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    • 4. 发明申请
    • 7-Heteroarylsulfonyl-tetrahydro-3-benzazepine derivatives as antipsychotic agents
    • US20070093473A1
    • 2007-04-26
    • US10571220
    • 2004-09-09
    • David CooperIan ForbesVincenzo GarzyaAndrew GribbleAndrew LightfootAndrew PayneAlexander Smith
    • David CooperIan ForbesVincenzo GarzyaAndrew GribbleAndrew LightfootAndrew PayneAlexander Smith
    • A61K31/55C07D403/02C07D409/02
    • C04B35/632C07D401/12C07D409/12
    • The invention provides compounds of formula (I): wherein A and B represent the groups —(CH2)m— and —(CH2)n— respectively; R1 represents hydrogen or C1-6alkyl; R2 represents hydrogen, halogen, hydroxy, cyano, nitro, hydroxyC1-6alkyl, trifluoromethyl, trifluoromethoxy, C1-6alkyl, C1-6alkoxy, C1-6fluoroalkoxy, —(CH2)pC3-6cycloalkyl, —(CH2)pOC3-6cycloalkyl, —COC1-6alkyl, —SO2C1-6alkyl, —SOC1-6alkyl, —S—C1-6alkyl, —CO2C1-6alkyl, —CO2NR3R4, —SO2NR3R4, —(CH2)pNR3R4, —(CH2)pNR3COR4, optionally substituted aryl ring, optionally substituted heteroaryl ring, a fused bicyclic heteroaromatic ring system or optionally substituted heterocyclyl ring; Ar1 represents optionally substituted heteroaryl ring; Ar2 represents optionally substituted aryl ring or optionally substituted heteroaryl ring; Z represents —(CH2)qX— wherein the —(CH2)q— group is attached to Ar2, or —X(CH2)q— wherein X is attached to Ar2, and wherein any of the —CH2— groups may be optionally substituted by one or more C1-6alkyl groups; X represents oxygen, —CH(OR5)—, —NR5— or —CH2— wherein the —CH2— group may be optionally substituted by one or more C1-6alkyl groups; R3 and R4 each independently represent hydrogen, C1-6alkyl or, together with the nitrogen or other atoms to which they are attached, form an azacycloalkyl ring or an oxo-substituted azacycloalkyl ring; R5 represents hydrogen or C1-6alkyl; m and n independently represent an integer selected from 1 and 2; p independently represents an integer selected from 0, 1, 2 and 3; q independently represents an integer selected from 0, 1, 2 and 3; or a pharmaceutically acceptable salt or solvate thereof, with the proviso that when Ar1 is a pyridyl group, and Z is —CH2X— where X is attached to the Ar1 group, X is selected from —CH(OR5)—, —NR5— and —CH2— wherein the —CH2— group may be optionally substituted by one or more C1-6alkyl groups. The compounds of formula (I) are useful in therapy, in particular as antipsychotic agents.
    • 6. 发明申请
    • Airport pavement management system
    • 机场路面管理系统
    • US20060036378A1
    • 2006-02-16
    • US11145170
    • 2005-06-06
    • Alexander SmithThomas Breen
    • Alexander SmithThomas Breen
    • G06F19/00
    • E01C23/00
    • The AirScene™ Pavement Management System of the present invention automatically tracks data required to determine various factors in an assessment of current and future pavement maintenance needs and utilizes this data to quantify the pavement damage caused by each individual aircraft movement and thus compute pavement condition based on an initial survey and the calculations of accrued damage over time. This information can be displayed through AirScene™ in the form of tables, graphs, or graphically represented on an airport diagram showing present conditions, rates of accruing damage, and future wear rates and areas. The system draws on the data from the AirScene™ Data Warehouse (ADW), a single repository for all the information acquired from a number of different sources. These data include: Aircraft or vehicle type (wheel layout, weight, vehicle specific parameters, and the like), Aircraft or vehicle location (ground track, position, gate used, and the like), Aircraft or vehicle dynamics (velocity, acceleration, take off, touchdown, and the like), Aircraft or vehicle actual weight (cargo load, fuel load, and the like), as well as Future operational data (flight schedules, increasing flight loads and demand, and the like).
    • 本发明的AirScene TM路面管理系统自动跟踪在当前和未来路面维护需求的评估中确定各种因素所需的数据,并且利用该数据来量化由每个单独的飞机运动引起的路面损坏,从而计算路面状况 基于初步调查和随时间的累计损害的计算。 该信息可以通过AirScene(TM)以表格,图形的形式显示,或在机场图上以图形方式显示,显示现状,累积损害率和未来的磨损率和面积。 该系统利用来自AirScene(TM)数据仓库(ADW)的数据,该数据仓库是从许多不同来源获取的所有信息的单一存储库。 这些数据包括:飞机或车辆类型(车轮布局,重量,车辆特定参数等),飞机或车辆位置(地面轨道,位置,使用门等),飞机或车辆动力学(速度,加速度, 起飞,触地等),飞机或车辆实际重量(货物负载,燃料负载等)以及未来的运行数据(航班时刻表,增加的飞行负载和需求等)。
    • 7. 发明申请
    • Aircraft boundary transition warnings and auto alerting
    • 飞机边界过渡警告和自动警报
    • US20050200501A1
    • 2005-09-15
    • US11111957
    • 2005-04-22
    • Alexander Smith
    • Alexander Smith
    • G01S13/78G08B23/00G08G5/04G08G5/06
    • G08G5/0013G01S5/0284G01S5/06G01S13/781G01S13/86G08G5/006G08G5/0082
    • In combination with a Geographic Information System (GIS), 3-dimensional shapes may be used to designate or identify blocks of airspace. These shapes may be defined in many ways including lat/long, local coordinates, or FAA transmitted directions for TFRs and ADIZs. These restricted areas and zones may be modeled using suitably modified AirScene™ software from Rannoch Corporation. AirScene™ software can locate various aircraft in the vicinity of restricted airspace, determine whether the aircraft is about to enter restricted airspace, and issue a warning to the pilot of such aircraft that restricted airspace is about to be violated. Such a warning can be audible (e.g., radio communication message) or visual (e.g., graphic display or even a flashing light or text message) and is much less distracting than having a laser shining in the cockpit. Since the AirScene™ system is ground-based, ground personnel can also be advised if restricted airspace is being violated, or even about to be violated.
    • 结合地理信息系统(GIS),可以使用三维形状来指定或识别空域。 这些形状可以以许多方式定义,包括TFR和ADIZs的纬度/长度,局部坐标或FAA传输方向。 这些限制区域和区域可以使用来自Rannoch Corporation的适当改进的AirScene(TM)软件进行建模。 AirScene(TM)软件可以在受限制的空域附近定位各种飞机,确定飞机是否即将进入有限的空域,并向受限制的空域即将违反的飞机的飞行员发出警告。 可以听到这样的警告(例如,无线电通信消息)或视觉(例如,图形显示,甚至闪烁的光或文本消息),并且比在驾驶舱中照射激光的分心更少。 由于AirScene(TM)系统是基于地面的,因此如果受限制的空域被侵犯或甚至被侵犯,也可以告知地面人员。
    • 9. 发明授权
    • Splitting and merging routing domains
    • 拆分和合并路由域
    • US08572485B2
    • 2013-10-29
    • US13157100
    • 2011-06-09
    • Alexander SmithVagish Madrahalli
    • Alexander SmithVagish Madrahalli
    • G06F3/00
    • H04L45/02H04L45/04H04L45/42H04L45/62H04L45/66
    • Apparatuses and methods for merging multiple domains into a merged domain and splitting a single domain into multiple domains in an Automatically Switched Optical Network (ASON) are disclosed. For merging, a node in a first domain can be identified to be a new Routing Controller (RC) for the merged domain. A second domain can be identified to be merged with the first domain. Nodes, including old RCs, in the first domain and the second domain are notified of the identity of the new RC in the merged domain. The topology of the old RC's domain is sent to the new RC. The new topology is computed by the new RC from the topology information given by the old RCs. The updated topology is distributed to nodes in the merged domain via the new RC.
    • 公开了将多个域合并到合并域中并将单个域分割成自动交换光网络(ASON)中的多个域的装置和方法。 为了合并,可以将第一域中的节点识别为合并域的新路由控制器(RC)。 第二个域可以被识别为与第一个域合并。 在第一个域和第二个域中的节点(包括旧的RC)被通知合并域中的新的RC的身份。 旧RC域的拓扑被发送到新的RC。 新拓扑结构由旧的RC由拓扑信息计算。 更新的拓扑通过新的RC分发到合并域中的节点。