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1. 发明授权

US06589199B1 System for implanting a cross-linked polysaccharide fiber and methods of forming and inserting the fiber 失效
标题翻译：用于植入交联多糖纤维的系统和形成和插入纤维的方法
公开(公告)号：US06589199B1
公开(公告)日：2003-07-08
申请号：US09538152
申请日：2000-03-29
申请人： Jennifer McCrory , Patrik Lüscher , Kalpana Kamath , Ronald Sahatjian
发明人： Jennifer McCrory , Patrik Lüscher , Kalpana Kamath , Ronald Sahatjian
IPC分类号： A61F1320
CPC分类号： A61B17/12131 , A61B17/12022 , A61B17/12113 , A61B17/12186 , A61B2017/00495
摘要： Systems and methods are disclosed for implanting and forming both a polysaccharide fiber and an implant formed of the fiber. In one system, a liquid including polysaccharide and a liquid including a cross linking agent are mixed in a cannula to form a cross linked polysaccharide fiber in the cannula. In another system, a carrier fluid delivers a previously manufactured fiber through a cannula. A cutter is optionally provided on the cannula to sever the fiber after a sufficient length of fiber is implanted.
摘要翻译：公开了用于植入和形成由纤维形成的多糖纤维和植入物的系统和方法。在一个系统中，将包含多糖和包含交联剂的液体的液体在插管中混合以在套管中形成交联的多糖纤维。在另一系统中，载体流体通过套管递送先前制造的纤维。任选地在套管上设置切割器，以在植入足够长度的纤维之后切断纤维。

2. 发明授权

US06258055B1 System for implanting a cross-linked polysaccharide fiber and methods of forming and inserting the fiber 失效
标题翻译：用于植入交联多糖纤维的系统和形成和插入纤维的方法
公开(公告)号：US06258055B1
公开(公告)日：2001-07-10
申请号：US09617132
申请日：2000-07-14
申请人： Jennifer McCrory , Patrik Lüscher , Kalpana Kamath , Ronald Sahatjian
发明人： Jennifer McCrory , Patrik Lüscher , Kalpana Kamath , Ronald Sahatjian
IPC分类号： A61M3100
CPC分类号： A61B17/12131 , A61B17/12022 , A61B17/12186 , A61B2017/00495 , A61B2017/1205 , A61M37/00
摘要： Systems and methods are disclosed for implanting and forming both a polysaccharide fiber and an implant formed of the fiber. In one system, a liquid including polysaccharide and a liquid including a cross linking agent are mixed in a cannula to form a cross linked polysaccharide fiber in the cannula. In another system, a carrier fluid delivers a previously manufactured fiber through a cannula. A cutter is optionally provided on the cannula to sever the fiber after a sufficient length of fiber is implanted. The disclosed methods include a method of forming a polysaccharide fiber in the cannula while the cannula is inserted in a body, and a method of making a cross linked polysaccharide fiber for loading in a delivery system.
摘要翻译：公开了用于植入和形成由纤维形成的多糖纤维和植入物的系统和方法。在一个系统中，将包含多糖和包含交联剂的液体的液体在插管中混合以在套管中形成交联的多糖纤维。在另一系统中，载体流体通过套管递送先前制造的纤维。任选地在套管上设置切割器，以在植入足够长度的纤维之后切断纤维。所公开的方法包括在套管插入体内时在套管中形成多糖纤维的方法，以及制备用于装载到递送系统中的交联多糖纤维的方法。

3. 发明授权

US06440098B1 Device for implanting filamentous materials 失效
标题翻译：用于植入丝状材料的装置
公开(公告)号：US06440098B1
公开(公告)日：2002-08-27
申请号：US09508709
申请日：2000-04-12
申请人： Patrik Lüscher
发明人： Patrik Lüscher
IPC分类号： A61M3100
CPC分类号： A61B17/12022 , A61B17/0467 , A61B17/12131 , A61B17/12168 , A61B17/12186 , A61B17/1219 , A61B2017/00539 , A61B2017/1205
摘要： A device for applying a filamentous implant by means of a pressure-generating and fluid-containing unit which is connected to a housing containing the thread to be implanted. The housing opens out into a channel used for delivering the thread externally. The pressure generation unit generates a static pressure on a fluid contained inside the device, said fluid pushing the thread to be implanted through the distal narrowed tip of the channel, towards the exterior or into a tissue or a body cavity. The fluid remains inside the device in the course of this process. The distal end of the device can be plugged in order to prevent the fluid from exiting after application of the implant. The application can be stopped once an adequate quantity of the implant material has been implanted by severing the thread in the vicinity of the distal end of the channel or at the proximal end.
摘要翻译：一种用于通过压力产生和流体容纳单元施加丝状植入物的装置，其连接到容纳待植入的线的壳体。外壳开启外部用于传送螺纹的通道。压力产生单元在装置内容纳的流体上产生静压力，所述流体将待注入的线通过通道的远端变窄的尖端推向外部或组织或体腔。在此过程中流体保留在设备内部。可以将装置的远端堵塞以防止在施加植入物之后流体离开。一旦通过切断通道的远端附近的线或近端植入了足够数量的植入材料，就可以停止施用。

4. 发明授权

US06299590B1 Implant, and method and device for inserting the implant 有权
标题翻译：植入物，以及用于插入植入物的方法和装置
公开(公告)号：US06299590B1
公开(公告)日：2001-10-09
申请号：US09225682
申请日：1999-01-06
申请人： Patrik Lüscher , Erich Wintermantel
发明人： Patrik Lüscher , Erich Wintermantel
IPC分类号： A61M2100
CPC分类号： A61B17/12131 , A61B17/12022 , A61B17/12186 , A61B2017/00495 , A61B2017/1205 , A61M37/00
摘要： A ball-shaped implant made out of a pliable fiber. The fiber is introduced into the body and when it encounters body tissue it folds upon itself to form a ball-shaped implant. A fluid may be placed around the implant either to hold it in place or to add a biologically active agent to the implant. The fiber of the implant may be biodegradable, or hollow and porous to allow for drugs placed inside the fiber to be administered to the body. One end of the fiber may be long enough to extend out of the body for later removal.
摘要翻译：由柔韧纤维制成的球形植入物。纤维被引入体内，并且当其遇到身体组织时，其折叠在其上以形成球形植入物。流体可以放置在植入物周围以将其保持在适当位置或将生物活性剂添加到植入物。植入物的纤维可以是可生物降解的，或者是空心的和多孔的，以允许放置在纤维内部的药物施用于身体。纤维的一端可能足够长以伸出体外以便以后去除。

5. 发明授权

US06296632B1 Ball-shaped fiber implant, and method and device for inserting the implant 失效
标题翻译：球形纤维植入物，以及用于插入植入物的方法和装置
公开(公告)号：US06296632B1
公开(公告)日：2001-10-02
申请号：US08776943
申请日：1997-04-21
申请人： Patrik Lüscher , Erich Wintermantel
发明人： Patrik Lüscher , Erich Wintermantel
IPC分类号： A61K922
CPC分类号： A61B17/12131 , A61B17/12022 , A61B17/12186 , A61B2017/00495 , A61B2017/1205 , A61M37/00
摘要： In the method proposed, the implant material in the form of a fibre is unwound from a bobbin (10) with the aid of a stream of air (24) and injected through a tube (19) into the body (22). In front of the distal opening (20) of the fibre injection tube, the implant material forms a coherent, open-pore structure in the form of a ball of fibre (25). The fibre-injection tube (19) can be a syringe needle, a catheter or an endoscope tube. This enables the implant (25) to be inserted using minimum-invasive surgery. The size and shape of the implant thus produced can be very variable and can be determined intra-operatively. Various implant materials and fibre shapes can be used. Possible applications of the implant are in the filling of body cavities, systems for the controlled release of systemically acting drugs or chemotherapeutic agents, the induction of tissue, cell transplantation and therapeutic embolization.
摘要翻译：在所提出的方法中，纤维形式的植入材料借助于空气流（24）从筒管（10）展开并通过管（19）注入到主体（22）中。在纤维注入管的远端开口（20）的前方，植入材料形成纤维球（25）形式的相干的开孔结构。纤维注射管（19）可以是注射针，导管或内窥镜管。这使得能够使用最小侵入性手术插入植入物（25）。由此产生的植入物的尺寸和形状可以是非常可变的并且可以在手术中确定。可以使用各种种植体材料和纤维形状。植入物的可能应用是填充体腔，用于受控释放全身作用药物或化学治疗剂的系统，组织诱导，细胞移植和治疗性栓塞。

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