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1. 发明申请

US20190150815A1 BIOSENSOR ARRAY FOR THE DETECTION OF ANALYTES 审中-公开
公开(公告)号：US20190150815A1
公开(公告)日：2019-05-23
申请号：US16198363
申请日：2018-11-21
申请人： Jeffrey LaBelle , David Probst , Bin Mu
发明人： Jeffrey LaBelle , David Probst , Bin Mu
IPC分类号： A61B5/1486 , A61B5/145
摘要： Embodiments of the present disclosure relate generally devices for detecting analytes in a subject. More particularly, the present disclosure provides a biosensor array for detecting analytes in a subject. Embodiments of the present disclosure include a biosensor array comprising a plurality of sensor cells for detecting an analyte in a subject. In accordance with these embodiments, the plurality of sensor cells comprise at least one electrode, at least one antibody immobilized on a surface of the at least one electrode, and a biodegradable coating in contact with the at least one antibody.

2. 发明申请

US20220192551A1 BIOSENSOR ARRAY FOR THE DETECTION OF ANALYTES 有权
公开(公告)号：US20220192551A1
公开(公告)日：2022-06-23
申请号：US17511901
申请日：2021-10-27
申请人： Jeffrey LaBelle , David Probst , Bin Mu
发明人： Jeffrey LaBelle , David Probst , Bin Mu
IPC分类号： A61B5/1486 , A61B5/145 , A61B5/1473
摘要： Embodiments of the present disclosure relate generally devices for detecting analytes in a subject. More particularly, the present disclosure provides a biosensor array for detecting analytes in a subject. Embodiments of the present disclosure include a biosensor array comprising a plurality of sensor cells for detecting an analyte in a subject. In accordance with these embodiments, the plurality of sensor cells comprises at least one electrode, at least one antibody immobilized on a surface of the at least one electrode, and a biodegradable coating in contact with the at least one antibody.

3. 发明授权

US11185263B2 Biosensor array for the detection of analytes 有权
公开(公告)号：US11185263B2
公开(公告)日：2021-11-30
申请号：US16198363
申请日：2018-11-21
申请人： Jeffrey LaBelle , David Probst , Bin Mu
发明人： Jeffrey LaBelle , David Probst , Bin Mu
IPC分类号： A61B5/1486 , A61B5/145 , A61B5/1473 , G01N27/327
摘要： Embodiments of the present disclosure relate generally devices for detecting analytes in a subject. More particularly, the present disclosure provides a biosensor array for detecting analytes in a subject. Embodiments of the present disclosure include a biosensor array comprising a plurality of sensor cells for detecting an analyte in a subject. In accordance with these embodiments, the plurality of sensor cells comprise at least one electrode, at least one antibody immobilized on a surface of the at least one electrode, and a biodegradable coating in contact with the at least one antibody.

4. 发明授权

US11672449B2 Biosensor array for the detection of analytes 有权
公开(公告)号：US11672449B2
公开(公告)日：2023-06-13
申请号：US17511901
申请日：2021-10-27
申请人： Jeffrey LaBelle , David Probst , Bin Mu
发明人： Jeffrey LaBelle , David Probst , Bin Mu
IPC分类号： A61B5/1486 , A61B5/145 , A61B5/1473 , G01N27/327
CPC分类号： A61B5/14865 , A61B5/14546 , A61B5/14735 , A61B5/145 , A61B5/1486 , A61B5/14503 , A61B5/14507 , G01N27/3271 , G01N27/3275 , G01N2333/62
摘要： Embodiments of the present disclosure relate generally devices for detecting analytes in a subject. More particularly, the present disclosure provides a biosensor array for detecting analytes in a subject. Embodiments of the present disclosure include a biosensor array comprising a plurality of sensor cells for detecting an analyte in a subject. In accordance with these embodiments, the plurality of sensor cells comprises at least one electrode, at least one antibody immobilized on a surface of the at least one electrode, and a biodegradable coating in contact with the at least one antibody.

5. 发明申请

US20130183243A1 Methods and Device for Tuning Multiplexed Markers for Disease Assay 审中-公开
标题翻译：用于调节多重标记物进行疾病测定的方法和装置
公开(公告)号：US20130183243A1
公开(公告)日：2013-07-18
申请号：US13809387
申请日：2011-07-12
申请人： Jeffrey LaBelle , Ugur Demirok
发明人： Jeffrey LaBelle , Ugur Demirok
IPC分类号： G01N27/02 , A61B5/0205 , G01N33/68
CPC分类号： G01N27/026 , A61B5/0205 , G01N27/3278 , G01N33/5438 , G01N33/6869
摘要： The present invention relates to a diagnostic device and methods of using the same for diagnostic assays for monitoring the presence of biological samples wherein the device allows for the determination of at least two assay components on one sensor. More specifically, the invention relates to a multi-marker electrochemical impedance spectroscopy sensor comprising a plurality of molecular recognition elements wherein the sensor comprises multiple different molecular recognition element types that are tuned in a manner that alters the frequency of the molecular recognition element type such that it is at a detectably different frequency to the frequency of other molecular recognition element types on the same sensor.
摘要翻译：本发明涉及一种诊断装置及其用于诊断测定用于监测生物样品的存在的方法，其中该装置允许在一个传感器上确定至少两个测定组分。更具体地，本发明涉及包括多个分子识别元件的多标记电化学阻抗光谱传感器，其中传感器包括多个不同的分子识别元件类型，其以改变分子识别元件类型的频率的方式进行调谐，使得与同一传感器上的其他分子识别元件类型的频率具有可检测的不同频率。

6. 发明申请

US20060008893A1 NANOENGINEERED BIOPHOTONIC HYBRID DEVICE 失效
标题翻译：纳米生物化学杂交装置
公开(公告)号：US20060008893A1
公开(公告)日：2006-01-12
申请号：US10658541
申请日：2003-09-08
申请人： Jeffrey LaBelle , Vincent Pizziconi
发明人： Jeffrey LaBelle , Vincent Pizziconi
IPC分类号： C12N1/00
CPC分类号： B01L3/5085 , B01L2300/168 , G01N21/31
摘要： An improved method for the design and development of high performance hybrid devices having biological and nonbiological components. A figure of merit is developed for the biological component or components. The component is subjected to various environmental variables as it or its biological source organism is grown. The biological component is force adapted to cause its figure of merit to reach a goal or an acceptable measure. The biological component is used in hybrid constructs that may be nanostructures, given the small size of the biological parts. In one specific embodiment, force-adapted chlorosomes of C. aurantiacus enhance performance of a silicon photovoltaic cell. The bacteria, Chloroflexus aurantiacus (C. aurantiacus), strain J-10-f1, has the A.T.C.C. designation number 29366, having been deposited in July, 1976.
摘要翻译：一种用于设计和开发具有生物和非生物组分的高性能混合设备的改进方法。为生物组分开发了一个品质因素。该组分经受各种环境变量，因为它或其生物源生物体生长。生物组成部分是力量使其品质因数达到目标或可接受的措施。考虑到生物部件的小尺寸，生物组分用于可能是纳米结构的杂交构建体中。在一个具体实施方案中，C.aurantiacus的力适应性的氯代体增强了硅光伏电池的性能。细菌，黄曲霉（C. aurantiacus），菌株J-10-f1，具有A.T.C.C. 名称为29366，已于1976年7月交存。

7. 发明授权

US10948366B2 Flexible sensors incorporating piezoresistive composite materials and fabrication methods 有权
公开(公告)号：US10948366B2
公开(公告)日：2021-03-16
申请号：US16339340
申请日：2017-10-04
申请人： Jeffrey LaBelle , Steven Lathers
发明人： Jeffrey LaBelle , Steven Lathers
IPC分类号： G01L1/00 , G01L1/18 , B33Y80/00 , H01B1/24 , H01B13/00 , B33Y10/00 , B33Y30/00 , B29C64/118 , B29K9/06 , B29K507/04 , B29L31/34 , B29L31/00
摘要： A flexible sensor includes a first electrode, a second electrode, and a piezoresistive element incorporating piezoresistive composite material arranged between the first electrode and the second electrode. Piezoresistive composite materials include a thermoplastic elastomer (TPE) and a conductive filler material (e.g., carbon), may have an elastic modulus value of preferably less than about 1×10−3 GPa, and exhibit a change in electrical resistance responsive to a change in pressure applied thereto. Exemplary flexible sensors may have a thickness and a feel similar to human skin, may be amenable to simple fabrication techniques (e.g., fused filament fabrication (FFF) three-dimensional (3D) printing or molding), and can be manufactured into user-specific geometries.

8. 发明申请

US20190330163A1 UNIQUE SELF-ASSEMBLED POLY-AMIDOAMINE POLYMERS AND THEIR ELETROCHEMICAL REACTIVITY 审中-公开
公开(公告)号：US20190330163A1
公开(公告)日：2019-10-31
申请号：US16440848
申请日：2019-06-13
申请人： Jeffrey LaBelle , Trevor Saxman , Brittney Cardinell
发明人： Jeffrey LaBelle , Trevor Saxman , Brittney Cardinell
IPC分类号： C07D245/04 , G01N33/66 , C08G83/00 , C08G73/02
摘要： Synthesis of novel and unique PAMAM (poly-amidoamine) polymers. PAMAM polymers can be grown by systematic alternation between ethylenediamine (EDA) and methacrylate. By taking advantage of the alternating terminal ends, successive generations G1 and G0.5 were combined under acidic conditions with Pluronic P123 as a liquid-crystal template. The resulting polymer was imaged with TEM and the product was circular and amorphous of no characteristic size ranging between about 5 nm to about 600 nm, with remarkable electrochemical activity unseen in any of the generations of PAMAM. Applications of this electroactive poly-amidoamine organic polymer include use as a new electron transfer reagent for amperometric biosensors.

9. 发明申请

US20190234816A1 FLEXIBLE SENSORS INCORPORATING PIEZORESISTIVE COMPOSITE MATERIALS AND FABRICATION METHODS 审中-公开
公开(公告)号：US20190234816A1
公开(公告)日：2019-08-01
申请号：US16339340
申请日：2017-10-04
申请人： Jeffrey LaBelle , Steven Lathers
发明人： Jeffrey LaBelle , Steven Lathers
IPC分类号： G01L1/18 , H01B1/24 , H01B13/00 , B33Y80/00
CPC分类号： G01L1/18 , B29C64/118 , B29K2009/06 , B29K2507/045 , B29K2995/0005 , B29L2031/34 , B29L2031/7532 , B33Y10/00 , B33Y30/00 , B33Y80/00 , H01B1/24 , H01B13/0016
摘要： Flexible sensors incorporating piezoresistive composite materials and their fabrication methods are provided. A flexible sensor includes a first electrode, a second electrode, and a piezoresistive element comprising piezoresistive composite material arranged between the first electrode and the second electrode. Piezoresistive composite materials include a thermoplastic elastomer (TPE) and a conductive filler material (e.g., carbon), and have an elastic modulus value of preferably less than about 1×10−3 GPa. Piezoresistive composite material may be placed between electrodes, and exhibit a change in electrical resistance responsive to a change in pressure applied thereto. Piezoresistive composite materials may be fabricated by fused filament fabrication (FFF) three-dimensional (3D) printing or molding. Exemplary flexible sensors may have a thickness and a feel similar to human skin, may be amenable to simple fabrication techniques, and can be manufactured into user-specific geometries.

10. 发明授权

US11346798B2 Methods and device for tuning multiplexed markers for disease assay 有权
公开(公告)号：US11346798B2
公开(公告)日：2022-05-31
申请号：US13809387
申请日：2011-07-12
申请人： Jeffrey LaBelle , Ugur Demirok
发明人： Jeffrey LaBelle , Ugur Demirok
IPC分类号： G01N27/02 , G01N33/543 , G01N27/327 , A61B5/0205 , G01N33/68
摘要： The present invention relates to a diagnostic device and methods of using the same for diagnostic assays for monitoring the presence of biological samples wherein the device allows for the determination of at least two assay components on one sensor. More specifically, the invention relates to a multi-marker electrochemical impedance spectroscopy sensor comprising a plurality of molecular recognition elements wherein the sensor comprises multiple different molecular recognition element types that are tuned in a manner that alters the frequency of the molecular recognition element type such that it is at a detectably different frequency to the frequency of other molecular recognition element types on the same sensor.

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