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1. 发明申请

US20080287349A1 Fibroblast growth factor 20 and methods of use thereof 审中-公开
标题翻译：成纤维细胞生长因子20及其使用方法
公开(公告)号：US20080287349A1
公开(公告)日：2008-11-20
申请号：US10980458
申请日：2004-11-03
申请人： Jeffrey Peterson , Paul Sciore , Erik Gunther , Marie Ruiz-Martinez , Galina Chernaya , William J. LaRochelle , Michael E. Jeffers , Henri Lichenstein , Peter Mezes
发明人： Jeffrey Peterson , Paul Sciore , Erik Gunther , Marie Ruiz-Martinez , Galina Chernaya , William J. LaRochelle , Michael E. Jeffers , Henri Lichenstein , Peter Mezes
IPC分类号： A61K38/17 , A61K31/711 , C07H21/04 , C12N15/63 , C12N5/06 , C12N1/00 , C12P21/00 , C07K14/00 , A61P19/00 , A61P19/02
CPC分类号： A61K38/1825 , A61K31/711 , C07K14/50
摘要： The present invention relates to compositions and methods for preventing and treating a disease (e.g., a joint disease, ischemic stroke, hemorrhagic stroke, trauma, spinal cord damage, heavy metal or toxin poisoning, or neurodegenerative diseases). More particularly, the present invention provides methods for preventing and/or treating a disease (e.g., a joint disease, ischemic stroke, hemorrhagic stroke, trauma, spinal cord damage, heavy metal or toxin poisoning, or neurodegenerative diseases) by using compositions comprising FGF-20, a fragment, a derivative, a variant, a homolog, or an analog thereof.
摘要翻译：本发明涉及用于预防和治疗疾病（例如关节疾病，缺血性中风，出血性中风，创伤，脊髓损伤，重金属或毒素中毒或神经变性疾病）的组合物和方法。更具体地，本发明通过使用包含FGF的组合物提供了预防和/或治疗疾病（例如关节疾病，缺血性中风，出血性中风，创伤，脊髓损伤，重金属或毒素中毒或神经变性疾病）的方法 -20，片段，衍生物，变体，同系物或其类似物。

2. 发明申请

US20050256039A1 Novel fibroblast growth factors and methods of use thereof 审中-公开
标题翻译：新型成纤维细胞生长因子及其使用方法
公开(公告)号：US20050256039A1
公开(公告)日：2005-11-17
申请号：US10842206
申请日：2004-05-10
申请人： Jeffery Peterson , Paul Sciore , Peter Mezes , Henri Lichenstein , Michael Jeffers , William LaRochelle , Marie Ruiz-Martinez , Galina Chernaya
发明人： Jeffery Peterson , Paul Sciore , Peter Mezes , Henri Lichenstein , Michael Jeffers , William LaRochelle , Marie Ruiz-Martinez , Galina Chernaya
IPC分类号： A61K38/17 , A61K38/18 , C07H21/04 , C07K14/47 , C07K14/50 , C12N15/09 , C12P21/06
CPC分类号： A61K38/1825 , C07K14/50
摘要： The present invention relates to compositions and methods of treatment of various conditions, including but are not limited to, stroke, wound healing, and joint diseases (e.g., osteoarthritis and rheumatoid arthritis). More particularly, the present invention relates to compositions comprising a member of the fibroblast growth factor family, FGF-CX (also known as CG53135-05 or FGF-20), its related polypeptides, nucleic acids encoding such polypeptides, and their uses for treating a condition, such as but is not limited to, stroke, would healing, and joint diseases (e.g., osteoarthritis and rheumatoid arthritis).
摘要翻译：本发明涉及治疗各种病症的组合物和方法，包括但不限于中风，伤口愈合和关节疾病（例如骨关节炎和类风湿性关节炎）。更具体地，本发明涉及包含成纤维细胞生长因子家族成员，FGF-CX（也称为CG53135-05或FGF-20）的成员，其相关多肽，编码这些多肽的核酸及其用于治疗一种情况，例如但不限于中风，会愈合，以及关节疾病（例如骨关节炎和类风湿性关节炎）。

3. 发明申请

US20050208514A1 Novel fibroblast growth factor and nucleic acids encoding dame 审中-公开
标题翻译：新型成纤维细胞生长因子和编码dame的核酸
公开(公告)号：US20050208514A1
公开(公告)日：2005-09-22
申请号：US10980659
申请日：2004-11-03
申请人： John Alsobrook , Ferenc Boldog , Michael Jeffers , William LaRochelle , Denise Lepley , Henri Lichenstein , Richard Shimkets , Meijia Yang , Marie Ruiz-Martinez , Galina Chernaya , Muralidhara Padigaru , Sudhirdas Prayaga , Mei Zhong
发明人： John Alsobrook , Ferenc Boldog , Michael Jeffers , William LaRochelle , Denise Lepley , Henri Lichenstein , Richard Shimkets , Meijia Yang , Marie Ruiz-Martinez , Galina Chernaya , Muralidhara Padigaru , Sudhirdas Prayaga , Mei Zhong
IPC分类号： A61K38/00 , A61K38/18 , C07K14/50 , C12Q1/68
CPC分类号： C07K14/50 , A61K38/00
摘要： The present invention generally relates to nucleic acids, proteins, and antibodies. The invention relates more particularly to nucleic acid molecules, proteins, and antibodies of Fibroblast Growth Factor-20 (FGF-20), or its fragments, derivatives, variants, homologs, analogs, or a combination thereof.
摘要翻译：本发明一般涉及核酸，蛋白质和抗体。本发明更具体涉及成纤维细胞生长因子-20（FGF-20）或其片段，衍生物，变体，同系物，类似物或其组合的核酸分子，蛋白质和抗体。

4. 发明授权

US07056885B1 Fibroblast growth factor and nucleic acids encoding same 失效
标题翻译：成纤维细胞生长因子和核酸编码相同
公开(公告)号：US07056885B1
公开(公告)日：2006-06-06
申请号：US09609543
申请日：2000-07-03
申请人： Michael Jeffers , Richard A. Shimkets , Sudhirdas K. Prayaga , Ferenc L. Boldog , Meijia Yang , Catherine Burgess , Elma Fernandes , John L. Herrmann , William J. LaRochelle , Henri Lichenstein
发明人： Michael Jeffers , Richard A. Shimkets , Sudhirdas K. Prayaga , Ferenc L. Boldog , Meijia Yang , Catherine Burgess , Elma Fernandes , John L. Herrmann , William J. LaRochelle , Henri Lichenstein
IPC分类号： A61K38/18 , C07K14/50
CPC分类号： C07K14/50 , A61K38/00 , A61K48/00 , A61K2039/505
摘要： The present invention provides FGF-CX polypeptides and polynucleotides, and antibodies that immunospecifically bind to FGF-CX or any derivative, variant, mutant, or fragment of the FGF-CX polypeptide, polynucleotide or antibody. The invention additionally provides methods of use for the FGF-CX polypeptide, polynucleotide and antibody.
摘要翻译：本发明提供FGF-CX多肽和多核苷酸，以及免疫特异性结合FGF-CX或FGF-CX多肽，多核苷酸或抗体的任何衍生物，变体，突变体或片段的抗体。本发明另外提供了用于FGF-CX多肽，多核苷酸和抗体的方法。

5. 发明授权

US07253266B2 Polypeptides of FGF-CX 失效
标题翻译： FGF-CX多肽
公开(公告)号：US07253266B2
公开(公告)日：2007-08-07
申请号：US10174394
申请日：2002-06-17
申请人： Richard A. Shimkets , Michael Jeffers , Sudhirdas K. Prayaga , Ferenc L. Boldog , Meijia Yang , Catherine Burgess , Elma Fernandes , John L. Herrmann , William J. LaRochelle , Henri Lichenstein , Linda Gorman , Mei Zhong , Muralidhara Padigaru , Carol E. A. Pena , John P. Alsobrook, II , Denise M. Lepley , Daniel K. Rieger , William Grosse
发明人： Richard A. Shimkets , Michael Jeffers , Sudhirdas K. Prayaga , Ferenc L. Boldog , Meijia Yang , Catherine Burgess , Elma Fernandes , John L. Herrmann , William J. LaRochelle , Henri Lichenstein , Linda Gorman , Mei Zhong , Muralidhara Padigaru , Carol E. A. Pena , John P. Alsobrook, II , Denise M. Lepley , Daniel K. Rieger , William Grosse
IPC分类号： C07K14/50 , A61K38/18 , A61K38/00 , G01N33/53
CPC分类号： C07K14/50 , A61K38/1825 , A61K48/00 , A61K2039/505 , Y10S435/975
摘要： The present invention provides FGF-CX, a novel isolated polypeptide, as well as a polynucleotide encoding FGF-CX and antibodies that immunospecifically bind to FGF-CX or any derivative, variant, mutant, or fragment of the FGF-CX polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the FGF-CX polypeptide, polynucleotide and antibody are used in detection and treatment of a broad range of pathological states, as well as other uses.
摘要翻译：本发明提供了FGF-CX，一种新的分离的多肽，以及编码FGF-CX的多核苷酸和免疫特异性结合FGF-CX或FGF-CX多肽的任何衍生物，变体，突变体或片段的多核苷酸或抗体。本发明另外提供了FGF-CX多肽，多核苷酸和抗体用于检测和治疗广泛的病理状态以及其它用途的方法。

6. 发明授权

US08846873B2 Antibodies directed to GPNMB and uses thereof 有权
标题翻译：针对GPNMB的抗体及其用途
公开(公告)号：US08846873B2
公开(公告)日：2014-09-30
申请号：US13355366
申请日：2012-01-20
申请人： Feng Xiao , Xiao-Chi Jia , Meina Liang , Orit Foord , Scott Klakamp , Kam Fai Tse , Vincent A. Pollack , Luca Rastelli , John Herrmann , Henri Lichenstein , Michael Jeffers , William LaRochelle , Gulshan Ara , Peter Mezes , Andrei Chapoval , Cyrus Karkaria , Michael Torgov , Juan Davagnino
发明人： Feng Xiao , Xiao-Chi Jia , Meina Liang , Orit Foord , Scott Klakamp , Kam Fai Tse , Vincent A. Pollack , Luca Rastelli , John Herrmann , Henri Lichenstein , Michael Jeffers , William LaRochelle , Gulshan Ara , Peter Mezes , Andrei Chapoval , Cyrus Karkaria , Michael Torgov , Juan Davagnino
IPC分类号： C07K16/30 , C07K19/00 , C07K16/28 , A61K47/48 , A61K39/00
CPC分类号： C07K16/3053 , A61K47/6803 , A61K47/6849 , A61K47/6851 , A61K2039/505 , A61K2039/545 , C07K16/2809 , C07K16/30 , C07K16/3061 , C07K2317/21 , C07K2317/31 , C07K2317/565 , C07K2317/62 , C07K2317/622 , C07K2317/73 , C07K2317/732 , C07K2317/77 , C07K2317/94
摘要： The present invention provides fully human monoclonal antibodies that specifically bind to GPNMB, and uses thereof. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDRs) are provided. The present invention also provides immunoconjugates comprising anti-GPNMB antibodies and methods of using such immunoconjugates. The present invention further provides bi-specific antibodies comprising an anti-GPNMB antibody component and an anti-CD3 component, and methods of using such bispecific antibodies.
摘要翻译：本发明提供了完全与GPNMB结合的人单克隆抗体及其应用。提供了编码的核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列。本发明还提供了包含抗GPNMB抗体的免疫缀合物和使用这种免疫缀合物的方法。本发明还提供了包含抗GPNMB抗体组分和抗-CD3组分的双特异性抗体，以及使用这种双特异性抗体的方法。

7. 发明申请

US20130022597A1 Antibodies Directed To GPNMB And Uses Thereof 有权
标题翻译：针对GPNMB的抗体及其用途
公开(公告)号：US20130022597A1
公开(公告)日：2013-01-24
申请号：US13355366
申请日：2012-01-20
申请人： Meina Liang , Orit Foord , Scott Klakamp , Vincent A. Pollack , Luca Rastelli , John Herrmann , Henri Lichenstein , Michael Jeffers , William LaRochelle , Peter Mezes , Andrei Chapoval , Cyrus Karkaria , Michael Torgov , Juan Davagnino
发明人： Feng Xiao , Xiao-Chi Jia , Meina Liang , Orit Foord , Scott Klakamp , Kam Fai Tse , Vincent A. Pollack , Luca Rastelli , John Herrmann , Henri Lichenstein , Michael Jeffers , William LaRochelle , Gulshan Ara , Peter Mezes , Andrei Chapoval , Cyrus Karkaria , Michael Torgov , Juan Davagnino
IPC分类号： A61K39/395 , C12N15/13 , C40B30/04 , C12N15/63 , C12N1/21 , C12N5/10 , C07K16/18 , A61P35/00
CPC分类号： C07K16/3053 , A61K47/6803 , A61K47/6849 , A61K47/6851 , A61K2039/505 , A61K2039/545 , C07K16/2809 , C07K16/30 , C07K16/3061 , C07K2317/21 , C07K2317/31 , C07K2317/565 , C07K2317/62 , C07K2317/622 , C07K2317/73 , C07K2317/732 , C07K2317/77 , C07K2317/94
摘要： The present invention provides fully human monoclonal antibodies that specifically bind to GPNMB, and uses thereof. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDRs) are provided. The present invention also provides immunoconjugates comprising anti-GPNMB antibodies and methods of using such immunoconjugates. The present invention further provides bi-specific antibodies comprising an anti-GPNMB antibody component and an anti-CD3 component, and methods of using such bispecific antibodies.
摘要翻译：本发明提供了完全与GPNMB结合的人单克隆抗体及其应用。提供了编码的核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列。本发明还提供了包含抗GPNMB抗体的免疫缀合物和使用这种免疫缀合物的方法。本发明还提供了包含抗GPNMB抗体组分和抗-CD3组分的双特异性抗体，以及使用这种双特异性抗体的方法。

8. 发明申请

US20050164929A1 Methods of preventing and treating inflammatory bowel disease 审中-公开
标题翻译：预防和治疗炎症性肠病的方法
公开(公告)号：US20050164929A1
公开(公告)日：2005-07-28
申请号：US10980764
申请日：2004-11-03
申请人： Enrique Alvarez , Jeffrey Peterson , William LaRochelle , Henri Lichenstein , Michael Jeffers
发明人： Enrique Alvarez , Jeffrey Peterson , William LaRochelle , Henri Lichenstein , Michael Jeffers
IPC分类号： A61K38/00 , A61K38/18 , A61K38/19 , C07K14/49 , C07K14/50 , C07K14/51 , C07K14/52 , A61K48/00 , A61K38/17
CPC分类号： C07K14/49 , A61K38/00 , C07K14/50 , C07K14/51 , C07K14/52 , Y02A50/473
摘要： The present invention relates to compositions and methods for preventing and treating an inflammatory disorder of a mucosa, including but is not limited to, inflammatory bowel disease and irritable bowel syndrome. More particularly, the present invention relates to compositions comprising FGF-20, a fragment, a derivative, a variant, a homolog, or an analog thereof, and their uses in preventing and treating an inflammatory disorder of a mucosa, such as inflammatory bowel disease or irritable bowel syndrome.
摘要翻译：本发明涉及用于预防和治疗粘膜炎症性疾病的组合物和方法，包括但不限于炎性肠病和肠易激综合征。更具体地，本发明涉及包含FGF-20，片段，衍生物，变体，同源物或类似物的组合物，以及它们在预防和治疗粘膜炎症性疾病如炎症性肠病中的用途或肠易激综合征。

9. 发明申请

US20080274120A1 Histone Deacetylase (Hdac) Inhibitors (Pxd101) for the Treatment of Cancer Alone or in Combination With Chemotherapeutic Agent 有权
标题翻译：组蛋白脱乙酰酶（Hdac）抑制剂（Pxd101）用于单独治疗癌症或与化疗药物组合
公开(公告)号：US20080274120A1
公开(公告)日：2008-11-06
申请号：US12093069
申请日：2006-11-10
申请人： Henri Lichenstein , Nicholas Edwards , James Ritchie , Kamille Dumong Petersen , Jane Plumb
发明人： Henri Lichenstein , Nicholas Edwards , James Ritchie , Kamille Dumong Petersen , Jane Plumb
IPC分类号： A61K31/395 , A61K31/195 , A61P35/02 , C12N5/00 , A61P35/00
CPC分类号： A61K31/475 , A61K31/10 , A61K31/185 , A61K31/196 , A61K31/573 , A61K31/65 , A61K31/69 , A61K39/3955 , A61K45/06 , A61K2300/00
摘要： The present invention relates generally to methods for treating cancer. In one respect, the present invention relates to a method of treating a hematological cancer (e.g., multiple myeloma, leukemia, lymphoma) comprising administering to a patient in need thereof a therapeutically effective amount of a histone deacetylase inhibitor, for example, a histone deacetylase (HDAC) inhibitor as described herein, for example, PXD-101. In another respect, the present invention relates to a method of treating cancer (e.g., solid tumour cancer, e.g., rectal cancer, colon cancer, ovarian cancer; hematological cancer, e.g., multiple myeloma, leukemia, lymphoma) comprising administering to a patient in need thereof, a first amount of a histone deacetylase (HDAC) inhibitor, for example, a histone deacetylase inhibitor as described herein, for example, PXD-101, and a second amount of an other chemotherapeutic agent, for example, an other chemotherapeutic agent selected from: an antibody against VEGF, Avastin®, an antibody against CD20, rituximab, bortezomib, thalidomide, dexamethasone, vincristine, doxorubicin, and melphalan, wherein the first and second amounts together comprise a therapeutically effective amount.
摘要翻译：本发明一般涉及治疗癌症的方法。在一个方面，本发明涉及一种治疗血液癌症（例如多发性骨髓瘤，白血病，淋巴瘤）的方法，包括向有需要的患者施用治疗有效量的组蛋白脱乙酰酶抑制剂，例如组蛋白脱乙酰酶（HDAC）抑制剂，例如PXD-101。在另一方面，本发明涉及一种治疗癌症的方法（例如，实体肿瘤癌症，例如直肠癌，结肠癌，卵巢癌;血液癌症，例如多发性骨髓瘤，白血病，淋巴瘤），其包括向患者施用需要第一量的组蛋白脱乙酰酶（HDAC）抑制剂，例如本文所述的组蛋白脱乙酰酶抑制剂，例如PXD-101，和第二量的其它化学治疗剂，例如其它化学治疗剂选自：针对VEGF的抗体，Avastin，针对CD20的抗体，利妥昔单抗，硼替佐米，沙利度胺，地塞米松，长春新碱，多柔比星和美法仑，其中第一和第二量一起包含治疗有效量。

10. 发明申请

US20060094647A1 Treatment of inflammatory bowel disease using growth factors 审中-公开
标题翻译：用生长因子治疗炎症性肠病
公开(公告)号：US20060094647A1
公开(公告)日：2006-05-04
申请号：US09992840
申请日：2001-11-06
申请人： Michael Jeffers , Richard Shimkets , Sudhirdas Prayaga , Ferenc Boldog , Meijia Yang , Catherine Burgess , Elma Fernandes , Beth Rittman , Juliette Shimkets , William LaRochelle , Henri Lichenstein
发明人： Michael Jeffers , Richard Shimkets , Sudhirdas Prayaga , Ferenc Boldog , Meijia Yang , Catherine Burgess , Elma Fernandes , Beth Rittman , Juliette Shimkets , William LaRochelle , Henri Lichenstein
IPC分类号： A61K38/17
CPC分类号： A61K38/1825 , C07K14/49 , C07K14/50 , C07K14/51 , C07K14/52
摘要： The present invention is based upon methods of treating inflammatory conditions in the intestinal tract of mammals using growth factor related polypeptides. Methods of using fibroblast growth factor-CX (FGF-CX) polynucleotide sequences and the FGF-CX polypeptides encoded by such nucleic acid sequences, or variants, fragments and homologs thereof, are claimed in the invention. Similarly, methods of using FCTRX polynucleotide sequences and the FCTRX polypeptides encoded by such nucleic acid sequences, or variants, fragments and homologs thereof, alone or in combination, are also claimed in the invention. FCTRX collectively refers to any of six variant FCTRX sequences, variously designated FCTR1, FCTR2, FCTR3, FCTR4, FCTR5 and FCTR6.
摘要翻译：本发明是基于使用生长因子相关多肽治疗哺乳动物肠道炎症状况的方法。在本发明中要求使用成纤维细胞生长因子CX（FGF-CX）多核苷酸序列和由这种核酸序列编码的FGF-CX多肽或其变体，片段和同系物的方法。类似地，在本发明中还要求保护使用FCTRX多核苷酸序列和由此类核酸序列编码的FCTRX多肽，或其变体，片段和同源物单独或组合使用的方法。 FCTRX统称为六种变体FCTRX序列中的任何一种，分别为FCTR1，FCTR2，FCTR3，FCTR4，FCTR5和FCTR6。

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