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1. 发明公开

EP0934406A2 ARTIFICIAL PROMOTER LIBRARIES FOR SELECTED ORGANISMS AND PROMOTERS DERIVED FROM SUCH LIBRARIES 失效
标题翻译：人工启动子库中选择的生物和文章ENTSTAMMENDE发起人
公开(公告)号：EP0934406A2
公开(公告)日：1999-08-11
申请号：EP97936613.0
申请日：1997-08-25
申请人： Jensen, Peter Ruhdal
发明人： JENSEN, Peter Ruhdal , HAMMER, Karin
IPC分类号： C12N15
CPC分类号： C12N15/63 , C12N15/1051
摘要： An artificial promoter library for a selected organism or group of organisms is constructed as a mixture of double stranded DNA fragments, the sense strands of which comprise at least two consensus sequences of efficient promoters from said organism or group of organisms, or parts thereof comprising at least half of each, and surrounding or intermediate nucleotide sequences (spacers) of variable length in which at least 7 nucleotides are selected randomly among the nucleobases A, T, C and G. The sense strands of the double stranded DNA fragments may also include a regulatory DNA sequence imparting a specific regulatory feature, such as activation by a change in the growth conditions, to the promoters of the library. Further, they may have a sequence comprising one or more recognition sites for restriction endonucleases added to one of or both their ends. The selected organism or group or organisms may be selected from prokaryotes and from eukaryotes; and in prokaryotes the consensus sequences to be retained most often will comprise the -35 signal (-35 to -30): TTGACA and the -10 signal (-12 to -7): TATAAT or parts of both comprising at least 3 conserved nucleotides of each, while in eukaryotes said consensus sequences should comprise a TATA box and at least one upstream activation sequence (UAS). Such artificial promoter libraries can be used i.a. for optimizing the expression of specific genes in various selected organisms.

2. 发明授权

EP0934406B1 ARTIFICIAL PROMOTER LIBRARIES FOR SELECTED ORGANISMS AND PROMOTERS DERIVED FROM SUCH LIBRARIES 失效
标题翻译：人工启动子库中选择的生物和文章ENTSTAMMENDE发起人
公开(公告)号：EP0934406B1
公开(公告)日：2008-11-19
申请号：EP97936613.5
申请日：1997-08-25
申请人： Jensen, Peter Ruhdal
发明人： JENSEN, Peter Ruhdal , HAMMER, Karin
IPC分类号： C12N15/11 , C12N15/63
CPC分类号： C12N15/63 , C12N15/1051

3. 发明申请

WO2007082541A2 METHOD FOR THE DETECTION OF VIRUS INFECTED CELLS 审中-公开
标题翻译：用于检测病毒感染细胞的方法
公开(公告)号：WO2007082541A2
公开(公告)日：2007-07-26
申请号：PCT/DK2007/050001
申请日：2007-01-16
申请人： DANMARKS TEKNISKE UNIVERSITET , JENSEN, Peter Ruhdal , MICHELSEN, Ole
发明人： JENSEN, Peter Ruhdal , MICHELSEN, Ole
IPC分类号： C12Q1/04 , G01N15/14 , G01N35/00
CPC分类号： C12Q1/04 , G01N33/56983 , G01N2333/335
摘要： The present invention relates to a method for determining one or more stressed cell(s) in a medium. The method comprises the steps of (i) providing a sample from the medium, and (ii) determining a change in the sample relative to a normal sample of non-stressed cell(s).
摘要翻译：本发明涉及用于确定介质中的一个或多个应激细胞的方法。该方法包括以下步骤：（i）从介质提供样品，和（ii）确定样品相对于非应激细胞的正常样品的变化。

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