专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20160147738A1 SYSTEM AND METHOD FOR MULTI-LINGUAL TRANSLATION 审中-公开
标题翻译：用于多重翻译的系统和方法
公开(公告)号：US20160147738A1
公开(公告)日：2016-05-26
申请号：US14552452
申请日：2014-11-24
申请人： Jeff Geurts , Daryl McMillan , David Lockhart
发明人： Jeff Geurts , Daryl McMillan , David Lockhart
IPC分类号： G06F17/28
CPC分类号： G09B5/00 , G06F17/2836
摘要： Systems and methods for multi-lingual translation of content for an electronic learning platform that involve receiving translated content in a translation language, wherein the translated content is generated based on content in a source language; linking the content in the source language to the translated content in the translation language; receiving an update to the content in the source language; and receiving a corresponding update to the translated content in the translation language using the linking between the content and the translated content.
摘要翻译：用于电子学习平台的内容的多语言翻译涉及以翻译语言接收翻译的内容的系统和方法，其中所述翻译的内容基于源语言的内容生成; 将源语言中的内容与翻译语言中的翻译内容相链接; 接收源语言内容的更新; 以及使用所述内容和所翻译的内容之间的链接来接收对所述翻译语言的翻译内容的相应更新。

2. 发明授权

US09336382B2 Systems, methods, and apparatus for securing user documents 有权
公开(公告)号：US09336382B2
公开(公告)日：2016-05-10
申请号：US13156045
申请日：2011-06-08
申请人： Brian John Cepuran , Daryl McMillan , David Lockhart , Dariusz Grabka
发明人： Brian John Cepuran , Daryl McMillan , David Lockhart , Dariusz Grabka
IPC分类号： H04L29/06 , G06F21/51
摘要： The invention is directed to systems, methods and apparatus for securing documents. The system comprises a server having a processor and a data storage device for storing documents, at least one document provider connected to the server, the at least one document provider operable to provide user documents to the server for storage in the data storage device, the user documents containing at least one object of security concern, and at least one document consumer connected to the server, the at least one document consumer operable to receive the user documents containing the at least one object of security concern from the server. The processor in the server is operable to determine whether to provide the at least one object of security concern to the at least one document consumer based on at least one security setting, and based on the decision either provide the documents with the at least one object of security concern or provide a replacement documents without the security of concern and an indication on each replacement document that that the at least one object of security concern has been excluded.

3. 发明授权

US09465935B2 Systems, methods, and apparatus for securing user documents 有权
标题翻译：用于保护用户文档的系统，方法和设备
公开(公告)号：US09465935B2
公开(公告)日：2016-10-11
申请号：US13156045
申请日：2011-06-08
申请人： Brian John Cepuran , Daryl McMillan , David Lockhart , Dariusz Grabka
发明人： Brian John Cepuran , Daryl McMillan , David Lockhart , Dariusz Grabka
IPC分类号： H04L29/06 , G06F21/51
CPC分类号： G06F21/51 , G06F2221/2119 , G06F2221/2149 , H04L63/101 , H04L63/102 , H04L63/145
摘要： The invention is directed to systems, methods and apparatus for securing documents. The system comprises a server having a processor and a data storage device for storing documents, at least one document provider connected to the server, the at least one document provider operable to provide user documents to the server for storage in the data storage device, the user documents containing at least one object of security concern, and at least one document consumer connected to the server, the at least one document consumer operable to receive the user documents containing the at least one object of security concern from the server. The processor in the server is operable to determine whether to provide the at least one object of security concern to the at least one document consumer based on at least one security setting, and based on the decision either provide the documents with the at least one object of security concern or provide a replacement documents without the security of concern and an indication on each replacement document that that the at least one object of security concern has been excluded.
摘要翻译：本发明涉及用于保护文件的系统，方法和装置。该系统包括具有处理器和用于存储文档的数据存储设备的服务器，连接到服务器的至少一个文档提供者，所述至少一个文档提供器可操作以向服务器提供用于存储在数据存储设备中的用户文档，包含至少一个安全关注对象的用户文档和连接到服务器的至少一个文档使用者，所述至少一个文档消费者可操作以从服务器接收包含至少一个安全关注对象的用户文档。服务器中的处理器可操作以基于至少一个安全设置来确定是否向至少一个文档消费者提供安全关注的至少一个对象，并且基于该决定向文档提供至少一个对象或提供替换文件，而不需要担心的安全性，以及每个替换文件的说明，表明至少有一个安全性关注对象被排除在外。

4. 发明申请

US20110307960A1 SYSTEMS, METHODS, AND APPARATUS FOR SECURING USER DOCUMENTS 有权
标题翻译：用于保护用户文档的系统，方法和设备
公开(公告)号：US20110307960A1
公开(公告)日：2011-12-15
申请号：US13156045
申请日：2011-06-08
申请人： Brian John Cepuran , Daryl McMillan , David Lockhart , Dariusz Grabka
发明人： Brian John Cepuran , Daryl McMillan , David Lockhart , Dariusz Grabka
IPC分类号： G06F21/00
CPC分类号： G06F21/51 , G06F2221/2119 , G06F2221/2149 , H04L63/101 , H04L63/102 , H04L63/145
摘要： The invention is directed to systems, methods and apparatus for securing documents. The system comprises a server having a processor and a data storage device for storing documents, at least one document provider connected to the server, the at least one document provider operable to provide user documents to the server for storage in the data storage device, the user documents containing at least one object of security concern, and at least one document consumer connected to the server, the at least one document consumer operable to receive the user documents containing the at least one object of security concern from the server. The processor in the server is operable to determine whether to provide the at least one object of security concern to the at least one document consumer based on at least one security setting, and based on the decision either provide the documents with the at least one object of security concern or provide a replacement documents without the security of concern and an indication on each replacement document that that the at least one object of security concern has been excluded.
摘要翻译：本发明涉及用于保护文件的系统，方法和装置。该系统包括具有处理器和用于存储文档的数据存储设备的服务器，连接到服务器的至少一个文档提供者，所述至少一个文档提供器可操作以向服务器提供用于存储在数据存储设备中的用户文档，包含至少一个安全关注对象的用户文档和连接到服务器的至少一个文档使用者，所述至少一个文档消费者可操作以从服务器接收包含至少一个安全关注对象的用户文档。服务器中的处理器可操作以基于至少一个安全设置来确定是否向至少一个文档消费者提供安全关注的至少一个对象，并且基于该决定向文档提供至少一个对象或提供替换文件，而不需要担心的安全性，以及每个替换文件的说明，表明至少有一个安全性关注对象被排除在外。

5. 发明申请

US20100196279A1 TREATMENT OF GAUCHER DISEASE WITH SPECIFIC PHARMACOLOGICAL CHAPERONES AND MONITORING TREATMENT USING SURROGATE MARKERS 失效
标题翻译：用特定的药物治疗方法治疗高血压病和使用现代标记物进行监测治疗
公开(公告)号：US20100196279A1
公开(公告)日：2010-08-05
申请号：US12595071
申请日：2008-04-11
申请人： David Lockhart
发明人： David Lockhart
IPC分类号： A61K49/00 , A61P43/00
CPC分类号： G01N33/92 , G01N2405/10 , G01N2800/52
摘要： Provided is a method of monitoring the treatment of Gaucher disease with specific pharmacological chaperones using systemic and/or cellular surrogate markers. Also provided is a new biomarker that may be used to monitor the progress of such treatment.
摘要翻译：提供了使用全身和/或细胞代谢标记物来监测具有特定药物伴侣的戈谢病治疗的方法。还提供了可用于监测这种治疗进展的新生物标志物。

6. 发明申请

US20050202500A1 Expression monitoring to high density oligonucleotide arrays 审中-公开
标题翻译：对高密度寡核苷酸阵列的表达监测
公开(公告)号：US20050202500A1
公开(公告)日：2005-09-15
申请号：US11118974
申请日：2005-04-28
申请人： David Lockhart , Eugene Brown , Gordon Wong , Mark Chee , Thomas Gingeras
发明人： David Lockhart , Eugene Brown , Gordon Wong , Mark Chee , Thomas Gingeras
IPC分类号： G01N33/53 , C12N15/09 , C12Q1/68 , G01N15/14 , G01N37/00 , C12P19/34 , G01N33/48 , G01N33/50 , G06F19/00
CPC分类号： C12Q1/6809 , C12Q1/6837 , G01N15/1475 , C12Q2565/507
摘要： This invention provides methods of monitoring the expression levels of a multiplicity of genes. The methods involve hybridizing a nucleic acid sample to a high density array of oligonucleotide probes where the high density array contains oligonucleotide probes complementary to subsequences of target nucleic acids in the nucleic acid sample. In one embodiment, the method involves providing a pool of target nucleic acids comprising RNA transcripts of one or more target genes, or nucleic acids derived from the RNA transcripts, hybridizing said pool of nucleic acids to an array of oligonucleotide probes immobilized on surface, where the array comprising more than 100 different oligonucleotides and each different oligonucleotide is localized in a predetermined region of the surface, the density of the different oligonucleotides is greater than about 60 different oligonucleotides per 1 cm2, and the olignucleotide probes are complementary to the RNA transcripts or nucleic acids derived from the RNA transcripts; and quantifying the hybridized nucleic acids in the array.
摘要翻译：本发明提供监测多种基因的表达水平的方法。所述方法包括将核酸样品与寡核苷酸探针的高密度阵列杂交，其中高密度阵列含有与核酸样品中靶核酸的子序列互补的寡核苷酸探针。在一个实施方案中，所述方法包括提供包含一个或多个靶基因的RNA转录物或衍生自RNA转录物的核酸的靶核酸库，将所述核酸库与固定在表面上的寡核苷酸探针阵列杂交，其中包含超过100种不同寡核苷酸的阵列和每种不同的寡核苷酸定位在表面的预定区域中，不同寡核苷酸的密度大于每1cm 2大约60个不同的寡核苷酸，并且寡核苷酸探针与衍生自RNA转录物的RNA转录物或核酸互补; 并量化阵列中的杂交核酸。

7. 发明申请

US20050158744A1 Surface-bound, unimolecular, double-stranded DNA 审中-公开
标题翻译：表面结合，单分子，双链DNA
公开(公告)号：US20050158744A1
公开(公告)日：2005-07-21
申请号：US10995043
申请日：2004-11-19
申请人： David Lockhart , Dirk Vetter , Martin Diggelmann
发明人： David Lockhart , Dirk Vetter , Martin Diggelmann
IPC分类号： B01J19/00 , C07B61/00 , C07H21/00 , C07K7/06 , C12N15/10 , C12Q1/68 , C12Q1/6811 , C12Q1/6837 , C40B40/06 , G01N33/53 , G01N33/551 , C07H21/02 , A61K48/00
CPC分类号： C12N15/1093 , B01J19/0046 , B01J2219/00529 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00626 , B01J2219/00635 , B01J2219/00637 , B01J2219/00659 , B01J2219/00722 , C07B2200/11 , C07H21/00 , C07K7/06 , C12Q1/6811 , C12Q1/6837 , C40B40/00 , C40B40/06 , G01N33/5308 , G01N33/551 , C12Q2565/525 , C12Q2525/205
摘要： Libraries of unimolecular, double-stranded oligonucleotides on a solid support. These libraries are useful in pharmaceutical discovery for the screening of numerous biological samples for specific interactions between the double-stranded oligonucleotides, and peptides, proteins, drugs and RNA. In a related aspect, the present invention provides libraries of conformationally restricted probes on a solid support. The probes are restricted in their movement and flexibility using double-stranded oligonucleotides as scaffolding. The probes are also useful in various screening procedures associated with drug discovery and diagnosis. The present invention further provides methods for the preparation and screening of the above libraries.
摘要翻译：固体支持物上单分子双链寡核苷酸的文库。这些文库在药物发现中可用于筛选许多生物样品，用于双链寡核苷酸与肽，蛋白质，药物和RNA之间的特异性相互作用。在相关方面，本发明提供了在固体支持物上的构象限制探针的文库。使用双链寡核苷酸作为脚手架，探针的运动和灵活性受到限制。探针也可用于与药物发现和诊断相关的各种筛选程序。本发明还提供了制备和筛选上述文库的方法。

8. 发明授权

US06705754B2 Device and methods for mixing fluids 有权
标题翻译：混合流体的装置和方法
公开(公告)号：US06705754B2
公开(公告)日：2004-03-16
申请号：US10062431
申请日：2002-01-30
申请人： James L. Winkler , Mark Chee , David Lockhart
发明人： James L. Winkler , Mark Chee , David Lockhart
IPC分类号： B01F1100
CPC分类号： B01J19/28 , B01F9/0021 , B01J2219/00488 , B01J2219/00529 , B01J2219/00596 , B01J2219/00608 , B01J2219/00659 , B01J2219/00722 , C40B40/06 , C40B60/14 , Y10S435/809
摘要： The invention provides exemplary devices, systems and methods for mixing of fluids, such as biological fluids. One exemplary device comprises is particularly adapted for holding at least one cartridge having a chamber containing a biological fluid, with the chamber having a generally planar face. The device comprises a rotatable body having a rotational axis. The rotatable body includes at least one mounting element which is adapted to mount the rotatable body such that the face of the chamber is generally perpendicular to the rotational axis.
摘要翻译：本发明提供了用于混合流体例如生物流体的示例性装置，系统和方法。一个示例性装置包括特别适用于保持具有包含生物流体的腔室的至少一个筒，该腔室具有大致平坦的面。该装置包括具有旋转轴线的可转动体。可旋转主体包括至少一个安装元件，该安装元件适于安装可旋转主体，使得腔室的表面大致垂直于旋转轴线。

9. 发明授权

US06203989B1 Methods and compositions for amplifying detectable signals in specific binding assays 有权
公开(公告)号：US06203989B1
公开(公告)日：2001-03-20
申请号：US09276774
申请日：1999-03-25
申请人： Martin J. Goldberg , Govinda Rao S. Yelagalawadi , Eugene Yuji Tanimoto , Huu Minh Tran , Helin Dong , David Lockhart , Thomas B. Ryder , Janet A. Warrington , Jody Beecher
发明人： Martin J. Goldberg , Govinda Rao S. Yelagalawadi , Eugene Yuji Tanimoto , Huu Minh Tran , Helin Dong , David Lockhart , Thomas B. Ryder , Janet A. Warrington , Jody Beecher
IPC分类号： C12Q168
CPC分类号： C12Q1/682 , C12Q1/6804 , Y10S436/807 , C12Q2565/501 , C12Q2563/131 , C12Q2527/125 , C12Q2563/107 , C12Q2563/125 , C12Q2563/143 , C12Q2537/125
摘要： Methods and compounds are provided for detecting target molecules in a sample using specific binding assays. In particular, methods are provided for detecting a nucleic acid target in a sample. In one embodiment, the method comprises hybridizing a nucleic acid target, comprising a target nucleic acid sequence, to a nucleic acid probe, comprising a probe nucleic acid sequence, wherein the target comprises a binding ligand. The hydridized target is contacted with a receptor comprising multiple sites capable of binding the binding ligand to complex the receptor to the binding ligand, and the receptor is contacted with an amplification reagent, comprising a plurality of the binding ligands, to complex the amplification reagent to the receptor. The presence of the complexed amplification reagent then is detected, for example, by detecting the presence of a detectable label, such as a fluorescent label, for example, on the receptor or the amplification reagent. Optionally, the amplification reagent, comprising a plurality of the binding ligands, is contacted with labeled receptor molecules thereby to complex a plurality of labeled receptor molecules to the amplification reagent, and the labeled receptor molecules complexed to the amplification reagent are detected. This permits the detectable signal to be enhanced and amplified. In one embodiment, the binding ligand is biotin, the receptor is streptavidin, and the amplification reagent is an antibody or a DNA matrix. In another embodiment, an array of different nucleic acid probes immobilized on a surface, each having a defined sequence and location on the surface, may be used in the assays, thus permitting screening and detection of binding of a large number of nucleic acids.

10. 发明授权

US07851143B2 Assays for diagnosing and evaluating treatment options for Fabry disease 有权
标题翻译：用于诊断和评估法布里病治疗选择的方法
公开(公告)号：US07851143B2
公开(公告)日：2010-12-14
申请号：US11749512
申请日：2007-05-16
申请人： Christine Kaneski , Sang-Hoon Shin , Gary Murray , Karin Ludwig , David Lockhart , Jeff Castelli
发明人： Christine Kaneski , Sang-Hoon Shin , Gary Murray , Karin Ludwig , David Lockhart , Jeff Castelli
IPC分类号： C12Q1/00 , C12Q1/02 , C12Q1/34
CPC分类号： A61K31/445 , A61K9/0053 , A61K9/48 , A61K31/45 , A61K45/06 , C07D211/46 , G01N33/5094 , G01N2333/924 , G01N2333/94 , G01N2800/04 , G01N2800/52 , A61K2300/00
摘要： Provided are in vitro and in vivo methods for determining whether a patient with Fabry disease will respond to treatment with a specific pharmacological chaperone.
摘要翻译：提供了用于确定法布里病患者是否将以特定药物伴侣的治疗反应的体外和体内方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式