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1. 发明授权

US5965706A Regulator of gene transcription 失效
标题翻译：基因转录调节子
公开(公告)号：US5965706A
公开(公告)日：1999-10-12
申请号：US66262
申请日：1998-04-24
申请人： Jennifer L. Hillman , Surya K. Goli , David G. Streeter
发明人： Jennifer L. Hillman , Surya K. Goli , David G. Streeter
IPC分类号： A61K38/00 , C07K14/47 , C12N15/12 , C07K5/00
CPC分类号： C07K14/4702 , A61K38/00
摘要： The present invention provides a human regulator of gene transcription (HRGT) and polynucleotides which encode HRGT. The invention also provides expression vectors, host cells, agonists, antisense molecules, antibodies, or antagonists. The invention also provides methods for treating disorders associated with expression of HRGT.
摘要翻译：本发明提供编码HRGT的人基因转录调节子（HRGT）和多核苷酸。本发明还提供表达载体，宿主细胞，激动剂，反义分子，抗体或拮抗剂。本发明还提供了治疗与HRGT表达相关的疾病的方法。

2. 发明授权

US5776698A Regulation of gene transcription 失效
标题翻译：基因转录调控
公开(公告)号：US5776698A
公开(公告)日：1998-07-07
申请号：US839710
申请日：1997-04-14
申请人： Jennifer L. Hillman , Surya K. Goli , David G. Streeter
发明人： Jennifer L. Hillman , Surya K. Goli , David G. Streeter
IPC分类号： A61K38/00 , C07K14/47 , C12N15/12 , C12P21/06 , C07H21/02 , C12N5/00 , C12N15/00
CPC分类号： C07K14/4702 , A61K38/00
摘要： The present invention provides a human regulator of gene transcription (HRGT) and polynucleotides which encode HRGT. The invention also provides expression vectors, host cells, agonists, antisense molecules, antibodies, or antagonists. The invention also provides methods for treating disorders associated with expression of HRGT.
摘要翻译：本发明提供编码HRGT的人基因转录调节子（HRGT）和多核苷酸。本发明还提供表达载体，宿主细胞，激动剂，反义分子，抗体或拮抗剂。本发明还提供了治疗与HRGT表达相关的疾病的方法。

3. 发明授权

US06399345B2 Subunits of NADH dehydrogenase 失效
标题翻译： NADH脱氢酶亚基
公开(公告)号：US06399345B2
公开(公告)日：2002-06-04
申请号：US09151412
申请日：1998-09-10
申请人： Olga Bandman , Surya K. Goli , Jennifer L. Hillman
发明人： Olga Bandman , Surya K. Goli , Jennifer L. Hillman
IPC分类号： C12N906
CPC分类号： C12N9/0036 , A61K38/00
摘要： The present invention provides four NADH dehydrogenase subunits (designated individually as NDS-1, NDS-2, NDS-3, and NDS-4 and collectively as NDS) and polynucleotides which identify and encode NDS. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding NDS and a method for producing NDS. The invention also provides for use of NDS and agonists, antibodies, or antagonists specifically binding NDS, in the prevention and treatment of diseases associated with expression of NDS. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding NDS for the treatment of diseases associated with the expression of NDS. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding NDS.
摘要翻译：本发明提供四种NADH脱氢酶亚基（分别称为NDS-1，NDS-2，NDS-3和NDS-4，统称为NDS）和鉴定和编码NDS的多核苷酸。本发明还提供了遗传工程改造的表达载体和包含编码NDS的核酸序列和产生NDS的方法的宿主细胞。本发明还提供使用NDS和特异性结合NDS的激动剂，抗体或拮抗剂来预防和治疗与NDS表达相关的疾病。另外，本发明提供反义分子用于编码NDS的多核苷酸用于治疗与NDS表达相关的疾病。本发明还提供了利用多核苷酸或其片段或其补体以及特异性结合NDS的抗体的诊断测定法。

4. 发明授权

US06307021B1 Human apoptosis regulator 失效
标题翻译：人类凋亡调节因子
公开(公告)号：US06307021B1
公开(公告)日：2001-10-23
申请号：US09199892
申请日：1998-11-24
申请人： Olga Bandman , Surya K. Goli , Jennifer L. Hillman
发明人： Olga Bandman , Surya K. Goli , Jennifer L. Hillman
IPC分类号： C07K100
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention provides a human apoptosis regulator protein (APRG) and polynucleotides which identify and encode APRG. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding APRG and a method for producing APRG. The invention also provides for agonists, antibodies, or antagonists specifically binding APRG, and their use, in the prevention and treatment of diseases associated with expression of APRG. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding APRG for the treatment of diseases associated with the expression of APRG. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding APRG.
摘要翻译：本发明提供了鉴定和编码APRG的人细胞凋亡调节蛋白（APRG）和多核苷酸。本发明还提供了遗传工程改造的表达载体和宿主细胞，其包含编码APRG的核酸序列和生产APRG的方法。本发明还提供了特异性结合APRG的激动剂，抗体或拮抗剂及其在预防和治疗与APRG表达相关的疾病中的用途。此外，本发明提供了反义分子用于编码APRG的多核苷酸用于治疗与APRG表达相关的疾病的用途。本发明还提供利用多核苷酸或其片段或其补体以及特异性结合APRG的抗体的诊断测定法。

5. 发明授权

US06303297B1 Database for storage and analysis of full-length sequences 失效
标题翻译：数据库用于存储和分析全长序列
公开(公告)号：US06303297B1
公开(公告)日：2001-10-16
申请号：US08969987
申请日：1997-11-13
申请人： Steve E. Lincoln , Tod M. Klingler , Janice Au-Young , Y. Tom Tang , Richard D. Goold , Ingrid E. Akerblom , Jeffrey J. Seilhamer , Phillip R. Hawkins , Lynn E. Murry , Angelo M. Delegeane , Wendy B. Levine , Jennifer L. Hillman , Surya K. Goli , Christina M. Altus , Olga Bandman , Samuel T. LaBrie , Purvi Shah
发明人： Steve E. Lincoln , Tod M. Klingler , Janice Au-Young , Y. Tom Tang , Richard D. Goold , Ingrid E. Akerblom , Jeffrey J. Seilhamer , Phillip R. Hawkins , Lynn E. Murry , Angelo M. Delegeane , Wendy B. Levine , Jennifer L. Hillman , Surya K. Goli , Christina M. Altus , Olga Bandman , Samuel T. LaBrie , Purvi Shah
IPC分类号： C12Q168
CPC分类号： C12N9/6445 , A61K38/00 , C07K14/47 , C07K14/4703 , C07K14/82 , C07K16/303 , C12Q1/68 , C12Q1/6809 , G01N33/574 , G06F19/18 , G06F19/22 , G06F19/28
摘要： The present invention is a computerized storage and retrieval system for genetic information and related annotated information. The data of the system is stored in a relational database which interfaces with public databases to allow analysis both within the database of the invention and between information within that database and external public databases. The sequence data is edited before entry into the system, and is stored in a curated, functional clustering organization. The information associated with the data is stored in an expression database that is linked to the storage of the sequence data.
摘要翻译：本发明是用于遗传信息和相关注释信息的计算机化存储和检索系统。系统的数据存储在与公共数据库接口的关系数据库中，以便在本发明的数据库内以及该数据库内的信息和外部公共数据库之间进行分析。序列数据在进入系统之前进行编辑，并存储在策略化的功能集群组织中。与数据相关联的信息存储在链接到序列数据的存储的表达式数据库中。

6. 发明授权

US6136314A Histone fusion protein 失效
标题翻译：组蛋白融合蛋白
公开(公告)号：US6136314A
公开(公告)日：2000-10-24
申请号：US353688
申请日：1999-07-14
申请人： Jennifer L. Hillman , Surya K. Goli
发明人： Jennifer L. Hillman , Surya K. Goli
IPC分类号： A61K38/00 , C07K14/47 , C12P21/06 , C07H21/04 , C07K1/00 , C12N1/20 , C12N15/00
CPC分类号： C07K14/47 , A61K38/00 , C07K2319/00
摘要： The present invention provides a human histone fusion protein (HFP) and polynucleotides which identify and encode HFP. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. In addition, the invention also provides methods for producing HFP and for treating or preventing disorders associated with expression of HFP.
摘要翻译：本发明提供了人组蛋白融合蛋白（HFP）和识别和编码HFP的多核苷酸。本发明还提供表达载体，宿主细胞，激动剂，抗体和拮抗剂。此外，本发明还提供了用于生产HFP和用于治疗或预防与HFP表达相关的病症的方法。

7. 发明授权

US6083704A Human cytochrome b5 失效
标题翻译：人细胞色素b5
公开(公告)号：US6083704A
公开(公告)日：2000-07-04
申请号：US178881
申请日：1998-10-26
申请人： Jennifer L. Hillman , Surya K. Goli , David Gray Streeter
发明人： Jennifer L. Hillman , Surya K. Goli , David Gray Streeter
IPC分类号： A61K38/00 , C07K14/80 , C12N1/21 , C12N15/12 , C12Q1/68 , C07H21/04
CPC分类号： C07K14/80 , A61K38/00
摘要： The present invention provides a human cytochrome b5 (HCB5) and polynucleotides which encode HCB5. The invention also provides genetically engineered expression vectors and host cells and a method for producing HCBS. The invention also provides for agonists, antisense molecules, antibodies, or antagonists of HCB5, and their use in the prevention and treatment of diseases associated with expression of HCB5. The invention also provides a method for detecting polynucleotides which encode HCB5.
摘要翻译：本发明提供人细胞色素b5（HCB5）和编码HCB5的多核苷酸。本发明还提供基因工程表达载体和宿主细胞以及生产HCBS的方法。本发明还提供HCB5的激动剂，反义分子，抗体或拮抗剂及其在预防和治疗与HCB5表达有关的疾病中的用途。本发明还提供了一种检测编码HCB5的多核苷酸的方法。

8. 发明授权

US5962646A ATP synthase Fo subunit 失效
标题翻译： ATP合酶Fo亚基
公开(公告)号：US5962646A
公开(公告)日：1999-10-05
申请号：US216625
申请日：1998-12-16
申请人： Jennifer L. Hillman , Surya K. Goli
发明人： Jennifer L. Hillman , Surya K. Goli
IPC分类号： A61K38/00 , C12N9/14 , C07K14/00
CPC分类号： C12N9/14 , A61K38/00
摘要： The present invention provides a human ATP synthase d subunit (ASYSD) and polynucleotides which encode ASYSD. The invention also provides expression vectors, host cells, agonists, antisense molecules, antibodies, or antagonists. The invention also provides to methods for producing ASYSD and for treating disorders associated with expression of ASYSD.
摘要翻译：本发明提供了人ATP合成酶d亚基（ASYSD）和编码ASYSD的多核苷酸。本发明还提供表达载体，宿主细胞，激动剂，反义分子，抗体或拮抗剂。本发明还提供了用于产生ASYSD和用于治疗与ASYSD表达相关的疾病的方法。

9. 发明授权

US5955428A DNA encoding human metallothionein 失效
标题翻译：编码人金属硫蛋白的DNA
公开(公告)号：US5955428A
公开(公告)日：1999-09-21
申请号：US123850
申请日：1997-07-28
申请人： Jennifer L. Hillman , Surya K. Goli
发明人： Jennifer L. Hillman , Surya K. Goli
IPC分类号： C12N15/09 , A61K38/00 , A61P35/00 , A61P37/00 , A61P39/02 , C07K14/825 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12Q1/68
CPC分类号： C07K14/825 , A61K38/00
摘要： The present invention provides a human metallothionein (HMBP-I) and polynucleotides which identify and encode HMBP-I. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HMBP-I and a method for producing HMBP-I. The invention also provides for agonists, antibodies, or antagonists specifically binding HMBP-I, and their use, in the prevention and treatment of diseases associated with expression of HMBP-I. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HMBP-I for the treatment of diseases associated with the expression of HMBP-I. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HMBP-I.
摘要翻译：本发明提供人金属硫蛋白（HMBP-1）和识别和编码HMBP-1的多核苷酸。本发明还提供了包含编码HMBP-1的核酸序列和生产HMBP-1的方法的遗传工程表达载体和宿主细胞。本发明还提供了特异性结合HMBP-1的激动剂，抗体或拮抗剂及其用于预防和治疗与HMBP-1表达有关的疾病的用途。此外，本发明提供了反义分子用于编码HMBP-1的多核苷酸用于治疗与HMBP-1表达相关的疾病的用途。本发明还提供利用多核苷酸或其片段或其补体以及特异性结合HMBP-1的抗体的诊断测定法。

10. 发明授权

US5948625A Method of screening for ATP synthase Fo subunit 失效
标题翻译：筛选ATP合酶Fo亚基的方法
公开(公告)号：US5948625A
公开(公告)日：1999-09-07
申请号：US94080
申请日：1998-06-09
申请人： Jennifer L. Hillman , Surya K. Goli
发明人： Jennifer L. Hillman , Surya K. Goli
IPC分类号： A61K38/00 , C12N9/14 , C07H21/04 , C12Q1/68
CPC分类号： C12N9/14 , A61K38/00
摘要： The present invention provides a human ATP synthase d subunit (ASYSD) and polynucleotides which encode ASYSD. The invention also provides expression vectors, host cells, agonists, antisense molecules, antibodies, or antagonists. The invention also provides methods for producing ASYSD and for treating disorders associated with expression of ASYSD.
摘要翻译：本发明提供了人ATP合成酶d亚基（ASYSD）和编码ASYSD的多核苷酸。本发明还提供表达载体，宿主细胞，激动剂，反义分子，抗体或拮抗剂。本发明还提供了用于产生ASYSD和用于治疗与ASYSD表达相关的疾病的方法。

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