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1. 发明申请

US20080261906A1 METHODS AND COMPOSITIONS FOR IDENTIFYING ANTI-HCV AGENTS 失效
标题翻译：鉴定抗HCV药物的方法和组合物
公开(公告)号：US20080261906A1
公开(公告)日：2008-10-23
申请号：US11844993
申请日：2007-08-24
申请人： Jeffrey Glenn , Ella Sklan , Kirk Staschke , Tina Myers Oakes
发明人： Jeffrey Glenn , Ella Sklan , Kirk Staschke , Tina Myers Oakes
IPC分类号： A61K31/7052 , C12Q1/70 , A61P31/12
CPC分类号： C07K14/005 , C07K2319/40 , C07K2319/60 , C07K2319/61 , C12N15/1138 , C12N2310/14 , C12N2770/24222 , C12Q1/18 , G01N2333/186
摘要： The invention features methods and compositions for screening for agents that modulate replication of a virus, particularly Flaviviridae virus (particularly hepatitis C virus (HCV)), where the methods provide for detection of agents that modulate the binding of TBC and NS5A, the inhibition of TBC activity, inhibition of Rab1 activity, and/or the expression of the TBC protein and/or Rab1 protein. The invention also features methods of controlling viral replication, and agents useful in such methods.
摘要翻译：本发明的特征在于用于筛选调节病毒，特别是黄病毒科病毒（特别是丙型肝炎病毒（HCV））的复制的试剂的方法和组合物，其中所述方法提供了调节TBC和NS5A的结合的试剂的检测， TBC活性，Rab1活性的抑制和/或TBC蛋白和/或Rab1蛋白的表达。本发明还具有控制病毒复制的方法，以及在这些方法中有用的试剂。

2. 发明授权

US07655419B2 Methods and compositions for identifying anti-HCV agents 失效
标题翻译：用于鉴定抗HCV药物的方法和组合物
公开(公告)号：US07655419B2
公开(公告)日：2010-02-02
申请号：US11844993
申请日：2007-08-24
申请人： Jeffrey Glenn , Ella Sklan , Kirk A. Staschke , Tina Myers Oakes
发明人： Jeffrey Glenn , Ella Sklan , Kirk A. Staschke , Tina Myers Oakes
IPC分类号： G01N33/53 , A61K39/29
CPC分类号： C07K14/005 , C07K2319/40 , C07K2319/60 , C07K2319/61 , C12N15/1138 , C12N2310/14 , C12N2770/24222 , C12Q1/18 , G01N2333/186
摘要： The invention features methods and compositions for screening for agents that modulate replication of a virus, particularly Flaviviridae virus (particularly hepatitis C virus (HCV)), where the methods provide for detection of agents that modulate the binding of TBC and NS5A, the inhibition of TBC activity, inhibition of Rab1 activity, and/or the expression of the TBC protein and/or Rab1 protein. The invention also features methods of controlling viral replication, and agents useful in such methods.
摘要翻译：本发明的特征在于用于筛选调节病毒，特别是黄病毒科病毒（特别是丙型肝炎病毒（HCV））的复制的试剂的方法和组合物，其中所述方法提供了调节TBC和NS5A的结合的试剂的检测， TBC活性，Rab1活性的抑制和/或TBC蛋白和/或Rab1蛋白的表达。本发明还具有控制病毒复制的方法，以及在这些方法中有用的试剂。

3. 发明申请

US20110076697A1 LATERAL-FLOW IMMUNO-CHROMATOGRAPHIC ASSAY DEVICES 审中-公开
标题翻译：侧向流动免疫色谱测定装置
公开(公告)号：US20110076697A1
公开(公告)日：2011-03-31
申请号：US12768706
申请日：2010-04-27
申请人： Igor Ruvinsky , Ella Sklan
发明人： Igor Ruvinsky , Ella Sklan
IPC分类号： G01N33/53 , C12M1/34
CPC分类号： G01N33/558 , G01N33/54386 , G01N33/6887 , G01N2333/4712
摘要： Device including migration membrane, conjugate pad on migration membrane, plasma separation membrane on conjugate pad, pre-filter on plasma separation membrane. Migration membrane has test line configured for loading one or plurality of capture antibodies having specific binding affinity for assay target. Migration membrane configured for allowing lateral flow of blood plasma or serum across migration membrane to test line. Conjugate pad configured for loading one or plurality of detection antibodies having specific binding affinity for assay target. Plasma separation membrane configured for allowing passage of blood plasma or serum and trapping erythrocytes. Pre-filter configured for loading assay sample including erythrocytes and either or both blood plasma and blood serum. Pre-filter configured for allowing passage of blood plasma or serum through pre-filter and causing lateral flow of blood plasma or serum within pre-filter. Method includes providing device and carrying out diagnostic assay cycle.
摘要翻译：装置包括迁移膜，迁移膜上的结合垫，缀合垫上的血浆分离膜，血浆分离膜上的预过滤。迁移膜具有配置用于装载一种或多种对测定靶具有特异性结合亲和力的捕获抗体的测试线。迁移膜被配置为允许血浆或血清横向流动通过迁移膜到测试线。缀合垫，其配置用于装载一种或多种对测定靶具有特异性结合亲和力的检测抗体。血浆分离膜被配置为允许血浆或血清通过并捕获红细胞。配置用于装载测定样品的预过滤器，包括红细胞和血浆和血清中的任一种或两种。预过滤器配置为允许血浆或血清通过预过滤器并导致血浆或血清在预过滤器内侧向流动。方法包括提供装置和进行诊断测定循环。

4. 发明授权

US07494783B2 Method for assessing trait anxiety by determining cholinergic status 失效
标题翻译：通过确定胆碱能状态来评估性状焦虑的方法
公开(公告)号：US07494783B2
公开(公告)日：2009-02-24
申请号：US11400224
申请日：2006-04-10
申请人： Hermona Soreq , Ella Sklan , Raz Yirmiya , Keren Ailon , Irit Shapira-Lichter
发明人： Hermona Soreq , Ella Sklan , Raz Yirmiya , Keren Ailon , Irit Shapira-Lichter
IPC分类号： C12Q1/46
CPC分类号： C12Q1/6883 , C12Q1/34 , C12Q1/46 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172 , G01N33/573 , G01N2800/301
摘要： The invention provides methods/kits for assessing levels of trait or state anxiety in a subject by comparing genotypes and/or expression patterns at the ACHE, PON1 and/or BChE genes to the genotype and/or expression pattern of the genes in a reference population whose genotype and/or expression pattern of the genes is known or by correlating AChE levels activity to those of PON.
摘要翻译：本发明提供了通过将ACHE，PON1和/或BChE基因的基因型和/或表达模式与参考群体中基因的基因型和/或表达模式进行比较来评估受试者的性状或状态焦虑水平的方法/试剂盒其基因的基因型和/或表达模式是已知的或通过将AChE水平活性与PON的活性相关联。

5. 发明申请

US20120065251A1 MIR-21 PROMOTER DRIVEN TARGETED CANCER THERAPY 有权
标题翻译： MIR-21推销员驾驶癌症癌症治疗
公开(公告)号：US20120065251A1
公开(公告)日：2012-03-15
申请号：US13145332
申请日：2010-01-19
申请人： Rina Rosin-Arbesfeld , Ella Sklan , Alona Zilberberg , Naama David
发明人： Rina Rosin-Arbesfeld , Ella Sklan , Alona Zilberberg , Naama David
IPC分类号： A61K31/7088 , C12N15/52 , C12N15/12 , C12N15/31 , C12N1/21 , C12N15/63 , A61P35/00 , A61P35/02 , C12N5/10 , C12N1/19 , C12N15/11 , C12N15/29
CPC分类号： A61K48/0058 , A61K38/164 , C07K14/34 , C07K2319/33 , C07K2319/55 , C12N15/113 , C12N15/85 , C12N2310/141 , C12N2830/008 , C12N2830/85
摘要： The invention provides a nucleic acid construct comprising a promoter sequence derived from microRNA-21 (miR-21) linked to a nucleic acid sequence encoding an anti-cancer agent, an example of which is a toxin. The constructs of the invention are particularly useful for treating tumors expressing miR-21.
摘要翻译：本发明提供了包含与编码抗癌剂的核酸序列连接的微小RNA-21（miR-21）的启动子序列的核酸构建体，其实例是毒素。本发明的构建体特别可用于治疗表达miR-21的肿瘤。

6. 发明授权

US08492133B2 MIR-21 promoter driven targeted cancer therapy 有权
公开(公告)号：US08492133B2
公开(公告)日：2013-07-23
申请号：US13145332
申请日：2010-01-19
申请人： Rina Rosin-Arbesfeld , Ella Sklan , Alona Zilberberg , Naama David
发明人： Rina Rosin-Arbesfeld , Ella Sklan , Alona Zilberberg , Naama David
IPC分类号： C12N15/85
CPC分类号： A61K48/0058 , A61K38/164 , C07K14/34 , C07K2319/33 , C07K2319/55 , C12N15/113 , C12N15/85 , C12N2310/141 , C12N2830/008 , C12N2830/85
摘要： The invention provides a nucleic acid construct comprising a promoter sequence derived from microRNA-21 (miR-21) linked to a nucleic acid sequence encoding an anti-cancer agent, an example of which is a toxin. The constructs of the invention are particularly useful for treating tumors expressing miR-21.

7. 发明申请

US20070037241A1 Method and kit for assessing anxiety or disposition thereto in a subject 失效
标题翻译：评估受试者焦虑或处置情况的方法和试剂盒
公开(公告)号：US20070037241A1
公开(公告)日：2007-02-15
申请号：US11400224
申请日：2006-04-10
申请人： Hermona Soreq , Ella Sklan , Raz Yirmiya , Keren Ailon , Irit Shapira-Lichter
发明人： Hermona Soreq , Ella Sklan , Raz Yirmiya , Keren Ailon , Irit Shapira-Lichter
IPC分类号： C12Q1/46
CPC分类号： C12Q1/6883 , C12Q1/34 , C12Q1/46 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172 , G01N33/573 , G01N2800/301
摘要： The invention provides methods/kits for assessing levels of trait or state anxiety in a subject by comparing genotypes and/or expression patterns at the ACHE, PON1 and/or BChE genes to the genotype and/or expression pattern of the genes in a reference population whose genotype and/or expression pattern of the genes is known or by correlating AChE levels activity to those of PON.
摘要翻译：本发明提供了通过将ACHE，PON1和/或BChE基因的基因型和/或表达模式与参考群体中基因的基因型和/或表达模式进行比较来评估受试者的性状或状态焦虑水平的方法/试剂盒其基因的基因型和/或表达模式是已知的或通过将AChE水平活性与PON的活性相关联。

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