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1. 发明授权

US07148242B2 N-formyl hydroxylamine compounds, compositions and methods of use 失效
标题翻译： N-甲酰羟胺化合物，组合物和使用方法
公开(公告)号：US07148242B2
公开(公告)日：2006-12-12
申请号：US10171706
申请日：2002-06-14
申请人： Jeffrey Jacobs , Rakesh K. Jain , Dinesh V. Patel , Zhengyu Yuan
发明人： Jeffrey Jacobs , Rakesh K. Jain , Dinesh V. Patel , Zhengyu Yuan
IPC分类号： A61K31/44 , A61K31/426 , A61K31/40 , A61K31/36 , C07D417/12 , C07D401/12 , C07D407/12
CPC分类号： C07D207/16 , C07D401/12 , C07D405/12
摘要： N-[1-oxo-2-alkyl-3-(N-hydroxyformamido)-propyl]-(carbonylamino-aryl or -heteroaryl)-azacyclo4-7alkanes or thiazacyclo4-7alkanes or imidazacyclo4-7alkanes have interesting properties, e.g., in the treatment or prevention of disorders amenable to treatment by peptidyl deformylase inhibitors such as treatment of bacterial infections.
摘要翻译： N- [1-氧代-2-烷基-3-（N-羟基甲酰氨基） - 丙基] - （羰基氨基 - 芳基或 - 杂芳基） - 氮杂环基4-7-烷基或噻唑烷基4- 7烷烃或咪唑环-4-7烷烃具有令人感兴趣的性质，例如在治疗或预防易于由肽基变性酶抑制剂治疗的疾病，例如治疗细菌感染。

2. 发明授权

US06987104B2 Pyrrolidine bicyclic compounds and its derivatives, compositions and methods of use 失效
标题翻译：吡咯烷双环化合物及其衍生物，组合物和使用方法
公开(公告)号：US06987104B2
公开(公告)日：2006-01-17
申请号：US10171705
申请日：2002-06-14
申请人： Jeffrey Jacobs , Rakesh K. Jain , Jason G. Lewis , Dinesh V. Patel , Zhengyu Yuan
发明人： Jeffrey Jacobs , Rakesh K. Jain , Jason G. Lewis , Dinesh V. Patel , Zhengyu Yuan
IPC分类号： A01N43/46 , C07D403/12 , A61K31/55
CPC分类号： C07D207/08 , C07D401/04 , C07D403/04 , C07D413/04 , C07D417/04
摘要： N-[1-oxo-(optionally 2-aza)-2-alkyl-3-(carboxyl or thiol or hydroxyaminocarbonyl or N-hydroxyformamido)-propyl]-(aryl or heteroaryl)-azacyclo4-7alkanes or thiazacyclo4-7alkanes, salts or prodrugs thereof have interesting properties, e.g., in the treatment or prevention of disorders amenable to treatment by PDF inhibitors, such as treatment of bacterial infections.
摘要翻译： N- [1-氧代（任选的2-氮杂）-2-烷基-3-（羧基或硫醇或羟基氨基羰基或N-羟基甲酰氨基） - 丙基] - （芳基或杂芳基） - 氮杂环基4-7 烷烃或噻唑烷类4-7烷烃，其盐或前药具有有趣的性质，例如在治疗或预防易受PDF抑制剂治疗的疾病例如细菌感染的治疗。

3. 发明授权

US07612059B2 Pyrrolidine bicyclic compounds and its derivatives, compositions and methods of use 失效
标题翻译：吡咯烷双环化合物及其衍生物，组合物和使用方法
公开(公告)号：US07612059B2
公开(公告)日：2009-11-03
申请号：US11151131
申请日：2005-06-13
申请人： Jeffrey Jacobs , Rakesh K Patel , Jason G Lewis , Dinesh V Patel , Zhengyu Yuan
发明人： Jeffrey Jacobs , Rakesh K Patel , Jason G Lewis , Dinesh V Patel , Zhengyu Yuan
IPC分类号： A01N43/46 , C07D403/12 , A61K31/55
CPC分类号： C07D207/08 , C07D401/04 , C07D403/04 , C07D413/04 , C07D417/04
摘要： N-[1-oxo-(optionally 2-aza)-2-alkyl-3-(carboxyl or thiol or hydroxyaminocarbonyl or N-hydroxyformamido)-propyl]-(aryl or heteroaryl)-azacyclo4-7alkanes or thiazacyclo4-7alkanes, salts or prodrugs thereof have interesting properties, e.g., in the treatment or prevention of disorders amenable to treatment by PDF inhibitors, such as treatment of bacterial infections.
摘要翻译： N- [1-氧代（任选的2-氮杂）-2-烷基-3-（羧基或硫醇或羟基氨基羰基或N-羟基甲酰氨基） - 丙基] - （芳基或杂芳基） - 氮杂环丁烷-4-氮杂环丁烷或噻唑烷-4- 或其前药具有有趣的性质，例如在治疗或预防易于通过PDF抑制剂治疗的疾病例如细菌感染的治疗。

4. 发明授权

US07615635B2 N-formyl hydroxylamines 失效
标题翻译： N-甲酰羟胺
公开(公告)号：US07615635B2
公开(公告)日：2009-11-10
申请号：US11914659
申请日：2006-05-22
申请人： Kathryn Rene Bracken , Simon Bushell , Karl Dean , Charles Francavilla , Rakesh K. Jain , Kwangho Lee , Mohindra Seepersaud , Lei Shu , Arathi Sundaram , Zhengyu Yuan
发明人： Kathryn Rene Bracken , Simon Bushell , Karl Dean , Charles Francavilla , Rakesh K. Jain , Kwangho Lee , Mohindra Seepersaud , Lei Shu , Arathi Sundaram , Zhengyu Yuan
IPC分类号： C07D403/12 , A61K31/501 , A61K31/497 , A61K31/506 , A61K31/4439 , C07D401/12 , C07D309/10 , C07D207/08 , A61P31/04
CPC分类号： C07D401/12 , C07D403/12
摘要： Novel N-formyl hydroxylamine compounds and their derivatives are disclosed. These N-formyl hydroxylamine compounds inhibit peptidyl deformylase (PDF), an enzyme present in prokaryotes. The compounds are useful as antimicrobials and antibiotics. The compounds of the invention display selective inhibition of peptidyl deformylase versus other metalloproteinases such as MMPs. Methods of preparation and use of the compounds are also disclosed.
摘要翻译：公开了新的N-甲酰羟胺化合物及其衍生物。这些N-甲酰基羟胺化合物抑制肽原甲酰化酶（PDF），一种存在于原核生物中的酶。这些化合物可用作抗微生物剂和抗生素。本发明的化合物显示出对其它金属蛋白酶如MMP的肽基变性酶的选择性抑制。还公开了化合物的制备和使用方法。

5. 发明申请

US20100063278A1 N-Formyl Hydroxylamines compounds 失效
标题翻译： N-甲酰基羟胺化合物
公开(公告)号：US20100063278A1
公开(公告)日：2010-03-11
申请号：US12476824
申请日：2009-06-02
申请人： Kathryn Rene Bracken , Simon Bushell , Karl Dean , Charles Francavilla , Rakesh K. Jain , Kwangho Lee , Mohindra Seepersaud , Lei Shu , Arathi Sundaram , Zhengyu Yuan
发明人： Kathryn Rene Bracken , Simon Bushell , Karl Dean , Charles Francavilla , Rakesh K. Jain , Kwangho Lee , Mohindra Seepersaud , Lei Shu , Arathi Sundaram , Zhengyu Yuan
IPC分类号： C07D403/12 , C07D401/12
CPC分类号： C07D401/12 , C07D403/12
摘要： Novel N-formyl hydroxylamine compounds and their derivatives are discloses. These N-formyl hydroxylamine compounds inhibit peptidyl deformylase (PDF), an enzyme present in prokaryotes. The compounds are useful as antimicrobials and antibiotics. The compounds of the invention display selective inhibition of peptidyl deformylase versus other metalloproteinases such as MMPs. Methods of preparation and use of the compounds are also disclosed.
摘要翻译：公开了新的N-甲酰羟胺化合物及其衍生物。这些N-甲酰基羟胺化合物抑制肽原甲酰化酶（PDF），一种存在于原核生物中的酶。这些化合物可用作抗微生物剂和抗生素。本发明的化合物显示出对其它金属蛋白酶如MMP的肽基变性酶的选择性抑制。还公开了化合物的制备和使用方法。

6. 发明申请

US20080161558A1 N-Formyl Hydroxylamines 失效
标题翻译： N-甲酰基羟胺
公开(公告)号：US20080161558A1
公开(公告)日：2008-07-03
申请号：US11914659
申请日：2006-05-22
申请人： Kathryn Rene Bracken , Simon Bushell , Karl Dean , Charles Francavilla , Rakesh K. Jain , Kwangho Lee , Mohindra Seepersaud , Lei Shu , Arathi Sundaram , Zhengyu Yuan
发明人： Kathryn Rene Bracken , Simon Bushell , Karl Dean , Charles Francavilla , Rakesh K. Jain , Kwangho Lee , Mohindra Seepersaud , Lei Shu , Arathi Sundaram , Zhengyu Yuan
IPC分类号： C07D403/12 , C07D401/12
CPC分类号： C07D401/12 , C07D403/12
摘要： Novel N-formyl hydroxylamine compounds and their derivatives are disclosed. These N-formyl hydroxylamine compounds inhibit peptidyl deformylase (PDF), an enzyme present in prokaryotes. The compounds are useful as antimicrobials and antibiotics. The compounds of the invention display selective inhibition of peptidyl deformylase versus other metalloproteinases such as MMPs. Methods of preparation and use of the compounds are also disclosed.
摘要翻译：公开了新的N-甲酰羟胺化合物及其衍生物。这些N-甲酰基羟胺化合物抑制肽原甲酰化酶（PDF），一种存在于原核生物中的酶。这些化合物可用作抗微生物剂和抗生素。本发明的化合物显示出对其它金属蛋白酶如MMP的肽基变性酶的选择性抑制。还公开了化合物的制备和使用方法。

7. 发明授权

US08044199B2 N-formyl hydroxylamines compounds 失效
标题翻译： N-甲酰羟胺化合物
公开(公告)号：US08044199B2
公开(公告)日：2011-10-25
申请号：US12476824
申请日：2009-06-02
申请人： Kathryn Rene Bracken , Simon Bushell , Karl Dean , Charles Francavilla , Rakesh K. Jain , Kwangho Lee , Mohindra Seepersaud , Lei Shu , Arathi Sundaram , Zhengyu Yuan
发明人： Kathryn Rene Bracken , Simon Bushell , Karl Dean , Charles Francavilla , Rakesh K. Jain , Kwangho Lee , Mohindra Seepersaud , Lei Shu , Arathi Sundaram , Zhengyu Yuan
IPC分类号： C07D403/02
CPC分类号： C07D401/12 , C07D403/12
摘要： Novel N-formyl hydroxylamine compounds of formula I: wherein R1 is hydrogen, alkyl, heteroaryl, heterocycloalkyl, aryl, heteroaryl or cycloalkyl; R3 is hydrogen, halogen or alkoxy; R4 is pyridazinyl; n is 0 to 3; and wherein one or more of the ring nitrogen heteroatoms of said pyridazinyl is optionally oxidized and their derivatives are disclosed. These N-formyl hydroxylamine compounds inhibit peptidyl deformylase (PDF), an enzyme present in prokaryotes. The compounds are useful as antimicrobials and antibiotics. The compounds of the invention display selective inhibition of peptidyl deformylase versus other metalloproteinases such as MMPs. Methods of preparation and use of the compounds are also disclosed.
摘要翻译：式I的新型N-甲酰基羟胺化合物：其中R 1是氢，烷基，杂芳基，杂环烷基，芳基，杂芳基或环烷基; R3是氢，卤素或烷氧基; R4是哒嗪基; n为0〜3; 并且其中所述哒嗪基的一个或多个环氮杂原子被任选地氧化并且其公开了它们的衍生物。这些N-甲酰基羟胺化合物抑制肽原甲酰化酶（PDF），一种存在于原核生物中的酶。这些化合物可用作抗微生物剂和抗生素。本发明的化合物显示出对其它金属蛋白酶如MMP的肽基变性酶的选择性抑制。还公开了化合物的制备和使用方法。

8. 发明申请

US20050277683A1 Novel pyrrolidine bicyclic compounds and its derivatives, compositions and methods of use 失效
标题翻译：新型吡咯烷双环化合物及其衍生物，组合物和使用方法
公开(公告)号：US20050277683A1
公开(公告)日：2005-12-15
申请号：US11151131
申请日：2005-06-13
申请人： Jeffrey Jacobs , Rakesh Jain , Jason Lewis , Dinesh Patel , Zhengyu Yuan
发明人： Jeffrey Jacobs , Rakesh Jain , Jason Lewis , Dinesh Patel , Zhengyu Yuan
IPC分类号： C12N5/06 , A61K31/40 , A61K31/4184 , A61K31/422 , A61K31/427 , A61K31/4439 , A61P31/04 , A61P43/00 , C07D207/06 , C07D207/08 , C07D401/04 , C07D403/04 , C07D413/04 , C07D417/04 , C07D277/38 , A61K31/426
CPC分类号： C07D207/08 , C07D401/04 , C07D403/04 , C07D413/04 , C07D417/04
摘要： N-[1-oxo-(optionally 2-aza)-2-alkyl-3-(carboxyl or thiol or hydroxyaminocarbonyl or N-hydroxyformamido)-propyl]-(aryl or heteroaryl)-azacyclo4-7alkanes or thiazacyclo4-7alkanes, salts or prodrugs thereof have interesting properties, e.g., in the treatment or prevention of disorders amenable to treatment by PDF inhibitors, such as treatment of bacterial infections.
摘要翻译： N- [1-氧代（任选的2-氮杂）-2-烷基-3-（羧基或硫醇或羟基氨基羰基或N-羟基甲酰氨基） - 丙基] - （芳基或杂芳基） - 氮杂环基4-7 烷烃或噻唑烷类4-7烷烃，其盐或前药具有有趣的性质，例如在治疗或预防易受PDF抑制剂治疗的疾病例如细菌感染的治疗。

9. 发明申请

US20120157434A1 Antimicrobial heterocyclic compounds for treatment of bacterial infections 审中-公开
标题翻译：用于治疗细菌感染的抗菌杂环化合物
公开(公告)号：US20120157434A1
公开(公告)日：2012-06-21
申请号：US12072978
申请日：2008-02-29
申请人： Mikhail Fedorovich Gordeev , Zhengyu Yuan , Jinqian Liu
发明人： Mikhail Fedorovich Gordeev , Zhengyu Yuan , Jinqian Liu
IPC分类号： A61K31/4439 , A61K31/424 , A61P31/00 , A61K31/5377 , A61K31/438 , C07D498/14 , C07D498/04 , A61K31/437
CPC分类号： C07D498/04 , C07D498/14 , C07D519/00
摘要： The present invention provides heterocyclic compounds of the following formula I: or pharmaceutically acceptable salts, prodrugs, solvates, or hydrates thereof useful as antibacterial agents, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds.
摘要翻译：本发明提供下式I的杂环化合物或其用作抗菌剂的药学上可接受的盐，前体药物，溶剂合物或水合物，含有它们的药物组合物，其用途及其制备方法。

10. 发明申请

US20110150055A1 Active Auxiliary Channel Buffering 有权
标题翻译：主动辅助通道缓冲
公开(公告)号：US20110150055A1
公开(公告)日：2011-06-23
申请号：US12645240
申请日：2009-12-22
申请人： Ming Qu , Zhengyu Yuan , Kochung Lee
发明人： Ming Qu , Zhengyu Yuan , Kochung Lee
IPC分类号： H04B1/38
CPC分类号： G09G5/006 , G09G2330/021 , G09G2350/00 , G09G2370/045 , G09G2370/10 , H04L65/4023 , H04L65/4092 , H04L67/34
摘要： A system and a method for communicating configuration data between a source device and a sink are described. An active buffer receives data from an auxiliary communication channel which communicates data between the source device and the sink device. The active buffer modifies data received from the auxiliary communication channel. For example, the active buffer amplifies the received data or electrically reshapes the received data. The modified data is then transmitted from the active buffer to a destination device. In one embodiment, the auxiliary communication channel is bi-directional and upon receiving data from a first device, the active buffer is modified to permit uni-directional transmission of data from the first device to a second device.
摘要翻译：描述用于在源设备和宿之间传送配置数据的系统和方法。主动缓冲器从辅助通信信道接收数据，该辅助通信信道在源设备和宿设备之间传送数据。主动缓冲器修改从辅助通信信道接收到的数据。例如，有源缓冲器放大所接收的数据或电接收数据。然后将修改的数据从活动缓冲器发送到目的地设备。在一个实施例中，辅助通信信道是双向的，并且在从第一设备接收数据时，主动缓冲器被修改以允许将数据从第一设备单向传输到第二设备。

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