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1. 发明授权

US5023250A Steroidal 14.alpha.-carboxy-alkyl derivatives as regulators of HMG-COA reductase 失效
标题翻译：甾体14α-羧基烷基衍生物作为HMG-COA还原酶的调节剂
公开(公告)号：US5023250A
公开(公告)日：1991-06-11
申请号：US398206
申请日：1989-08-24
申请人： Jerry L. Adams , Timothy F. Gallagher , Ruth J. Mayer , Brian W. Metcalf
发明人： Jerry L. Adams , Timothy F. Gallagher , Ruth J. Mayer , Brian W. Metcalf
IPC分类号： C07J9/00 , C07J31/00 , C07J41/00 , C07J51/00
CPC分类号： C07J51/00 , C07J31/006 , C07J41/0094 , C07J9/00
摘要： New 14.alpha.-carboxyalkyl sterols are regulators of HMG-CoA reductase and inhibitors of mammalian 14.alpha.-methyl demethylase and are useful in lowering serum cholesterol levels and treating fungal infections.
摘要翻译：新的14α-羧甲基甾醇是HMG-CoA还原酶的调节剂和哺乳动物14α-甲基脱甲基酶的抑制剂，并且可用于降低血清胆固醇水平和治疗真菌感染。

2. 发明授权

US5545669A Anti-inflammatory compounds 失效
公开(公告)号：US5545669A
公开(公告)日：1996-08-13
申请号：US252717
申请日：1994-06-02
申请人： Jerry L. Adams , Ralph F. Hall , Dennis Lee , Ruth J. Mayer , George L. Seibel
发明人： Jerry L. Adams , Ralph F. Hall , Dennis Lee , Ruth J. Mayer , George L. Seibel
IPC分类号： A61K31/60 , A61K31/18 , A61K31/195 , A61P1/00 , A61P9/00 , A61P11/00 , A61P17/00 , A61P27/16 , A61P29/00 , A61P35/00 , A61P43/00 , C07C311/08 , C07C311/13 , C07C311/17 , C07C311/21 , C07C311/29 , C07C323/37 , C07C323/63
CPC分类号： C07C311/29 , C07C311/13 , C07C311/17 , C07C311/21
摘要： This invention relates to the novel compounds and pharmaceutical compositions of Formula (I).This invention also relates to a method of treating or reducing inflammation in a mammal in need thereof, which comprises administering to said mammal an effective amount of a compound or composition of Formula (I).

3. 发明授权

US4325877A Production of intermediates for enzyme inhibitors 失效
标题翻译：生产酶抑制剂的中间体
公开(公告)号：US4325877A
公开(公告)日：1982-04-20
申请号：US160057
申请日：1980-06-16
申请人： Brian W. Metcalf , Jerry L. Adams
发明人： Brian W. Metcalf , Jerry L. Adams
IPC分类号： C07C69/66 , C07C69/716 , C07C69/74 , C07C117/08
CPC分类号： C07C247/00 , C07C323/00
摘要： 5-Amino-4-oxo-pentanoic acids of the formula ##STR1## wherein R is CF.sub.3, CHF.sub.2 or CH.sub.2 F; R.sub.1 is H or akyl of 1-4 carbon atoms; and R.sub.2 is H or alkyl or 1-4 carbon atoms or benzyl, which are intermediates to ACE inhibitors or elastase inhibitors, are produced by reacting a 1-(methylthio)-1-methylsulfinyl)-2-R.sub.1 -ethylmetal with an ester of a 3-R-acrylic acid; optionally R.sub.2 -alkylating the thus-produced ester enolate anion of 4-(methylsulfinyl)-4-(methylthio)-5-R.sub.1 R-pentanoic acid followed by splitting off of methylsulfinic acid; reacting the thus-produced 2-R.sub.2 -5-R.sub.1 -4-(methylthio)-3-R-4-pentenoic acid ester with a source of Br.sup.+ to produce a 5-bromo-substituted acid or ester thereof otherwise corresponding to the desired 5-amino-4-oxo-pentanoic acid; and replacing the bromine atom with an amino group, e.g., via the corresponding 5-azido- and 5-N-acylamino- compounds, with hydrolysis of the ester group, if still remaining.
摘要翻译：其中R是CF 3，CHF 2或CH 2 F的5-氨基-4-氧代 - 戊酸; R1是H或1-4个碳原子的烷基; R2是H或烷基或1-4个碳原子，或作为ACE抑制剂或弹性蛋白酶抑制剂的中间体的苄基是通过使1-（甲硫基）-1-甲基亚磺酰基）-2-R 1 - 乙基金属与 3-R-丙烯酸; 任选地将4-（甲基亚磺酰基）-4-（甲硫基）-5-R1R-戊酸由此产生的酯烯醇化物阴离子R2-烷基化，随后分解出甲基亚磺酸; 使由此产生的2-R2-5-R1-4-（甲硫基）-3-R-4-戊烯酸酯与Br +源反应，产生5-溴取代的酸或酯，否则对应于所需的 5-氨基-4-氧代 - 戊酸; 并且如果仍然存在，则通过相应的5-叠氮基 - 和5-N-酰基氨基化合物用氨基取代溴原子，同时酯基的水解。

4. 发明授权

US5955366A Polynucleotides encoding cytokine suppressive anti-inflammatory drug binding proteins 失效
标题翻译：编码细胞因子抑制性抗炎药物结合蛋白的多核苷酸
公开(公告)号：US5955366A
公开(公告)日：1999-09-21
申请号：US950449
申请日：1997-10-14
申请人： John C. Lee , Jerry L. Adams , Timothy F. Gallagher , David W. Green , John Richard Heys , Peter C. McDonnell , Dean E. McNulty , James E. Strickler , Peter R. Young
发明人： John C. Lee , Jerry L. Adams , Timothy F. Gallagher , David W. Green , John Richard Heys , Peter C. McDonnell , Dean E. McNulty , James E. Strickler , Peter R. Young
IPC分类号： A01K67/027 , A61K38/00 , A61K39/395 , A61K48/00 , A61P29/00 , C07H21/04 , C07K14/47 , C07K14/705 , C07K14/715 , C07K16/24 , C12N1/19 , C12N1/21 , C12N9/12 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/00 , C12Q1/68 , C12R1/19 , C12R1/865 , G01N33/53 , G01N33/566 , C12N1/11 , C12N1/20 , C12N5/10
CPC分类号： C07K14/705 , C07K14/47 , C12N9/12 , C12Q1/6876 , A61K38/00 , C12Q2600/136
摘要： This invention relates to drug binding proteins, to genes encoding same and to assays and methods for screening pharmaceuticals. More specifically, this invention relates to a Cytokine Suppressive Anti-Inflammatory Drug (CSAID) binding protein, to a gene encoding same and to assays and screens useful in the evaluation and characterization of drugs of this pharmacologic class.
摘要翻译：本发明涉及药物结合蛋白，与编码该基因的基因以及用于筛选药物的测定和方法。更具体地，本发明涉及细胞因子抑制性抗炎药（CSAID）结合蛋白，涉及编码该基因的基因以及可用于该药理学类药物的评估和表征的测定和筛选。

5. 发明授权

US5593992A Compounds 失效
标题翻译：化合物
公开(公告)号：US5593992A
公开(公告)日：1997-01-14
申请号：US472366
申请日：1995-06-07
申请人： Jerry L. Adams , Peter W. Sheldrake , Timothy F. Gallagher , Ravishanker Garigipati
发明人： Jerry L. Adams , Peter W. Sheldrake , Timothy F. Gallagher , Ravishanker Garigipati
IPC分类号： A61K8/19 , A61K8/00 , A61K8/20 , A61K8/23 , A61K31/00 , A61K31/165 , A61K31/4168 , A61K31/4178 , A61K31/44 , A61K31/4409 , A61K31/4427 , A61K31/4439 , A61K31/445 , A61K31/4545 , A61K31/47 , A61K31/505 , A61K31/506 , A61K31/535 , A61K31/5377 , A61P1/00 , A61P1/04 , A61P3/00 , A61P3/06 , A61P3/10 , A61P7/00 , A61P7/02 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P17/00 , A61P17/06 , A61P19/00 , A61P19/02 , A61P19/06 , A61P19/08 , A61P19/10 , A61P21/00 , A61P25/04 , A61P25/28 , A61P29/00 , A61P31/04 , A61P31/06 , A61P31/12 , A61P31/16 , A61P31/18 , A61P35/00 , A61P37/00 , A61P39/00 , A61P43/00 , A61Q1/00 , A61Q1/12 , A61Q19/00 , C07B61/00 , C07C20060101 , C07C231/12 , C07C231/14 , C07C233/05 , C07C233/36 , C07C311/30 , C07C315/00 , C07C315/02 , C07C317/28 , C07C317/32 , C07C317/40 , C07C319/14 , C07C319/20 , C07C323/25 , C07C323/29 , C07C323/31 , C07C323/41 , C07C323/45 , C07D213/00 , C07D213/53 , C07D213/61 , C07D215/12 , C07D233/54 , C07D239/02 , C07D239/38 , C07D239/42 , C07D295/04 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/00 , C07D409/14 , C07D413/00 , C07D413/04 , C07D413/14
CPC分类号： C07D401/04 , C07C315/00 , C07D239/38 , C07D401/14 , C07D403/04 , C07D405/14 , Y10S514/866 , Y10S514/903
摘要： Novel 1,4,5-substituted imidazole compounds and compositions for use in therapy as cytokine inhibitors.
摘要翻译：新型1,4,5-取代的咪唑化合物和用作治疗作为细胞因子抑制剂的组合物。

6. 发明授权

US5783664A Cytokine suppressive anit-inflammatory drug binding proteins 失效
标题翻译：细胞因子抑制性抗炎药物结合蛋白
公开(公告)号：US5783664A
公开(公告)日：1998-07-21
申请号：US250975
申请日：1994-05-31
申请人： John C. Lee , Jerry L. Adams , Timothy F. Gallagher , David W. Green , John Richard Heys , Peter C. McDonnell , Dean E. McNulty , James E. Strickler , Peter R. Young
发明人： John C. Lee , Jerry L. Adams , Timothy F. Gallagher , David W. Green , John Richard Heys , Peter C. McDonnell , Dean E. McNulty , James E. Strickler , Peter R. Young
IPC分类号： A61K38/00 , C07K14/47 , C07K14/705 , C12N9/12 , C12N15/54 , C12Q1/00 , C07K14/435 , C12N15/12
CPC分类号： C12N9/12 , C07K14/47 , C07K14/705 , A61K38/00
摘要： This invention relates to drug binding proteins, to genes encoding same and to assays and methods for screening pharmaceuticals. More specifically, this invention relates to a Cytokine Suppressive Anti-Inflammatory Drug (CSAID) binding protein, to a gene encoding same and to assays and screens useful in the evaluation and characterization of drugs of this pharmacologic class.
摘要翻译：本发明涉及药物结合蛋白，与编码该基因的基因以及用于筛选药物的测定和方法。更具体地，本发明涉及细胞因子抑制性抗炎药（CSAID）结合蛋白，涉及编码该基因的基因以及可用于该药理学类药物的评估和表征的测定和筛选。

7. 发明授权

US4520028A .alpha.-Aminobutyric acid transaminase inhibitors 失效
标题翻译： α-氨基丁酸转氨酶抑制剂
公开(公告)号：US4520028A
公开(公告)日：1985-05-28
申请号：US647867
申请日：1984-09-05
申请人： Jerry L. Adams , Brian W. Metcalf , Bruce J. Lippert
发明人： Jerry L. Adams , Brian W. Metcalf , Bruce J. Lippert
IPC分类号： C07D333/38 , A61K31/38 , C07D333/00
CPC分类号： C07D333/38
摘要： This application relates to 4-amino-4,5-dihydro-2-thiophenecarboxylic acid, the C.sub.1-6 alkyl esters thereof and to their use in the treatment of epilepsy.
摘要翻译：本申请涉及4-氨基-4,5-二氢-2-噻吩羧酸，其C1-6烷基酯及其在治疗癫痫中的用途。

8. 发明授权

US06361773B1 Antibodies produced against cytokine suppressive anti-inflammatory drug binding proteins 失效
标题翻译：针对细胞因子抑制性抗炎药物结合蛋白产生的抗体
公开(公告)号：US06361773B1
公开(公告)日：2002-03-26
申请号：US08943353
申请日：1997-10-01
申请人： John C. Lee , Jerry L. Adams , Timothy F. Gallagher , David W. Green , John Richard Heys , Peter C. McDonnell , Dean E. McNulty , Peter R. Young , James E. Strickler
发明人： John C. Lee , Jerry L. Adams , Timothy F. Gallagher , David W. Green , John Richard Heys , Peter C. McDonnell , Dean E. McNulty , Peter R. Young , James E. Strickler
IPC分类号： A61K39395
CPC分类号： C07K14/705 , A61K38/00 , C07K14/47 , C12N9/12
摘要： This invention relates to drug binding proteins, to genes encoding same and to assays and methods for screening pharmaceuticals. More specifically, this invention relates to a Cytokine Suppressive Anti-Inflammatory Drug (CSAID) binding protein, to a gene encoding same and to assays and screens useful in the evaluation and characterization of drugs of this pharmacologic class.
摘要翻译：本发明涉及药物结合蛋白，与编码该基因的基因以及用于筛选药物的测定和方法。更具体地，本发明涉及细胞因子抑制性抗炎药（CSAID）结合蛋白，涉及编码该基因的基因以及可用于该药理学类药物的评估和表征的测定和筛选。

9. 发明授权

US5777097A Oligonucleotides comprising a region of a cytokine suppressive anti-inflammatory drug binding protein 失效
标题翻译：由细胞因子抑制性抗炎药物结合蛋白的区域组成的寡核苷酸
公开(公告)号：US5777097A
公开(公告)日：1998-07-07
申请号：US469421
申请日：1995-06-06
申请人： John C. Lee , Jerry L. Adams , Timothy F. Gallagher , David W. Green , John Richard Heys , Peter C. McDonnell , Dean E. McNulty , Peter R. Young , James E. Strickler
发明人： John C. Lee , Jerry L. Adams , Timothy F. Gallagher , David W. Green , John Richard Heys , Peter C. McDonnell , Dean E. McNulty , Peter R. Young , James E. Strickler
IPC分类号： A01K67/027 , A61K38/00 , A61K39/395 , A61K48/00 , A61P29/00 , C07H21/04 , C07K14/47 , C07K14/705 , C07K14/715 , C07K16/24 , C12N1/19 , C12N1/21 , C12N9/12 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/00 , C12Q1/68 , C12R1/19 , C12R1/865 , G01N33/53 , G01N33/566
CPC分类号： C07K14/705 , C07K14/47 , C12N9/12 , C12Q1/6876 , A61K38/00 , C12Q2600/136
摘要： This invention relates to drug binding proteins, to genes encoding same and to assays and methods for screening pharmaceuticals. More specifically, this invention relates to a Cytokine Suppressive Anti-Inflammatory Drug (CSAID) binding protein, to a gene encoding same and to assays and screens useful in the evaluation and characterization of drugs of this pharmacologic class.
摘要翻译：本发明涉及药物结合蛋白，与编码该基因的基因以及用于筛选药物的测定和方法。更具体地，本发明涉及细胞因子抑制性抗炎药（CSAID）结合蛋白，涉及编码该基因的基因以及可用于该药理学类药物的评估和表征的测定和筛选。

10. 发明授权

US08058282B2 2,4,8-trisubstituted-8H-pyrido[2,3-d]pyrimidin-7-one compounds and compositions for use in therapy 有权
标题翻译： 2,4,8-三取代-8H-吡啶并[2,3-d]嘧啶-7-酮化合物和用于治疗的组合物
公开(公告)号：US08058282B2
公开(公告)日：2011-11-15
申请号：US12859645
申请日：2010-08-19
申请人： Jerry L. Adams , Jeffrey C. Boehm , Ralph Hall , Qi Jin , Jiri Kasparec , Domingos J. Silva , John J. Taggart
发明人： Jerry L. Adams , Jeffrey C. Boehm , Ralph Hall , Qi Jin , Jiri Kasparec , Domingos J. Silva , John J. Taggart
IPC分类号： A61P19/00 , A61P31/00 , A61K31/505 , C07D239/02 , C07D471/02
CPC分类号： C07D239/47 , C07D471/04
摘要： Novel substituted 2,4,8-trisubstituted-8H-pyrido[2,3-d]pyrimidin-7-one compounds and compositions for use in therapy as CSBP/p38 kinase inhibitors.
摘要翻译：新型取代的2,4,8-三取代-8H-吡啶并[2,3-d]嘧啶-7-酮化合物和用作CSBP / p38激酶抑制剂治疗的组合物。

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