体和交联的合成聚合物，其中当暴露于流体状态的变化时，聚合物包含不稳定基团以降解聚合物。

10. 发明授权

US09134821B2 Method and device for implemeting original calligraphy of handwriting 有权
标题翻译：手写原版书法的方法和装置
公开(公告)号：US09134821B2
公开(公告)日：2015-09-15
申请号：US13981083
申请日：2012-01-18
申请人： Xueping Zou , Jia Zhou , Guoying Du
发明人： Xueping Zou , Jia Zhou , Guoying Du
IPC分类号： G06F3/0354 , G06T11/20 , G06F3/0488
CPC分类号： G06F3/03545 , G06F3/04883 , G06T11/203
摘要： Provided are a method and device for implementing the original calligraphy of handwriting. The method comprises: carrying out a real time sampling of a contact to obtain position information about the sampling point and the pen width at the sampling point; determining a central line of the stroke determined by adjacent sampling points; determining position information about a key point of the corresponding stroke according to the central line and the pen width at the sampling point; dividing the key point of the stroke into groups to determine the type thereof; generating a calligraphy outline of the corresponding stroke by drawing an arc and/or a line according to the type of the key point and the position information about the same; and finally filling the outline for displaying. The displayed handwriting trace has the same calligraphy of handwriting as characters written on paper.
摘要翻译：提供了一种用于实现原始书法书法的方法和装置。该方法包括：对接触点进行实时取样以获取关于取样点的位置信息和采样点的笔宽度; 确定由相邻采样点确定的行程的中心线; 根据中心线和采样点的笔宽确定关于相应笔画的关键点的位置信息; 将笔画的关键点划分成组，以确定其类型; 通过根据关键点的类型和关于该关键点的位置信息绘制圆弧和/或线来产生对应行程的书法轮廓; 最后填写轮廓显示。显示的手写痕迹具有与写在纸上的字符相同的笔迹书法。

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