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1. 发明授权

US07118738B2 Recombinant pox virus for immunization against MUC1 tumor-associated antigen 有权
公开(公告)号：US07118738B2
公开(公告)日：2006-10-10
申请号：US10057136
申请日：2002-01-25
申请人： Jeffrey Schlom , Judith Kantor , Donald Kufe , Dennis Panicali , Linda Gritz
发明人： Jeffrey Schlom , Judith Kantor , Donald Kufe , Dennis Panicali , Linda Gritz
IPC分类号： A01N63/00 , A61K48/00 , C12N15/00 , C12N15/09 , C12N15/63 , C12N15/70 , C12N15/74
CPC分类号： C12Q1/6897 , A61K39/00 , C07K14/4727 , C07K14/705 , C07K14/70532 , C12N2799/021 , C12N2799/023 , C12Q1/6883 , C12Q1/6886
摘要： Recombinant pox viruses capable of expressing an immunogenic fragment of the MUC1 tumor-associated antigen are disclosed. The recombinant viruses can be used as vaccines to prevent the establishment of or treat tumors or pre-tumorous cells expressing the MUC1 tumor-associated antigen. The vaccines can be provided as an admixture comprising: (1) a recombinant pox virus encoding the immunogenic fragment of the MUC1 tumor-associated antigen, and (2) a recombinant pox virus encoding a T-cell co-stimulatory factor. The vaccine admixture can be used, e.g., to prevent establishment of tumors or pre-tumorous cells expressing the MUC1 tumor-associated antigen. The MUC1 specific cytotoxic T-cells can be isolated and expanded and used in a method for treating a host having a tumor expressing MCU1 positive tumor cells.

2. 发明申请

US20070105767A1 Modulation of the interaction of muc1 with muc1 ligands 有权
标题翻译：调节muc1与muc1配体的相互作用
公开(公告)号：US20070105767A1
公开(公告)日：2007-05-10
申请号：US10577003
申请日：2004-10-21
申请人： Surender Kharbanda , Donald Kufe
发明人： Surender Kharbanda , Donald Kufe
IPC分类号： A61K38/17 , C07K14/82 , C07H21/04 , C12P21/06
CPC分类号： C07K14/4748 , A61K38/00 , C07K14/705 , C07K2319/00 , C07K2319/30
摘要： The present invention provides for chimeric proteins comprising a MUC1 extracellular (MUC1-EC) polypeptide and a carrier polypeptide that function as traps for MUC1 ligands.
摘要翻译：本发明提供了包含MUC1细胞外（MUC1-EC）多肽和作为MUC1配体陷阱的载体多肽的嵌合蛋白质。

3. 发明申请

US20060148753A1 Methods for administering DPD inhibitors in combination with 5-FU and 5-FU prodrugs 有权
标题翻译：给予DPD抑制剂与5-FU和5-FU前药组合的方法
公开(公告)号：US20060148753A1
公开(公告)日：2006-07-06
申请号：US11294643
申请日：2005-12-05
申请人： Thomas Spector , William Peters , Donald Kufe , Brian Huber
发明人： Thomas Spector , William Peters , Donald Kufe , Brian Huber
IPC分类号： A61K31/7072 , A61K31/513
CPC分类号： A61K31/513 , A61K31/505 , A61K31/7072 , A61K45/06 , A61K2300/00
摘要： Methods for improved administration and dosing of DPD inhibitors in combination with 5-FU and/or 5-FU prodrugs are provided, comprising first administering to a patient in need thereof a DPD inhibitor that substantially eliminates activity of the enzyme and thereafter administering 5-FU or a 5-FU prodrug, wherein the level of 5-FU or 5-FU prodrug is in substantial excess of DPD inhibitor in the patient.
摘要翻译：提供了用于改进DPD抑制剂与5-FU和/或5-FU前药组合的给药和给药方法，包括首先向有需要的患者施用基本上消除酶活性的DPD抑制剂，然后施用5-FU 或5-FU前药，其中5-FU或5-FU前药的水平在患者体内基本上超过DPD抑制剂。

4. 发明申请

US20060128720A1 Inhibition of cell death responses induced by oxidative stress 审中-公开
标题翻译：抑制氧化应激引起的细胞死亡反应
公开(公告)号：US20060128720A1
公开(公告)日：2006-06-15
申请号：US10518665
申请日：2003-03-20
申请人： Donald Kufe , Rima Kaddurah-Daouk
发明人： Donald Kufe , Rima Kaddurah-Daouk
IPC分类号： A61K31/506
CPC分类号： A61K31/513 , A61K31/505 , A61K31/506
摘要： The invention provides methods of reducing or preventing oxidative stress-induced cell death by contacting a cell with a compound that inhibits the kinase activity and/or the mitochondrial translocation of c-Abl. The methods of the invention can be used to treat individuals individual diagnosed as having or being at risk of contracting a disorder characterized by excessive oxidative stress-induced cell death.
摘要翻译：本发明提供了通过使细胞与抑制c-Abl的激酶活性和/或线粒体易位的化合物接触来减少或预防氧化应激诱导的细胞死亡的方法。本发明的方法可用于治疗个体被诊断为具有或处于以过度氧化应激诱导的细胞死亡为特征的疾病的风险中的个体。

5. 发明申请

US20080118471A1 CONSTITUTIVE GENE EXPRESSION IN CONJUNCTION WITH IONIZING RADIATION 有权
标题翻译：与辐射相关的组成型基因表达
公开(公告)号：US20080118471A1
公开(公告)日：2008-05-22
申请号：US12019428
申请日：2008-01-24
申请人： Ralph Weichselbaum , Dennis Hallahan , Donald Kufe , Vikas Sukhatme
发明人： Ralph Weichselbaum , Dennis Hallahan , Donald Kufe , Vikas Sukhatme
IPC分类号： A61K48/00
CPC分类号： A61K48/005 , C12N2799/022
摘要： The present disclosure demonstrates the successful use of constitutive promoters operatively linked to genes encoding radiosensitizing or radioprotecting factors, administered to cells, tissues, or patients in conjunction with radiation exposure. Also disclosed are pharmacological preparations to be used to increase the levels of radiosensitizing compounds such as TNF-α, or radioprotective compounds such as MnSOD, in specified tissues or tumors of a subject.
摘要翻译：本公开内容显示了与辐射照射联合施用于细胞，组织或患者的与编码放射增敏剂或放射防护因子的基因有效连接的组成型启动子的成功应用。还公开了用于在受试者的特定组织或肿瘤中增加放射增敏化合物如TNF-α或放射防护化合物如MnSOD的药理学制剂。

6. 发明申请

US20070212298A1 USE OF THE COMBINATION COMPRISING TEMOZOLOMIDE AND TNF-ALPHA FOR TREATING GLIOBLASTOMA 审中-公开
标题翻译：包含TEMOZOLOMIDE和TNF-ALPHA联合治疗GLIOBLASTOMA的应用
公开(公告)号：US20070212298A1
公开(公告)日：2007-09-13
申请号：US11574108
申请日：2005-08-25
申请人： Ralph Weichselbaum , Donald Kufe
发明人： Ralph Weichselbaum , Donald Kufe
IPC分类号： A61K38/19 , A61K51/00 , C07K14/52 , C12N5/08
CPC分类号： A01K67/0271 , A01K2227/105 , A01K2267/0331 , A61K31/41 , A61K38/191 , A61K41/0038 , A61K2300/00
摘要： Disclosed are methods of synergistically inhibiting growth of a glioma cell comprising contacting the cell with temozolomide and TNFα, or with temozolomide, TNFα, and radiation. Also disclosed are methods of synergistically inhibiting growth of a glioma in a human cancer patient comprising administering temozolomide and TNFα, or with temozolomide, TNFα, and radiation. Pharmaceutical combinations and therapeutic combinations suitable for use in the methods of the invention are also disclosed.
摘要翻译：公开了协同抑制神经胶质瘤细胞生长的方法，包括使细胞与替莫唑胺和TNFα或与替莫唑胺，TNFα和辐射接触。还公开了协同抑制人类癌症患者中神经胶质瘤生长的方法，包括给予替莫唑胺和TNFα，或与替莫唑胺，TNFα和辐射。还公开了适用于本发明方法的药物组合和治疗组合。

7. 发明授权

US06652848B1 Dendritic cell hybrids 有权
标题翻译：树突状细胞杂种
公开(公告)号：US06652848B1
公开(公告)日：2003-11-25
申请号：US09618917
申请日：2000-07-18
申请人： Jianlin Gong , Donald Kufe
发明人： Jianlin Gong , Donald Kufe
IPC分类号： A01N6500
CPC分类号： C12N5/16 , A61K38/00 , A61K39/0011 , A61K2039/5152 , A61K2039/5154 , A61K2039/5156 , A61K2039/5158 , C12N2501/22 , C12N2501/23 , C12N2510/00
摘要： Immunostimulatory compositions that contain fused cells formed by fusion between dendritic cells and non-dendritic cells, methods of using these compositions, and methods of generating dendritic cell hybrids.
摘要翻译：含有通过树突状细胞和非树突细胞融合形成的融合细胞的免疫刺激组合物，使用这些组合物的方法，以及产生树突状细胞杂交体的方法。

8. 发明授权

US5874415A Enhancer sequence for modulating expression in epithelial cells 失效
标题翻译：用于调节上皮细胞表达的增强子序列
公开(公告)号：US5874415A
公开(公告)日：1999-02-23
申请号：US465981
申请日：1995-06-06
申请人： Donald Kufe , Miyako Abe
发明人： Donald Kufe , Miyako Abe
IPC分类号： A61K48/00 , C12N15/85 , A01N43/04 , A61K38/16 , C07H21/04
CPC分类号： A61K48/00 , C12N15/85 , A01K2217/05 , C12N2830/30
摘要： Isolated DNA encompassing the DF3 enhancer as well as a sequence encoding a heterologous polypeptide provides epithelial tissue-selective gene expression of the heterologous polypeptide, useful in methods of therapy.
摘要翻译：包含DF3增强子的分离的DNA以及编码异源多肽的序列提供了可用于治疗方法的异源多肽的上皮组织选择性基因表达。

9. 发明申请

US20080107661A1 MUC1 and ABL 审中-公开
标题翻译： MUC1和ABL
公开(公告)号：US20080107661A1
公开(公告)日：2008-05-08
申请号：US11829687
申请日：2007-07-27
申请人： Donald Kufe
发明人： Donald Kufe
IPC分类号： A61K38/00 , C12Q1/48 , G06G7/48 , A61K31/195 , A61P43/00 , C12N5/06 , A61K39/395
CPC分类号： G01N33/5011 , G01N2333/4725 , G01N2333/91215 , G01N2500/02
摘要： The present disclosure provides methods of identifying and making compounds and pharmaceutical compositions thereof that inhibit the interaction between MUC1 and Abl. The invention also provides in vivo, in vitro, and ex vivo methods of inhibiting such an interaction. Also featured are in vitro and in vivo methods of stimulating the Abl-dependent apoptotic pathway in cells expressing MUC1. In such methods, the compounds, compositions, and methods described herein are generally useful in the treatment of various cancers. The disclosure also provides methods for inhibiting Abl, and such methods, and compounds and compositions for use in the methods are generally useful for the treatment of cancers, inflammatory conditions, atherosclerotic lesions, and neurologic disorders.
摘要翻译：本公开提供了鉴定和制备抑制MUC1和Ab1之间的相互作用的化合物及其药物组合物的方法。本发明还提供了抑制这种相互作用的体内，体外和离体方法。还特征在于在表达MUC1的细胞中刺激Abl依赖性凋亡途径的体外和体内方法。在这些方法中，本文所述的化合物，组合物和方法通常可用于治疗各种癌症。本公开还提供了抑制Abl的方法，并且用于该方法的这些方法和化合物和组合物通常可用于治疗癌症，炎性病症，动脉粥样硬化病变和神经障碍。

10. 发明授权

US07070968B2 DNA damaging agents in combination with tyrosine kinase inhibitors 失效
公开(公告)号：US07070968B2
公开(公告)日：2006-07-04
申请号：US10375684
申请日：2003-02-24
申请人： Donald Kufe , Ralph R. Weichselbaum
发明人： Donald Kufe , Ralph R. Weichselbaum
IPC分类号： C12N13/00
CPC分类号： A61N5/10 , A61K31/365 , A61K31/40 , A61K31/70 , A61K31/704 , A61K31/7048 , A61K31/7072 , A61K41/0019 , A61K41/0023 , A61K31/35 , A61K2300/00 , A61K31/495 , A61K31/41 , A61K31/38
摘要： The present invention relates to the signalling pathways connecting DNA damage, such as that induced by ionizing radiation or alkylating agents, and phosphorylation by tyrosine kinases.

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