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1. 发明申请

US20130089546A1 THERAPEUTIC NUCLEASE COMPOSITIONS AND METHODS 审中-公开
公开(公告)号：US20130089546A1
公开(公告)日：2013-04-11
申请号：US13505421
申请日：2010-11-02
申请人： Jeffrey A. Ledbetter , Martha Hayden-Ledbetter , Keith Elkon , Xizhang Sun
发明人： Jeffrey A. Ledbetter , Martha Hayden-Ledbetter , Keith Elkon , Xizhang Sun
IPC分类号： C12N11/06
CPC分类号： C12N9/22 , A61K38/00 , C07K16/18 , C07K2319/30 , C12N9/96 , C12N11/06 , C12Y301/27005 , Y02P20/582
摘要： Hybrid nuclease molecules and methods for treating an immune-related disease or disorder in a mammal, and a pharmaceutical composition for treating an immune-related disease in a mammal.

2. 发明申请

US20140044711A1 Therapeutic Nuclease Compositions and Methods 审中-公开
标题翻译：治疗性核酸酶组合物和方法
公开(公告)号：US20140044711A1
公开(公告)日：2014-02-13
申请号：US13822215
申请日：2012-04-27
申请人： Jeffrey A. Ledbetter , Martha Hayden-Ledbetter , Keith Elkon , Xizhang Sun
发明人： Jeffrey A. Ledbetter , Martha Hayden-Ledbetter , Keith Elkon , Xizhang Sun
IPC分类号： C12N9/22 , C07K16/46
CPC分类号： C12N9/22 , A61K38/465 , A61K47/68 , A61K47/6815 , C07K16/44 , C07K2319/30 , C12Y301/27005
摘要： Hybrid nuclease molecules and methods for treating an immune-related disease or disorder in a mammal, and a pharmaceutical composition for treating an immune-related disease in a mammal.
摘要翻译：杂交核酸酶分子和用于治疗哺乳动物免疫相关疾病或病症的方法和用于治疗哺乳动物免疫相关疾病的药物组合物。

3. 发明授权

US10202588B2 Therapeutic nuclease compositions and methods 有权
公开(公告)号：US10202588B2
公开(公告)日：2019-02-12
申请号：US13822215
申请日：2012-04-27
申请人： Jeffrey A. Ledbetter , Martha Hayden-Ledbetter , Keith Elkon , Xizhang Sun
发明人： Jeffrey A. Ledbetter , Martha Hayden-Ledbetter , Keith Elkon , Xizhang Sun
IPC分类号： A61K39/00 , C12N9/22 , C07K16/44 , A61K47/68 , C07K1/00 , A61K38/46
摘要： Hybrid nuclease molecules and methods for treating an immune-related disease or disorder in a mammal, and a pharmaceutical composition for treating an immune-related disease in a mammal.

4. 发明授权

US08841416B2 Therapeutic nuclease compositions and methods 有权
标题翻译：治疗性核酸酶组合物和方法
公开(公告)号：US08841416B2
公开(公告)日：2014-09-23
申请号：US13197731
申请日：2011-08-03
申请人： Jeffrey A. Ledbetter , Martha Hayden-Ledbetter , Keith Elkon , Xizhang Sun
发明人： Jeffrey A. Ledbetter , Martha Hayden-Ledbetter , Keith Elkon , Xizhang Sun
IPC分类号： C07K17/00 , C07K16/00 , A61K39/02 , A61K39/002 , A61K39/385 , C12N9/96 , C12N9/22 , C12N11/06 , C12P21/08 , A61K38/00
CPC分类号： C12N9/22 , A61K38/00 , C07K16/18 , C07K2319/30 , C12N9/96 , C12N11/06 , C12Y301/27005 , Y02P20/582
摘要： Hybrid nuclease molecules and methods for treating an immune-related disease or disorder in a mammal, and a pharmaceutical composition for treating an immune-related disease in a mammal.
摘要翻译：杂交核酸酶分子和用于治疗哺乳动物免疫相关疾病或病症的方法和用于治疗哺乳动物免疫相关疾病的药物组合物。

5. 发明申请

US20120225066A1 THERAPEUTIC NUCLEASE COMPOSITIONS AND METHODS 有权
标题翻译：治疗核素组合物和方法
公开(公告)号：US20120225066A1
公开(公告)日：2012-09-06
申请号：US13197731
申请日：2011-08-03
申请人： Jeffrey A. Ledbetter , Martha Hayden-Ledbetter , Keith Elkon , Xizhang Sun
发明人： Jeffrey A. Ledbetter , Martha Hayden-Ledbetter , Keith Elkon , Xizhang Sun
IPC分类号： A61K39/395 , C12N15/63 , C12N1/21 , C12N1/19 , A61P1/04 , C12N5/10 , C12N15/62 , A61P19/02 , A61P37/00 , A61P15/08 , C12N9/96 , C12N1/15
CPC分类号： C12N9/22 , A61K38/00 , C07K16/18 , C07K2319/30 , C12N9/96 , C12N11/06 , C12Y301/27005 , Y02P20/582
摘要： Hybrid nuclease molecules and methods for treating an immune-related disease or disorder in a mammal, and a pharmaceutical composition for treating an immune-related disease in a mammal.
摘要翻译：杂交核酸酶分子和用于治疗哺乳动物免疫相关疾病或病症的方法和用于治疗哺乳动物免疫相关疾病的药物组合物。

6. 发明授权

US08632773B2 Antibody composition with altered Fab sialylation 有权
标题翻译：具有改变的Fab唾液酸化的抗体组合物
公开(公告)号：US08632773B2
公开(公告)日：2014-01-21
申请号：US13260202
申请日：2010-03-26
申请人： Fabian Käsermann , Monika Rüegsegger , Sylvia Miescher , Keith Elkon
发明人： Fabian Käsermann , Monika Rüegsegger , Sylvia Miescher , Keith Elkon
IPC分类号： A61K39/395 , A61K35/12 , A61K35/14 , A61K35/16 , C07K16/00
CPC分类号： C07K16/00 , A61K2039/505 , C07K1/22 , C07K16/081 , C07K16/088 , C07K16/1027 , C07K16/1081 , C07K16/1282 , C07K2317/21 , C07K2317/41 , C07K2317/54 , C07K2317/55
摘要： The present invention relates to a population of antibodies enriched from an antibody preparation, wherein the enriched population of antibodies has an altered amount of sialylation in the Fab region of the antibodies as compared to the antibody preparation prior to enrichment. Furthermore, the present invention relates to a method of enriching a population of antibodies from an antibody preparation, wherein the enriched population of antibodies has an altered amount of sialylation in the Fab region of the antibodies as compared to the antibody preparation prior to enrichment. The present invention also relates to the population of antibodies of the invention for use in medicine, a pharmaceutical composition comprising the populations of antibodies of the invention and the use of the population of antibodies of the invention in the prevention and/or treatment of atherosclerosis, cancer and infections such as bacterial, viral or fungal infections.
摘要翻译：本发明涉及从抗体制备物富集的抗体群，其中与富集之前的抗体制备物相比，富集的抗体群体在抗体的Fab区中具有改变的唾液酸化量。此外，本发明涉及从抗体制剂中富集抗体群体的方法，其中与富集前的抗体制备物相比，富集的抗体群体在抗体的Fab区域中具有改变的唾液酸化量。本发明还涉及本发明用于医药的抗体群体，包含本发明抗体种群和本发明抗体群在预防和/或治疗动脉粥样硬化中的用途的药物组合物，癌症和感染如细菌，病毒或真菌感染。

7. 发明授权

US4865970A Method of detecting ribosomal protein antibodies in systemic lupus erythematosus 失效
标题翻译：检测系统性红斑狼疮中核糖体蛋白抗体的方法
公开(公告)号：US4865970A
公开(公告)日：1989-09-12
申请号：US834717
申请日：1986-02-28
申请人： Nathan Brot , Keith Elkon , Susan M. Skelly , Herbert Weissbach
发明人： Nathan Brot , Keith Elkon , Susan M. Skelly , Herbert Weissbach
IPC分类号： C07K14/47 , C07K17/08 , G01N33/564
CPC分类号： C07K14/4713 , C07K17/08 , G01N33/564 , G01N2800/104 , Y10S436/811 , Y10S530/806
摘要： This invention provides methods for the diagnosis of systemic lupus erythematosus in patients, the sera of which contain antibodies reactive against ribosomal proteins P0, P1 and P2. A peptide containing an amino acid sequence corresponding to the carboxyl termini of the ribosomal proteins, which peptide is bound to a solid carrier, is also provided for use in such methods.
摘要翻译：本发明提供了用于诊断患者系统性红斑狼疮的方法，其血清含有对核糖体蛋白质P0，P1和P2具有反应性的抗体。还提供了含有对应于核糖体蛋白的羧基末端的氨基酸序列的肽，该肽与固体载体结合，用于此类方法。

8. 发明申请

US20120009189A1 ANTIBODY COMPOSITION WITH ALTERED FAB SIALYLATION 有权
标题翻译：具有改性FAB SIALYLATION的抗体组合物
公开(公告)号：US20120009189A1
公开(公告)日：2012-01-12
申请号：US13260202
申请日：2010-03-26
申请人： Fabian Käsermann , Monika Rüegsegger , Sylvia Miescher , Keith Elkon
发明人： Fabian Käsermann , Monika Rüegsegger , Sylvia Miescher , Keith Elkon
IPC分类号： A61K39/395 , A61P37/02 , C07K16/00
CPC分类号： C07K16/00 , A61K2039/505 , C07K1/22 , C07K16/081 , C07K16/088 , C07K16/1027 , C07K16/1081 , C07K16/1282 , C07K2317/21 , C07K2317/41 , C07K2317/54 , C07K2317/55
摘要： The present invention relates to a population of antibodies enriched from an antibody preparation, wherein the enriched population of antibodies has an altered amount of sialylation in the Fab region of the antibodies as compared to the antibody preparation prior to enrichment. Furthermore, the present invention relates to a method of enriching a population of antibodies from an antibody preparation, wherein the enriched population of antibodies has an altered amount of sialylation in the Fab region of the antibodies as compared to the antibody preparation prior to enrichment. The present invention also relates to the population of antibodies of the invention for use in medicine, a pharmaceutical composition comprising the populations of antibodies of the invention and the use of the population of antibodies of the invention in the prevention and/or treatment of atherosclerosis, cancer and infections such as bacterial, viral or fungal infections.
摘要翻译：本发明涉及从抗体制备物富集的抗体群，其中与富集之前的抗体制备物相比，富集的抗体群体在抗体的Fab区中具有改变的唾液酸化量。此外，本发明涉及从抗体制剂中富集抗体群体的方法，其中与富集前的抗体制备物相比，富集的抗体群体在抗体的Fab区域中具有改变的唾液酸化量。本发明还涉及用于医药的本发明抗体群体，包含本发明抗体种群和本发明抗体群在预防和/或治疗动脉粥样硬化中的用途的药物组合物，癌症和感染如细菌，病毒或真菌感染。

9. 发明授权

US06525029B1 Method of inhibiting and immune response to a recombinant vector 失效
标题翻译：对重组载体的抑制和免疫应答的方法
公开(公告)号：US06525029B1
公开(公告)日：2003-02-25
申请号：US09182567
申请日：1998-10-29
申请人： Erik S. Falck-Pedersen , Keith Elkon
发明人： Erik S. Falck-Pedersen , Keith Elkon
IPC分类号： A61K4800
CPC分类号： C12N15/86 , A61K38/00 , A61K48/00 , C07K14/70517 , C07K14/70578 , C07K14/7151 , C07K14/7156 , C07K2319/00 , C12N2710/10343
摘要： The present invention provides, among other things, a method of inhibiting an immune response to a recombinant vector, such as a viral vector, specifically an adenoviral vector. The method comprises contacting a cell with (i) a recombinant vector, preferably a viral vector, most preferably an adenoviral vector, comprising a transgene and (ii) a means of inhibiting an immune response to the recombinant vector selected from the group consisting of a TNF receptor fusion protein, a Fas receptor fusion protein, an IFN receptor fusion protein, a gene encoding a TNF receptor fusion protein, a gene encoding a Fas receptor fusion protein, and a gene encoding an IFN receptor fusion protein, whereupon an immune response to the recombinant vector is inhibited. In this regard, the present invention also provides a recombinant vector and a composition for use in the method.
摘要翻译：本发明尤其提供了抑制重组载体如病毒载体，特别是腺病毒载体的免疫应答的方法。该方法包括使细胞与（i）包含转基因的重组载体，优选病毒载体，最优选腺病毒载体接触，和（ii）抑制对重组载体的免疫应答的方法，所述重组载体选自 TNF受体融合蛋白，Fas受体融合蛋白，IFN受体融合蛋白，编码TNF受体融合蛋白的基因，编码Fas受体融合蛋白的基因和编码IFN受体融合蛋白的基因，重组载体被抑制。在这方面，本发明还提供了用于该方法的重组载体和组合物。

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