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1. 发明授权

US06413938B1 Benzimidazole derivatives for the treatment of viral infections 失效
标题翻译：苯并咪唑衍生物用于治疗病毒感染
公开(公告)号：US06413938B1
公开(公告)日：2002-07-02
申请号：US09367260
申请日：1999-08-25
申请人： Jeffrey H. Tidwell , Stanley D. Chamberlain , George A. Freeman , Joseph H. Chan , George W. Koszalka , Leroy B. Townsend , John C. Drach
发明人： Jeffrey H. Tidwell , Stanley D. Chamberlain , George A. Freeman , Joseph H. Chan , George W. Koszalka , Leroy B. Townsend , John C. Drach
IPC分类号： A61K3170
CPC分类号： C07H19/052 , A61K31/7056 , Y10S514/934
摘要： According to a first aspect of the invention there is provided compounds of formula (I): wherein: R1 is hydroxy; O-acetyl; or a halo atom; R2 is hydroxy; O-acetyl; or a halo atom; R3 is hydrogen; a halo atom; azido; C2-6alkenyl; C2-6alkynyl; C6-14aryl C2-6alkenyl; C6-14arylC2-6alkynyl —NR8R9 (where R8 and R9 may be the same or different and are hydrogen, C1-8alkyl, cyanoC1-8alkyl, hydroxyC1-8alkyl, haloC1-8alkyl, C3-7cycloalkyl, C1-8alkylC3-7cycloalkyl, C2-6alkenyl, C3-7cycloalkylC1-8alkyl, C2-6alkynyl, C6-14aryl, C6-14arylC1-8alkyl, heterocycleC1-8alkyl, C1-8alkylcarbonyl, C6-14arylsulfonyl, C1-8alkysulfonyl, or R8R9 together with the N atom to which they are attached form a 3,4,5 or 6 membered heterocyclic ring); —OR10 (where R10 is hydrogen, C1-8alkyl, C6-14aryl, or C6-14arylC1-8alkyl, C2-6alkenyl, C2-6alkynyl, C6-14aryl C2-6alkenyl or C6-14arylC2-6alkynyl); or —SR11 (where R11 is hydrogen, C1-8alkyl, C6-14aryl, or C6-14arylC1-8alkyl).
摘要翻译：根据本发明的第一方面，提供式（I）的化合物：其中：R 1是羟基; O-乙酰基; 或卤原子; R 2为羟基; O-乙酰基; 或卤素原子; R 3是氢; 卤素原子叠氮 C2-6烯基; C 2-6炔基; C6-14芳基C2-6烯基; C 6-14芳基C 2-6炔基-NR 8 R 9（其中R 8和R 9可以相同或不同，为氢，C 1-8烷基，氰基C 1-8烷基，羟基C 1-8烷基，卤代C 1-8烷基，C 3-7环烷基，C 1-8烷基C 3-7环烷基， C 1-6烷基，C 3-7环烷基C 1-8烷基，C 2-6炔基，C 6-14芳基，C 6-14芳基C 1-8烷基，杂环C 1-8烷基，C 1-8烷基羰基，C 6-14芳基磺酰基，C 1-8炔基磺酰基或R 8 R 9与它们所连接的N原子一起形成3,4,5或6元杂环）; -OR 10（其中R 10是氢，C 1-8烷基，C 6-14芳基或C 6-14芳基C 1-8烷基，C 2-6烯基，C 2-6炔基，C 6-14芳基C 2-6烯基或C 6-14芳基C 2-6炔基）; 或-SR 11（其中R 11是氢，C 1-8烷基，C 6-14芳基或C 6-14芳基C 1-8烷基）。

2. 发明授权

US07034030B2 Pyralopyridines, process for their preparation and use as therapeutic compounds 失效
标题翻译：吡咯并吡啶，其制备方法和用作治疗化合物
公开(公告)号：US07034030B2
公开(公告)日：2006-04-25
申请号：US10473196
申请日：2002-03-20
申请人： Michael John Alberti , Stanley D. Chamberlain , Mui Cheung , Kristjan Gudmundsson , Philip Anthony Harris , Brian A. Johns , David Kendall Jung , Michael Robert Peel , Jennifer Badiang Stanford
发明人： Michael John Alberti , Stanley D. Chamberlain , Mui Cheung , Kristjan Gudmundsson , Philip Anthony Harris , Brian A. Johns , David Kendall Jung , Michael Robert Peel , Jennifer Badiang Stanford
IPC分类号： C07D403/04 , A61K31/505
CPC分类号： C07D471/04
摘要： The present invention provides compounds of formula (I): wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.
摘要翻译：本发明提供式（I）化合物：其中所有变量如本文所定义，含有该化合物的药物组合物，其制备方法及其作为药剂的用途。

3. 发明授权

US07160897B2 Therapeutic compounds 失效
标题翻译：治疗化合物
公开(公告)号：US07160897B2
公开(公告)日：2007-01-09
申请号：US11084410
申请日：2005-03-18
申请人： Stanley D. Chamberlain , Kristjan Gudmundsson , Brian A. Johns
发明人： Stanley D. Chamberlain , Kristjan Gudmundsson , Brian A. Johns
IPC分类号： C07D401/04 , A61K31/4439
CPC分类号： C07D471/04
摘要： The present invention provides compounds of formula (I): wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.
摘要翻译：本发明提供式（I）化合物：其中所有变量如本文所定义，含有该化合物的药物组合物，其制备方法及其作为药剂的用途。

4. 发明授权

US07087618B2 Pyrazolopyridinyl pyrimidine therapeutic compounds 失效
标题翻译：吡唑并吡啶基嘧啶治疗化合物
公开(公告)号：US07087618B2
公开(公告)日：2006-08-08
申请号：US11082466
申请日：2005-03-17
申请人： Stanley D. Chamberlain , Kristjan Gudmundsson , Brian A. Johns
发明人： Stanley D. Chamberlain , Kristjan Gudmundsson , Brian A. Johns
IPC分类号： C07D403/04 , A61K31/506
CPC分类号： C07D471/04
摘要： The present invention provides compounds of formula (I):wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents
摘要翻译：本发明提供式（I）化合物：其中所有变量如本文所定义，含有该化合物的药物组合物，其制备方法及其作为药剂的用途

5. 发明授权

US07109209B2 Pyrazolopyridines, process for their preparation and use as therapeutic compounds 失效
标题翻译：吡唑并吡啶，其制备方法和用作治疗化合物
公开(公告)号：US07109209B2
公开(公告)日：2006-09-19
申请号：US11245972
申请日：2005-10-07
申请人： Michael John Alberti , Stanley D. Chamberlain , Mui Cheung , Kristjan Gudmundsson , Philip Anthony Harris , Brian A. Johns , David Kendall Jung , Michael Robert Peel , Jennifer Badiang Stanford
发明人： Michael John Alberti , Stanley D. Chamberlain , Mui Cheung , Kristjan Gudmundsson , Philip Anthony Harris , Brian A. Johns , David Kendall Jung , Michael Robert Peel , Jennifer Badiang Stanford
IPC分类号： C07D471/04 , A61K31/4162
CPC分类号： C07D471/04
摘要： The present invention provides compounds of formula (I): wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.
摘要翻译：本发明提供式（I）化合物：其中所有变量如本文所定义，含有该化合物的药物组合物，其制备方法及其作为药剂的用途。

6. 发明授权

US06919352B2 Pyrazolopyridinyl pyridine and pyrimidine therapeutic compounds 失效
公开(公告)号：US06919352B2
公开(公告)日：2005-07-19
申请号：US10433884
申请日：2001-11-26
申请人： Stanley D. Chamberlain , Kristjan Gudmundsson , Brian A. Johns
发明人： Stanley D. Chamberlain , Kristjan Gudmundsson , Brian A. Johns
IPC分类号： A61K31/506 , A61P31/12 , A61P31/22 , C07D471/04 , C07D401/04 , C07D31/4162
CPC分类号： C07D471/04
摘要： The present invention provides compounds of formula (I): wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.

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