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1. 发明申请

US20050076915A1 Tracheotomy surgical device 审中-公开
标题翻译：气管切开手术器械
公开(公告)号：US20050076915A1
公开(公告)日：2005-04-14
申请号：US11002410
申请日：2004-12-02
申请人： Jeremy Melker , Richard Melker
发明人： Jeremy Melker , Richard Melker
IPC分类号： A61M16/04 , A61M16/00
CPC分类号： A61M16/0472
摘要： Disclosed herein is a novel surgical instrument, and method of using same, designed for performing tracheotomy. According to specific embodiments, the subject surgical instrument comprises a novel foot plate that is anatomically curved to follow the contours of the inner wall of the trachea.
摘要翻译：本文公开了一种新颖的手术器械及其使用方法，设计用于执行气管切开术。根据具体实施例，所述主体外科器械包括新颖的脚踏板，其解剖学上弯曲以跟随气管内壁的轮廓。

2. 发明申请

US20060160134A1 Novel application of biosensors for diagnosis and treatment of disease 审中-公开
标题翻译：新型应用生物传感器诊断和治疗疾病
公开(公告)号：US20060160134A1
公开(公告)日：2006-07-20
申请号：US11296757
申请日：2005-12-07
申请人： Richard Melker , Donn Dennis , Charles Martin , Jon Stewart
发明人： Richard Melker , Donn Dennis , Charles Martin , Jon Stewart
IPC分类号： G01N33/53
CPC分类号： G01N33/531 , G01N33/53 , G01N33/542 , G01N33/58 , G01N33/582
摘要： A method for detecting compounds of interest in bodily fluids, including exhaled breath and blood. The present invention uses biosensors that mimic naturally occurring cellular mechanisms, including RNA oligonucleotide chains or “aptamers,” in combination with signaling agents or nanotechnology to provide an effective and efficient method for diagnosing a condition and/or disease within a patient. The subject invention also provides a method for screening those analytes/biomarkers likely to be present in exhaled breath.
摘要翻译：一种用于检测体液中感兴趣的化合物的方法，包括呼出的呼吸和血液。本发明使用模拟天然存在的细胞机制的生物传感器，包括RNA寡核苷酸链或“适体”，与信号传导剂或纳米技术组合，以提供用于诊断患者内的病症和/或疾病的有效和有效的方法。本发明还提供了用于筛选可能存在于呼出气中的那些分析物/生物标志物的方法。

3. 发明申请

US20050233459A1 Marker detection method and apparatus to monitor drug compliance 审中-公开
标题翻译：监测药物依从性的标记检测方法和仪器
公开(公告)号：US20050233459A1
公开(公告)日：2005-10-20
申请号：US11097647
申请日：2005-04-01
申请人： Richard Melker , Donn Dennis , Laszlo Prokai
发明人： Richard Melker , Donn Dennis , Laszlo Prokai
IPC分类号： A61B5/00 , A61M11/00
CPC分类号： G01N33/497 , A61B5/082 , A61B5/411 , A61B5/4833 , Y10T436/13
摘要： The present invention includes systems and methods for monitoring therapeutic drug concentration in blood by detecting markers, such as odors, upon exhalation by a patient after the drug is taken, wherein such markers result either directly from the drug itself or from an additive combined with the drug. In the case of olfactory markers, the invention preferably utilizes electronic sensor technology, such as the commercial devices referred to as “artificial” or “electronic” noses or tongues, to non-invasively monitor drug levels in blood. The invention further includes a reporting system capable of tracking drug concentrations in blood (remote or proximate locations) and providing the necessary alerts with regarding to ineffective or toxic drug dosages in a patient.
摘要翻译：本发明包括通过在药物摄取之后通过检测患者呼气时检测诸如气味的标记物来监测血液中的治疗药物浓度的系统和方法，其中这样的标记物直接从药物本身或与药物本身结合的添加剂药物。在嗅觉标记的情况下，本发明优选利用诸如被称为“人造”或“电子”鼻子或舌头的商业装置的电子传感器技术非侵入性地监测血液中的药物水平。本发明还包括能够跟踪血液（偏远或邻近位置）中的药物浓度并提供关于患者中无效或有毒药物剂量的必要警报的报告系统。

4. 发明申请

US20050182297A1 Imaging scope 审中-公开
标题翻译：成像范围
公开(公告)号：US20050182297A1
公开(公告)日：2005-08-18
申请号：US10982154
申请日：2004-11-05
申请人： Dietrich Gravenstein , Samsun Lampotang , Richard Melker
发明人： Dietrich Gravenstein , Samsun Lampotang , Richard Melker
IPC分类号： A61B1/04 , A61B1/267 , A61M16/04 , A61B1/00 , A62B9/06
CPC分类号： A61B1/2676 , A61B1/00167 , A61B1/0017 , A61B1/042 , A61B1/07 , A61B5/064
摘要： Disclosed is an intubation imaging stylet for intubating a patient by use in a tube/imaging stylet combination, said imaging stylet comprising: a malleable stylet having a longitudinal axis and a proximal end and a distal end; a flexible image guide having a longitudinal axis and a proximal end and a distal end, said image guide being connected to said stylet such that a portion of said image guide runs parallel to a portion of said stylet along the longitudinal axis of said stylet and such that the distal end of said image guide is co-extensive with the distal end of said stylet; and at least one flexible illumination fiber having a proximal end and a distal end, said illumination fiber being connected to said stylet such that a portion of said illumination fiber runs parallel to a portion of said stylet along the longitudinal axis of said stylet and such that the distal end of said illumination fiber is co-extensive with the distal end of said stylet; such that in use, said imaging stylet is disposed within a tube for intubating a patient thereby forming an imaging stylet/tube combination which in use is held by gripping the tube in a pen-like fashion. The imaging stylet/tube combination is thus in use held in one hand, freeing the other hand of the user for other tasks if necessary, as well as permitting intubation in the conventional manner. To facilitate this, the center of gravity of the imaging stylet/tube combination is located in essentially the same location along the tube as with a conventional stylet/tube combination.
摘要翻译：公开了一种插管成像探针，用于通过使用管/成像探针组合来插入患者，所述成像探针包括：具有纵向轴线和近端和远端的可延展的探针; 具有纵向轴线和近端和远端的柔性图像引导件，所述图像引导件连接到所述探针，使得所述图像引导件的一部分沿着所述探针的纵向轴线平行于所述探针的一部分平行，所述图像引导件的远端与所述探针的远端共同延伸; 以及至少一个具有近端和远端的柔性照明光纤，所述照明光纤连接到所述探针，使得所述照明光纤的一部分沿着所述探针的纵向轴线平行于所述探针的一部分延伸，并且使得所述照明光纤的远端与所述探针的远端共同延伸; 使得在使用中，所述成像探针设置在用于插管患者的管内，从而形成成像探针/管组合，其在使用中通过以笔状夹持管来保持。因此，一方面使用成像探针/管组合，如果必要，释放用户的另一只手用于其他任务，并且以常规方式允许插管。为了促进这一点，成像探针/管组合的重心位于沿着管的基本相同的位置，与传统的探针/管组合一样。

5. 发明申请

US20150073233A1 SYSTEMS AND METHODS FOR PHYSIOLOGICAL MONITORING USING MULTIPLE SIGNAL PROCESSING DEVICES 有权
标题翻译：使用多个信号处理设备进行生理监测的系统和方法
公开(公告)号：US20150073233A1
公开(公告)日：2015-03-12
申请号：US14310569
申请日：2014-06-20
申请人： David Rich , Andrew Kersey , Sean Cohen , Richard Melker
发明人： David Rich , Andrew Kersey , Sean Cohen , Richard Melker
IPC分类号： A61B5/0205 , A61B5/00
摘要： Provided according to embodiments of the invention are systems for monitoring a physiological state of an individual that include a PPG sensor, which optionally includes an auxiliary physiological sensor integrated with or connected thereto; a first signal processing device in electronic communication with the PPG sensor, whereby the PPG sensor transmits PPG signals to the first signal processing device; and a second signal processing device that detects at least a portion of the signals transmitted by the PPG sensor to the first signal processing device, at least a portion of signals transmitted by the auxiliary physiological sensor, or both. Related methods are also provided herein.
摘要翻译：根据本发明的实施例提供的是用于监视个体的生理状态的系统，其包括PPG传感器，其可选地包括与其集成或连接的辅助生理传感器; 与PPG传感器电子通信的第一信号处理装置，由此PPG传感器将PPG信号传输到第一信号处理装置; 以及第二信号处理装置，其将由PPG传感器发送的信号的至少一部分检测到第一信号处理装置，由辅助生理传感器发送的信号的至少一部分或两者。本文还提供了相关方法。

6. 发明授权

US07258120B2 Endotracheal tube apparatus and method for using the same to reduce the risk of infections 失效
标题翻译：气管内管装置及其使用方法可降低感染的风险
公开(公告)号：US07258120B2
公开(公告)日：2007-08-21
申请号：US10157003
申请日：2002-05-29
申请人： Richard Melker
发明人： Richard Melker
IPC分类号： A61M16/00
CPC分类号： A61M16/04 , A61M16/0404 , A61M16/0427 , A61M16/0434 , A61M16/0443 , A61M16/0445 , A61M16/0459 , A61M16/0463 , A61M16/0479 , A61M16/0486
摘要： Disclosed herein is a novel tube-in-tube endotracheal tube apparatus that allows for replacement or cleaning of an inner (first) tube without having to re-intubate the patient. The novel endotracheal tube apparatus enables the application of continuous suction or intermittent suction. The endotracheal device also serves to decrease the incidence of ventilator-associated pneumonia (VAP).
摘要翻译：本文公开了一种新型管中管气管插管装置，其允许更换或清洁内（第一）管，而不必再次插管患者。新型气管插管装置能够实现连续抽吸或间歇抽吸。气管插管装置还可减少呼吸机相关性肺炎（VAP）的发生率。

7. 发明申请

US20050191757A1 Method and apparatus for detecting humans and human remains 审中-公开
标题翻译：用于检测人类和人类遗体的方法和装置
公开(公告)号：US20050191757A1
公开(公告)日：2005-09-01
申请号：US11039111
申请日：2005-01-19
申请人： Richard Melker , Bruce Goldberger
发明人： Richard Melker , Bruce Goldberger
IPC分类号： G01N21/00 , G01N29/02 , G01N29/24 , G01N29/44
CPC分类号： G01N29/022 , G01N27/126 , G01N29/2462 , G01N29/2468 , G01N29/4427 , G01N29/4481 , G01N33/0031 , G01N33/0032 , G01N33/0034 , G01N33/0047 , G01N2291/0215 , G01N2291/0256 , G01N2291/0423 , G01N2291/0427 , G01N2291/101 , G08B21/22
摘要： The present invention includes a method and apparatus for detecting humans or human remains by analyzing air, fluid, or soil using electronic sensor technology, including surface acoustic-wave gas sensor technology. The method determines the presence and concentration of the target compound (or a class of compounds) associated with humans or human decomposition. Diagnostic software is used to identify target compounds where a stored library of signatures is compared to the signature obtained from the system. Signal processing and neural networks are preferably utilized in the analysis.
摘要翻译：本发明包括通过使用包括表面声波气体传感器技术的电子传感器技术来分析空气，流体或土壤来检测人或人类遗体的方法和装置。该方法确定与人或人类分解相关的目标化合物（或一类化合物）的存在和浓度。诊断软件用于识别将存储的签名库与从系统获取的签名进行比较的目标化合物。在分析中优选使用信号处理和神经网络。

8. 发明申请

US20050154320A1 Methods and devices for accurate pressure monitoring 审中-公开
标题翻译：用于精确压力监测的方法和装置
公开(公告)号：US20050154320A1
公开(公告)日：2005-07-14
申请号：US10755071
申请日：2004-01-09
申请人： Michael Froelich , Richard Melker , Johannes Oostrom
发明人： Michael Froelich , Richard Melker , Johannes Oostrom
IPC分类号： A61B5/00 , A61B5/02 , A61B5/0215
CPC分类号： A61B5/0215 , A61B5/6887 , A61B5/704 , A61B2560/0261
摘要： Disclosed herein are methods, devices and systems for accurately monitoring various pressures of a patient. The invention embodiments herein allow for taking into account pressure changes attributed to changes in elevation and tilt attitudes of the patient. Further disclosed herein is a unique and new pressure correction unit that comprises a tilt sensor affixed thereto or integrated therein.
摘要翻译：本文公开了用于精确地监测患者的各种压力的方法，装置和系统。本文的发明实施例允许考虑由于患者的升高和倾斜态度的变化引起的压力变化。本文进一步公开的是独特的和新的压力校正单元，其包括附接到其上或集成在其中的倾斜传感器。

9. 发明申请

US20050037374A1 Combined nanotechnology and sensor technologies for simultaneous diagnosis and treatment 审中-公开
标题翻译：联合纳米技术和传感器技术同时进行诊断和治疗
公开(公告)号：US20050037374A1
公开(公告)日：2005-02-17
申请号：US10744789
申请日：2003-12-23
申请人： Richard Melker , Donn Dennis
发明人： Richard Melker , Donn Dennis
IPC分类号： A61B5/00 , A61K9/51 , A61K47/48 , G01N29/02 , G01N29/036 , G01N29/44 , G01N33/00 , G01N33/15 , G01N33/497 , G01N33/53 , C12Q1/68
CPC分类号： G01N33/5308 , A61B5/00 , A61B5/411 , A61K9/0092 , A61K9/51 , A61K47/6931 , B82Y5/00 , G01N29/022 , G01N29/036 , G01N29/4481 , G01N2291/0256 , G01N2291/0423 , G01N2291/0426 , G01N2291/0427 , G01N2800/52 , Y02A50/60
摘要： Systems and methods for diagnosing and/or treating conditions, diseases, or disorders. The present invention uses nanoparticle-based assemblies, which comprise a nanoparticle; a surrogate marker; and a means for detecting a specific chemical entity. Such nanoparticle-based assemblies combine nanotechnology and sensor technology to provide an efficient and accurate means for diagnosing a condition, disease, or disorder as well as for focused treatment regimens.
摘要翻译：用于诊断和/或治疗病症，疾病或病症的系统和方法。本发明使用纳米颗粒组合物，其包含纳米颗粒; 替代标记以及用于检测特定化学实体的手段。这种基于纳米颗粒的组合结合了纳米技术和传感器技术，以提供用于诊断病症，疾病或障碍以及重点治疗方案的有效和准确的手段。

10. 发明授权

US06322498B1 Imaging scope 失效
标题翻译：成像范围
公开(公告)号：US06322498B1
公开(公告)日：2001-11-27
申请号：US09007939
申请日：1998-01-16
申请人： Dietrich Gravenstein , Samsun Lampotang , Richard Melker , Andrea Gabrielli
发明人： Dietrich Gravenstein , Samsun Lampotang , Richard Melker , Andrea Gabrielli
IPC分类号： A61B1267
CPC分类号： A61B1/2676 , A61B1/00165 , A61B1/042 , A61B1/05 , A61B1/07
摘要： The subject invention pertains to a system for imaging the human airway having highly advantageous optical, mechanical, ergonomical and physical characteristics. In a specific embodiment, the human airway can be imaged during the intubation procedure. The subject imaging scopes can incorporate a malleable stylet which retains its shape when bent, in order to facilitate intubation of a patient. In a preferred embodiment, a solid metal stylet, for example, a conventional endotracheal tube stylet, can be utilized. In a specific embodiment the subject intubation scope allows for a user to utilize conventional techniques for the insertion of an endotracheal tube, reducing the training needed for use of the subject intubation scope. Preferably, the subject imaging scopes also incorporate at least one illumination fiber to convey light to the distal tip of the subject imaging scopes, for illumination of the objects to be imaged.
摘要翻译：本发明涉及一种用于对具有高度有利的光学，机械，人体工程学和物理特性的人类气道成像系统。在一个具体实施例中，人气道可以在插管过程中成像。主题成像范围可以包括弯曲时保持其形状的可延展的管心针，以便于患者的插管。在优选实施例中，可以使用固体金属探针，例如常规的气管内导管探针。在具体实施例中，所述插管范围允许使用者利用常规技术来插入气管插管，减少使用所述受试者插管范围所需的训练。优选地，本发明的成像范围还包括至少一个照明光纤以将光传送到目标成像范围的远侧末端，以照射待成像的物体。

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