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1. 发明授权

US06963774B2 Safety pacing in multi-site CRM devices 有权
标题翻译：多站点CRM设备中的安全起搏
公开(公告)号：US06963774B2
公开(公告)日：2005-11-08
申请号：US10291459
申请日：2002-11-08
申请人： Jeffrey E. Stahmann , Andrew P. Kramer , Hugh Calkins
发明人： Jeffrey E. Stahmann , Andrew P. Kramer , Hugh Calkins
IPC分类号： A61N1/362 , A61N1/368
CPC分类号： A61N1/368 , A61N1/3622 , A61N1/3627 , A61N1/3684
摘要： An apparatus and method for providing pacing pulses to a second site when the pacing pulses are inhibited from being provided to a first site. A first cardiac signal and a second cardiac signal are sensed, where both the first and second cardiac signals include indications of cardiac events. A cardiac rate is determined from the cardiac events in one of the first cardiac signal or the second cardiac signal, and pacing pulses are provided to the first cardiac region in order to maintain the cardiac rate at at least a minimum rate value. A pace protection interval starts when a cardiac event is detected in the first cardiac signal. The pace protection interval inhibits delivery of pacing pulses to the first cardiac region. When pacing pulses to the first cardiac region are inhibited because of the pace protection interval, pacing pulses are provided to the second cardiac region at a safety interval timed from the inhibited pacing pulse to the first cardiac region.
摘要翻译：一种用于当起搏脉冲被禁止提供给第一部位时，将起搏脉冲提供给第二部位的装置和方法。感测第一心脏信号和第二心脏信号，其中第一和第二心脏信号都包括心脏事件的指示。从第一心脏信号或第二心脏信号之一的心脏事件确定心率，并且将起搏脉冲提供给第一心脏区域，以便将心率保持在至少最小速率值。当在第一心脏信号中检测到心脏事件时，起搏保护间隔开始。步速保护间隔禁止将起搏脉冲传送到第一心脏区域。当起搏脉冲到第一心脏区域由于步速保护间隔而被抑制时，起搏脉冲以从被抑制的起搏脉冲到第一心脏区域的安全间隔提供给第二心脏区域。

2. 发明授权

US07630765B2 Safety pacing in multi-site CRM devices 有权
标题翻译：多站点CRM设备中的安全起搏
公开(公告)号：US07630765B2
公开(公告)日：2009-12-08
申请号：US11421660
申请日：2006-06-01
申请人： Jeffrey E. Stahmann , Andrew P. Kramer , Hugh Calkins
发明人： Jeffrey E. Stahmann , Andrew P. Kramer , Hugh Calkins
IPC分类号： A61N1/362
CPC分类号： A61N1/368 , A61N1/3622 , A61N1/3627 , A61N1/3684
摘要： Safety pacing in multi-site cardiac rhythm management (CRM) devices is provided. According to various method embodiments, a first cardiac signal from a first cardiac region and a second cardiac signal from a second cardiac region are sensed. The first cardiac region is paced to maintain at least a minimum cardiac rate, and the second cardiac region is paced to maintain at least the minimum cardiac rate when a pace in the first cardiac region is inhibited. Other aspects and embodiments are provided herein.
摘要翻译：提供了多站点心律管理（CRM）设备中的安全起搏。根据各种方法实施例，感测来自第一心脏区域的第一心脏信号和来自第二心脏区域的第二心脏信号。第一心脏区域起搏以保持至少最小心率，并且当第一心脏区域中的步调被抑制时，第二心脏区域起搏以保持至少最小心率。本文提供了其它方面和实施例。

3. 发明授权

US07058449B2 Safety pacing in multi-site CRM devices 有权
公开(公告)号：US07058449B2
公开(公告)日：2006-06-06
申请号：US10839268
申请日：2004-05-05
申请人： Jeffrey E. Stahmann , Andrew P. Kramer , Hugh Calkins
发明人： Jeffrey E. Stahmann , Andrew P. Kramer , Hugh Calkins
IPC分类号： A61N1/368
CPC分类号： A61N1/368 , A61N1/3622 , A61N1/3627 , A61N1/3684
摘要： Safety pacing in multi-site cardiac rhythm management (CRM) devices is provided. According to various method embodiments, a first cardiac signal from a first cardiac region and a second cardiac signal from a second cardiac region are sensed. The first cardiac region is paced to maintain at least a minimum cardiac rate, and the second cardiac region is paced to maintain at least the minimum cardiac rate when a pace in the first cardiac region is inhibited. Other aspects and embodiments are provided herein.

4. 发明授权

US08260417B2 Safety pacing in multi-site CRM devices 有权
标题翻译：多站点CRM设备中的安全起搏
公开(公告)号：US08260417B2
公开(公告)日：2012-09-04
申请号：US12620312
申请日：2009-11-17
申请人： Jeffrey E. Stahmann , Andrew P. Kramer , Hugh Calkins
发明人： Jeffrey E. Stahmann , Andrew P. Kramer , Hugh Calkins
IPC分类号： A61N1/362
CPC分类号： A61N1/368 , A61N1/3622 , A61N1/3627 , A61N1/3684
摘要： Safety pacing in multi-site cardiac rhythm management (CRM) devices is provided. According to various method embodiments, a first cardiac signal from a first cardiac region and a second cardiac signal from a second cardiac region are sensed. The first cardiac region is paced to maintain at least a minimum cardiac rate, and the second cardiac region is paced to maintain at least the minimum cardiac rate when a pace in the first cardiac region is inhibited. Other aspects and embodiments are provided herein.
摘要翻译：提供了多站点心律管理（CRM）设备中的安全起搏。根据各种方法实施例，感测来自第一心脏区域的第一心脏信号和来自第二心脏区域的第二心脏信号。第一心脏区域起搏以保持至少最小心率，并且当第一心脏区域中的步调被抑制时，第二心脏区域起搏以保持至少最小心率。本文提供了其它方面和实施例。

5. 发明申请

US20100063560A1 SAFETY PACING IN MULTI-SITE CRM DEVICES 有权
标题翻译：多地点CRM设备中的安全防护
公开(公告)号：US20100063560A1
公开(公告)日：2010-03-11
申请号：US12620312
申请日：2009-11-17
申请人： Jeffrey E. Stahmann , Andrew P. Kramer , Hugh Calkins
发明人： Jeffrey E. Stahmann , Andrew P. Kramer , Hugh Calkins
IPC分类号： A61N1/365
CPC分类号： A61N1/368 , A61N1/3622 , A61N1/3627 , A61N1/3684
摘要： Safety pacing in multi-site cardiac rhythm management (CRM) devices is provided. According to various method embodiments, a first cardiac signal from a first cardiac region and a second cardiac signal from a second cardiac region are sensed. The first cardiac region is paced to maintain at least a minimum cardiac rate, and the second cardiac region is paced to maintain at least the minimum cardiac rate when a pace in the first cardiac region is inhibited. Other aspects and embodiments are provided herein.
摘要翻译：提供了多站点心律管理（CRM）设备中的安全起搏。根据各种方法实施例，感测来自第一心脏区域的第一心脏信号和来自第二心脏区域的第二心脏信号。第一心脏区域起搏以保持至少最小心率，并且当第一心脏区域中的步调被抑制时，第二心脏区域起搏以保持至少最小心率。本文提供了其它方面和实施例。

6. 发明授权

US06480740B2 Safety pacing in multi-site CRM devices 有权
标题翻译：多站点CRM设备中的安全起搏
公开(公告)号：US06480740B2
公开(公告)日：2002-11-12
申请号：US09748721
申请日：2000-12-26
申请人： Jeffrey E. Stahmann , Andrew P. Kramer , Hugh Calkins
发明人： Jeffrey E. Stahmann , Andrew P. Kramer , Hugh Calkins
IPC分类号： A61N1362
CPC分类号： A61N1/368 , A61N1/3622 , A61N1/3627 , A61N1/3684
摘要： An apparatus and method for providing pacing pulses to a second site when the pacing pulses are inhibited from being provided to a first site. A first cardiac signal and a second cardiac signal are sensed, where both the first and second cardiac signals include indications of cardiac events. A cardiac rate is determined from the cardiac events in one of the first cardiac signal or the second cardiac signal, and pacing pulses are provided to the first cardiac region in order to maintain the cardiac rate at at least a minimum rate value. A pace protection interval starts when a cardiac event is detected in the first cardiac signal. The pace protection interval inhibits delivery of pacing pulses to the first cardiac region. When pacing pulses to the first cardiac region are inhibited because of the pace protection interval, pacing pulses are provided to the second cardiac region at a safety interval timed from the inhibited pacing pulse to the first cardiac region.
摘要翻译：当起搏脉冲被禁止提供给第一部位时，用于向第二部位提供起搏脉冲的装置和方法。感测第一心脏信号和第二心脏信号，其中第一和第二心脏信号都包括心脏事件的指示。心率由第一心脏信号或第二心脏信号中的一个心脏事件确定，并且起搏脉冲被提供给第一心脏区域，以便将心率保持在至少最小速率值。当在第一心脏信号中检测到心脏事件时，起搏保护间隔开始。步速保护间隔禁止将起搏脉冲传送到第一心脏区域。当起搏脉冲到第一心脏区域由于步速保护间隔而被抑制时，起搏脉冲以从被抑制的起搏脉冲到第一心脏区域的安全间隔提供给第二心脏区域。

7. 发明授权

US08099151B2 System and method for magnetic-resonance-guided electrophysiologic and ablation procedures 有权
标题翻译：磁共振引导电生理和消融手术的系统和方法
公开(公告)号：US08099151B2
公开(公告)日：2012-01-17
申请号：US11314241
申请日：2005-12-22
申请人： Henry R Halperin , Ronald D. Berger , Ergin Atalar , Elliot R McVeigh , Albert Lardo , Hugh Calkins , Joao Lima
发明人： Henry R Halperin , Ronald D. Berger , Ergin Atalar , Elliot R McVeigh , Albert Lardo , Hugh Calkins , Joao Lima
IPC分类号： A61B5/05
CPC分类号： A61B5/055 , A61B5/415 , A61B5/418 , A61B18/1492 , A61B90/36 , A61B2017/00039 , A61B2017/00053 , A61B2090/374 , G01R33/285 , G01R33/34084 , G01R33/4808 , G01R33/5601
摘要： A system and method for using magnetic resonance imaging to increase the accuracy of electrophysiologic procedures includes an invasive combined electrophysiology and imaging antenna catheter which includes an RF antenna for receiving magnetic resonance signals and diagnostic electrodes for receiving electrical potentials. The combined electrophysiology and imaging antenna catheter is used in combination with a magnetic resonance imaging scanner to guide and provide visualization during electrophysiologic diagnostic or therapeutic procedures, such as ablation of cardiac arrhythmias. The combined electrophysiology and imaging antenna catheter may further include an ablation tip, and be used as an intracardiac device to deliver energy to selected areas of tissue and visualize the resulting ablation lesions. The antenna utilized in the combined electrophysiology and imaging catheter for receiving MR signals is preferably of the coaxial or “loopless” type. High-resolution images from the antenna may be combined with low-resolution images from surface coils of the MR scanner to produce a composite image. A system for eliminating the pickup of RF energy in which intracardiac wires are detuned by filtering so that they become very inefficient antennas. An RF filtering system is provided for suppressing the MR imaging signal while not attenuating the RF ablative current. Steering means may be provided for steering the invasive catheter under MR guidance. Other ablative methods can be used such as laser, ultrasound, and low temperatures.
摘要翻译：使用磁共振成像来提高电生理过程精度的系统和方法包括侵入性组合电生理学和成像天线导管，其包括用于接收磁共振信号的RF天线和用于接收电位的诊断电极。组合的电生理学和成像天线导管与磁共振成像扫描仪组合使用以在电生理诊断或治疗过程（例如心律失常消融）中引导和提供可视化。组合的电生理学和成像天线导管还可以包括消融尖端，并且用作心内装置以将能量传递到组织的选定区域并且可视化所得到的消融损伤。在组合的电生理学和成像导管中用于接收MR信号的天线优选地是同轴的或“无绒毛”的。来自天线的高分辨率图像可以与来自MR扫描器的表面线圈的低分辨率图像组合以产生合成图像。用于消除RF能量的拾取的系统，其中心内线通过滤波失谐，使得它们变得非常低效的天线。提供RF滤波系统，用于抑制MR成像信号，同时不衰减RF消融电流。可以提供转向装置用于在MR引导下转导侵入性导管。可以使用其他烧蚀方法，如激光，超声和低温。

8. 发明授权

US07844319B2 Systems and methods for magnetic-resonance-guided interventional procedures 有权
标题翻译：用于磁共振引导介入手术的系统和方法
公开(公告)号：US07844319B2
公开(公告)日：2010-11-30
申请号：US10123534
申请日：2002-04-15
申请人： Robert C. Susil , Gwyneth Susil , Ergin Atalar , Albert C. Lardo , Henry R. Halperin , Ronald D. Berger , Hugh Calkins , Paul Bottomley
发明人： Robert C. Susil , Gwyneth Susil , Ergin Atalar , Albert C. Lardo , Henry R. Halperin , Ronald D. Berger , Hugh Calkins , Paul Bottomley
IPC分类号： A61B5/055
CPC分类号： A61B5/055 , A61B5/7203 , A61B18/1492 , A61B2018/00839 , A61B2090/374 , A61N1/086 , G01R33/285
摘要： Herein is disclosed a probe, including a first electrode disposed at least partially on the probe surface, a second electrode disposed at least partially on the probe surface, a first conductor electrically coupled to the first electrode, a second conductor electrically coupled to the second electrode, and a reactive element electrically coupling the first conductor and the second conductor.
摘要翻译：本文公开了一种探针，包括至少部分地设置在探针表面上的第一电极，至少部分地设置在探针表面上的第二电极，电耦合到第一电极的第一导体，电耦合到第二电极的第二导体以及电耦合第一导体和第二导体的电抗元件。

9. 发明申请

US20080058635A1 MRI-GUIDED THERAPY METHODS AND RELATED SYSTEMS 有权
公开(公告)号：US20080058635A1
公开(公告)日：2008-03-06
申请号：US11924877
申请日：2007-10-26
申请人： Henry Halperin , Ronald Berger , Ergin Atalar , Elliot McVeigh , Albert Lardo , Hugh Calkins , Joao Lima
发明人： Henry Halperin , Ronald Berger , Ergin Atalar , Elliot McVeigh , Albert Lardo , Hugh Calkins , Joao Lima
IPC分类号： A61B5/055 , A61B18/12
CPC分类号： A61B5/055 , A61B5/415 , A61B5/418 , A61B18/1492 , A61B90/36 , A61B2017/00039 , A61B2017/00053 , A61B2090/374 , G01R33/285 , G01R33/34084 , G01R33/4808 , G01R33/5601
摘要： A system and method for using magnetic resonance imaging to increase the accuracy of electrophysiologic procedures is disclosed. The system in its preferred embodiment provides an invasive combined electrophysiology and imaging antenna catheter which includes an RF antenna for receiving magnetic resonance signals and diagnostic electrodes for receiving electrical potentials. The combined electrophysiology and imaging antenna catheter is used in combination with a magnetic resonance imaging scanner to guide and provide visualization during electrophysiologic diagnostic or therapeutic procedures. The invention is particularly applicable to catheter ablation, e.g., ablation of atrial fibrillation. In embodiments which are useful for catheter ablation, the combined electrophysiology and imaging antenna catheter may further include an ablation tip, and such embodiment may be used as an intracardiac device to both deliver energy to selected areas of tissue and visualize the resulting ablation lesions, thereby greatly simplifying production of continuous linear lesions. The invention further includes embodiments useful for guiding electrophysiologic diagnostic and therapeutic procedures other than ablation. Imaging of ablation lesions may be further enhanced by use of MR contrast agents. The antenna utilized in the combined electrophysiology and imaging catheter for receiving MR signals is preferably of the coaxial or “loopless” type. High-resolution images from the antenna may be combined with low-resolution images from surface coils of the MR scanner to produce a composite image. The invention further provides a system for eliminating the pickup of RF energy in which intracardiac wires are detuned by filtering so that they become very inefficient antennas. An RF filtering system is provided for suppressing the MR imaging signal while not attenuating the RF ablative current. Steering means may be provided for steering the invasive catheter under MR guidance. Other ablative methods can be used such as laser, ultrasound, and low temperatures.

10. 发明申请

US20060100506A1 System and method for magnetic-resonance-guided electrophysiologic and ablation procedures 有权
标题翻译：磁共振引导电生理和消融手术的系统和方法
公开(公告)号：US20060100506A1
公开(公告)日：2006-05-11
申请号：US11314241
申请日：2005-12-22
申请人： Henry Halperin , Ronald Berger , Ergin Atalar , Elliot McVeigh , Albert Lardo , Hugh Calkins , Joao Lima
发明人： Henry Halperin , Ronald Berger , Ergin Atalar , Elliot McVeigh , Albert Lardo , Hugh Calkins , Joao Lima
IPC分类号： A61B5/05
CPC分类号： A61B5/055 , A61B5/415 , A61B5/418 , A61B18/1492 , A61B90/36 , A61B2017/00039 , A61B2017/00053 , A61B2090/374 , G01R33/285 , G01R33/34084 , G01R33/4808 , G01R33/5601
摘要： A system and method for using magnetic resonance imaging to increase the accuracy of electrophysiologic procedures includes an invasive combined electrophysiology and imaging antenna catheter which includes an RF antenna for receiving magnetic resonance signals and diagnostic electrodes for receiving electrical potentials. The combined electrophysiology and imaging antenna catheter is used in combination with a magnetic resonance imaging scanner to guide and provide visualization during electrophysiologic diagnostic or therapeutic procedures, such as ablation of cardiac arrhythmias. The combined electrophysiology and imaging antenna catheter may further include an ablation tip, and be used as an intracardiac device to deliver energy to selected areas of tissue and visualize the resulting ablation lesions. The antenna utilized in the combined electrophysiology and imaging catheter for receiving MR signals is preferably of the coaxial or “loopless” type. High-resolution images from the antenna may be combined with low-resolution images from surface coils of the MR scanner to produce a composite image. A system for eliminating the pickup of RF energy in which intracardiac wires are detuned by filtering so that they become very inefficient antennas. An RF filtering system is provided for suppressing the MR imaging signal while not attenuating the RF ablative current. Steering means may be provided for steering the invasive catheter under MR guidance. Other ablative methods can be used such as laser, ultrasound, and low temperatures.
摘要翻译：使用磁共振成像来提高电生理过程精度的系统和方法包括侵入性组合电生理学和成像天线导管，其包括用于接收磁共振信号的RF天线和用于接收电位的诊断电极。组合的电生理学和成像天线导管与磁共振成像扫描仪组合使用以在电生理诊断或治疗过程（例如心律失常消融）中引导和提供可视化。组合的电生理学和成像天线导管还可以包括消融尖端，并且用作心内装置以将能量传递到组织的选定区域并且可视化所得到的消融损伤。在组合的电生理学和成像导管中用于接收MR信号的天线优选地是同轴的或“无绒毛”的。来自天线的高分辨率图像可以与来自MR扫描器的表面线圈的低分辨率图像组合以产生合成图像。用于消除RF能量的拾取的系统，其中心内线通过滤波失谐，使得它们变得非常低效的天线。提供RF滤波系统，用于抑制MR成像信号，同时不衰减RF消融电流。可以提供转向装置用于在MR引导下转导侵入性导管。可以使用其他烧蚀方法，如激光，超声和低温。

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