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1. 发明授权

US06830893B2 T20/DP178 is an activator of human phagocyte formyl peptide receptors 失效
标题翻译： T20 / DP178是人类吞噬细胞甲酰肽受体的激活剂
公开(公告)号：US06830893B2
公开(公告)日：2004-12-14
申请号：US10005305
申请日：2001-11-02
申请人： Ji Ming Wang , Joost J. Oppenheim , Shao-Bo Su , Wang Hua Gong , Ji-Liang Gao , Philip M. Murphy
发明人： Ji Ming Wang , Joost J. Oppenheim , Shao-Bo Su , Wang Hua Gong , Ji-Liang Gao , Philip M. Murphy
IPC分类号： G01N3350
CPC分类号： C07K14/005 , A61K38/00 , C12N2740/16122
摘要： The present invention relates to the discovery that T20/DP178, T21/DP107, and fragments thereof interact with members of the formyl peptide receptor family and thereby modulate cell migration and activation. Novel biological tools, prophylactics, therapeutics and methods of use of the foregoing for modulating an inflammatory response are disclosed.
摘要翻译：本发明涉及T20 / DP178，T21 / DP107及其片段与甲酰基肽受体家族的成员相互作用并由此调节细胞迁移和活化的发现。公开了新的生物工具，预防剂，治疗剂和前述用于调节炎症反应的方法。

2. 发明授权

US08198042B2 CC chemokine receptor 5 DNA, new animal models and therapeutic agents for HIV infection 有权
标题翻译： CC趋化因子受体5 DNA，新型动物模型和HIV感染治疗剂
公开(公告)号：US08198042B2
公开(公告)日：2012-06-12
申请号：US10846185
申请日：2004-05-14
申请人： Christophe Combadiere , Philip M. Murphy
发明人： Christophe Combadiere , Philip M. Murphy
IPC分类号： C12N15/12 , C07K14/705
CPC分类号： C07K14/7158 , A01K2217/05 , A61K38/00
摘要： The susceptibility of human macrophages to human immunodeficiency virus (HIV) infection depends on cell surface expression of the human CD4 molecule and CC cytokine receptor 5. CCR5 is a member of the 7-transmembrane segment superfamily of G-protein-coupled cell surface molecules. CCR5 plays an essential role in the membrane fusion step of infection by some HIV isolates. The establishment of stable, nonhuman cell lines and transgenic mammals having cells that coexpress human CD4 and CCR5 provides valuable tools for the continuing research of HIV infection. In addition, antibodies which bind to CCR5, CCR5 variants, and CCR5-binding agents, capable of blocking membrane fusion between HIV and target cells represent potential anti-HIV therapeutics for macrophage-tropic strains of HIV.
摘要翻译：人类巨噬细胞对人类免疫缺陷病毒（HIV）感染的易感性取决于人CD4分子和CC细胞因子受体5的细胞表面表达。CCR5是G蛋白偶联细胞表面分子的7-跨膜段超家族的成员。 CCR5在一些HIV分离物感染的膜融合步骤中起着重要作用。建立稳定的非人细胞系和具有共表达人CD4和CCR5的细胞的转基因哺乳动物为继续研究艾滋病毒感染提供了宝贵的工具。此外，结合CCR5，CCR5变体和CCR5结合剂的能够阻断HIV和靶细胞之间的膜融合的抗体代表了HIV巨噬细胞趋化株的潜在的抗HIV治疗剂。

3. 发明授权

US07151087B2 CC chemokine receptor 5 DNA, new animal models and therapeutic agents for HIV infection 有权
公开(公告)号：US07151087B2
公开(公告)日：2006-12-19
申请号：US10700313
申请日：2003-10-31
申请人： Christophe Combadiere , Yu Feng , Ghalib Alkhatib , Edward A. Berger , Philip M. Murphy , Christopher C. Broder , Paul E. Kennedy
发明人： Christophe Combadiere , Yu Feng , Ghalib Alkhatib , Edward A. Berger , Philip M. Murphy , Christopher C. Broder , Paul E. Kennedy
IPC分类号： A61K38/00
CPC分类号： C07K14/7158 , A01K2217/05 , A61K38/00
摘要： The susceptibility of human macrophages to human immunodeficiency virus (HIV) infection depends on cell surface expression of the human CD4 molecule and CC cytokine receptor 5. CCR5 is a member of the 7-transmembrane segment superfamily of G-protein-coupled cell surface molecules. CCR5 plays an essential role in the membrane fusion step of infection by some HIV isolates. The establishment of stable, nonhuman cell lines and transgenic mammals having cells that coexpress human CD4 and CCR5 provides valuable tools for the continuing research of HIV infection. In addition, antibodies which bind to CCR5, CCR5 variants, and CCR5-binding agents, capable of blocking membrane fusion between HIV and target cells represent potential anti-HIV therapeutics for macrophage-tropic strains of HIV.

4. 发明申请

US20110117101A1 CC CHEMOKINE RECEPTOR 5 DNA, NEW ANIMAL MODELS AND THERAPEUTIC AGENTS FOR HIV INFECTION 审中-公开
标题翻译： CC CHEMOKINE RECEPTOR 5 DNA，新动物模型和艾滋病毒感染治疗剂
公开(公告)号：US20110117101A1
公开(公告)日：2011-05-19
申请号：US13012482
申请日：2011-01-24
申请人： Christophe Combadiere , Philip M. Murphy , Edward A. Berger
发明人： Christophe Combadiere , Philip M. Murphy , Edward A. Berger
IPC分类号： A61K39/395 , A61P31/18 , C12N5/071
CPC分类号： C07K14/7158 , A01K2217/05 , A61K38/00
摘要： The susceptibility of human macrophages to human immunodeficiency virus (HIV) infection depends on cell surface expression of the human CD4 molecule and CC cytokine receptor 5. CCR5 is a member of the 7-transmembrane segment superfamily of G-protein-coupled cell surface molecules. CCR5 plays an essential role in the membrane fusion step of infection by some HIV isolates. The establishment of stable, nonhuman cell lines and transgenic mammals having cells that coexpress human CD4 and CCR5 provides valuable tools for the continuing research of HIV infection. In addition, antibodies which bind to CCR5, CCR5 variants, and CCR5-binding agents, capable of blocking membrane fusion between HIV and target cells represent potential anti-HIV therapeutics for macrophage-tropic strains of HIV.
摘要翻译：人类巨噬细胞对人类免疫缺陷病毒（HIV）感染的易感性取决于人CD4分子和CC细胞因子受体5的细胞表面表达。CCR5是G蛋白偶联细胞表面分子的7-跨膜段超家族的成员。 CCR5在一些HIV分离物感染的膜融合步骤中起着重要作用。建立稳定的非人细胞系和具有共表达人CD4和CCR5的细胞的转基因哺乳动物为继续研究艾滋病毒感染提供了宝贵的工具。此外，结合CCR5，CCR5变体和CCR5结合剂的能够阻断HIV和靶细胞之间的膜融合的抗体代表了HIV巨噬细胞趋化株的潜在的抗HIV治疗剂。

5. 发明授权

US5374506A Amino acid sequence for a functional human interleukin-8 receptor 失效
标题翻译：功能性人白细胞介素-8受体的氨基酸序列
公开(公告)号：US5374506A
公开(公告)日：1994-12-20
申请号：US759568
申请日：1991-09-13
申请人： Philip M. Murphy
发明人： Philip M. Murphy
IPC分类号： A61K38/00 , C07K14/715 , C07K13/00
CPC分类号： C07K14/715 , A61K38/00
摘要： A cDNA clone from HL60 neutrophils, designated p2, which encodes a human interleukin-8 receptor. This IL-8 receptor can be expressed in oocytes or transfected host cells. This receptor has 77% amino acid identity with a second human neutrophil receptor isotype that also binds IL-8. It also exhibits 69% amino acid identity with a protein reported to be an N-formyl peptide receptor from rabbit neutrophils.
摘要翻译：来自HL60嗜中性粒细胞的cDNA克隆，命名为p2，其编码人白细胞介素-8受体。该IL-8受体可以在卵母细胞或转染的宿主细胞中表达。该受体与也能结合IL-8的第二人嗜中性粒细胞受体同种型具有77％的氨基酸同一性。它还与来自兔嗜中性粒细胞的报道为N-甲酰基肽受体的蛋白质显示69％的氨基酸同一性。

6. 发明申请

US20080241167A1 CC CHEMOKINE RECEPTOR 5 DNA, NEW ANIMAL MODELS AND THERAPEUTIC AGENTS FOR HIV INFECTION 审中-公开
标题翻译： CC CHEMOKINE RECEPTOR 5 DNA，新动物模型和艾滋病毒感染治疗剂
公开(公告)号：US20080241167A1
公开(公告)日：2008-10-02
申请号：US12044845
申请日：2008-03-07
申请人： Christophe Combadiere , Yu Feng , Ghalib Alkhatib , Edward A. Berger , Philip M. Murphy , Christopher C. Broder , Paul E. Kennedy
发明人： Christophe Combadiere , Yu Feng , Ghalib Alkhatib , Edward A. Berger , Philip M. Murphy , Christopher C. Broder , Paul E. Kennedy
IPC分类号： A61K39/395 , C12N5/06 , G01N33/566 , G01N33/53 , C12Q1/70 , C12Q1/02 , A61K31/7052 , C12N15/87 , A61P31/18
CPC分类号： C07K14/7158 , A01K2217/05 , A61K38/00
摘要： The susceptibility of human macrophages to human immunodeficiency virus (HIV) infection depends on cell surface expression of the human CD4 molecule and CC cytokine receptor 5. CCR5 is a member of the 7-transmembrane segment superfamily of G-protein-coupled cell surface molecules. CCR5 plays an essential role in the membrane fusion step of infection by some HIV isolates. The establishment of stable, nonhuman cell lines and transgenic mammals having cells that coexpress human CD4 and CCR5 provides valuable tools for the continuing research of HIV infection. In addition, antibodies which bind to CCR5, CCR5 variants, and CCR5-binding agents, capable of blocking membrane fusion between HIV and target cells represent potential anti-HIV therapeutics for macrophage-tropic strains of HIV.
摘要翻译：人类巨噬细胞对人类免疫缺陷病毒（HIV）感染的易感性取决于人CD4分子和CC细胞因子受体5的细胞表面表达。CCR5是G蛋白偶联细胞表面分子的7-跨膜段超家族的成员。 CCR5在一些HIV分离物感染的膜融合步骤中起着重要作用。建立稳定的非人细胞系和具有共表达人CD4和CCR5的细胞的转基因哺乳动物为继续研究艾滋病毒感染提供了宝贵的工具。此外，结合CCR5，CCR5变体和CCR5结合剂的能够阻断HIV和靶细胞之间的膜融合的抗体代表了HIV巨噬细胞趋化株的潜在的抗HIV治疗剂。

7. 发明授权

US06383746B1 Functional promoter for CCR5 失效
标题翻译： CCR5功能启动子
公开(公告)号：US06383746B1
公开(公告)日：2002-05-07
申请号：US09177437
申请日：1998-10-21
申请人： Florence Guignard , Philip M. Murphy , Christophe Combadiere , H. Lee Tiffany
发明人： Florence Guignard , Philip M. Murphy , Christophe Combadiere , H. Lee Tiffany
IPC分类号： C12Q168
CPC分类号： C07K14/7158 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158
摘要： A functional promoter for the chemokine receptor CCR5 is provided. The invention provides a nucleic acid sequence for the promoter and methods of reducing inflammation and susceptibility to HIV infection by suppressing the activity of the promoter.
摘要翻译：提供趋化因子受体CCR5的功能启动子。本发明提供了启动子的核酸序列和通过抑制启动子的活性来减少炎症和易感性的方法。

8. 发明授权

US07374872B2 CC chemokine receptor 5 DNA, new animal models and therapeutic agents for HIV infection 有权
标题翻译： CC趋化因子受体5 DNA，新型动物模型和HIV感染治疗剂
公开(公告)号：US07374872B2
公开(公告)日：2008-05-20
申请号：US11594375
申请日：2006-11-07
申请人： Christophe Combadiere , Philip M. Murphy
发明人： Christophe Combadiere , Philip M. Murphy
IPC分类号： C12Q1/00
CPC分类号： C07K14/7158 , A01K2217/05 , A61K38/00
摘要： The susceptibility of human macrophages to human immunodeficiency virus (HIV) infection depends on cell surface expression of the human CD4 molecule and CC cytokine receptor 5. CCR5 is a member of the 7-transmembrane segment superfamily of G-protein-coupled cell surface molecules. CCR5 plays an essential role in the membrane fusion step of infection by some HIV isolates. The establishment of stable, nonhuman cell lines and transgenic mammals having cells that coexpress human CD4 and CCR5 provides valuable tools for the continuing research of HIV infection. In addition, antibodies which bind to CCR5, CCR5 variants, and CCR5-binding agents, capable of blocking membrane fusion between HIV and target cells represent potential anti-HIV therapeutics for macrophage-tropic strains of HIV.
摘要翻译：人类巨噬细胞对人类免疫缺陷病毒（HIV）感染的易感性取决于人CD4分子和CC细胞因子受体5的细胞表面表达。CCR5是G蛋白偶联细胞表面分子的7-跨膜段超家族的成员。 CCR5在一些HIV分离物感染的膜融合步骤中起着重要作用。建立稳定的非人细胞系和具有共表达人CD4和CCR5的细胞的转基因哺乳动物为继续研究艾滋病毒感染提供了宝贵的工具。此外，结合CCR5，CCR5变体和CCR5结合剂的能够阻断HIV和靶细胞之间的膜融合的抗体代表了HIV巨噬细胞趋化株的潜在的抗HIV治疗剂。

9. 发明授权

US5652133A Cloning and expression of the human macrophage inflammatory protein-1.alpha . .alpha.) /rantes receptor 失效
标题翻译：克隆和表达人巨噬细胞炎症蛋白-1（MIP-1α）/兰特受体
公开(公告)号：US5652133A
公开(公告)日：1997-07-29
申请号：US12988
申请日：1993-01-28
申请人： Philip M. Murphy
发明人： Philip M. Murphy
IPC分类号： C07K14/715 , C12N15/12 , C07K14/705
CPC分类号： C07K14/715
摘要： This invention provides for the cloning and expression of the human Macrophage Inflammatory Protein-1.alpha. (MIP-1.alpha.)/RANTES Receptor. This receptor binds two cytokines MIP-1.alpha. and RANTES which are pro-inflammatory cytokines. The receptor is useful for assaying the levels of these cytokines in biological specimens. These cytokines play key roles in the inflammatory processes afflicting man.
摘要翻译：本发明提供人巨噬细胞炎症蛋白-1（MIP-1α）/ RANTES受体的克隆和表达。该受体结合作为促炎细胞因子的两种细胞因子MIP-1α和RANTES。该受体可用于测定生物标本中这些细胞因子的水平。这些细胞因子在患有炎症过程的人中起关键作用。

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