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1. 发明申请

US20060030595A1 Potassium channel inhibitors 有权
公开(公告)号：US20060030595A1
公开(公告)日：2006-02-09
申请号：US11188466
申请日：2005-07-25
申请人： Mark Bilodeau , Christopher Dinsmore , Jeffrey Bergman , B. Trotter , Lou Neilson , Zhicai Wu , Peter Manley , John Hartnett
发明人： Mark Bilodeau , Christopher Dinsmore , Jeffrey Bergman , B. Trotter , Lou Neilson , Zhicai Wu , Peter Manley , John Hartnett
IPC分类号： A61K31/506 , A61K31/444 , C07D401/14 , C07D403/14
CPC分类号： C07D213/57 , C07D213/06 , C07D213/30 , C07D213/42 , C07D213/61 , C07D213/64 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/76 , C07D213/81 , C07D213/84 , C07D401/14 , C07D413/14 , C07D417/14
摘要： The present invention relates to compounds having the structure useful as potassium channel inhibitors to treat cardiac arrhythmias, and the like.

2. 发明申请

US20070078154A1 Quinoline potassium channel inhibitors 有权
公开(公告)号：US20070078154A1
公开(公告)日：2007-04-05
申请号：US10572167
申请日：2004-09-17
申请人： Christopher Dinsmore , Jeffrey Bergman
发明人： Christopher Dinsmore , Jeffrey Bergman
IPC分类号： A61K31/4741 , A61K31/4709 , A61K31/4704 , C07D413/02 , C07D401/02
CPC分类号： C07D215/227 , C07D215/38 , C07D215/54 , C07D401/06 , C07D413/06 , C07D413/14
摘要： The present invention relates to compounds having the structure (I) useful as potassium channel inhibitors to treat cardiac arrhythmias, and the like.

3. 发明申请

US20080008708A1 Tyrosine kinase inhibitors 审中-公开
标题翻译：酪氨酸激酶抑制剂
公开(公告)号：US20080008708A1
公开(公告)日：2008-01-10
申请号：US11890755
申请日：2007-08-07
申请人： Christopher Dinsmore , Douglas Beshore , Jeffrey Bergman , Craig Lindsley
发明人： Christopher Dinsmore , Douglas Beshore , Jeffrey Bergman , Craig Lindsley
IPC分类号： A61K31/404 , A61K31/4196 , A61K31/4535 , A61K39/395 , A61P35/00 , C07D209/04 , C07D249/08
CPC分类号： C07D403/12 , C07D209/42 , C07D401/12 , C07D405/12 , C07D409/12
摘要： The present invention relates to compounds that are capable of inhibiting, modulating and/or regulating signal transduction of both receptor-type and non-receptor type tyrosine kinases. The compounds of the instant invention possess a core structure that comprises an indole-sulfonamide moiety. The present invention is also related to the pharmaceutically acceptable salts, hydrates and stereoisomers of these compounds.
摘要翻译：本发明涉及能够抑制，调节和/或调节受体型和非受体型酪氨酸激酶的信号转导的化合物。本发明的化合物具有包含吲哚磺酰胺部分的核心结构。本发明还涉及这些化合物的药学上可接受的盐，水合物和立体异构体。

4. 发明申请

US20050261496A1 Tyrosine kinase inhibitors 有权
标题翻译：酪氨酸激酶抑制剂
公开(公告)号：US20050261496A1
公开(公告)日：2005-11-24
申请号：US10523285
申请日：2003-08-05
申请人： Christopher Dinsmore , Douglas Beshore , Jeffrey Bergman , Craig Lindsley
发明人： Christopher Dinsmore , Douglas Beshore , Jeffrey Bergman , Craig Lindsley
IPC分类号： C07D487/10 , A61K31/138 , A61K31/337 , A61K31/40 , A61K31/404 , A61K31/407 , A61K31/438 , A61K31/44 , A61K31/4465 , A61K31/4535 , A61K31/454 , A61K31/4545 , A61K31/495 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/547 , A61K31/55 , A61K31/551 , A61K31/553 , A61K39/395 , A61K45/00 , A61P1/04 , A61P3/10 , A61P27/02 , A61P35/00 , A61P37/02 , A61P43/00 , C07D20060101 , C07D209/02 , C07D209/42 , C07D209/96 , C07D211/02 , C07D215/02 , C07D267/02 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/02 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D413/02 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D451/02 , C07D491/04 , C07D491/048 , C07D491/08 , C07D491/10 , C07D491/107 , C07D491/12 , C07D498/04 , C07D513/04 , C07D513/08
CPC分类号： C07D487/10 , C07D209/42 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D491/04 , C07D491/10 , C07D513/04 , C07D513/08
摘要： The present invention relates to compounds that are capable of inhibiting, modulating and/or regulating signal transduction of both receptor-type and non-receptor type tyrosine kinases. The compounds of the instant invention possess a core structure that comprises a sulfonyl indole moiety. The present invention is also related to the pharmaceutically acceptable salts, hydrates and stereoisomers of these compounds.
摘要翻译：本发明涉及能够抑制，调节和/或调节受体型和非受体型酪氨酸激酶的信号转导的化合物。本发明的化合物具有包含磺酰基吲哚部分的核心结构。本发明还涉及这些化合物的药学上可接受的盐，水合物和立体异构体。

5. 发明申请

US20070043042A1 Quinoline potassium channel inhibitors 失效
标题翻译：喹啉钾通道抑制剂
公开(公告)号：US20070043042A1
公开(公告)日：2007-02-22
申请号：US10571841
申请日：2004-09-17
申请人： Christopher Dinsmore , Jeffrey Bergman
发明人： Christopher Dinsmore , Jeffrey Bergman
IPC分类号： A61K31/5377 , A61K31/496 , A61K31/4709 , C07D413/02 , C07D403/02 , C07D401/02
CPC分类号： C07D215/48 , C07D401/02 , C07D401/04 , C07D401/12 , C07D403/02 , C07D413/02 , C07D413/12 , C07D413/14
摘要： The present invention relates to compounds having the structure (I) useful as potassium channel inhibitors to treat cardiac arrhythmias, and the like.
摘要翻译：本发明涉及具有用作治疗心律失常的钾通道抑制剂的结构（I）的化合物等。

6. 发明申请

US20060128783A1 Tyrosine kinase inhibitors 审中-公开
标题翻译：酪氨酸激酶抑制剂
公开(公告)号：US20060128783A1
公开(公告)日：2006-06-15
申请号：US10523286
申请日：2003-08-05
申请人： Christopher Dinsmore , Douglas Beshore , Jeffrey Bergman , Craig Lindsley
发明人： Christopher Dinsmore , Douglas Beshore , Jeffrey Bergman , Craig Lindsley
IPC分类号： A61K31/404 , C07D403/02 , C07D209/36
CPC分类号： C07D403/12 , C07D209/42 , C07D401/12 , C07D405/12 , C07D409/12
摘要： The present invention relates to compounds that are capable of inhibiting, modulating and/or regulating signal transduction of both receptor-type and non-receptor type tyrosine kinases. The compounds of the instant invention possess a core structure that comprises an indole-sulfonamide moiety. The present invention is also related to the pharmaceutically acceptable salts, hydrates and stereoisomers of these compounds.
摘要翻译：本发明涉及能够抑制，调节和/或调节受体型和非受体型酪氨酸激酶的信号转导的化合物。本发明的化合物具有包含吲哚磺酰胺部分的核心结构。本发明还涉及这些化合物的药学上可接受的盐，水合物和立体异构体。

7. 发明授权

US5780488A Inhibitors of farnesyl-protein transferase 失效
公开(公告)号：US5780488A
公开(公告)日：1998-07-14
申请号：US824588
申请日：1997-03-26
申请人： Jeffrey Bergman , Christopher Dinsmore
发明人： Jeffrey Bergman , Christopher Dinsmore
IPC分类号： C07D213/53 , C07D233/22 , C07D233/24 , C07D233/54 , A61K31/415 , A61K31/44 , C07D213/02
CPC分类号： C07D213/53 , C07D233/22 , C07D233/24
摘要： The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.

8. 发明申请

US20080090794A1 Potassium Channel Inhibitors 有权
标题翻译：钾通道抑制剂
公开(公告)号：US20080090794A1
公开(公告)日：2008-04-17
申请号：US11658114
申请日：2005-07-27
申请人： Christoph Dinsmore , Jeffrey Bergman , Douglas Beshore , B. Wesley Trotter , Kausik Nanda , Richard Isaacs , Linda Payne , Lou Anne Neilson , Zhicai Wu , Mark Bilodeau , Peter Manley , Adrianne Balitza
发明人： Christoph Dinsmore , Jeffrey Bergman , Douglas Beshore , B. Wesley Trotter , Kausik Nanda , Richard Isaacs , Linda Payne , Lou Anne Neilson , Zhicai Wu , Mark Bilodeau , Peter Manley , Adrianne Balitza
IPC分类号： A61K31/5377 , A61K31/397 , A61K31/438 , A61K31/4412 , A61K31/4439 , A61P9/04 , C07D213/04 , C07D221/20 , C07D401/14 , C07D413/02 , C07D413/00 , C07D401/02 , C07D213/63 , A61P9/06 , A61P9/00 , A61K31/444 , A61K31/497 , A61K31/506
CPC分类号： C07D213/36 , C07D213/30 , C07D213/32 , C07D213/38 , C07D213/40 , C07D213/42 , C07D213/55 , C07D213/56 , C07D213/64 , C07D401/06 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/08 , C07D491/08
摘要： The present invention relates to compounds having the structure useful as potassium channel inhibitors to treat cardiac arrhythmias, and the like.
摘要翻译：本发明涉及具有用作治疗心律失常的钾通道抑制剂的结构的化合物等。

9. 发明申请

US20080038342A1 Stable Pharmaceutical Composition Comprising an Ace Inhibitor 审中-公开
标题翻译：包含Ace抑制剂的稳定的药物组合物
公开(公告)号：US20080038342A1
公开(公告)日：2008-02-14
申请号：US10590816
申请日：2005-02-15
申请人： Jeffrey Bergman , Pratibha Pilgaonkar , Maharuk Rustomjee , Amita Surana , Rizwana Mulagath , Atul Kelkar
发明人： Jeffrey Bergman , Pratibha Pilgaonkar , Maharuk Rustomjee , Amita Surana , Rizwana Mulagath , Atul Kelkar
IPC分类号： A61K9/30 , A61K31/403 , A61P9/04 , A61P9/12 , A61P9/10 , A61K31/47
CPC分类号： A61K9/2059 , A61K9/2054
摘要： The present invention relates to a stable pharmaceutical composition comprising an ACE inhibitor or a pharmaceutically acceptable salt or derivative thereof. In particular, the invention relates to a pharmaceutical composition, which comprises an ACE inhibitor, or a pharmaceutically acceptable salt or a derivative thereof, and a C16-C28 glyceride. ACE inhibitors useful in the present invention are susceptible to heat and/or mechanical stress-induced degradation. Preferred ACE inhibitors are ramipril, trandolapril, quinapril and pharmaceutically acceptable salts and derivatives thereof. The composition of the present invention may be for use as a medicament for the treatment or prevention of a cardiovascular disease, a coronary heart disease, a cerebrovascular disease, a peripheral vascular disease, arrhythmia, hypertension, cardiac failure, cardiovascular death, myocardial infraction, stroke or angina. The present invention further relates to a method of preparing the pharmaceutical composition of the present invention. The present invention also relates to a method of providing a stable pharmaceutical composition comprising an ACE inhibitor, or a pharmaceutically acceptable salt or derivative thereof, by incorporating a C16-C28 glyceride into the composition. The present invention further relates to a use of C16-C28 glyceride to provide a stable pharmaceutical composition comprising an ACE inhibitor or a pharmaceutically acceptable salt or derivative thereof.
摘要翻译：本发明涉及包含ACE抑制剂或其药学上可接受的盐或衍生物的稳定药物组合物。特别地，本发明涉及药物组合物，其包含ACE抑制剂或其药学上可接受的盐或衍生物，以及C 16 -C 28脂肪酸甘油酯。可用于本发明的ACE抑制剂易受热和/或机械应激诱导的降解。优选的ACE抑制剂是雷米普利，群多普利，喹那普利及其药学上可接受的盐和衍生物。本发明的组合物可以用作治疗或预防心血管疾病，冠心病，脑血管疾病，外周血管疾病，心律失常，高血压，心力衰竭，心血管死亡，心肌梗死，中风或心绞痛本发明还涉及制备本发明的药物组合物的方法。本发明还涉及一种提供包含ACE抑制剂或其药学上可接受的盐或衍生物的稳定药物组合物的方法，该方法是通过引入C 16 -C 28 - 甘油酯加入组合物。本发明还涉及C 16-16 -C 28脂肪酸甘油酯的用途，以提供包含ACE抑制剂或其药学上可接受的盐或衍生物的稳定药物组合物。

10. 发明授权

US08978997B2 Aromatic cover 有权
标题翻译：芳香盖
公开(公告)号：US08978997B2
公开(公告)日：2015-03-17
申请号：US13371917
申请日：2012-02-13
申请人： Jeffrey Bergman , Yao Lujian
发明人： Jeffrey Bergman , Yao Lujian
IPC分类号： A24F25/00 , A47G9/00 , A61L9/12
CPC分类号： A47G9/007 , A61L9/12
摘要： An aromatic cover is provided. An aromatic cover includes a flexible enclosure defining an outer surface and an inner surface. A cartridge fastener is attached to the inner surface. The cartridge fastener is configured to releasably retain an aromatic cartridge containing a quantity of aromatic material at a semi-fixed position along the inner surface. An aroma-permeable region of the flexible enclosure is proximate to the semi-fixed position, wherein the aroma-permeable region is configured to allow for a release of the aromatic material from the aromatic cartridge to the outer surface.
摘要翻译：提供了一个芳香的盖子。芳香盖包括限定外表面和内表面的柔性外壳。筒式紧固件附接到内表面。盒紧固件被构造成沿着内表面可释放地将包含一定量芳族材料的芳香药盒保持在半固定位置。柔性外壳的香味可渗透区域靠近半固定位置，其中芳香透气区域构造成允许将芳香物质从芳香药盒释放到外表面。

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