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1. 发明授权

US06858224B2 Method of preventing aggregation of a lipid:nucleic acid complex 失效
标题翻译：防止脂质聚集的方法：核酸复合物
公开(公告)号：US06858224B2
公开(公告)日：2005-02-22
申请号：US09875805
申请日：2001-06-05
申请人： Jeffrey Wheeler , Marcel B. Bally , Yuan-Peng Zhang , Dorothy L. Reimer , Michael Hope
发明人： Jeffrey Wheeler , Marcel B. Bally , Yuan-Peng Zhang , Dorothy L. Reimer , Michael Hope
IPC分类号： A61K9/127 , C12N15/88 , A61K31/70 , G01N33/53
CPC分类号： A61K9/1272 , A61K47/6911 , C12N15/88 , Y10S436/829
摘要： Particle aggregation of lipid:nucleic acid complex particles is prevented by incorporating a non-cationic lipid into lipid:nucleic acid complex particles containing a cationic lipid and a nucleic acid polymer. The non-cationic lipid is a polyethylene glycol-based polymer.
摘要翻译：通过将非阳离子脂质掺入含有阳离子脂质和核酸聚合物的脂质：核酸复合物颗粒中来防止脂质：核酸复合物颗粒的颗粒聚集。非阳离子脂质是聚乙二醇基聚合物。

2. 发明申请

US20070172950A1 Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use of gene transfer 审中-公开
标题翻译：通过疏水性脂质 - 核酸复合物中间体制备的脂质 - 核酸颗粒和使用基因转移
公开(公告)号：US20070172950A1
公开(公告)日：2007-07-26
申请号：US11728134
申请日：2007-03-23
申请人： Jeffrey Wheeler , Marcel Bally , Yuan-Peng Zhang , Dorothy Reimer , Michael Hope , Pieter Cullis , Peter Scherrer
发明人： Jeffrey Wheeler , Marcel Bally , Yuan-Peng Zhang , Dorothy Reimer , Michael Hope , Pieter Cullis , Peter Scherrer
IPC分类号： C12N15/88
CPC分类号： A61K9/1272 , A61K47/6911 , C12N15/88 , Y10S436/829
摘要： Novel lipid-nucleic acid particulate complexes which are useful for in vitro or in vivo gene transfer are described. The particles can be formed using either detergent dialysis methods or methods which utilize organic solvents. Upon removal of a solubilizing component (i.e., detergent or an organic solvent) the lipid-nucleic acid complexes form particles wherein the nucleic acid is serum-stable and is protected from degradation. The particles thus formed have access to extravascular sites and target cell populations and are suitable for the therapeutic delivery of nucleic acids.
摘要翻译：描述了可用于体外或体内基因转移的新型脂质 - 核酸颗粒复合物。可以使用洗涤剂透析方法或利用有机溶剂的方法形成颗粒。在除去增溶组分（即洗涤剂或有机溶剂）后，脂质 - 核酸复合物形成其中核酸是血清稳定的并且被保护免于降解的颗粒。由此形成的颗粒可以进入血管外部位和靶细胞群，并且适合于治疗性递送核酸。

3. 发明授权

US07047526B1 Generic command interface for multiple executable routines 有权
标题翻译：用于多个可执行例程的通用命令界面
公开(公告)号：US07047526B1
公开(公告)日：2006-05-16
申请号：US09604880
申请日：2000-06-28
申请人： Jeffrey Wheeler , Paul Mustoe
发明人： Jeffrey Wheeler , Paul Mustoe
IPC分类号： G06F9/44
CPC分类号： G06F17/30961 , Y10S707/99933 , Y10S707/99943
摘要： A processor based system having a parser is configured for validating a generic command received from a user relative to a command parse tree. The command parse tree includes multiple elements, each specifying at least one corresponding generic command component and a corresponding at least one command action value. The parser, upon identifying a best match among the elements, issues a prescribed command for a selected one of the management programs according to the corresponding command format based on the selected command action value. Hence, a user may control multiple management programs having respective command formats, by using a set of generic commands that are independent from the command formats, eliminating the necessity that the user needs to learn the detailed command formats and syntax.
摘要翻译：具有解析器的基于处理器的系统被配置用于验证从用户相对于命令解析树接收的通用命令。命令解析树包括多个元素，每个元素指定至少一个对应的通用命令组件和相应的至少一个命令动作值。解析器在识别元素之间的最佳匹配时，基于所选择的命令动作值，根据相应的命令格式向所选择的一个管理程序发出规定的命令。因此，用户可以通过使用独立于命令格式的一组通用命令来控制具有相应命令格式的多个管理程序，消除了用户需要学习详细命令格式和语法的必要性。

4. 发明申请

US20050144812A1 Sports shoe cover 审中-公开
标题翻译：运动鞋套
公开(公告)号：US20050144812A1
公开(公告)日：2005-07-07
申请号：US10505465
申请日：2003-02-20
申请人： Jeffrey Wheeler
发明人： Jeffrey Wheeler
IPC分类号： A43B3/20 , A43B5/02 , A43B5/18 , A43C7/06
CPC分类号： A43B23/24 , A43B3/0078 , A43B3/20 , A43B5/02 , A43B5/025 , A43B5/18 , A43C7/06
摘要： A cover for a lace-up football boot has a continuous, elastically expandable sleeve (1). The sleeve is, in use, stretched around the boot so that the latter extends through the sleeve with the toe of the boot protruding from the end of the sleeve, and that the underside of the sleeve engages the portion of the underside of the boot in a region between the heal and the toe (i.e. under the arch of the foot). This engagement between the sleeve and the boot is sufficient to hold the sleeve in position on the boot in use, the sleeve also covering the bootlaces to prevent the latter from untying. At least part of the cover may also be transparent so as to reveal ornamental features or indicia on the boot.
摘要翻译：用于系带足球靴的罩具有连续的弹性可膨胀套筒（1）。在使用中，套筒被拉伸在靴子周围，使得后者延伸穿过套筒，靴子的脚趾从套筒的端部突出，并且套筒的下侧与靴子的下侧部分接合治疗和脚趾之间的区域（即在脚下）。袖子和靴子之间的接合足以在使用时将套管保持在靴子上的适当位置，套筒还覆盖靴子以防止其脱离。盖的至少一部分也可以是透明的，以便露出靴子上的装饰特征或标记。

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