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1. 发明授权

US08584669B2 Inhaler 有权
标题翻译：吸入器
公开(公告)号：US08584669B2
公开(公告)日：2013-11-19
申请号：US12296560
申请日：2007-04-11
申请人： Jens Besseler , Hubert Kunze , Achim Moser , Ralf Thoemmes , Gilbert Wuttke , Dieter Hochrainer , Heinrich Kladders , Christoph Dworzak , Josef Eckert , Antonio Lanci , Markus Mast , Elmar Mock , Andre Klopfenstein
发明人： Jens Besseler , Hubert Kunze , Achim Moser , Ralf Thoemmes , Gilbert Wuttke , Dieter Hochrainer , Heinrich Kladders , Christoph Dworzak , Josef Eckert , Antonio Lanci , Markus Mast , Elmar Mock , Andre Klopfenstein
IPC分类号： A61M13/00
CPC分类号： A61M15/0028 , A61M15/0021 , A61M15/0033 , A61M15/0051 , A61M15/0055 , A61M15/0073 , A61M15/0081 , A61M2202/064
摘要： An inhaler (1) is proposed (see FIG. 1), for the inhalation of a formulation (2) from capsules (3) that each contain one dose of the formulation. The capsules are preferably each emptied in a capsule chamber (4) by being set in motion by a stream of air flowing through the capsule chamber. The stream of air can be generated by the inhalation of a user or patient and/or can be generated actively generated by the inhaler. For simple handling, the inhaler has a means for, in particular, automatic filling, emptying and/or cleaning of the capsule chamber, if the latter is used more than once. Alternatively, the inhaler has a large number of capsule chambers that each preferably already contain a capsule and re preferably used just once.
摘要翻译：提出了一种吸入器（1），用于从每个含有一剂制剂的胶囊（3）吸入制剂（2）。胶囊优选通过流过胶囊室的空气流而被设置在胶囊室（4）中。可以通过吸入用户或患者产生空气流和/或可以由吸入器主动产生的空气流。为了简单的处理，吸入器具有用于特别是自动填充，排空和/或清洁胶囊腔的装置，如果后者被使用不止一次。或者，吸入器具有大量的胶囊室，每个胶囊室优选地已经包含胶囊，并且优选仅使用一次。

2. 发明申请

US20090194105A1 INHALER 有权
标题翻译：吸入器
公开(公告)号：US20090194105A1
公开(公告)日：2009-08-06
申请号：US12296560
申请日：2007-04-11
申请人： Jens Besseler , Hubert Kunze , Achim Moser , Ralf Thoemmes , Gilbert Wuttke , Dieter Hochrainer , Heinrich Kladders , Christoph Dworzak , Josef Eckert , Antonio Lanci , Markus Mast , Elmar Mock , Andre Klopfenstein
发明人： Jens Besseler , Hubert Kunze , Achim Moser , Ralf Thoemmes , Gilbert Wuttke , Dieter Hochrainer , Heinrich Kladders , Christoph Dworzak , Josef Eckert , Antonio Lanci , Markus Mast , Elmar Mock , Andre Klopfenstein
IPC分类号： A61M15/00
CPC分类号： A61M15/0028 , A61M15/0021 , A61M15/0033 , A61M15/0051 , A61M15/0055 , A61M15/0073 , A61M15/0081 , A61M2202/064
摘要： An inhaler (1) is proposed (see FIG. 1), for the inhalation of a formulation (2) from capsules (3) that each contain one dose of the formulation. The capsules are preferably each emptied in a capsule chamber (4) by being set in motion by a stream of air flowing through the capsule chamber. The stream of air can be generated by the inhalation of a user or patient and/or can be generated actively generated by the inhaler. For simple handling, the inhaler has a means for, in particular, automatic filling, emptying and/or cleaning of the capsule chamber, if the latter is used more than once. Alternatively, the inhaler has a large number of capsule chambers that each preferably already contain a capsule and re preferably used just once.
摘要翻译：提出了一种吸入器（1），用于从每个含有一剂制剂的胶囊（3）吸入制剂（2）。胶囊优选通过流过胶囊室的空气流而被设置在胶囊室（4）中。可以通过吸入用户或患者产生空气流和/或可以由吸入器主动产生的空气流。为了简单的处理，吸入器具有用于特别是自动填充，排空和/或清洁胶囊腔的装置，如果后者被使用不止一次。或者，吸入器具有大量的胶囊室，每个胶囊室优选地已经包含胶囊，并且优选仅使用一次。

3. 发明申请

US20060016449A1 Cartridge for a liquid 有权
标题翻译：墨盒用于液体
公开(公告)号：US20060016449A1
公开(公告)日：2006-01-26
申请号：US11232896
申请日：2005-09-23
申请人： Joachim Eicher , Johannes Geser , Matthias Hausmann , Michael Schyra , Gilbert Wuttke , Andreas Fiol , Heinrich Kladders , Dieter Hochrainer , Bernd Zierenberg
发明人： Joachim Eicher , Johannes Geser , Matthias Hausmann , Michael Schyra , Gilbert Wuttke , Andreas Fiol , Heinrich Kladders , Dieter Hochrainer , Bernd Zierenberg
IPC分类号： A61M11/00
CPC分类号： B05B11/0054 , A61M15/0065 , B05B11/0008 , B05B11/00412 , B05B11/0044 , B05B11/00444 , B05B11/00446
摘要： For meteredly dispensing a liquid over a period of several months from a container which can be stored over a long period of time, the need is for a container which is practically diffusion-tight and in which the liquid does not come into contact with the ambient atmosphere. The cartridge according to the invention is a three-shell container comprising a collapsible bag which contains the liquid, a container which is stable in respect of shape and a stiff metal casing. The cartridge can be releasably connected to a dispensing device. The cartridge can be provided with a micro-opening with which the time for pressure equalisation between the cartridge and the ambient atmosphere can be adjusted. The cartridge is suitable for aqueous and for alcoholic liquids which contain a pharmaceutically active substance. The liquid in the cartridge is protected from external influences. The cartridge can be used in an atomiser for producing an inhalable aerosol for the treatment of illnesses.
摘要翻译：对于可以长时间储存的容器在几个月的时间内计量分配液体，需要一种几乎不扩散的容器，其中液体不会与环境接触大气层。根据本发明的墨盒是一种三壳容器，其包括容纳液体的可折叠袋，相对于形状稳定的容器和刚性金属外壳。盒可以可释放地连接到分配装置。墨盒可以设置有微孔，可以调节墨盒和环境大气之间的压力均衡时间。该药筒适用于含有药物活性物质的水溶液和含酒精液体。保护盒中的液体免受外部影响。墨盒可用于雾化器中，用于产生用于治疗疾病的可吸入气雾剂。

4. 发明授权

US06223933B1 Pressure compensation device for a two-part container 有权
标题翻译：用于两部分集装箱的压力补偿装置
公开(公告)号：US06223933B1
公开(公告)日：2001-05-01
申请号：US09437275
申请日：1999-11-10
申请人： Dieter Hochrainer , Bernd Zierenberg , Heinrich Kladders , Martin Essing , Gilbert Wuttke , Matthias Hausmann , Joachim Eicher
发明人： Dieter Hochrainer , Bernd Zierenberg , Heinrich Kladders , Martin Essing , Gilbert Wuttke , Matthias Hausmann , Joachim Eicher
IPC分类号： B67D542
CPC分类号： B65D83/0055 , B05B11/00412 , B05B11/0044 , B05B11/00444 , B05B11/00446
摘要： For medical fluids, two-part containers are used which consist of an inner container and an outer container which is impenetrable to diffusion. The inner container collapses when the fluid is removed. For the purposes of pressure compensation between the gaseous space, disposed between the inner- and outer containers, and the surroundings of the two-part container, a pressure compensation device is required by means of which at the same time the loss of fluid through diffusion from the collapsible inner container is kept as little as possible. To that end, at least one channel is used which communicates the gas-filled intermediate space with the surroundings of the two-part container. The time constant for compensation of a pressure differential of a few millibars is within the region of quite a few hours. It is obtained by selecting the length of the channel and channel cross-section. The, at least one, channel can be produced individually, or a plurality of channels can be present in the form of pores in an open-pore sintered material or in a permeable membrane. The pressure compensation device permits storage of the two-part container for many years, and use for many weeks as fluid is being removed in portion-wise manner. During these times, the quantity of fluid in the inner container, or the concentration thereof, changes substantially less than with the use of a known two-part container.
摘要翻译：对于医疗流体，使用两部分容器，其由内部容器和不容易扩散的外部容器组成。内部容器在流体被移除时塌陷。为了在设置在内部和外部容器之间的气体空间与两部分容器的周围之间的压力补偿的目的，需要一个压力补偿装置，借助于此，同时通过从可折叠的内部容器扩散而导致的流体损失保持尽可能少。为此，使用至少一个通道将气体填充的中间空间与两部分容器的周围环境连通。补偿几毫巴压力差的时间常数在不到几个小时的时间内。通过选择通道和通道横截面的长度来获得。可以单独制造至少一个通道，或者可以在开孔烧结材料或渗透膜中以孔的形式存在多个通道。压力补偿装置允许储存两部分容器多年来，随着流体以分开的方式被去除，使用了好几个星期。在这些时间内，内部容器中的流体量或其浓度相对于使用已知的两部分容器而言变化明显更小。

5. 发明授权

US06988496B1 Cartridge for a liquid 有权
标题翻译：墨盒用于液体
公开(公告)号：US06988496B1
公开(公告)日：2006-01-24
申请号：US09511267
申请日：2000-02-23
申请人： Joachim Eicher , Johannes Geser , Matthias Hausmann , Michael Schyra , Gilbert Wuttke , Andreas Fiol , Heinrich Kladders , Dieter Hochrainer , Bernd Zierenberg
发明人： Joachim Eicher , Johannes Geser , Matthias Hausmann , Michael Schyra , Gilbert Wuttke , Andreas Fiol , Heinrich Kladders , Dieter Hochrainer , Bernd Zierenberg
IPC分类号： A61M11/00 , B67D5/00
CPC分类号： B05B11/0054 , A61M15/0065 , B05B11/0008 , B05B11/00412 , B05B11/0044 , B05B11/00444 , B05B11/00446
摘要： For meteredly dispensing a liquid over a period of several months from a container which can be stored over a long period of time, the need is for a container which is practically diffusion-tight and in which the liquid does not come into contact with the ambient atmosphere.The cartridge according to the invention is a three-shell container comprising a collapsible bag which contains the liquid, a container which is stable in respect of shape and a stiff metal casing. The cartridge can be releasably connected to a dispensing device. The cartridge can be provided with a micro-opening with which the time for pressure equalisation between the cartridge and the ambient atmosphere can be adjusted. The cartridge is suitable for aqueous and for alcoholic liquids which contain a pharmacologically active substance. The liquid in the cartridge is protected from external influences.The cartridge can be used in an atomiser for producing an inhalable aerosol for the treatment of illnesses.
摘要翻译：对于可以长时间储存的容器在几个月的时间内计量分配液体，需要一种几乎不扩散的容器，其中液体不会与环境接触大气层。根据本发明的墨盒是一种三壳容器，其包括容纳液体的可折叠袋，相对于形状稳定的容器和刚性金属外壳。盒可以可释放地连接到分配装置。墨盒可以设置有微孔，可以调节墨盒和环境大气之间的压力均衡时间。该墨盒适用于含有药理活性物质的含水液体和含酒精液体。保护盒中的液体免受外部影响。墨盒可用于雾化器中，用于产生用于治疗疾病的可吸入气雾剂。

6. 发明授权

US07802568B2 Cartridge for a liquid 有权
标题翻译：墨盒用于液体
公开(公告)号：US07802568B2
公开(公告)日：2010-09-28
申请号：US11232896
申请日：2005-09-23
申请人： Joachim Eicher , Johannes Geser , Matthias Hausmann , Michael Schyra , Gilbert Wuttke , Andreas Fiol , Heinrich Kladders , Dieter Hochrainer , Bernd Zierenberg
发明人： Joachim Eicher , Johannes Geser , Matthias Hausmann , Michael Schyra , Gilbert Wuttke , Andreas Fiol , Heinrich Kladders , Dieter Hochrainer , Bernd Zierenberg
IPC分类号： A61M11/00 , A61M15/00
CPC分类号： B05B11/0054 , A61M15/0065 , B05B11/0008 , B05B11/00412 , B05B11/0044 , B05B11/00444 , B05B11/00446
摘要： For meteredly dispensing a liquid over a period of several months from a container which can be stored over a long period of time, the need is for a container which is practically diffusion-tight and in which the liquid does not come into contact with the ambient atmosphere. The cartridge according to the invention is a three-shell container comprising a collapsible bag which contains the liquid, a container which is stable in respect of shape and a stiff metal casing. The cartridge can be releasably connected to a dispensing device. The cartridge can be provided with a micro-opening with which the time for pressure equalisation between the cartridge and the ambient atmosphere can be adjusted. The cartridge is suitable for aqueous and for alcoholic liquids which contain a pharmaceutically active substance. The liquid in the cartridge is protected from external influences. The cartridge can be used in an atomiser for producing an inhalable aerosol for the treatment of illnesses.
摘要翻译：对于可以长时间储存的容器在几个月的时间内计量分配液体，需要一种几乎不扩散的容器，其中液体不会与环境接触大气层。根据本发明的墨盒是一种三壳容器，其包括容纳液体的可折叠袋，相对于形状稳定的容器和刚性金属外壳。盒可以可释放地连接到分配装置。墨盒可以设置有微孔，可以调节墨盒和环境大气之间的压力均衡时间。该药筒适用于含有药物活性物质的水溶液和含酒精液体。保护盒中的液体免受外部影响。墨盒可用于雾化器中，用于产生用于治疗疾病的可吸入气雾剂。

7. 发明授权

US07090093B2 Pressure compensation device for a two-part container 有权
标题翻译：用于两部分集装箱的压力补偿装置
公开(公告)号：US07090093B2
公开(公告)日：2006-08-15
申请号：US10815531
申请日：2004-04-01
申请人： Dieter Hochrainer , Bernd Zierenberg , Heinrich Kladders , Martin Essing , Gilbert Wuttke , Matthias Hausmann , Joachim Eicher
发明人： Dieter Hochrainer , Bernd Zierenberg , Heinrich Kladders , Martin Essing , Gilbert Wuttke , Matthias Hausmann , Joachim Eicher
IPC分类号： B67D5/42 , B65D1/32
CPC分类号： B65D83/0055 , B05B11/00412 , B05B11/0044 , B05B11/00444 , B05B11/00446
摘要： For medical fluids, two-part containers are used which consist of an inner container and an outer container which is impenetrable to diffusion. The inner container collapses when the fluid is removed. For the purposes of pressure compensation between the gaseous space, disposed between the inner- and outer containers, and the surroundings of the two-part container, a pressure compensation device is required by means of which at the same time the loss of fluid through diffusion from the collapsible inner container is kept as little as possible. To that end, at least one channel is used which communicates the gas-filled intermediate space with the surroundings of the two-part container. The time constant for compensation of a pressure differential of a few millibars is within the region of quite a few hours. It is obtained by selecting the length of the channel and channel cross-section. The, at least one, channel can be produced individually, or a plurality of channels can be present in the form of pores in an open-pore sintered material or in a permeable membrane. The pressure compensation device permits storage of the two-part container for many years, and use for many weeks as fluid is being removed in portion-wise manner. During these times, the quantity of fluid in the inner container, or the concentration thereof changes substantially less than with the use of a known two-part container.
摘要翻译：对于医疗流体，使用两部分容器，其由内部容器和不容易扩散的外部容器组成。当流体被移除时，内部容器塌陷。为了在设置在内部和外部容器之间的气体空间与两部分容器的周围之间的压力补偿之间进行压力补偿，需要压力补偿装置，同时通过该压力补偿装置损失流体通过扩散从可折叠的内部容器保持尽可能少。为此，使用至少一个通道将气体填充的中间空间与两部分容器的周围环境连通。补偿几毫巴压力差的时间常数在不到几个小时的时间内。通过选择通道和通道横截面的长度来获得。可以单独制造至少一个通道，或者多个通道可以以开孔烧结材料或渗透膜中的孔的形式存在。压力补偿装置可以容纳两部分容器的存放多年，并且以分段方式移除流体使用多个星期。在这些时间内，内部容器中的流体量或其浓度变化明显小于使用已知的两部分容器。

8. 发明授权

US07537006B2 Nebulizer 有权
标题翻译：喷雾器
公开(公告)号：US07537006B2
公开(公告)日：2009-05-26
申请号：US11064616
申请日：2005-02-24
申请人： Gilbert Wuttke , Hubert Kunze , Ralf Thoemmes
发明人： Gilbert Wuttke , Hubert Kunze , Ralf Thoemmes
IPC分类号： A61M11/00
CPC分类号： A61M15/0065 , A61M15/0018 , A61M2016/0021 , A61M2016/0039 , A61M2205/44 , B05B11/0005 , B05B11/3091 , B05B12/004
摘要： A nebulizer for a fluid having a pressure generator for conveying and nebulizing the fluid, particularly in the form of an inhaler, is proposed. To improve the user guidance it is envisaged that the nebulizer should have a signal device for generating at least one acoustic and/or vibratory signal, particularly during a nebulizing process.
摘要翻译：提出了一种用于具有用于输送和雾化流体的压力发生器的流体雾化器，特别是以吸入器的形式。为了改善用户指导，设想雾化器应该具有用于产生至少一个声和/或振动信号的信号装置，特别是在雾化过程期间。

9. 发明申请

US20050183719A1 Nebulizer 有权
标题翻译：喷雾器
公开(公告)号：US20050183719A1
公开(公告)日：2005-08-25
申请号：US11064616
申请日：2005-02-24
申请人： Gilbert Wuttke , Hubert Kunze , Ralf Thoemmes
发明人： Gilbert Wuttke , Hubert Kunze , Ralf Thoemmes
IPC分类号： A61M15/00 , A61M16/00 , B05B11/00 , B05B12/00 , B05B12/08 , A61M11/00 , B05B17/06
CPC分类号： A61M15/0065 , A61M15/0018 , A61M2016/0021 , A61M2016/0039 , A61M2205/44 , B05B11/0005 , B05B11/3091 , B05B12/004
摘要： A nebulizer for a fluid having a pressure generator for conveying and nebulizing the fluid, particularly in the form of an inhaler, is proposed. To improve the user guidance it is envisaged that the nebulizer should have a signal device for generating at least one acoustic and/or vibratory signal, particularly during a nebulizing process.
摘要翻译：提出了一种用于具有用于输送和雾化流体的压力发生器的流体雾化器，特别是以吸入器的形式。为了改善用户指导，设想雾化器应该具有用于产生至少一个声和/或振动信号的信号装置，特别是在雾化过程期间。

10. 发明授权

US09050428B2 Device, cartridge and method for dispensing a liquid 有权
标题翻译：用于分配液体的装置，盒和方法
公开(公告)号：US09050428B2
公开(公告)日：2015-06-09
申请号：US13147655
申请日：2009-08-17
申请人： Stephen T. Dunne , Holger Holakovsky , Alexander Bach , Jens Besseler , Manuel Krakowka , Gilbert Wuttke
发明人： Stephen T. Dunne , Holger Holakovsky , Alexander Bach , Jens Besseler , Manuel Krakowka , Gilbert Wuttke
IPC分类号： A61M15/00 , A61M11/02 , A61M11/06 , B65D83/62 , A61M11/00 , B05B11/00 , B65D83/38 , B65D83/48
CPC分类号： A61M15/0065 , A61M11/007 , A61M11/06 , A61M15/009 , A61M2202/0468 , B05B11/3091 , B65D83/386 , B65D83/48 , B65D83/62
摘要： A device, cartridge and method for dispensing a liquid, preferably a drug, are proposed. The liquid is pressurized in a cartridge to a first lower pressure and, then, pressurized in doses by a pump to a second higher pressure. A valve arranged between the cartridge and the pump is normally closed and/or opened only temporarily. Thus, evaporation and dripping of liquid can be avoided or minimized.
摘要翻译：提出了用于分配液体，优选药物的装置，盒和方法。将液体在筒中加压至第一较低压力，然后通过泵以剂量加压至第二较高压力。布置在墨盒和泵之间的阀门通常仅被暂时关闭和/或打开。因此，可以避免或最小化液体的蒸发和滴落。

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