专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20110165675A1 CAPPING BIOPROSTHETIC TISSUE TO REDUCE CALCIFICATION 有权
标题翻译： CAPPING BIOPROSTHETIC TISSUE减少计算
公开(公告)号：US20110165675A1
公开(公告)日：2011-07-07
申请号：US12777994
申请日：2010-05-11
申请人： Jeffrey Dove , Darin Dobler , Jim Davidson , Gregory A. Wright
发明人： Jeffrey Dove , Darin Dobler , Jim Davidson , Gregory A. Wright
IPC分类号： C12N5/071 , C12N5/00
CPC分类号： A61F2/2415 , A61F2/0095 , A61F2/24 , A61F2/2412 , A61F2/2418 , A61L27/3604 , A61L27/3625 , A61L27/3629 , A61L27/3687 , A61L27/3691 , A61L27/507 , A61L2400/02 , A61L2430/20
摘要： A treatment for bioprosthetic tissue used in implants or for assembled bioprosthetic heart valves to reduce in vivo calcification. The method includes applying a calcification mitigant such as a capping agent or an antioxidant to the tissue to specifically inhibit oxidation in tissue. Also, the method can be used to inhibit oxidation in dehydrated tissue. The capping agent suppresses the formation of binding sites in the tissue that are exposed or generated by the oxidation and otherwise would, upon implant, attract calcium, phosphate, immunogenic factors, or other precursors to calcification. In one method, tissue leaflets in assembled bioprosthetic heart valves are pretreated with an aldehyde capping agent prior to dehydration and sterilization.
摘要翻译：用于植入物或组装的生物假体心脏瓣膜中用于减少体内钙化的生物假体组织的治疗。该方法包括将钙化缓解剂如封端剂或抗氧化剂施用于组织以特异性抑制组织中的氧化。此外，该方法可用于抑制脱水组织中的氧化。封端剂抑制由氧化暴露或产生的组织中的结合位点的形成，否则在植入时会吸引钙，磷酸盐，免疫原性因子或钙化的其它前体。在一种方法中，组装的生物假体心脏瓣膜中的组织小叶在脱水和灭菌之前用醛封端剂预处理。

2. 发明授权

US08357387B2 Capping bioprosthetic tissue to reduce calcification 有权
公开(公告)号：US08357387B2
公开(公告)日：2013-01-22
申请号：US12338872
申请日：2008-12-18
申请人： Jeffery Dove , Darin Dobler , Jim Davidson , Gregory A. Wright
发明人： Jeffery Dove , Darin Dobler , Jim Davidson , Gregory A. Wright
IPC分类号： A61F2/24
CPC分类号： A61F2/2415 , A61F2/0095 , A61F2/24 , A61F2/2412 , A61F2/2418 , A61L27/3604 , A61L27/3625 , A61L27/3629 , A61L27/3687 , A61L27/3691 , A61L27/507 , A61L2400/02 , A61L2430/20
摘要： A treatment for bioprosthetic tissue used in implants or for assembled bioprosthetic heart valves to reduce in vivo calcification. The method includes applying a calcification mitigant such as a capping agent or an antioxidant to the tissue to specifically inhibit oxidation in tissue. Also, the method can be used to inhibit oxidation in dehydrated tissue. The capping agent suppresses the formation of binding sites in the tissue that are exposed or generated by the oxidation and otherwise would, upon implant, attract calcium, phosphate, immunogenic factors, or other precursors to calcification. In one method, tissue leaflets in assembled bioprosthetic heart valves are pretreated with an aldehyde capping agent prior to dehydration and sterilization.

3. 发明申请

US20090164005A1 Capping Bioprosthetic Tissue to Reduce Calcification 有权
标题翻译：封闭生物假体组织以减少钙化
公开(公告)号：US20090164005A1
公开(公告)日：2009-06-25
申请号：US12338872
申请日：2008-12-18
申请人： Jeffery Dove , Darin Dobler , Jim Davidson , Gregory A. Wright
发明人： Jeffery Dove , Darin Dobler , Jim Davidson , Gregory A. Wright
IPC分类号： A61F2/24 , A01N1/02
CPC分类号： A61F2/2415 , A61F2/0095 , A61F2/24 , A61F2/2412 , A61F2/2418 , A61L27/3604 , A61L27/3625 , A61L27/3629 , A61L27/3687 , A61L27/3691 , A61L27/507 , A61L2400/02 , A61L2430/20
摘要： A treatment for bioprosthetic tissue used in implants or for assembled bioprosthetic heart valves to reduce in vivo calcification. The method includes applying a calcification mitigant such as a capping agent or an antioxidant to the tissue to specifically inhibit oxidation in tissue. Also, the method can be used to inhibit oxidation in dehydrated tissue. The capping agent suppresses the formation of binding sites in the tissue that are exposed or generated by the oxidation and otherwise would, upon implant, attract calcium, phosphate, immunogenic factors, or other precursors to calcification. In one method, tissue leaflets in assembled bioprosthetic heart valves are pretreated with an aldehyde capping agent prior to dehydration and sterilization.
摘要翻译：用于植入物或组装的生物假体心脏瓣膜中用于减少体内钙化的生物假体组织的治疗。该方法包括将钙化缓解剂如封端剂或抗氧化剂施用于组织以特异性抑制组织中的氧化。此外，该方法可用于抑制脱水组织中的氧化。封端剂抑制由氧化暴露或产生的组织中的结合位点的形成，否则在植入时会吸引钙，磷酸盐，免疫原性因子或钙化的其它前体。在一种方法中，组装的生物假体心脏瓣膜中的组织小叶在脱水和灭菌之前用醛封端剂预处理。

4. 发明授权

US09101691B2 Methods for pre-stressing and capping bioprosthetic tissue 有权
标题翻译：预应力和覆盖生物假体组织的方法
公开(公告)号：US09101691B2
公开(公告)日：2015-08-11
申请号：US12135507
申请日：2008-06-09
申请人： Jim Davidson , Jeff Dove , Darin Dobler
发明人： Jim Davidson , Jeff Dove , Darin Dobler
IPC分类号： A61L27/00 , A61L27/36 , A61L27/50
CPC分类号： A61L27/3625 , A61F2/2412 , A61F2210/0004 , A61F2210/0076 , A61L27/3683 , A61L27/3687 , A61L27/3691 , A61L27/507 , A61L2400/02 , A61L2430/20 , A61L2430/40
摘要： A treatment for bioprosthetic tissue used in implants or for assembled bioprosthetic heart valves to reduce in vivo calcification is disclosed. The method includes preconditioning, pre-stressing, or pre-damaging fixed bioprosthetic tissue in a manner that mimics the damage associated with post-implant use, while, and/or subsequently applying a calcification mitigant such as a capping agent or a linking agent to the damaged tissue. The capping agent suppresses the formation of binding sites in the tissue that are exposed or generated by the damage process (service stress) and otherwise would, upon implant, attract calcium, phosphate, immunogenic factors, or other precursors to calcification. The linking agent will act as an elastic reinforcement or shock-absorbing spring element in the tissue structure at the site of damage from the pre-stressing. In one method, tissue leaflets in assembled bioprosthetic heart valves are preconditioned by simulating actual flow conditions for a predetermined number of cycles, during or after which the valve is exposed to the capping agent.
摘要翻译：公开了用于植入物或组装的生物假体心脏瓣膜以减少体内钙化的生物假体组织的治疗。该方法包括以模拟与植入后使用相关的损伤的方式预处理，预应激或预破坏固定的生物假体组织，同时和/或随后将钙化缓解剂如封端剂或连接剂施用于受损的组织。封端剂抑制由损伤过程（服务压力）暴露或产生的组织中的结合位点的形成，否则将在植入时吸引钙，磷酸盐，免疫原性因子或其它钙化前体。连接剂将在预应力损伤部位作为组织结构中的弹性增强或减震弹簧元件。在一种方法中，组装的生物假体心脏瓣膜中的组织小叶通过在瓣膜暴露于封盖剂中或之后模拟实际流动条件预定数量的循环来预处理。

5. 发明授权

US07972376B1 Capping bioprosthetic tissue to reduce calcification 有权
标题翻译：封闭生物假体组织以减少钙化
公开(公告)号：US07972376B1
公开(公告)日：2011-07-05
申请号：US12777994
申请日：2010-05-11
申请人： Jeffery Dove , Darin Dobler , Jim Davidson , Gregory Wright
发明人： Jeffery Dove , Darin Dobler , Jim Davidson , Gregory Wright
IPC分类号： A61F2/24 , A01N1/02
CPC分类号： A61F2/2415 , A61F2/0095 , A61F2/24 , A61F2/2412 , A61F2/2418 , A61L27/3604 , A61L27/3625 , A61L27/3629 , A61L27/3687 , A61L27/3691 , A61L27/507 , A61L2400/02 , A61L2430/20
摘要： A treatment for bioprosthetic tissue used in implants or for assembled bioprosthetic heart valves to reduce in vivo calcification. The method includes applying a calcification mitigant such as a capping agent or an antioxidant to the tissue to specifically inhibit oxidation in tissue. Also, the method can be used to inhibit oxidation in dehydrated tissue. The capping agent suppresses the formation of binding sites in the tissue that are exposed or generated by the oxidation and otherwise would, upon implant, attract calcium, phosphate, immunogenic factors, or other precursors to calcification. In one method, tissue leaflets in assembled bioprosthetic heart valves are pretreated with an aldehyde capping agent prior to dehydration and sterilization.
摘要翻译：用于植入物或组装的生物假体心脏瓣膜中用于减少体内钙化的生物假体组织的治疗。该方法包括将钙化缓解剂如封端剂或抗氧化剂施用于组织以特异性抑制组织中的氧化。此外，该方法可用于抑制脱水组织中的氧化。封端剂抑制由氧化暴露或产生的组织中的结合位点的形成，否则在植入时会吸引钙，磷酸盐，免疫原性因子或钙化的其它前体。在一种方法中，组装的生物假体心脏瓣膜中的组织小叶在脱水和灭菌之前用醛封端剂预处理。

6. 发明申请

US20080302372A1 METHODS FOR PRE-STRESSING AND CAPPING BIOPROSTHETIC TISSUE 有权
标题翻译：预应力和覆盖生物组织的方法
公开(公告)号：US20080302372A1
公开(公告)日：2008-12-11
申请号：US12135507
申请日：2008-06-09
申请人： Jim Davidson , Jeff Dove , Darin Dobler
发明人： Jim Davidson , Jeff Dove , Darin Dobler
IPC分类号： A61L27/00 , A61L27/28 , A61L27/50
CPC分类号： A61L27/3625 , A61F2/2412 , A61F2210/0004 , A61F2210/0076 , A61L27/3683 , A61L27/3687 , A61L27/3691 , A61L27/507 , A61L2400/02 , A61L2430/20 , A61L2430/40
摘要： A treatment for bioprosthetic tissue used in implants or for assembled bioprosthetic heart valves to reduce in vivo calcification is disclosed. The method includes preconditioning, pre-stressing, or pre-damaging fixed bioprosthetic tissue in a manner that mimics the damage associated with post-implant use, while, and/or subsequently applying a calcification mitigant such as a capping agent or a linking agent to the damaged tissue. The capping agent suppresses the formation of binding sites in the tissue that are exposed or generated by the damage process (service stress) and otherwise would, upon implant, attract calcium, phosphate, immunogenic factors, or other precursors to calcification. The linking agent will act as an elastic reinforcement or shock-absorbing spring element in the tissue structure at the site of damage from the pre-stressing. In one method, tissue leaflets in assembled bioprosthetic heart valves are preconditioned by simulating actual flow conditions for a predetermined number of cycles, during or after which the valve is exposed to the capping agent.
摘要翻译：公开了用于植入物或组装的生物假体心脏瓣膜以减少体内钙化的生物假体组织的治疗。该方法包括以模拟与植入后使用相关的损伤的方式预处理，预应激或预破坏固定的生物假体组织，同时和/或随后将钙化缓解剂如封端剂或连接剂施用于受损的组织。封端剂抑制由损伤过程（服务压力）暴露或产生的组织中的结合位点的形成，否则将在植入时吸引钙，磷酸盐，免疫原性因子或其它钙化前体。连接剂将在预应力损伤部位作为组织结构中的弹性增强或减震弹簧元件。在一种方法中，组装的生物假体心脏瓣膜中的组织小叶通过在瓣膜暴露于封盖剂中或之后模拟实际流动条件预定数量的循环来预处理。

7. 发明授权

US08078614B2 Web page performance scoring 有权
标题翻译：网页性能评分
公开(公告)号：US08078614B2
公开(公告)日：2011-12-13
申请号：US12262054
申请日：2008-10-30
申请人： Robert D. Clary , Jim Davidson , Judson Valeski
发明人： Robert D. Clary , Jim Davidson , Judson Valeski
IPC分类号： G06F17/30
CPC分类号： H04L43/045 , G06F11/3419 , G06F11/3452 , G06F11/3476 , G06F17/3089 , H04L41/5009 , H04L41/5083 , H04L43/06 , Y10S707/99935 , Y10S707/99943 , Y10S707/99945
摘要： A browser-based tool is provided that loads a Webpage, accesses the document object model (DOM) of the page, collects information about the page structure and parses the page, determines through the use of heuristics such factors as how much text is found on the page and the like, produces statistical breakdown of the page, and calculates a score based on performance of the page. Key to the operation of the invention is the ability to observe operation of the Webpage as it actually loads in real time, scoring the page for several of various performance factors, and producing a combined score for the various factors.
摘要翻译：提供了一种基于浏览器的工具来加载页面，访问页面的文档对象模型（DOM），收集关于页面结构的信息并解析页面，通过使用启发式方法来确定这样的因素，如文档被找到多少页面等产生页面的统计分析，并且基于页面的性能来计算分数。本发明操作的关键在于能够实时观察网页的操作，对各种性能因素的页面进行评分，并为各种因素生成综合得分。

8. 发明授权

US07475067B2 Web page performance scoring 有权
标题翻译：网页性能评分
公开(公告)号：US07475067B2
公开(公告)日：2009-01-06
申请号：US10887956
申请日：2004-07-09
申请人： Robert D. Clary , Jim Davidson , Judson Valeski
发明人： Robert D. Clary , Jim Davidson , Judson Valeski
IPC分类号： G06F17/30
CPC分类号： H04L43/045 , G06F11/3419 , G06F11/3452 , G06F11/3476 , G06F17/3089 , H04L41/5009 , H04L41/5083 , H04L43/06 , Y10S707/99935 , Y10S707/99943 , Y10S707/99945
摘要： A browser-based tool is provided that loads a Webpage, accesses the document object model (DOM) of the page, collects information about the page structure and parses the page, determines through the use of heuristics such factors as how much text is found on the page and the like, produces statistical breakdown of the page, and calculates a score based on performance of the page. Key to the operation of the invention is the ability to observe operation of the Webpage as it actually loads in real time, scoring the page for several of various performance factors, and producing a combined score for the various factors.
摘要翻译：提供了一种基于浏览器的工具来加载页面，访问页面的文档对象模型（DOM），收集关于页面结构的信息并解析页面，通过使用启发式方法来确定这样的因素，如文档被找到多少页面等产生页面的统计分析，并且基于页面的性能来计算分数。本发明操作的关键在于能够实时观察网页的操作，对各种性能因素的页面进行评分，并为各种因素生成综合得分。

9. 发明申请

US20120198059A1 WEB PAGE PERFORMANCE SCORING 有权
公开(公告)号：US20120198059A1
公开(公告)日：2012-08-02
申请号：US13447006
申请日：2012-04-13
申请人： Robert D. CLARY , Jim Davidson , Judson Valeski
发明人： Robert D. CLARY , Jim Davidson , Judson Valeski
IPC分类号： G06F15/173
CPC分类号： H04L43/045 , G06F11/3419 , G06F11/3452 , G06F11/3476 , G06F17/3089 , H04L41/5009 , H04L41/5083 , H04L43/06 , Y10S707/99935 , Y10S707/99943 , Y10S707/99945
摘要： A browser-based tool is provided that loads a Webpage, accesses the document object model (DOM) of the page, collects information about the page structure and parses the page, determines through the use of heuristics such factors as how much text is found on the page and the like, produces statistical breakdown of the page, and calculates a score based on performance of the page. Key to the operation of the invention is the ability to observe operation of the Webpage as it actually loads in real time, scoring the page for several of various performance factors, and producing a combined score for the various factors.

10. 发明授权

US08161042B2 Web page performance scoring 有权
标题翻译：网页性能评分
公开(公告)号：US08161042B2
公开(公告)日：2012-04-17
申请号：US13290897
申请日：2011-11-07
申请人： Robert D. Clary , Jim Davidson , Judson Valeski
发明人： Robert D. Clary , Jim Davidson , Judson Valeski
IPC分类号： G06F17/30
CPC分类号： H04L43/045 , G06F11/3419 , G06F11/3452 , G06F11/3476 , G06F17/3089 , H04L41/5009 , H04L41/5083 , H04L43/06 , Y10S707/99935 , Y10S707/99943 , Y10S707/99945
摘要： A browser-based tool is provided that loads a Webpage, accesses the document object model (DOM) of the page, collects information about the page structure and parses the page, determines through the use of heuristics such factors as how much text is found on the page and the like, produces statistical breakdown of the page, and calculates a score based on performance of the page. Key to the operation of the invention is the ability to observe operation of the Webpage as it actually loads in real time, scoring the page for several of various performance factors, and producing a combined score for the various factors.
摘要翻译：提供了一种基于浏览器的工具来加载页面，访问页面的文档对象模型（DOM），收集关于页面结构的信息并解析页面，通过使用启发式方法来确定这样的因素，如文档被找到多少页面等产生页面的统计分析，并且基于页面的性能来计算分数。本发明操作的关键在于能够实时观察网页的操作，对各种性能因素的页面进行评分，并为各种因素生成综合得分。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式