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1. 发明申请

US20080112980A1 LAWSONIA INTRACELLULARIS OF EUROPEAN ORIGIN AND VACCINES, DIAGNOSTIC AGENTS AND METHODS OF USE THEREOF 有权
标题翻译：欧洲原始药物和疫苗的麻醉品细菌，诊断试剂及其使用方法
公开(公告)号：US20080112980A1
公开(公告)日：2008-05-15
申请号：US11935447
申请日：2007-11-06
申请人： Michael B. Roof , Jeremy J. Kroll , Jeffrey P. Knittel
发明人： Michael B. Roof , Jeremy J. Kroll , Jeffrey P. Knittel
IPC分类号： A61K39/02 , C12N1/20 , G01N33/554 , A01K67/027
CPC分类号： A61K39/105 , A61K2039/505 , A61K2039/521 , A61K2039/522 , C07K16/1203 , G01N2333/195 , Y10S424/825
摘要： The present invention relates to Lawsonia intracellularis vaccines and methods for protecting against and diagnosing L. intracellularis infection. The products and processes of the invention are attainable, in part, as the result of an improved method for cultivating large scale supplies of L. intracellularis, including both a novel isolate of L. intracellularis of European origin and a method of preparing a lyophilized product containing the attenuated European isolate as vaccine product.
摘要翻译：本发明涉及细胞内劳森氏菌疫苗以及用于保护和诊断细胞内感染的方法。本发明的产品和方法部分地可以通过用于培养大量细胞内源性物质的改进方法的结果，所述方法包括欧洲来源的细胞内分泌物的新型分离物和制备冻干产物的方法含有减毒的欧洲分离物作为疫苗产品。

2. 发明授权

US07758870B2 Lawsonia intracellularis of european origin and vaccines, diagnostic agents and methods of use thereof 有权
标题翻译：欧洲来源的细胞内劳森氏菌和疫苗，诊断剂及其使用方法
公开(公告)号：US07758870B2
公开(公告)日：2010-07-20
申请号：US11935447
申请日：2007-11-06
申请人： Michael B. Roof , Jeremy J. Kroll , Jeffrey P. Knittel
发明人： Michael B. Roof , Jeremy J. Kroll , Jeffrey P. Knittel
IPC分类号： A61K39/02
CPC分类号： A61K39/105 , A61K2039/505 , A61K2039/521 , A61K2039/522 , C07K16/1203 , G01N2333/195 , Y10S424/825
摘要： The present invention relates to Lawsonia intracellularis vaccines and methods for protecting against and diagnosing L. intracellularis infection. The products and processes of the invention are attainable, in part, as the result of an improved method for cultivating large scale supplies of L. intracellularis, including both a novel isolate of L. intracellularis of European origin and a method of preparing a lyophilized product containing the attenuated European isolate as vaccine product.
摘要翻译：本发明涉及细胞内劳森氏菌疫苗以及用于保护和诊断细胞内感染的方法。本发明的产品和方法部分地可以通过用于培养大量细胞内源性物质的改进方法的结果，所述方法包括欧洲来源的细胞内分泌物的新型分离物和制备冻干产物的方法含有减毒的欧洲分离物作为疫苗产品。

3. 发明授权

US5714375A Ileal symbiont intracellularis propagation in suspended host cells 失效
标题翻译：悬浮宿主细胞中细胞内共生菌共培养繁殖
公开(公告)号：US5714375A
公开(公告)日：1998-02-03
申请号：US465337
申请日：1995-06-05
申请人： Jeffrey P. Knittel , Michael B. Roof
发明人： Jeffrey P. Knittel , Michael B. Roof
IPC分类号： C07K16/12 , C12N1/20 , G01N33/569 , C12N1/12 , A61K39/02
CPC分类号： A61K39/105 , C07K16/1203 , C12N1/20 , C12R1/01 , G01N33/56911 , G01N33/56922 , A61K2039/521 , A61K2039/522 , A61K2039/552 , G01N2333/195
摘要： A method for large scale cultivation and attenuation of IS intracellularis bacteria by inoculating cells with IS intracellularis bacteria to infect the cells, incubating the infected cells in a reduced oxygen concentration and maintaining the infected cells in suspension. Anti-IS intracellularis vaccines are prepared from attenuated strains. Diagnostic agents are also disclosed.
摘要翻译：通过用IS细胞内源细菌接种细胞来感染细胞大规模培养和减少IS细胞内分泌细菌的方法，将感染的细胞以降低的氧浓度孵育并将感染的细胞保持在悬浮状态。抗细胞内抗原疫苗由减毒菌株制备。还公开了诊断剂。

4. 发明授权

US07312065B2 Lawsonia intracellularis of European origin and vaccines, diagnostic agents and methods of use thereof 有权
标题翻译：欧洲来源的细胞内劳森氏菌和疫苗，诊断剂及其使用方法
公开(公告)号：US07312065B2
公开(公告)日：2007-12-25
申请号：US10891745
申请日：2004-07-15
申请人： Michael B. Roof , Jeremy J. Kroll , Jeffrey P. Knittel
发明人： Michael B. Roof , Jeremy J. Kroll , Jeffrey P. Knittel
IPC分类号： C12N1/12
CPC分类号： A61K39/105 , A61K2039/505 , A61K2039/521 , A61K2039/522 , C07K16/1203 , G01N2333/195 , Y10S424/825
摘要： The present invention relates to Lawsonia intracellularis vaccines and methods for protecting against and diagnosing L. intracellularis infection. The products and processes of the invention are attainable, in part, as the result of an improved method for cultivating large scale supplies of L. intracellularis, including both a novel isolate of L. intracellularis of European origin and a method of preparing a lyophilized product containing the attenuated European isolate as vaccine product.
摘要翻译：本发明涉及细胞内劳森氏菌疫苗以及用于保护和诊断细胞内感染的方法。本发明的产品和方法部分地可以通过用于培养大量细胞内源性物质的改进方法的结果，所述方法包括欧洲来源的细胞内分泌物的新型分离物和制备冻干产物的方法含有减毒的欧洲分离物作为疫苗产品。

5. 发明授权

US5885823A Lawsonia intracellularis cultivation, anti-Lawsonia intracellularis vaccines and diagnostic agents 失效
标题翻译：细胞内劳氏菌培养，细胞内抗菌素疫苗和诊断剂
公开(公告)号：US5885823A
公开(公告)日：1999-03-23
申请号：US658194
申请日：1996-06-04
申请人： Jeffrey P. Knittel , Michael B. Roof
发明人： Jeffrey P. Knittel , Michael B. Roof
IPC分类号： G01N33/554 , A61K39/02 , A61K39/106 , A61K39/40 , A61P31/04 , C07K16/12 , C12N1/00 , C12N1/20 , C12N1/36 , C12N5/06 , C12N9/92 , C12Q1/02 , G01N33/569
CPC分类号： C12R1/01 , A61K39/105 , C07K16/1203 , C12N1/20 , G01N33/56911 , G01N33/56922 , A61K2039/521 , A61K2039/522 , A61K2039/552 , G01N2333/195 , G01N2469/20 , Y10S424/825
摘要： A method for large scale cultivation and attenuation of L. intracellularis bacteria by inoculating cells with L. intracellularis bacteria to infect the cells, incubating the infected cells in a reduced oxygen concentration and maintaining the infected cells in suspension. Anti-L. intracellularis vaccines are prepared from cultures grown in suspension. Diagnostic agents are also disclosed.
摘要翻译：通过用细胞内细胞细胞细胞接种细胞来感染细胞，大量培养和减少细胞内毒素细菌的方法，将感染的细胞以降低的氧浓度孵育并将感染的细胞保持在悬浮状态。反L 细胞内毒素疫苗由悬浮培养的培养物制备。还公开了诊断剂。

6. 发明申请

US20110150770A1 MULTIVALENT VACCINE AGAINST PORCINE TESCHOVIRUS AND OTHER DISEASE CAUSING ORGANISMS IN SWINE 审中-公开
标题翻译：多种疫苗对斑马鱼和其他疾病引起的毒素
公开(公告)号：US20110150770A1
公开(公告)日：2011-06-23
申请号：US12964073
申请日：2010-12-09
申请人： Elida BAUTISTA , Dianna M. Murphy JORDAN , Axel NEUBAUER , Abby Rae PATTERSON , Michael B. Roof , Eric M. VAUGHN , Joseph G. Victoria
发明人： Elida BAUTISTA , Dianna M. Murphy JORDAN , Axel NEUBAUER , Abby Rae PATTERSON , Michael B. Roof , Eric M. VAUGHN , Joseph G. Victoria
IPC分类号： A61K39/295 , A61K39/39 , A61K39/125 , A61K49/00 , A61P31/04 , A61P31/14 , B65D85/00
CPC分类号： A61K39/125 , A61K39/12 , A61K2039/5252 , A61K2039/543 , A61K2039/552 , A61K2039/55566 , A61K2039/70 , C12N7/00 , C12N2750/10034 , C12N2770/10034 , C12N2770/32034
摘要： An immunogenic composition or vaccine, and method of treatment are provided by the present invention. The immunogenic composition is useful for treating, preventing, and lessening the severity of clinical symptoms associated with disease-causing organisms in swine, utilizing one or more Porcine Teschovirus antigen(s) along with an antigen of the other disease-causing organism in swine and a pharmaceutically acceptable carrier.
摘要翻译：免疫原性组合物或疫苗以及治疗方法由本发明提供。免疫原性组合物可用于治疗，预防和减轻与猪中的致病生物体相关的临床症状的严重性，利用一种或多种猪Teschovirus抗原以及猪中其他致病生物的抗原，以及药学上可接受的载体。

7. 发明授权

US5468778A Method of lowering intraocular pressure by administering a pharmaceutical composition containing 7-(5-substituted cyclopentyl) and 7-(5-substituted-cyclopentenyl) 5-heptenoic acids and derivatives 失效
标题翻译：通过施用含有7-（5-取代的环戊基）和7-（5-取代的环戊烯基）-5-庚烯酸和衍生物的药物组合物来降低眼内压的方法
公开(公告)号：US5468778A
公开(公告)日：1995-11-21
申请号：US950855
申请日：1992-09-24
申请人： Michael E. Garst , Robert M. Burk , Ming F. Chan , Michael B. Roof
发明人： Michael E. Garst , Robert M. Burk , Ming F. Chan , Michael B. Roof
IPC分类号： A61K31/557 , A61K31/19 , A61K31/215
CPC分类号： A61K31/557 , Y10S514/913
摘要： Intraocular pressure is lowered in the eye of a mammal by administration of a pharmaceutical composition containing as active ingredient a compound of the formula ##STR1## where the dotted line represents a bond or the absence of a bond, wavy lines connected to the olefinic bond represent cis or trans configuration about the olefinic bond; R.sub.1 represents H, or CO-R.sub.3 where R.sub.3 is lower alkyl of 1 to 6 carbons, carbocyclic aryl or heterocyclic aryl; or carbocyclic aryl or heteroaryl substituted lower alkyl group; R.sub.2 represents H or lower alkyl of 1 to 6 carbons, and n is an integer between 0 and 8.
摘要翻译：通过给药含有作为活性成分的式“IMAGE”的化合物的药物组合物，在哺乳动物的眼睛中降低眼内压，其中虚线表示键或不存在键，与烯键连接的波浪线代表关于烯键的顺式或反式构型; R1表示H或CO-R3，其中R3是1至6个碳的低级烷基，碳环芳基或杂环芳基; 或碳环芳基或杂芳基取代的低级烷基; R2表示H或碳原子数为1〜6的低级烷基，n为0〜8的整数。

8. 发明授权

US06258844B1 Cyclopentane (ene) oic acid, 2-alkenyl derivatives as therapeutic agents 失效
标题翻译：环戊烷（烯）酸，2-烯基衍生物作为治疗剂
公开(公告)号：US06258844B1
公开(公告)日：2001-07-10
申请号：US09194457
申请日：1998-11-24
申请人： Michael E. Garst , Michael B. Roof , Ming F. Chan , David F. Woodward , Robert M. Burk , Todd S. Gac , Steven W. Andrews
发明人： Michael E. Garst , Michael B. Roof , Ming F. Chan , David F. Woodward , Robert M. Burk , Todd S. Gac , Steven W. Andrews
IPC分类号： A67K31215
CPC分类号： A61K31/5575 , C07C405/00 , Y10S514/913
摘要： The invention relates to the use of omega chain modified prostaglandins as ocular hypotensive. The derivatives used in accordance with the invention are encompassed by the following structure formula I: wherein the hatched segments represent &agr; bonds; the wavy segment represents an &agr; or &bgr; bond; dashed lines represent a double bond or a single bond; X is selected from the group consisting of —OR and N(R2); Y is=O or represents 2 hydrogen radicals, provided that Y represents 2 hydrogen radicals when X is OH; R is hydrogen or a lower alkyl radical having up to six carbon atoms; R1 is=O or hydroxy; m is 0, 2, 4 or 6, provided that m is not 4 when the wavy segment represents a &bgr; bond; n is 0, 2, 4 or 6; x and y are 0 or 1, provided that x is 1 when y is 0 and y is 1 when x is 0; or 9, 11 and/or 15 ester derivatives of said compound of formula I, e.g. a C1 to C6 alkyl ester derivative; or a pharmaceutically acceptable salt thereof. In a further aspect, the present invention relates to an ophthalmic solution comprising a therapeutically effective amount of a compound of formula (I), wherein the symbols have the above meanings, in admixture with a non-toxic, ophthalmically acceptable liquid vehicle, packaged in a container suitable for metered application.
摘要翻译：本发明涉及使用ω-链修饰的前列腺素作为眼压降低。根据本发明使用的衍生物包括下列结构式I：其中阴影线段代表α键; 波浪段表示α或β键; 虚线表示双键或单键; X选自-OR和N（R2）; Y为= O或表示2个氢原子，条件是当X为OH时，Y表示2个氢原子; R是氢或具有至多6个碳原子的低级烷基; R1为= O或羟基; m为0,2,4或6，条件是当波浪段代表β键时m不为4; n为0,2,4或6; x和y为0或1，条件是当y为0时x为1，当x为0时y为1; 或所述式I化合物的9,11和/或15酯衍生物，例如。 C1-C6烷基酯衍生物; 或其药学上可接受的盐。在另一方面，本发明涉及一种眼用溶液，其包含治疗有效量的式（I）化合物，其中符号具有上述含义，与无毒的眼科可接受的液体载体混合，包装在适用于计量应用的容器。

9. 发明授权

US08637047B2 Erysipelothrix rhusiopathiae-haemophilus parasuis vaccine and methods of using the same 有权
标题翻译：欧氏结核杆菌血吸虫嗜血杆菌疫苗及其使用方法
公开(公告)号：US08637047B2
公开(公告)日：2014-01-28
申请号：US10975702
申请日：2004-10-28
申请人： John Randall Swart , Eric Martin Vaughn , Karen E. Freking , Michael B. Roof , Phillip Wayne Hayes , Reid C. Phillips
发明人： John Randall Swart , Eric Martin Vaughn , Karen E. Freking , Michael B. Roof , Phillip Wayne Hayes , Reid C. Phillips
IPC分类号： A61K39/116 , A61K39/102
CPC分类号： A61K39/102 , A61K39/0241 , A61K2039/54 , A61K2039/552 , A61K2039/55566
摘要： The present invention provides a composition and an improved single dose vaccine against E. rhusiopathiae and an improved single dose vaccine against E. rhusiopathiae and H. parasuis which provides one or more of the following: 1) confers effective immunity against E. rhusiopathiae and/or H. parasuis; 2) decreases the risk of developing clinical signs of E. rhusiopathiae and/or H. parasuis infection; 3) induces an immune response against E. rhusiopathiae and/or H. parasuis; and 4) has a DOI against E. rhusiopathiae and/or H. parasuis of at least four months. The composition or E. rhusiopathiae vaccine as well as the combined E. rhusiopathiae-H. parasuis composition or vaccine each includes a bacterial component of inactivated E. rhusiopathiae bacteria and a suitable adjuvant. The combined E. rhusiopathiae-H. parasuis composition or vaccine further includes an amount of H. parasuis antigen. The vaccines can be administered to animals in any conventional manner. The amount of the dose for intramuscular administration is preferably less than 5 ml. The amount of E. rhusiopathiae and/or H. parasuis antigen in each dose should be enough to induce an immune response in the animal receiving the vaccine or composition and will preferably confer effective immunity against and decrease the risk of developing clinical signs resulting from E. rhusiopathiae and/or H. parasuis infection for a suitable duration of immunity.
摘要翻译：本发明提供组合物和改进的针对埃氏杆菌病的单一剂量疫苗和针对针对埃希氏杆菌和副猪嗜血杆菌的改进的单剂量疫苗，其提供以下一种或多种：1）赋予针对E.杆菌病和/ 或副猪嗜血菌 2）降低发生脑炎病毒和/或副猪嗜血杆菌感染的临床症状的风险; 3）诱导针对埃氏杆菌和/或副猪嗜血杆菌的免疫应答; 和4）具有至少四个月的针对埃氏杆菌和/或副猪嗜血杆菌的DOI。组合物或E.杆菌病疫苗以及组合的脑炎病毒H。副产物组合物或疫苗各自包括灭活的肠球菌属细菌的细菌组分和合适的佐剂。合并的脑炎病毒H。副产物组成或疫苗还包括一定量的副猪嗜血杆菌抗原。疫苗可以以任何常规方式施用于动物。肌内给药的剂量优选小于5ml。每种剂量的肠球菌和/或副猪嗜血杆菌抗原的量应足以在接受疫苗或组合物的动物中诱导免疫应答，并且优选地赋予有效的免疫力并降低由E引起的临床体征的风险 rhusiopathiae和/或副猪嗜血杆菌感染，具有合适的免疫持续时间。

10. 发明申请

US20110117129A1 Vaccine Against Highly Pathogenic Porcine Reproductive and Respiratory Syndrome (HP PRRS) 审中-公开
标题翻译：针对高致病性猪繁殖与呼吸综合征疫苗（HP PRRS）
公开(公告)号：US20110117129A1
公开(公告)日：2011-05-19
申请号：US13055590
申请日：2009-08-24
申请人： Michael B. Roof , Eric Vaughn
发明人： Michael B. Roof , Eric Vaughn
IPC分类号： A61K39/225 , A61P37/00
CPC分类号： C12N7/00 , A61K39/12 , A61K2039/5254 , A61K2039/552 , C12N2770/10034
摘要： The present invention is related to methods and attenuated viral compositions for use in preventing and treating a high fever disease forms associated with porcine reproductive and respiratory syndrome (PRRS), such as highly pathogenic porcine reproductive and respiratory syndrome (HP PRRS), a viral disease affecting swine.
摘要翻译：本发明涉及用于预防和治疗与猪繁殖与呼吸综合征（PRRS）相关的高发病形式的方法和减毒病毒组合物，例如高致病性猪繁殖与呼吸综合征（HP PRRS），病毒性疾病影响猪。

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