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1. 发明授权

US08608795B2 Tapered loading system for implantable medical devices 有权
标题翻译：用于可植入医疗器械的锥形加载系统
公开(公告)号：US08608795B2
公开(公告)日：2013-12-17
申请号：US12328157
申请日：2008-12-04
申请人： Jeffry S. Melsheimer , Sean D. Chambers , Arman H. Valaie , Ram H. Paul
发明人： Jeffry S. Melsheimer , Sean D. Chambers , Arman H. Valaie , Ram H. Paul
IPC分类号： A61F2/24 , A61F2/06
CPC分类号： A61F2/0095 , A61F2/95 , A61F2002/9522 , Y10T29/53
摘要： Loading systems for compressing and loading an implantable medical device into a device chamber of a medical device delivery system are described. The loading systems include an elongate holding chamber within which the intraluminal medical device is disposed. A plunger has one or more attached pushers adapted to axially advance the intraluminal medical device through an intermediate portion of the holding chamber that has a tapered surface, which compresses the intraluminal medical device over a dilator of a medical device delivery system that has been introduced through the distal end of the elongate holding chamber. The elongate holding chamber can be placed within an outer storage container with an appropriate seal to for storage of the intraluminal medical device within the loading system. Methods of preparing an intraluminal medical device for implantation in a patient and kits useful in such methods are also described.
摘要翻译：描述了用于将可植入医疗装置压缩和装载到医疗装置输送系统的装置室中的装载系统。装载系统包括细长的保持室，其中设置管腔内医疗装置。柱塞具有一个或多个附接的推动器，其适于轴向前进管腔内医疗装置通过具有锥形表面的保持室的中间部分，该锥形表面压缩管腔内医疗装置通过已经被引入的医疗装置输送系统的扩张器细长保持室的远端。细长保持室可以放置在具有适当密封件的外部存储容器内，以便将管腔内医疗装置储存在装载系统内。还描述了制备用于植入患者的管腔内医疗装置的方法和用于这些方法的试剂盒。

2. 发明申请

US20090143857A1 TAPERED LOADING SYSTEM FOR IMPLANTABLE MEDICAL DEVICES 有权
标题翻译：用于可植入医疗器械的切割加载系统
公开(公告)号：US20090143857A1
公开(公告)日：2009-06-04
申请号：US12328157
申请日：2008-12-04
申请人： Jeffry S. Melsheimer , Sean D. Chambers , Arman H. Valaie , Ram H. Paul
发明人： Jeffry S. Melsheimer , Sean D. Chambers , Arman H. Valaie , Ram H. Paul
IPC分类号： A61F2/24
CPC分类号： A61F2/0095 , A61F2/95 , A61F2002/9522 , Y10T29/53
摘要： Loading systems for compressing and loading an implantable medical device into a device chamber of a medical device delivery system are described. The loading systems include an elongate holding chamber within which the intraluminal medical device is disposed. A plunger has one or more attached pushers adapted to axially advance the intraluminal medical device through an intermediate portion of the holding chamber that has a tapered surface, which compresses the intraluminal medical device over a dilator of a medical device delivery system that has been introduced through the distal end of the elongate holding chamber. The elongate holding chamber can be placed within an outer storage container with an appropriate seal to for storage of the intraluminal medical device within the loading system. Methods of preparing an intraluminal medical device for implantation in a patient and kits useful in such methods are also described.
摘要翻译：描述了用于将可植入医疗装置压缩和装载到医疗装置输送系统的装置室中的装载系统。装载系统包括细长的保持室，其中设置管腔内医疗装置。柱塞具有一个或多个附接的推动器，其适于轴向前进管腔内医疗装置通过具有锥形表面的保持室的中间部分，该锥形表面压缩管腔内医疗装置通过已经被引入的医疗装置输送系统的扩张器细长保持室的远端。细长保持室可以放置在具有适当密封件的外部存储容器内，以便将管腔内医疗装置储存在装载系统内。还描述了制备用于植入患者的管腔内医疗装置的方法和用于这些方法的试剂盒。

3. 发明授权

US08372140B2 Implantable valve prosthesis with independent frame elements 有权
标题翻译：具有独立框架元件的植入式瓣膜假体
公开(公告)号：US08372140B2
公开(公告)日：2013-02-12
申请号：US12683670
申请日：2010-01-07
申请人： Grant T. Hoffman , Sean D. Chambers , Jeffry S. Melsheimer
发明人： Grant T. Hoffman , Sean D. Chambers , Jeffry S. Melsheimer
IPC分类号： A61F2/06
CPC分类号： A61F2/2412 , A61F2/2418 , A61F2/2475 , A61F2210/0076 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2220/0075 , A61F2230/0054
摘要： An implantable valve prosthesis is provided. The valve prosthesis includes a frame structure having first and second independent frame elements. A graft member is attached to both the first and second frame elements and includes a closure member, such as a valve leaflet. The closure member is movable between a first position that allows fluid flow through the prosthesis in a first, antegrade direction and a second position that restricts flow through the prosthesis in a second, retrograde direction.
摘要翻译：提供可植入瓣膜假体。瓣膜假体包括具有第一和第二独立框架元件的框架结构。移植构件附接到第一和第二框架元件两者并且包括封闭构件，例如瓣膜单元。闭合构件可在第一位置和第二位置之间移动，所述第一位置允许流体以第一顺行方向流过假体，而第二位置限制在第二逆行方向上流过假体的流动。

4. 发明申请

US20100174364A1 IMPLANTABLE VALVE PROSTHESIS WITH INDEPENDENT FRAME ELEMENTS 有权
标题翻译：可拆卸的阀门具有独立的框架元件
公开(公告)号：US20100174364A1
公开(公告)日：2010-07-08
申请号：US12683670
申请日：2010-01-07
申请人： Grant T. Hoffman , Sean D. Chambers , Jeffry S. Melsheimer
发明人： Grant T. Hoffman , Sean D. Chambers , Jeffry S. Melsheimer
IPC分类号： A61F2/24
CPC分类号： A61F2/2412 , A61F2/2418 , A61F2/2475 , A61F2210/0076 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2220/0075 , A61F2230/0054
摘要： An implantable valve prosthesis is provided. The valve prosthesis includes a frame structure having first and second independent frame elements. A graft member is attached to both the first and second frame elements and includes a closure member, such as a valve leaflet. The closure member is movable between a first position that allows fluid flow through the prosthesis in a first, antegrade direction and a second position that restricts flow through the prosthesis in a second, retrograde direction.
摘要翻译：提供可植入瓣膜假体。瓣膜假体包括具有第一和第二独立框架元件的框架结构。移植构件附接到第一和第二框架元件两者并且包括封闭构件，例如瓣膜单元。闭合构件可在第一位置和第二位置之间移动，所述第一位置允许流体以第一顺行方向流过假体，而第二位置限制在第二逆行方向上流过假体的流动。

5. 发明授权

US08585019B2 Loading apparatus and system for expandable intraluminal medical devices 有权
标题翻译：可扩展管腔内医疗器械的装载装置和系统
公开(公告)号：US08585019B2
公开(公告)日：2013-11-19
申请号：US12860422
申请日：2010-08-20
申请人： Jeffry S. Melsheimer , Jessica L. Burke , Sean D. Chambers , Arman Valaie
发明人： Jeffry S. Melsheimer , Jessica L. Burke , Sean D. Chambers , Arman Valaie
IPC分类号： A61F2/84
CPC分类号： A61F2/95 , A61F2/2436 , A61F2/844 , A61F2/92 , A61F2002/9511 , A61F2002/9522 , Y10T29/53843
摘要： Medical device loading apparatuses, systems, methods and kits are described. A loading apparatus comprises a main body having a proximal end defining a proximal opening, a distal end defining a distal opening, and a passageway extending between the proximal and distal openings. The passageway defines a proximal chamber having a first inner diameter, a distal chamber having a second inner diameter, and a transition chamber disposed between the proximal and distal chambers. The transition chamber has an inner diameter that transitions from the larger second inner diameter to the smaller first inner diameter. The main body has a separable connection that divides the main body between proximal and distal portions when disrupted. An expandable intraluminal medical device can be loaded into a delivery catheter using the loading apparatus by placing the device into the passageway such that it is in a radially-expanded configuration; pulling the device along an axial path through the loading apparatus such that the device transitions from the radially-expanded configuration to a radially-compressed configuration; and pushing the radially-compressed device along the axial path into the delivery catheter.
摘要翻译：描述了医疗装置装载装置，系统，方法和试剂盒。装载装置包括主体，其具有限定近端开口的近端，限定远侧开口的远端以及在近端开口和远端开口之间延伸的通道。所述通道限定具有第一内径的近侧腔室，具有第二内径的远侧腔室，以及设置在近端腔室和远端腔室之间的过渡腔室。过渡室具有从较大的第二内径向较小的第一内径转变的内径。主体具有可分离的连接，当中断时将主体分成近端部分和远端部分之间。可扩张的管腔内医疗装置可以通过将装置放置在通道中以使其处于径向展开的构型中而使用装载装置装载到输送导管中; 沿着轴向路径拉动装置通过装载装置，使得装置从径向展开的构型转变成径向压缩的构型; 并将径向压缩的装置沿轴向路径推入输送导管。

6. 发明申请

US20110046712A1 LOADING APPARATUS AND SYSTEM FOR EXPANDABLE INTRALUMINAL MEDICAL DEVICES 有权
标题翻译：用于可扩展的内镜医疗装置的装载装置和系统
公开(公告)号：US20110046712A1
公开(公告)日：2011-02-24
申请号：US12860422
申请日：2010-08-20
申请人： Jeffry S. Melsheimer , Jessica L. Burke , Sean D. Chambers , Arman Valaie
发明人： Jeffry S. Melsheimer , Jessica L. Burke , Sean D. Chambers , Arman Valaie
IPC分类号： A61F2/84
CPC分类号： A61F2/95 , A61F2/2436 , A61F2/844 , A61F2/92 , A61F2002/9511 , A61F2002/9522 , Y10T29/53843
摘要： Medical device loading apparatuses, systems, methods and kits are described. A loading apparatus comprises a main body having a proximal end defining a proximal opening, a distal end defining a distal opening, and a passageway extending between the proximal and distal openings. The passageway defines a proximal chamber having a first inner diameter, a distal chamber having a second inner diameter, and a transition chamber disposed between the proximal and distal chambers. The transition chamber has an inner diameter that transitions from the larger second inner diameter to the smaller first inner diameter. The main body has a separable connection that divides the main body between proximal and distal portions when disrupted. An expandable intraluminal medical device can be loaded into a delivery catheter using the loading apparatus by placing the device into the passageway such that it is in a radially-expanded configuration; pulling the device along an axial path through the loading apparatus such that the device transitions from the radially-expanded configuration to a radially-compressed configuration; and pushing the radially-compressed device along the axial path into the delivery catheter.
摘要翻译：描述了医疗装置装载装置，系统，方法和试剂盒。装载装置包括主体，其具有限定近端开口的近端，限定远侧开口的远端以及在近端开口和远端开口之间延伸的通道。所述通道限定具有第一内径的近侧腔室，具有第二内径的远侧腔室，以及设置在近端腔室和远端腔室之间的过渡腔室。过渡室具有从较大的第二内径向较小的第一内径转变的内径。主体具有可分离的连接，当中断时将主体分成近端部分和远端部分之间。可扩张的管腔内医疗装置可以通过将装置放置在通道中以使其处于径向展开的构型中而使用装载装置装载到输送导管中; 沿着轴向路径拉动装置通过装载装置，使得装置从径向展开的构型转变成径向压缩的构型; 并将径向压缩的装置沿轴向路径推入输送导管。

7. 发明公开

US20240058094A1 MRI Compatible Interventional Medical Devices and Related Methods 审中-公开
公开(公告)号：US20240058094A1
公开(公告)日：2024-02-22
申请号：US18234440
申请日：2023-08-16
申请人： Ram H. Paul, Jr. , Sean D. Chambers , David Gross , Neal Fearnot , Jesse Roll , Joshua F. Krieger , Carl A. Cook
发明人： Ram H. Paul, Jr. , Sean D. Chambers , David Gross , Neal Fearnot , Jesse Roll , Joshua F. Krieger , Carl A. Cook
IPC分类号： A61B90/00 , A61B5/055 , A61L31/02 , A61L31/14
CPC分类号： A61B90/39 , A61B5/055 , A61L31/022 , A61L31/14 , A61B2090/3954 , A61M2025/09075
摘要： The disclosure relates to methods of imaging a portion of a body vessel using magnetic resonance imaging (MRI), methods of performing interventional medical treatment under MRI, interventional medical devices, such as wire guides, useful in performing treatment under MRI, and methods of making interventional medical devices. A method of imaging a portion of a body vessel of a patient using MRI includes advancing through a body vessel an end of a wire guide comprising a continuous metal core member and a continuous jacket disposed over the entire core member through a body vessel and scanning the portion of the patient that is positioned within an MRI scanner and that includes a portion of the body vessel within which the end of the wire guide is disposed. A secondary medical device, such as a catheter, can be disposed over the wire guide and manipulated in the method.

8. 发明申请

US20130079867A1 Valve Frame 审中-公开
公开(公告)号：US20130079867A1
公开(公告)日：2013-03-28
申请号：US13681362
申请日：2012-11-19
申请人： Grant T. Hoffman , Sean D. Chambers , Ram H. Paul
发明人： Grant T. Hoffman , Sean D. Chambers , Ram H. Paul
IPC分类号： A61F2/24
CPC分类号： A61F2/2475 , A61F2/24 , A61F2/2418 , A61F2220/0008 , A61F2220/0016 , A61F2220/005 , A61F2220/0058
摘要： The disclosure relates to support frames for prosthetic implantable valves. The support frames may include a plurality of symmetrically arrayed interconnected U-shaped member structures. Preferred support frames are tubular structures enclosing a longitudinal axis and including a plurality of U-shaped member structures facing a distal or a proximal end of the support frame. Each U-shaped member structure may be connected to a single longitudinally adjacent U-shaped member facing in an opposite longitudinal direction, as well as two laterally adjacent U-shaped members.

9. 发明授权

US08128686B2 Branched vessel prosthesis 有权
标题翻译：分支血管假体
公开(公告)号：US08128686B2
公开(公告)日：2012-03-06
申请号：US12425911
申请日：2009-04-17
申请人： Ram H. Paul, Jr. , Sean D. Chambers
发明人： Ram H. Paul, Jr. , Sean D. Chambers
IPC分类号： A61F2/06
CPC分类号： A61F2/86 , A61F2/2418 , A61F2/2475 , A61F2/856 , A61F2/954 , A61F2002/061 , A61F2002/065 , A61F2002/075 , A61F2002/825 , A61F2002/9505 , A61F2002/9511 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2220/0075 , A61F2230/0054
摘要： The present disclosure describes an implantable branched vessel prosthesis, such as a prosthetic valve, having both a radially expandable annular portion and a laterally extendable branch portion. Methods of delivering the branched vessel prosthesis to a branched body vessel are also provided, as well as delivery systems comprising the branched vessel prosthesis. The branched vessel prostheses are useful, for example, as implantable prosthetic venous valves for treating venous valve insufficiency. The delivery system is configured to deploy independently both the annular portion within a primary vessel and the branch portion within a branch vessel with only one delivery system.
摘要翻译：本公开描述了一种可植入的分支血管假体，例如假体瓣膜，其具有径向可扩张的环形部分和可横向延伸的分支部分。还提供将分支血管假体递送到分支体血管的方法，以及包括分支血管假体的递送系统。分支血管假体可用作例如用于治疗静脉瓣膜功能不全的可植入假体静脉瓣。输送系统被配置为仅在一个主容器内部的环形部分和仅具有一个输送系统的分支容器内的分支部分。

10. 发明授权

US09192473B2 Valve frame 有权
标题翻译：阀框
公开(公告)号：US09192473B2
公开(公告)日：2015-11-24
申请号：US13681362
申请日：2012-11-19
申请人： Grant T. Hoffman , Sean D. Chambers , Ram H. Paul
发明人： Grant T. Hoffman , Sean D. Chambers , Ram H. Paul
IPC分类号： A61F2/24
CPC分类号： A61F2/2475 , A61F2/24 , A61F2/2418 , A61F2220/0008 , A61F2220/0016 , A61F2220/005 , A61F2220/0058
摘要： The disclosure relates to support frames for prosthetic implantable valves. The support frames may include a plurality of symmetrically arrayed interconnected U-shaped member structures. Preferred support frames are tubular structures enclosing a longitudinal axis and including a plurality of U-shaped member structures facing a distal or a proximal end of the support frame. Each U-shaped member structure may be connected to a single longitudinally adjacent U-shaped member facing in an opposite longitudinal direction, as well as two laterally adjacent U-shaped members.
摘要翻译：本公开涉及用于假体植入式阀的支撑框架。支撑框架可以包括多个对称排列的互连的U形构件结构。优选的支撑框架是包围纵向轴线并且包括面向支撑框架的远端或近端的多个U形构件结构的管状结构。每个U形构件结构可以连接到面向相反纵向方向的单个纵向相邻的U形构件以及两个横向相邻的U形构件。

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