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1. 发明授权

US5192295A Angioplasty dilatation balloon catheter/guidewire system 失效
标题翻译： ANGIOPLASTY DILATATION BALLOON CATHETER / GUIDEWIRE SYSTEM
公开(公告)号：US5192295A
公开(公告)日：1993-03-09
申请号：US540957
申请日：1990-06-20
申请人： John W. Danforth , Jeff L. Kraus , Michael J. Horzewski , Hugh R. Sharkey
发明人： John W. Danforth , Jeff L. Kraus , Michael J. Horzewski , Hugh R. Sharkey
IPC分类号： A61M25/00 , A61M25/01 , A61M29/02
CPC分类号： A61M25/104 , A61M25/09 , A61M2025/0183 , A61M2025/09175 , A61M2025/1063 , A61M2025/1079 , A61M2025/1093
摘要： An angioplasty catheter system is disclosed which allows insertion and removal of a guidewire through the inner member of the catheter, yet which inner member includes a portion which is smaller than the cross-section of portions of the guidewire. Advancement and removal of the guidewire are achieved by forming the first portion of the inner member of the catheter shaft from material which is expandable, or which is sufficiently thin to be folded and temporarily secured in place using several techniques.

2. 发明授权

US5273052A Guidewire with reversible contact seal for releasable securement to catheter 失效
标题翻译：导丝带可逆接触密封，可释放固定到导管
公开(公告)号：US5273052A
公开(公告)日：1993-12-28
申请号：US817939
申请日：1992-01-08
申请人： Jeff L. Kraus , John W. Danforth , Michael J. Horzewski
发明人： Jeff L. Kraus , John W. Danforth , Michael J. Horzewski
IPC分类号： A61F2/958 , A61M25/01 , A61M29/02 , A61M25/00
CPC分类号： A61M25/0905 , A61M25/09041 , A61M25/104 , A61M2025/0063 , A61M2025/1004
摘要： An exchangeable catheter-guidewire system is disclosed in which the guidewire can be manipulated to seize and to release itself from the catheter body while both are in place in a vasculature or other body vessel. For balloon dilatation catheters, this arrangement permits one to transmit the fluid used for perfusion and/or balloon inflation through the same lumen through which the guidewire passes. Balloon catheters which utilize the invention have the capacity to secure the position of the guidewire relative to the catheter body, as well as to seal the lumen and balloon to retain fluid under pressure, both by remote control from the proximal end of the catheter. The seizure and sealing are achieved by a deformable section on the guidewire, which expands upon deformation to seize a tubular section of the catheter body. Two examples of deformation are given, the first occurring with a deformable section which is sufficiently flexible to gather into folds upon longitudinal compression, the folds being bulky enough to expand outward, and the second occurring with a deformable section which is inflatable. In either case, the guidewire in preferred embodiments is constructed as a hollow tube with a central rod which in both cases serves to enhance the longitudinal strength of the guidewire and, in the first case, also serves as a means of compressing and re-extending the deformable section of the tube. Either mechanism permits the construction of an exchangeable catheter system with the crossing profile of non-exchangeable systems.

3. 发明授权

US5201756A Radially-expandable tubular elements for use in the construction of medical devices 失效
标题翻译：用于构建医疗器械的径向可扩展的管状元件
公开(公告)号：US5201756A
公开(公告)日：1993-04-13
申请号：US846742
申请日：1992-03-06
申请人： Michael J. Horzewski , John W. Danforth , Jeff L. Kraus , Hugh R. Sharkey
发明人： Michael J. Horzewski , John W. Danforth , Jeff L. Kraus , Hugh R. Sharkey
IPC分类号： A61M25/00 , A61M25/06
CPC分类号： A61M25/0662 , A61M25/0023 , A61M2025/0024
摘要： A radially expandable intravascular medical device is disclosed. The device typically includes two members. The first member is an outer tube-shaped sheath which is radially expandable by being formed from elastic material or other means and having relatively low column strength. The second member is an inner portion extending throughout the outer tube. This inner portion includes a slit to allow it to expand radially as well. Using the structure diagnostic, therapeutic, or other desired objects may be conveyed through the device yet still enable the device to have a smaller cross-sectional area throughout most of its length than the object conveyed therethrough.
摘要翻译：公开了一种可径向膨胀的血管内医疗装置。设备通常包括两个成员。第一构件是通过由弹性材料或其他装置形成且具有相对较低柱强度的径向可膨胀的外管状护套。第二构件是贯穿整个外管延伸的内部部分。该内部部分包括允许其径向膨胀的狭缝。使用结构诊断，治疗或其他期望的物体可以通过该装置传送，但是仍然使得该装置在其大部分长度上具有比从其传送的物体更小的横截面积。

4. 发明授权

US5141494A Variable wire diameter angioplasty dilatation balloon catheter 失效
标题翻译：可变丝直径血管成形术扩张球囊导管
公开(公告)号：US5141494A
公开(公告)日：1992-08-25
申请号：US481478
申请日：1990-02-15
申请人： John W. Danforth , Michael J. Horzewski , Jeff L. Kraus , Robert D. Lashinski
发明人： John W. Danforth , Michael J. Horzewski , Jeff L. Kraus , Robert D. Lashinski
IPC分类号： A61F2/958 , A61M25/00 , A61M29/02
CPC分类号： A61M25/104 , A61M2025/09183 , A61M2025/107 , A61M2025/1093 , A61M25/0068 , A61M25/1002
摘要： A dilatation balloon catheter is disclosed with an inelastic balloon wrapped about a smaller section of a guidewire. During introduction across a region of a stenosis, the balloon is wrapped around a guidewire in such a way that the guidewire contained therein can rotated freely, but cannot advance independently of the balloon. The wrapped configuration is maintained by means of a temporary bond. Inflation of the balloon, following proper positioning of the catheter breaks the bond, permitting the balloon to unwrap from the guidewire contained therein. Typically, the distal end of the guidewire is tapered and the guide wire is controllably clamped to the catheter for advancement into the patient.
摘要翻译：公开了一种扩张球囊导管，其中包裹有导丝线的较小部分的非弹性球囊。在穿过狭窄区域的引入期间，气球以导线所包围的方式缠绕在导丝上，使得其中的导丝可以自由旋转，但不能独立于气囊前进。包裹的配置通过临时保固来维护。在适当定位导管之后，气囊的充气破坏了接合，允许气囊从包含在其中的导丝展开。通常，导丝的远端是锥形的并且导丝可控制地夹紧到导管以进入患者体内。

5. 发明授权

US5318588A Radially-expandable tubular elements for use in the construction of medical devices 失效
标题翻译：用于构建医疗器械的径向可扩展的管状元件
公开(公告)号：US5318588A
公开(公告)日：1994-06-07
申请号：US14027
申请日：1993-02-05
申请人： Michael J. Horzewski , John W. Danforth , Jeff L. Kraus , Hugh R. Sharkey
发明人： Michael J. Horzewski , John W. Danforth , Jeff L. Kraus , Hugh R. Sharkey
IPC分类号： A61M25/00 , A61M25/06 , A61M29/00
CPC分类号： A61M25/0662 , A61M25/0023 , A61M2025/0024
摘要： A radially expandable intravascular medical device is disclosed. The device typically includes two members. The first member is an outer tube-shaped sheath which is radially expandable by being formed from elastic material or other means and having relatively low column strength. The second member is an inner portion extending throughout the outer tube. This inner portion includes a slit to allow it to expand radially as well. Using the structure diagnostic, therapeutic, or other desired objects may be conveyed through the device yet still enable the device to have a smaller cross-sectional area throughout most of its length than the object conveyed therethrough.
摘要翻译：公开了一种可径向膨胀的血管内医疗装置。设备通常包括两个成员。第一构件是通过由弹性材料或其他装置形成且具有相对较低柱强度的径向可膨胀的外管状护套。第二构件是延伸穿过外管的内部部分。该内部部分包括允许其径向膨胀的狭缝。使用结构诊断，治疗或其他期望的物体可以通过该装置传送，但是仍然使得该装置在其大部分长度上具有比从其传送的物体更小的横截面积。

6. 发明授权

US5073168A Y-adaptor and percutaneous sheath for intravascular catheters 失效
标题翻译： Y型适配器和经皮鞘用于血管内导管
公开(公告)号：US5073168A
公开(公告)日：1991-12-17
申请号：US560241
申请日：1990-07-30
申请人： John W. Danforth
发明人： John W. Danforth
IPC分类号： A61M39/06
CPC分类号： A61M39/0606 , A61M2039/062 , A61M2039/0633
摘要： A Y-adapter (2) includes a check valve (22) having an entrance section (24) and a sealing section (26). The sealing section includes two or more flexible, thin, conformable sheets (48, 50) having normally abutting sealing surfaces extending axially at least twice the diameter of the therapeutic catheter (6). The sealing section collapses onto the catheter so that the patient's blood pressure seals the sheets against the catheter to prevent blood loss even during insertion and removal of the catheter. The main bore (10) is sealed adjacent the side port (20) to eliminate dead space where blood clots can form. The flexible, conformable sheets provide very little resistance to the insertion of the catheter to minimize damage to the catheter.
摘要翻译： Y适配器（2）包括具有入口部分（24）和密封部分（26）的止回阀（22）。密封部分包括两个或多个柔性，薄的，适形的片材（48,50），其具有沿轴向延伸至少两倍于治疗导管（6）的直径的正常邻接的密封表面。密封部分塌陷到导管上，使得患者的血压将片材抵靠导管密封，以防止即使在插入和移除导管期间失血。主孔（10）邻近侧端口（20）密封，以消除可能形成血块的死腔。柔性的，适形的片材对插入导管非常小的阻力以最小化对导管的损伤。

7. 发明授权

US4909787A Controllable flexibility catheter with eccentric stiffener 失效
标题翻译：带偏心加强筋的柔性导管
公开(公告)号：US4909787A
公开(公告)日：1990-03-20
申请号：US231625
申请日：1988-08-11
申请人： John W. Danforth
发明人： John W. Danforth
IPC分类号： A61M25/00 , A61M25/01 , A61M29/02
CPC分类号： A61M25/0155 , A61M25/0054 , A61M25/09025 , A61M25/104 , A61M2025/0036 , A61M2025/0063 , A61M2025/0161 , A61M25/0032
摘要： A guiding catheter 20 of variable, operator-controlled flexibility to be used in the performance of a percutaneous translumenal coronary angioplasty procedure is described which includes an elongate housing 42 suitable for insertion into an artery, as well as an operator-controlled variable stiffener coupled to the distal aspect of the catheter to permit the operator performing the angioplasty procedure to increase the rigidity of the catheter. In a preferred embodiment the stiffening apparatus consists of a fluid-filled chamber eccentrically displaced along the longitudinal axis of the catheter housing nearly encompassing the housing that contains a segment capable of asymmetric elongation when subjected to hydrostatic pressure resulting in the development of torque and increased rigidity of the distal end as desired by the operator. Increasing the rigidity of the guiding catheter, once installed within the coronary ostium, precludes disengagement of the guiding catheter, thus expediting the performance and enhancing the safety of the procedure.
摘要翻译：描述了用于执行经皮冠状动脉血管成形术程序的可变的，操作者控制的柔性的引导导管20，其包括适于插入动脉的细长壳体42以及耦合到导管的远端方面允许操作者执行血管成形术程序以增加导管的刚度。在优选实施例中，加强装置由沿着导管壳体的纵向轴线偏心移动的流体填充室组成，几乎包围壳体，当受到静水压力而导致转矩增加和刚度增加时，该壳体包含能够不对称伸长的区段的远端。一旦安装在冠状口内，增加引导导管的刚度就可以防止引导导管分离，从而加快了性能，提高了手术的安全性。

8. 发明授权

US4881547A Angioplasty dilitation balloon catheter 失效
标题翻译：血管成形术扩张气囊导管
公开(公告)号：US4881547A
公开(公告)日：1989-11-21
申请号：US239061
申请日：1988-09-01
申请人： John W. Danforth
发明人： John W. Danforth
IPC分类号： A61B17/00 , A61F2/958 , A61M29/02
CPC分类号： A61M25/104 , A61M25/1002 , A61B2017/00783 , A61M2025/0183
摘要： A dilitation balloon catheter with an inelastic balloon disposed in a streamlined configuration having a smaller deflated cross-sectional profile than any catheter hereto available and yet a potentially larger inflation caliber than prior art "low profile" catheters. During introduction across a region of stenosis, the balloon is wrapped around a guidewire in such a way that the guidewire contained therein can move freely. The wrapped configuration is maintained by means of a temporary bond. Inflation of the balloon, following proper positioning of the catheter results in disruption of the aforementioned bond, permitting a balloon to unwrap from the guidewire contained therein.
摘要翻译：具有非弹性球囊的膨胀球囊导管设置成流线型构造，其具有比现有技术“低轮廓”导管更可靠的潜在更大的充气口径，具有比目前可用的任何导管更小的放气截面轮廓。在穿过狭窄区域的引入期间，气囊以其中包含的导丝可自由移动的方式缠绕在导丝上。包裹的配置通过临时保固来维护。在适当定位导管之后，气囊的充气导致上述粘结的破坏，从而允许气囊从包含在其中的导丝展开。

9. 发明授权

US4822345A Controllable flexibility catheter 失效
标题翻译：可控柔性导管
公开(公告)号：US4822345A
公开(公告)日：1989-04-18
申请号：US170596
申请日：1988-03-16
申请人： John W. Danforth
发明人： John W. Danforth
IPC分类号： A61M25/00
CPC分类号： A61M25/0054 , A61M25/09025 , A61M2025/0063
摘要： A guiding catheter 40 of variable, operator-controlled flexibility to be used in the performance of a percutaneous translumenal coronary angioplasty procedure is described which includes an elongate housing 42 suitable for insertion into an artery, as well as an operator-controlled variable stiffener coupled to the distal aspect of the catheter to permit the operator performing the angioplasty procedure to increase the rigidity of the catheter. In a preferred embodiment the stiffening apparatus consists of a balloon 50 extending longitudinally along the distal end of the catheter to allow increases in rigidity of the distal end as desired by the operator. Increasing the rigidity of the guiding catheter, once installed within the coronary ostium, precludes disengagement of the guiding catheter, thus expediting the performance and enhancing the safety of the procedure.
摘要翻译：描述了用于执行经皮冠状动脉血管成形术程序的可变的，操作者控制的灵活性的引导导管40，其包括适于插入动脉的细长壳体42以及耦合到导管的远端方面允许操作者执行血管成形术程序以增加导管的刚度。在优选实施例中，加强装置由沿着导管的远端纵向延伸的球囊50组成，以允许操作者期望的远端的刚度增加。一旦安装在冠状口内，增加引导导管的刚度就可以防止引导导管分离，从而加快了性能，提高了手术的安全性。

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