专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5415874A Natural killer cell lines and clones with antigen specificity 失效
标题翻译：自然杀伤细胞系和具有抗原特异性的克隆
公开(公告)号：US5415874A
公开(公告)日：1995-05-16
申请号：US429353
申请日：1989-10-31
申请人： Jeffrey R. Bender , Ruggero Pardi , Edgar G. Engleman
发明人： Jeffrey R. Bender , Ruggero Pardi , Edgar G. Engleman
IPC分类号： C12N5/0783 , A61K39/00 , A61K35/14 , C07K1/00 , C12N5/00
CPC分类号： C12N5/0646 , A61K2039/5158
摘要： Lymphocytes of NK phenotype were cultured with stimulator cell lines in the presence of growth factor containing medium. The resulting lines and clones derived from these lines expressed CD16 and/or Leu 19, but lacked detectable CD3 or T cell receptor .gamma./.delta. complexes on the cell surface. In addition to displaying potent cytolytic activity against K562 erythroleukemia cells (a classical NK target), the vast majority of these lines and clones lysed their specific stimulator cell lines to a significantly greater extent than irrelevant cell lines. These results indicate that some CD3- lymphocytes, phenotypically indistinguishable from NK cells, can recognize and lyse allogeneic targets in a specific manner.
摘要翻译：在含生长因子的培养基存在下，用刺激细胞系培养NK表型的淋巴细胞。得自这些品系的品系和克隆表达CD16和/或Leu19，但在细胞表面缺乏可检测的CD3或T细胞受体γ/δ复合物。除了显示针对K562红白血病细胞（经典NK靶）的有效细胞溶解活性外，绝大多数这些系和克隆比不相关的细胞系明显地使其特异性刺激细胞系裂解。这些结果表明，一些表型上与NK细胞无法区分的CD3-淋巴细胞可以以特异性方式识别和裂解同种异体靶标。

2. 发明授权

US4234306A Method and apparatus for sensing jaw position and movements and utilizing sensed data 失效
标题翻译：用于检测颌位置和运动并利用感测数据的方法和装置
公开(公告)号：US4234306A
公开(公告)日：1980-11-18
申请号：US58689
申请日：1979-07-18
申请人： James H. Hamada , Jeffrey R. Bender , Earl T. Price , Dennis A. Ingebretsen
发明人： James H. Hamada , Jeffrey R. Bender , Earl T. Price , Dennis A. Ingebretsen
IPC分类号： A61C19/045
CPC分类号： A61C19/045
摘要： Method and apparatus for sensing jaw position and movements and for converting the sensed data to dental articulator settings for simulating said movement are disclosed. Included are a pair of clutches which are fitted to the patient's maxillary and mandibular teeth. The respective clutch plates are removably secured to the housing of a jaw movement recording device and to a movable indicia-bearing arm. At least three indicia are mounted at the inner end of the arm in a manner such that they are viewable from three mutually orthogonal directions. Photoresponsive means are included for sensing and/or recording the indicia during and/or following displacement of the indicia-bearing arm during and/or following condyle movements of the patient's mandible. By this means, information as to the position and skew angle of the indicia in three dimensions is provided. This information, together with measurements relating the hinge axis of the patient's jaws to the device, is used for determining border positions and/or movements of the right and left mandibular condyles during jaw movement, and dental articulator settings required to reproduce such movements. A properly programmed digital computer may be used for making such determinations.
摘要翻译：公开了用于感测颌位置和移动以及用于将感测到的数据转换为用于模拟所述移动的牙科咬合器设置的方法和装置。包括一对适合患者上颌和下颌牙的离合器。相应的离合器片可拆卸地固定到颚运动记录装置的壳体和可移动的标记支承臂。至少三个标记以可从三个相互正交的方向观看的方式安装在臂的内端。包括用于在患者下颌骨的髁运动期间和/或之后移动带标记的臂期间和/或之后的标记处的感光和/或记录光响应装置。通过这种方式，提供关于标记在三维中的位置和歪斜角度的信息。该信息以及将患者颌骨的铰链轴与装置相关的测量结果用于确定颌运动期间的右下颌骨髁的边界位置和/或运动，以及再现这种运动所需的牙科咬合器设置。可以使用正确编程的数字计算机进行这样的确定。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式