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    • 10. 发明申请
    • NOVEL PEPTIDE AND USE THEREOF
    • 新肽及其用途
    • US20130109626A1
    • 2013-05-02
    • US13701465
    • 2011-06-22
    • Hae Jin KimJe Wook LeeYoung Joon KwonEun Joung Moon
    • Hae Jin KimJe Wook LeeYoung Joon KwonEun Joung Moon
    • C07K7/06A61K38/18A61K38/08
    • C07K7/06A61K38/08A61K38/1841A61K2300/00
    • The present invention provides a peptide represented by formula (I) of X1-Leu-X2-Leu-X3 wherein X1 represents Glu or Asp, X2 represents His, Lys or Arg, X3 represents Asp or Glu, with Glu, Asp, Leu, His, Lys and Arg being respectively glutamic acid, aspartic acid, leucine, histidine, lysine and arginine; or a pharmaceutically acceptable salt thereof; a composition for the treatment or prevention of at least one selected from cartilage damage and arthritis, containing the same peptide or a pharmaceutically acceptable salt thereof as an active ingredient; and a composition containing the same peptide or a pharmaceutically acceptable salt thereof and TGFβ1. The above-mentioned peptide or a pharmaceutically acceptable salt thereof is effective for the treatment and/or prevention of cartilage damage and/or arthritis and is capable of exhibiting effects of the regeneration of cartilage tissue, the inhibition of the expression of cartilage tissue matrix degrading enzyme and/or the inhibition of cartilage tissue ossification.
    • 本发明提供了X1-Leu-X2-Leu-X3的式(I)所示的肽,其中X1表示Glu或Asp,X2表示His,Lys或Arg,X3表示Asp或Glu,Glu,Asp,Leu, 他的Lys和Arg分别是谷氨酸,天冬氨酸,亮氨酸,组氨酸,赖氨酸和精氨酸; 或其药学上可接受的盐; 用于治疗或预防选自软骨损伤和关节炎的至少一种的组合物,其含有相同的肽或其药学上可接受的盐作为活性成分; 和含有相同肽或其药学上可接受的盐和TGFbeta1的组合物。 上述肽或其药学上可接受的盐对于治疗和/或预防软骨损伤和/或关节炎是有效的,并且能够表现出软骨组织再生的作用,抑制软骨组织基质降解的表达 酶和/或抑制软骨组织骨化。