专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US07247615B2 Peptide agonists of prostate-specific antigen and uses therefor 有权
标题翻译：前列腺特异性抗原肽激动剂及其用途
公开(公告)号：US07247615B2
公开(公告)日：2007-07-24
申请号：US10497003
申请日：2002-11-26
申请人： Jeffrey Schlom , Kwong-yok Tsang
发明人： Jeffrey Schlom , Kwong-yok Tsang
IPC分类号： A61K38/08 , C12P21/02 , C12N1/21 , C12N1/19 , C12N15/63 , C12N5/10 , C07K7/06 , C07H21/04
CPC分类号： C12N9/6445 , A61K38/00
摘要： This invention relates to isolated peptides comprising agonist epitopes of prostate-specific antigen (PSA). In various aspects, the invention relates to peptides comprising agonist epitopes of the PSA-3 cytotoxic T lymphocyte epitope, and nucleic acids encoding peptides that comprise PSA-3 agonist epitopes. Also related are probes, primers, and vectors comprising these nucleic acids, as well as host cells comprising these vectors, and antibodies that bind to the PSA-3 agonist peptides. This invention further relates to diagnostic reagents and methods utilizing the disclosed nucleic acids or antibodies. The invention also relates to pharmaceutical compositions comprising the nucleic acids, host cells, and peptides of the invention, as well as methods of treatment or prevention of prostate cancer employing such compositions, for example, for peptide-mediated, cell-mediated, and vector-mediated immunotherapies.
摘要翻译：本发明涉及包含前列腺特异性抗原（PSA）的激动剂表位的分离的肽。在各个方面，本发明涉及包含PSA-3细胞毒性T淋巴细胞表位的激动剂表位的肽以及编码包含PSA-3激动剂表位的肽的核酸。还涉及包含这些核酸的探针，引物和载体，以及包含这些载体的宿主细胞，以及结合PSA-3激动剂肽的抗体。本发明还涉及利用所公开的核酸或抗体的诊断试剂和方法。本发明还涉及包含本发明的核酸，宿主细胞和肽的药物组合物，以及使用这种组合物治疗或预防前列腺癌的方法，例如肽介导的，细胞介导的和载体的介导的免疫治疗。

2. 发明申请

US20070098691A1 Prostate specific antigen oligo-epitope peptide 失效
标题翻译：前列腺特异性抗原寡表位肽
公开(公告)号：US20070098691A1
公开(公告)日：2007-05-03
申请号：US11606929
申请日：2006-12-01
申请人： Jeffrey Schlom , Kwong-yok Tsang , Sam Zaremba
发明人： Jeffrey Schlom , Kwong-yok Tsang , Sam Zaremba
IPC分类号： A61K48/00 , C07K14/82 , C12N15/86 , C12N7/00 , C12N5/06
CPC分类号： A61K39/0011 , A61K38/00 , A61K39/00 , A61K2035/124 , A61K2039/5154 , A61K2039/5156 , A61K2039/5158 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/55522 , A61K2039/55527 , C12N5/0636 , C12N9/6445 , C12N2710/24143 , Y10S435/975
摘要： The invention is a prostate specific antigen oligo-epitope peptide which comprises more than one PSA epitope peptide, which conforms to one or more human HLA class I motifs. The prostate specific antigen oligo-epitope peptide in combination with various HLA-class I molecules or interactions with various T-cell receptors elicits PSA specific cellular immune responses. The prostate specific antigen oligo-epitope peptide is useful as an immunogen in the prevention or treatment of prostatic cancer, in the inhibition of prostatic cancer cells and in the establishment and characterization of PSA-specific cytotoxic T-cell lines.
摘要翻译：本发明是前列腺特异性抗原寡表位肽，其包含多于一种PSA表位肽，其与一个或多个人HLA I类基序一致。前列腺特异性抗原寡表位肽与各种HLA-I类分子的组合或与各种T细胞受体的相互作用引起PSA特异性细胞免疫应答。前列腺特异性抗原寡表位肽可用作预防或治疗前列腺癌，抑制前列腺癌细胞以及PSA特异性细胞毒性T细胞系的建立和表征中的免疫原。

3. 发明授权

US08188214B2 Brachyury polypeptides and methods for use 有权
标题翻译： Brachyury多肽和使用方法
公开(公告)号：US08188214B2
公开(公告)日：2012-05-29
申请号：US12528796
申请日：2008-02-27
申请人： Jeffrey Schlom , Claudia M. Palena , Andrei P. Kozlov , Kwong-yok Tsang
发明人： Jeffrey Schlom , Claudia M. Palena , Andrei P. Kozlov , Kwong-yok Tsang
IPC分类号： C07K5/00 , A61K38/00 , A61K39/00 , C12N15/00 , C07H21/04
CPC分类号： C12N15/113 , A61K39/00 , A61K2039/53 , C07K14/4702 , C07K14/82 , G01N33/56972 , G01N33/574 , G01N2333/70517 , Y02A50/466
摘要： It is disclosed herein that Brachyury is expressed in human tumors, specifically in tumors of the small intestine, stomach, kidney, bladder, uterus, ovary, and testes, as well as in lung, colon and prostate carcinomas. Immunogenic Brachyury polypeptides are disclosed herein. These polypeptides can be used in diagnostic assays for Brachyury expression, as well as for inducing an immune response to Brachyury. Polynucleotides encoding the immunogenic Brachyury polypeptides, vectors including these polypeptides, host cells transformed with these vectors, and methods of using these polypeptides, polynucleotides, vectors, and host cells are provided. Methods of diagnosing a Brachyury-expressing cancer are also provided. Exemplary cancers include lung, colon, small intestine, stomach, kidney, bladder, uterus, ovary, and testes and prostate cancers. Methods of treating cancer are also disclosed.
摘要翻译：本文公开了Brachyury在人肿瘤中，特别是在小肠，胃，肾，膀胱，子宫，卵巢和睾丸以及肺，结肠和前列腺癌的肿瘤中表达。免疫原性Brachyury多肽在本文中公开。这些多肽可用于Brachyury表达的诊断测定，以及用于诱导Brachyury的免疫应答。提供了编码免疫原性Brachyury多肽的多核苷酸，包括这些多肽的载体，用这些载体转化的宿主细胞，以及使用这些多肽，多核苷酸，载体和宿主细胞的方法。还提供了诊断Brachyury表达癌症的方法。示例性的癌症包括肺，结肠，小肠，胃，肾，膀胱，子宫，卵巢，睾丸和前列腺癌。还公开了治疗癌症的方法。

4. 发明申请

US20050196806A1 Prostate specific antigen oligoepitope peptide 审中-公开
标题翻译：前列腺特异性抗原寡表位肽
公开(公告)号：US20050196806A1
公开(公告)日：2005-09-08
申请号：US11114069
申请日：2005-04-26
申请人： Jeffrey Schlom , Kwong-yok Tsang , Sam Zaremba
发明人： Jeffrey Schlom , Kwong-yok Tsang , Sam Zaremba
IPC分类号： A61K35/12 , A61K38/00 , A61K39/00 , C07H21/04 , C07K14/82 , C12N5/0783 , C12N9/64 , C12N15/57 , C12Q1/68
CPC分类号： A61K39/0011 , A61K38/00 , A61K39/00 , A61K2035/124 , A61K2039/5154 , A61K2039/5156 , A61K2039/5158 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/55522 , A61K2039/55527 , C12N5/0636 , C12N9/6445 , C12N2710/24143 , Y10S435/975
摘要： The invention is a prostate specific antigen oligo-epitope peptide which comprises more than one PSA epitope peptide, which conforms to one or more human HLA class I motifs. The prostate specific antigen oligo-epitope peptide in combination with various HLA-class I molecules or interactions with various T-cell receptors elicits PSA specific cellular immune responses. The prostate specific antigen oligo-epitope peptide is useful as an immunogen in the prevention or treatment of prostatic cancer, in the inhibition of prostatic cancer cells and in the establishment and characterization of PSA-specific cytotoxic T-cell lines.
摘要翻译：本发明是前列腺特异性抗原寡表位肽，其包含多于一种PSA表位肽，其与一个或多个人HLA I类基序一致。前列腺特异性抗原寡表位肽与各种HLA-I类分子的组合或与各种T细胞受体的相互作用引起PSA特异性细胞免疫应答。前列腺特异性抗原寡表位肽可用作预防或治疗前列腺癌，抑制前列腺癌细胞以及PSA特异性细胞毒性T细胞系的建立和表征中的免疫原。

5. 发明授权

US08613933B2 Brachyury polypeptides and methods for use 有权
标题翻译： Brachyury多肽和使用方法
公开(公告)号：US08613933B2
公开(公告)日：2013-12-24
申请号：US13460587
申请日：2012-04-30
申请人： Jeffrey Schlom , Claudia M. Palena , Andrei P. Kozlov , Kwong-yok Tsang
发明人： Jeffrey Schlom , Claudia M. Palena , Andrei P. Kozlov , Kwong-yok Tsang
IPC分类号： A61K39/12
CPC分类号： C12N15/113 , A61K39/00 , A61K2039/53 , C07K14/4702 , C07K14/82 , G01N33/56972 , G01N33/574 , G01N2333/70517 , Y02A50/466
摘要： It is disclosed herein that Brachyury is expressed in human tumors, specifically in tumors of the small intestine, stomach, kidney, bladder, uterus, ovary, and testes, as well as in lung, colon and prostate carcinomas. Immunogenic Brachyury polypeptides are disclosed herein. These polypeptides can be used in diagnostic assays for Brachyury expression, as well as for inducing an immune response to Brachyury. Polynucleotides encoding the immunogenic Brachyury polypeptides, vectors including these polypeptides, host cells transformed with these vectors, and methods of using these polypeptides, polynucleotides, vectors, and host cells are provided. Methods of diagnosing a Brachyury-expressing cancer are also provided. Exemplary cancers include small lung, colon, intestine, stomach, kidney, bladder, uterus, ovary, and testes and prostate cancers. Methods of treating cancer are also disclosed.
摘要翻译：本文公开了Brachyury在人肿瘤中，特别是在小肠，胃，肾，膀胱，子宫，卵巢和睾丸以及肺，结肠和前列腺癌的肿瘤中表达。免疫原性Brachyury多肽在本文中公开。这些多肽可用于Brachyury表达的诊断测定，以及用于诱导Brachyury的免疫应答。提供了编码免疫原性Brachyury多肽的多核苷酸，包括这些多肽的载体，用这些载体转化的宿主细胞，以及使用这些多肽，多核苷酸，载体和宿主细胞的方法。还提供了诊断Brachyury表达癌症的方法。示例性的癌症包括小肺，结肠，肠，胃，肾，膀胱，子宫，卵巢，睾丸和前列腺癌。还公开了治疗癌症的方法。

6. 发明申请

US20110091498A1 METHODS OF STIMULATING AN IMMUNE RESPONSE AGAINST PROSTATE SPECIFIC ANTIGEN 有权
标题翻译：刺激预防特异性抗原的免疫应答方法
公开(公告)号：US20110091498A1
公开(公告)日：2011-04-21
申请号：US12977660
申请日：2010-12-23
申请人： Jeffrey Schlom , Kwong-yok Tsang , Sam Zaremba
发明人： Jeffrey Schlom , Kwong-yok Tsang , Sam Zaremba
IPC分类号： A61K39/00 , A61K39/145 , A61K39/104 , A61K39/08 , A61P35/00 , A61P37/04
CPC分类号： A61K39/0011 , A61K38/00 , A61K39/00 , A61K2035/124 , A61K2039/5154 , A61K2039/5156 , A61K2039/5158 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/55522 , A61K2039/55527 , C12N5/0636 , C12N9/6445 , C12N2710/24143 , Y10S435/975
摘要： The invention provides a prostate specific antigen oligo-epitope peptide (PSA-OP) that is useful as an immunogen in the prevention or treatment of prostatic cancer and in the inhibition of prostatic cancer cells and in the establishment and characterization of PSA-specific cytotoxic T-cell lines. In particular, the invention provides methods for eliciting an immune response against PSA comprising administering (i) a priming inoculation of a first recombinant virus encoding PSA-OP and (ii) one or more boosting inoculations of a second recombinant virus encoding PSA-OP, wherein the first and second recombinant viruses are from a different genus.
摘要翻译：本发明提供了前列腺特异性抗原寡表位肽（PSA-OP），其可用作预防或治疗前列腺癌和抑制前列腺癌细胞的免疫原，以及PSA特异性细胞毒性T的建立和表征细胞线。特别地，本发明提供了引发针对PSA的免疫应答的方法，包括施用（i）编码PSA-OP的第一重组病毒的引发接种和（ii）编码PSA-OP的第二重组病毒的一种或多种加强接种，其中所述第一和第二重组病毒来自不同属。

7. 发明授权

US06946133B1 Prostate specific antigen oligo-epitope peptide 失效
标题翻译：前列腺特异性抗原寡表位肽
公开(公告)号：US06946133B1
公开(公告)日：2005-09-20
申请号：US08618936
申请日：1996-03-20
申请人： Jeffrey Schlom , Kwong-yok Tsang , Sam Zaremba
发明人： Jeffrey Schlom , Kwong-yok Tsang , Sam Zaremba
IPC分类号： A61K35/12 , A61K38/00 , A61K39/00 , C07H21/04 , C07K14/82 , C12N5/0783 , C12N9/64 , C12N15/57 , C12Q1/68 , C07K1/00 , C07K14/00 , C07K16/00
CPC分类号： A61K39/0011 , A61K38/00 , A61K39/00 , A61K2035/124 , A61K2039/5154 , A61K2039/5156 , A61K2039/5158 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/55522 , A61K2039/55527 , C12N5/0636 , C12N9/6445 , C12N2710/24143 , Y10S435/975
摘要： The invention is a prostate specific antigen oligo-epitope peptide which comprises more than one PSA epitope peptide, which conforms to one or more human HLA class I motifs. The prostate specific antigen oligo-epitope peptide in combination with various HLA-class I molecules or interactions with various T-cell receptors elicits PSA specific cellular immune responses. The prostate specific antigen oligo-epitope peptide is useful as an immunogen in the prevention or treatment of prostatic cancer, in the inhibition of prostatic cancer cells and in the establishment and characterization of PSA-specific cytotoxic T-cell lines.
摘要翻译：本发明是前列腺特异性抗原寡表位肽，其包含多于一种PSA表位肽，其与一个或多个人HLA I类基序一致。前列腺特异性抗原寡表位肽与各种HLA-I类分子的组合或与各种T细胞受体的相互作用引起PSA特异性细胞免疫应答。前列腺特异性抗原寡表位肽可用作预防或治疗前列腺癌，抑制前列腺癌细胞以及PSA特异性细胞毒性T细胞系的建立和表征中的免疫原。

8. 发明申请

US20120230948A1 BRACHYURY POLYPEPTIDES AND METHODS FOR USE 有权
公开(公告)号：US20120230948A1
公开(公告)日：2012-09-13
申请号：US13460587
申请日：2012-04-30
申请人： Jeffrey Schlom , Claudia M. Palena , Andrei P. Kozlov , Kwong-yok Tsang
发明人： Jeffrey Schlom , Claudia M. Palena , Andrei P. Kozlov , Kwong-yok Tsang
IPC分类号： A61K39/00 , A61K38/20 , G01N33/574 , A61K38/19 , A61P35/00 , C12N15/63 , A61K35/76 , A61K38/21
CPC分类号： C12N15/113 , A61K39/00 , A61K2039/53 , C07K14/4702 , C07K14/82 , G01N33/56972 , G01N33/574 , G01N2333/70517 , Y02A50/466
摘要： It is disclosed herein that Brachyury is expressed in human tumors, specifically in tumors of the small intestine, stomach, kidney, bladder, uterus, ovary, and testes, as well as in lung, colon and prostate carcinomas. Immunogenic Brachyury polypeptides are disclosed herein. These polypeptides can be used in diagnostic assays for Brachyury expression, as well as for inducing an immune response to Brachyury. Polynucleotides encoding the immunogenic Brachyury polypeptides, vectors including these polypeptides, host cells transformed with these vectors, and methods of using these polypeptides, polynucleotides, vectors, and host cells are provided. Methods of diagnosing a Brachyury-expressing cancer are also provided. Exemplary cancers include small lung, colon, intestine, stomach, kidney, bladder, uterus, ovary, and testes and prostate cancers. Methods of treating cancer are also disclosed.
摘要翻译：本文公开了Brachyury在人肿瘤中，特别是在小肠，胃，肾，膀胱，子宫，卵巢和睾丸以及肺，结肠和前列腺癌的肿瘤中表达。免疫原性Brachyury多肽在本文中公开。这些多肽可用于Brachyury表达的诊断测定，以及用于诱导Brachyury的免疫应答。提供了编码免疫原性Brachyury多肽的多核苷酸，包括这些多肽的载体，用这些载体转化的宿主细胞，以及使用这些多肽，多核苷酸，载体和宿主细胞的方法。还提供了诊断Brachyury表达癌症的方法。示例性的癌症包括小肺，结肠，肠，胃，肾，膀胱，子宫，卵巢，睾丸和前列腺癌。还公开了治疗癌症的方法。

9. 发明申请

US20090263425A1 METHODS OF STIMULATING AN IMMUNE RESPONSE AGAINST PROSTATE SPECIFIC ANTIGEN 有权
标题翻译：刺激预防特异性抗原的免疫应答方法
公开(公告)号：US20090263425A1
公开(公告)日：2009-10-22
申请号：US12479292
申请日：2009-06-05
申请人： Jeffrey Schlom , Kwong-yok Tsang , Sam Zaremba
发明人： Jeffrey Schlom , Kwong-yok Tsang , Sam Zaremba
IPC分类号： A61K39/275 , A61P35/00
CPC分类号： A61K39/0011 , A61K38/00 , A61K39/00 , A61K2035/124 , A61K2039/5154 , A61K2039/5156 , A61K2039/5158 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/55522 , A61K2039/55527 , C12N5/0636 , C12N9/6445 , C12N2710/24143 , Y10S435/975
摘要： The invention provides a prostate specific antigen oligo-epitope peptide (PSA-OP) that is useful as an immunogen in the prevention or treatment of prostatic cancer and in the inhibition of prostatic cancer cells and in the establishment and characterization of PSA-specific cytotoxic T-cell lines. In particular, the invention provides methods for eliciting an immune response against PSA comprising administering (i) a priming inoculation of a first recombinant virus encoding PSA-OP and (ii) one or more boosting inoculations of a second recombinant virus encoding PSA-OP, wherein the first and second recombinant viruses are from a different genus.
摘要翻译：本发明提供了前列腺特异性抗原寡表位肽（PSA-OP），其可用作预防或治疗前列腺癌和抑制前列腺癌细胞的免疫原，以及PSA特异性细胞毒性T的建立和表征细胞线。特别地，本发明提供了引发针对PSA的免疫应答的方法，包括施用（i）编码PSA-OP的第一重组病毒的引发接种和（ii）编码PSA-OP的第二重组病毒的一种或多种加强接种，其中所述第一和第二重组病毒来自不同属。

10. 发明授权

US07547773B2 Nucleic acid molecules encoding prostate specific antigen oligo epitope peptides 失效
标题翻译：编码前列腺特异性抗原寡核苷酸表位肽的核酸分子
公开(公告)号：US07547773B2
公开(公告)日：2009-06-16
申请号：US11606929
申请日：2006-12-01
申请人： Jeffrey Schlom , Kwong-yok Tsang , Sam Zaremba
发明人： Jeffrey Schlom , Kwong-yok Tsang , Sam Zaremba
IPC分类号： C07H21/02 , C12N1/20 , C12N7/00 , C12N15/00
CPC分类号： A61K39/0011 , A61K38/00 , A61K39/00 , A61K2035/124 , A61K2039/5154 , A61K2039/5156 , A61K2039/5158 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/55522 , A61K2039/55527 , C12N5/0636 , C12N9/6445 , C12N2710/24143 , Y10S435/975
摘要： The invention is a prostate specific antigen oligo-epitope peptide which comprises more than one PSA epitope peptide, which conforms to one or more human HLA class I motifs. The prostate specific antigen oligo-epitope peptide in combination with various HLA-class I molecules or interactions with various T-cell receptors elicits PSA specific cellular immune responses. The prostate specific antigen oligo-epitope peptide is useful as an immunogen in the prevention or treatment of prostatic cancer, in the inhibition of prostatic cancer cells and in the establishment and characterization of PSA-specific cytotoxic T-cell lines.
摘要翻译：本发明是前列腺特异性抗原寡表位肽，其包含多于一种PSA表位肽，其与一个或多个人HLA I类基序一致。前列腺特异性抗原寡表位肽与各种HLA-I类分子的组合或与各种T细胞受体的相互作用引起PSA特异性细胞免疫应答。前列腺特异性抗原寡表位肽可用作预防或治疗前列腺癌，抑制前列腺癌细胞以及PSA特异性细胞毒性T细胞系的建立和表征中的免疫原。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式