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1. 发明申请

US20090029344A1 Compositions and assays utilizing ADP or phosphate for detecting protein modulators 审中-公开
公开(公告)号：US20090029344A1
公开(公告)日：2009-01-29
申请号：US12150596
申请日：2008-04-28
申请人： Jeffrey T. Finer , Fady Malik , Roman Sakowicz , Christopher Shumate , Kenneth Wood
发明人： Jeffrey T. Finer , Fady Malik , Roman Sakowicz , Christopher Shumate , Kenneth Wood
IPC分类号： C12Q1/00
CPC分类号： C12Q1/34 , C12Q1/42 , C12Q1/485 , G01N33/573
摘要： Described herein are methods which identify candidate agents as binding to a protein or as a modulator of the binding characteristics or biological activity of a protein. Generally, the methods involve the use of ADP or phosphate. The assays can be used in a high throughput system to obviate the cumbersome steps of using gels or radioactive materials.

2. 发明授权

US07378254B2 Compositions and assays utilizing ADP or phosphate for detecting protein modulators 有权
标题翻译：使用ADP或磷酸盐检测蛋白质调节剂的组合物和测定法
公开(公告)号：US07378254B2
公开(公告)日：2008-05-27
申请号：US11655733
申请日：2007-01-18
申请人： Jeffrey T. Finer , Fady Malik , Roman Sakowicz , Christopher Shumate , Kenneth Wood
发明人： Jeffrey T. Finer , Fady Malik , Roman Sakowicz , Christopher Shumate , Kenneth Wood
IPC分类号： C12Q1/42 , C12Q1/50 , C12N9/18
CPC分类号： C12Q1/34 , C12Q1/42 , C12Q1/485 , G01N33/573
摘要： Described herein are methods which identify candidate agents as binding to a protein or as a modulator of the binding characteristics or biological activity of a protein. Generally, the methods involve the use of ADP or phosphate. The assays can be used in a high throughput system to obviate the cumbersome steps of using gels or radioactive materials.
摘要翻译：本文描述了鉴定候选试剂与蛋白质结合或作为蛋白质的结合特征或生物活性的调节剂的方法。通常，该方法涉及使用ADP或磷酸盐。该测定法可用于高通量系统以避免使用凝胶或放射性物质的繁琐步骤。

3. 发明授权

US07202051B1 Compositions and assays utilizing ADP or phosphate for detecting protein modulators 失效
公开(公告)号：US07202051B1
公开(公告)日：2007-04-10
申请号：US11270193
申请日：2005-11-08
申请人： Jeffrey T. Finer , Fady Malik , Roman Sakowicz , Christopher Shumate , Kenneth Wood
发明人： Jeffrey T. Finer , Fady Malik , Roman Sakowicz , Christopher Shumate , Kenneth Wood
IPC分类号： C12Q1/42 , C12Q1/48 , C12Q1/50 , C12Q1/52 , C12N9/18
CPC分类号： C12Q1/34 , C12Q1/42 , C12Q1/485 , G01N33/573
摘要： Described herein are methods which identify candidate agents as binding to a protein or as a modulator of the binding characteristics or biological activity of a protein. Generally, the methods involve the use of ADP or phosphate. The assays can be used in a high throughput system to obviate the cumbersome steps of using gels or radioactive materials.

4. 发明申请

US20090117534A1 COMPOSITIONS AND ASSAYS UTILIZING ADP OR PHOSPHATE FOR DETECTING PROTEIN MODULATORS 审中-公开
标题翻译：用于检测蛋白质调节剂的ADP或磷酸酯的组成和测定
公开(公告)号：US20090117534A1
公开(公告)日：2009-05-07
申请号：US12253877
申请日：2008-10-17
申请人： Jeffrey T. Finer , Fady Malik , Roman Sakowicz , Christopher Shumate , Kenneth Wood
发明人： Jeffrey T. Finer , Fady Malik , Roman Sakowicz , Christopher Shumate , Kenneth Wood
IPC分类号： C12Q1/25
CPC分类号： C12Q1/34 , C12Q1/42 , C12Q1/485 , G01N33/573
摘要： Described herein are methods which identify candidate agents as binding to a protein or as a modulator of the binding characteristics or biological activity of a protein. Generally, the methods involve the use of ADP or phosphate. The assays can be used in a high throughput system to obviate the cumbersome steps of using gels or radioactive materials.
摘要翻译：本文描述了鉴定候选试剂与蛋白质结合或作为蛋白质的结合特征或生物活性的调节剂的方法。通常，该方法涉及使用ADP或磷酸盐。该测定法可用于高通量系统以避免使用凝胶或放射性物质的繁琐步骤。

5. 发明授权

US06743599B1 Compositions and assays utilizing ADP or phosphate for detecting protein modulators 有权
标题翻译：使用ADP或磷酸盐检测蛋白质调节剂的组合物和测定法
公开(公告)号：US06743599B1
公开(公告)日：2004-06-01
申请号：US10106665
申请日：2002-03-25
申请人： Jeffrey T. Finer , Fady Malik , Roman Sakowicz , Christopher Shumate , Kenneth Wood
发明人： Jeffrey T. Finer , Fady Malik , Roman Sakowicz , Christopher Shumate , Kenneth Wood
IPC分类号： C12Q142
CPC分类号： C12Q1/50 , C12Q1/42 , C12Q1/48
摘要： Described herein are methods which identify candidate agents as binding to a protein or as a modulator of the binding characteristics or biological activity of a protein. Generally, the methods involve the use of ADP or phosphate. The assays can be used in a high throughput system to obviate the cumbersome steps of using gels or radioactive materials.
摘要翻译：本文描述了鉴定候选试剂与蛋白质结合或作为蛋白质的结合特征或生物活性的调节剂的方法。通常，该方法涉及使用ADP或磷酸盐。该测定法可用于高通量系统以避免使用凝胶或放射性物质的繁琐步骤。

6. 发明授权

US06410254B1 Compositions and assays utilizing ADP or phosphate for detecting protein modulators 有权
标题翻译：使用ADP或磷酸盐检测蛋白质调节剂的组合物和测定法
公开(公告)号：US06410254B1
公开(公告)日：2002-06-25
申请号：US09314464
申请日：1999-05-18
申请人： Jeffrey T. Finer , Fady Malik , Roman Sakowicz , Christopher Shumate , Kenneth Wood
发明人： Jeffrey T. Finer , Fady Malik , Roman Sakowicz , Christopher Shumate , Kenneth Wood
IPC分类号： C12Q142
CPC分类号： C12Q1/48 , C12Q1/42 , C12Q1/50
摘要： Described herein are methods which identify candidate agents as binding to a protein or as a modulator of the binding characteristics or biological activity of a protein. Generally, the methods involve the use of ADP or phosphate. The assays can be used in a high throughput system to obviate the cumbersome steps of using gels or radioactive materials.
摘要翻译：本文描述了鉴定候选试剂与蛋白质结合或作为蛋白质的结合特征或生物活性的调节剂的方法。通常，该方法涉及使用ADP或磷酸盐。该测定法可用于高通量系统以避免使用凝胶或放射性物质的繁琐步骤。

7. 发明申请

US20070254310A1 Compositions and assays utilizing ADP or phosphate for detecting protein modulators 有权
标题翻译：使用ADP或磷酸盐检测蛋白质调节剂的组合物和测定法
公开(公告)号：US20070254310A1
公开(公告)日：2007-11-01
申请号：US11655733
申请日：2007-01-18
申请人： Jeffrey Finer , Fady Malik , Roman Sakowicz , Christopher Shumate , Kenneth Wood
发明人： Jeffrey Finer , Fady Malik , Roman Sakowicz , Christopher Shumate , Kenneth Wood
IPC分类号： G01N33/573
CPC分类号： C12Q1/34 , C12Q1/42 , C12Q1/485 , G01N33/573
摘要： Described herein are methods which identify candidate agents as binding to a protein or as a modulator of the binding characteristics or biological activity of a protein. Generally, the methods involve the use of ADP or phosphate. The assays can be used in a high throughput system to obviate the cumbersome steps of using gels or radioactive materials.
摘要翻译：本文描述了鉴定候选试剂与蛋白质结合或作为蛋白质的结合特征或生物活性的调节剂的方法。通常，该方法涉及使用ADP或磷酸盐。该测定法可用于高通量系统以避免使用凝胶或放射性物质的繁琐步骤。

8. 发明申请

US20060234279A1 Screening using polarization anisotropy in FRET emissions 审中-公开
标题翻译：在FRET排放中使用偏振各向异性进行筛选
公开(公告)号：US20060234279A1
公开(公告)日：2006-10-19
申请号：US11398496
申请日：2006-04-04
申请人： Steven Miller , Paul Comita , Christopher Shumate , Evan Cromwell
发明人： Steven Miller , Paul Comita , Christopher Shumate , Evan Cromwell
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： G01N33/542 , G01N2500/00
摘要： Methods and apparatus are described for detecting specific binding between first and second chemical entities. The first chemical entity in association with a first fluorophore is immobilized. The second chemical entity is allowed to bind with the immobilized first chemical entity. The second chemical entity is or becomes coupled to a second fluorophore, which forms a FRET pair with the first fluorophore. The bound chemical entities are exposed to radiation at an excitation frequency for either the first or the second fluorophore, and polarization anisotropy of a FRET fluorescent signal from the bound chemical entities is measured to detect specific binding between the first and second chemical entities. Techniques are also disclosed for detecting whether a FRET interaction is occurring between a first chemical entity including a donor fluorophore and a second chemical entity including an acceptor fluorophore, using simultaneous anisotropy measurements at the wavelengths of the donor and acceptor fluorophores.
摘要翻译：描述了用于检测第一和第二化学实体之间的特异性结合的方法和装置。与第一荧光团相关联的第一化学实体被固定化。允许第二化学实体与固定化的第一化学实体结合。第二化学实体是或连接到与第一荧光团形成FRET对的第二荧光团。结合的化学实体以第一或第二荧光团的激发频率暴露于辐射，并且测量来自结合的化学实体的FRET荧光信号的偏振各向异性以检测第一和第二化学实体之间的特异性结合。还公开了用于检测在包括供体荧光团的第一化学实体和包括受体荧光团的第二化学实体之间是否发生FRET相互作用的技术，其使用在供体和受体荧光团的波长处的同时各向异性测量。

9. 发明申请

US20060003320A1 Exploring fluorophore microenvironments 有权
公开(公告)号：US20060003320A1
公开(公告)日：2006-01-05
申请号：US11173814
申请日：2005-07-01
申请人： Steven Miller , Paul Comita , Evan Cromwell , Christopher Shumate
发明人： Steven Miller , Paul Comita , Evan Cromwell , Christopher Shumate
IPC分类号： C12Q1/70 , C12Q1/68 , G01N33/53
CPC分类号： G01N33/582 , B82Y5/00 , B82Y10/00 , C12Q1/6816 , G01N21/6408 , G01N21/6428 , G01N21/6445 , G01N2021/6419 , G01N2021/6421 , G01N2021/6432 , G01N2021/6441 , G01N2021/6478 , G01N2021/6484 , G01N2201/067 , G01N2201/0697 , G01N2201/0833 , C12Q2563/107 , C12Q2561/119
摘要： Methods, apparatus, and system, implementing and using techniques for detecting a presence of one or more target analytes in particular regions of interest of one or more samples. One or more samples including objects and one or more target analytes are provided. Some of the target analytes are labeled with a fluorophore and are bound to some of the objects in the samples. The samples are illuminated with fluorescence inducing light and fluorescent light is collected from one or more regions of the one or more samples. At least one anisotropy measurement of the samples is performed to identify regions of interest where one or more target analytes are bound to the objects. The collected fluorescent light from the regions of interest is analyzed to determine a presence of target analytes that are bound to the objects in the one or more samples.

10. 发明申请

US20050271551A1 Liquid chemical distribution method and apparatus 审中-公开
标题翻译：液体化学分配方法和装置
公开(公告)号：US20050271551A1
公开(公告)日：2005-12-08
申请号：US11100322
申请日：2005-04-05
申请人： Christopher Shumate , Peter Coassin
发明人： Christopher Shumate , Peter Coassin
IPC分类号： G01N21/64 , A61K45/00 , B01J19/00 , B01L3/02 , B01L9/00 , C12M1/00 , C40B60/14 , G01N35/00 , G01N35/02 , G01N35/04 , G01N35/10 , G01N37/00
CPC分类号： B01L9/52 , B01J19/00 , B01J19/0046 , B01J2219/00011 , B01J2219/00315 , B01J2219/00328 , B01J2219/00691 , B01J2219/00695 , B01J2219/007 , B01J2219/00702 , B01J2219/00707 , B01L9/523 , B01L2300/0829 , B01L2300/0893 , C40B60/14 , G01N35/0099 , G01N35/028 , G01N35/1002 , G01N35/1074 , G01N2035/00326 , G01N2035/042 , G01N2035/0422 , G01N2035/0425 , Y10T436/11 , Y10T436/110833 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/25 , Y10T436/2575
摘要： A chemical solution distribution system and method that includes or employs a plurality of liquid handlers where each of the liquid handlers includes a movable table that engages a sample multiwell plate and can align pipettes of the station with different subsets of wells of the multiwell plate where the number of wells of the multiwell plate is a multiple of the number of pipettes of the head of the pipette station. The system further includes and employs four different pumps to enable the system and method to supply four different solutions to wash stations of each of the four liquid handlers.
摘要翻译：一种化学溶液分配系统和方法，其包括或采用多个液体处理器，其中每个液体处理器包括可移动工作台，其接合样品多孔板，并且可将工位的移液管与多孔板的不同子集对齐，其中多孔板的孔数是吸液管头的移液管数量的倍数。该系统还包括并采用四个不同的泵，以使系统和方法能够提供四种不同的解决方案来洗涤四个液体处理器中的每一个的洗涤站。

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