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1. 发明授权

US4140779A Aryloxy propyldiamines 失效
标题翻译：丙烯酰氧基丙基二胺
公开(公告)号：US4140779A
公开(公告)日：1979-02-20
申请号：US687850
申请日：1976-05-19
申请人： Jean-Marie Ferland , Real R. Laliberte , Wilbur Lippmann , Thomas A. Pugsley
发明人： Jean-Marie Ferland , Real R. Laliberte , Wilbur Lippmann , Thomas A. Pugsley
IPC分类号： C07D295/092 , C07D295/13 , C07D295/12 , A61K31/455
CPC分类号： C07D295/088 , C07D295/13
摘要： Disclosed herein are compounds of the formula ##STR1## in which Ar is l-naphthyl; R.sup.1 and R.sup.2 are either the same or different selected from the group consisting of hydrogen or lower alkyl, or R.sup.1 and R.sup.2 together with the nitrogen atom to which they are joined form a heterocyclic amine radical selected from the group consisting of 1-pyrrolidinyl, piperidine, morpholine and 4-(lower alkyl)-1-piperazinyl; and R.sup.3 and R.sup.4 are either the same or different selected from the group consisting of hydrogen or lower alkyl, or R.sup.3 and R.sup.4 together with the nitrogen to which they are joined represent a heterocyclic amine radical selected from the group consisting of 1-pyrrolidinyl, piperidino, morpholino and 4-(lower alkyl)-1-piperazinyl; or a therapeutically acceptable acid addition salt thereof. The compounds are antidepressant agents and methods for their preparation and use also are disclosed.
摘要翻译：本文公开的是其中Ar是1-萘基的式“IMAGE”1的化合物; R 1和R 2可以相同或不同，选自氢或低级烷基，或者R 1和R 2与它们所连接的氮原子一起形成杂环胺基，其选自1-吡咯烷基，哌啶，吗啉和4-（低级烷基）-1-哌嗪基; 并且R 3和R 4可以相同或不同，选自氢或低级烷基，或者R 3和R 4与它们所连接的氮一起代表杂环胺基，其选自1-吡咯烷基，哌啶子基，吗啉代和4-（低级烷基）-1-哌嗪基; 或其治疗上可接受的酸加成盐。这些化合物是抗抑郁剂，并且也公开了它们的制备和使用方法。

2. 发明授权

US4118511A Aryloxy aminobutanols for alleviating symptoms of depression 失效
标题翻译：用于缓解抑郁症状的芳氧基氨基丁醇
公开(公告)号：US4118511A
公开(公告)日：1978-10-03
申请号：US852657
申请日：1977-11-18
申请人： Jean-Marie Ferland , Real Laliberte , Wilbur Lippmann , Thomas A. Pugsley
发明人： Jean-Marie Ferland , Real Laliberte , Wilbur Lippmann , Thomas A. Pugsley
IPC分类号： A61K31/135 , C07C233/16
CPC分类号： A61K31/135 , C07C233/16
摘要： Disclosed herein are compounds of the formula ##STR1## in which Ar is phenyl or 1-naphthyl; R.sup.1 is hydrogen or lower alkyl; and R.sup.2 and R.sup.3 are either the same or different selected from the group consisting of hydrogen or lower alkyl; with the proviso that when R.sup.1 is lower alkyl then R.sup.2 is the same lower alkyl. The compounds are antidepressant agents and methods for their preparation and use also are disclosed.
摘要翻译：本文公开的是式“IMAGE”的化合物，其中Ar是苯基或1-萘基; R1是氢或低级烷基; 并且R 2和R 3可以相同或不同，选自氢或低级烷基; 条件是当R 1为低级烷基时，则R 2为相同的低级烷基。这些化合物是抗抑郁剂，并且也公开了它们的制备和使用方法。

3. 发明授权

US4060613A 3-Aryloxy-2(4-loweralkyl-1-piperazinyl)propanols, their alkylethers, and use thereof 失效
标题翻译： 3-芳氧基-2（4-低级烷基-1-哌嗪基）丙醇，其烷基醚及其用途
公开(公告)号：US4060613A
公开(公告)日：1977-11-29
申请号：US687851
申请日：1976-05-19
申请人： Jean-Marie Ferland , Real Laliberte , Wilbur Lippmann , Thomas A. Pugsley
发明人： Jean-Marie Ferland , Real Laliberte , Wilbur Lippmann , Thomas A. Pugsley
IPC分类号： C07D295/092 , C07D295/13 , A61K31/495 , C07D241/04
CPC分类号： C07D295/088 , C07D295/13
摘要： Disclosed herein are compounds of the formula ##STR1## in which Ar is phenyl or 1-naphthyl; R.sup.1 is hydrogen or lower alkyl; and R.sup.2 and R.sup.3 together with the nitrogen atom to which they are joined form a hyterocyclic amine radical selected from the group consisting of 1-pyrrolidinyl, piperidino, morpholino and 4-(lower alkyl)-1-piperazinyl. The compounds are antidepressant agents and methods for their preparation and use also are disclosed.
摘要翻译：本文公开的是式“IMAGE”的化合物，其中Ar是苯基或1-萘基; R1是氢或低级烷基; 和R2和R3与它们所连接的氮原子一起形成选自1-吡咯烷基，哌啶子基，吗啉代和4-（低级烷基）-1-哌嗪基的杂环胺基。这些化合物是抗抑郁剂，并且也公开了它们的制备和使用方法。

4. 发明授权

US4170653A Antidepressant naphthyloxy piperidino and pyrrolidino propanol ethers 失效
标题翻译：抗抑郁萘环氧基哌啶子基和吡咯烷子基丙醇醚
公开(公告)号：US4170653A
公开(公告)日：1979-10-09
申请号：US829769
申请日：1977-09-01
申请人： Jean-Marie Ferland , Real Laliberte , Wilbur Lippmann , Thomas A. Pugsley
发明人： Jean-Marie Ferland , Real Laliberte , Wilbur Lippmann , Thomas A. Pugsley
IPC分类号： C07D295/092 , C07D295/13 , A61K31/445 , C07D211/14
CPC分类号： C07D295/088 , C07D295/13
摘要： Disclosed herein are compounds of the formula ##STR1## in which Ar is phenyl or 1-naphthyl; R.sup.1 is hydrogen or lower alkyl; and R.sup.2 and R.sup.3 together with the nitrogen atom to which they are joined form a heterocyclic amine radical selected from the group consisting of 1-pyrrolidinyl, piperidino, morpholino and 4-(lower alkyl)-1-piperazinyl. The compounds are antidepressant agents and methods for their preparation and use also are disclosed.
摘要翻译：本文公开的是式“IMAGE”的化合物，其中Ar是苯基或1-萘基; R1是氢或低级烷基; 和R2和R3与它们所连接的氮原子一起形成选自1-吡咯烷基，哌啶子基，吗啉代和4-（低级烷基）-1-哌嗪基的杂环胺基。这些化合物是抗抑郁剂，并且也公开了它们的制备和使用方法。

5. 发明授权

US4071552A Aryloxy aminobutanols, their preparation and use thereof 失效
标题翻译：芳氧基氨基丁醇，其制备和用途
公开(公告)号：US4071552A
公开(公告)日：1978-01-31
申请号：US687852
申请日：1976-05-19
申请人： Jean-Marie Ferland , Real Laliberte , Wilbur Lippmann , Thomas A. Pugsley
发明人： Jean-Marie Ferland , Real Laliberte , Wilbur Lippmann , Thomas A. Pugsley
IPC分类号： A61K31/135 , C07C233/16 , C07C91/16 , C07C93/18
CPC分类号： A61K31/135 , C07C233/16
摘要： Disclosed herein are compounds of the formula ##STR1## in which Ar is phenyl or 1-naphthyl; R.sup.1 is hydrogen or lower alkyl; and R.sup.2 and R.sup.3 are either the same or different selected from the group consisting of hydrogen or lower alkyl; with the proviso that when R.sup.1 is lower alkyl then R.sup.2 is the same lower alkyl. The compounds are antidepressant agents and methods for their preparation and use also are disclosed.
摘要翻译：本文公开的是式“IMAGE”的化合物，其中Ar是苯基或1-萘基; R1是氢或低级烷基; 并且R 2和R 3可以相同或不同，选自氢或低级烷基; 条件是当R 1为低级烷基时，则R 2为相同的低级烷基。这些化合物是抗抑郁剂，并且也公开了它们的制备和使用方法。

6. 发明授权

US4131745A Aryloxy aminobutanols, their preparation and use thereof 失效
公开(公告)号：US4131745A
公开(公告)日：1978-12-26
申请号：US852656
申请日：1977-11-18
申请人： Jean-Marie Ferland , Real Laliberte , Wilbur Lippman , Thomas A. Pugsley
发明人： Jean-Marie Ferland , Real Laliberte , Wilbur Lippman , Thomas A. Pugsley
IPC分类号： A61K31/135 , C07C233/16 , C07C103/38
CPC分类号： A61K31/135 , C07C233/16
摘要： Disclosed herein are compounds of the formula ##STR1## in which Ar is phenyl or 1-naphthyl; R.sup.1 is hydrogen or lower alkyl; and R.sup.2 and R.sup.3 are either the same or different selected from the group consisting of hydrogen or lower alkyl; with the proviso that when R.sup.1 is lower alkyl then R.sup.2 is the same lower alkyl. The compounds are antidepressant agents and methods for their preparation and use also are disclosed.

7. 发明授权

US5338744A Angiotensin II antagonists used to treat reproductive functions associated with AT.sub.2 receptors 失效
标题翻译：血管紧张素II拮抗剂用于治疗与AT2受体相关的生殖功能
公开(公告)号：US5338744A
公开(公告)日：1994-08-16
申请号：US932167
申请日：1992-08-19
申请人： David T. Dudley , John C. Hodges , Thomas A. Pugsley , Michael D. Taylor
发明人： David T. Dudley , John C. Hodges , Thomas A. Pugsley , Michael D. Taylor
IPC分类号： A61K31/435 , A61K31/437 , A61K31/44 , A61K45/00 , A61K51/00 , A61K51/04 , A61P13/12 , A61P25/00 , A61P25/22 , A61P25/24 , A61P43/00 , C07D471/04 , A61K31/415 , A61K31/34
CPC分类号： A61K31/44 , A61K51/0455 , A61K2121/00 , Y10S514/841
摘要： The present invention relates to the use of 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acids and analogs thereof in antagonizing the binding of angiotensin II to AT.sub.2 receptors.
摘要翻译：本发明涉及4,5,6,7-四氢-1H-咪唑并[4,5-c]吡啶-6-羧酸及其类似物在拮抗血管紧张素II与AT2受体的结合中的用途。

8. 发明授权

US5977110A Substituted cyclohexylamines as central nervous systems agents 失效
标题翻译：取代的环己胺作为中枢神经系统药剂
公开(公告)号：US5977110A
公开(公告)日：1999-11-02
申请号：US43331
申请日：1998-03-20
申请人： Thomas R. Belliotti , Suzanne R. Kesten , Thomas A. Pugsley , David J. Wustrow
发明人： Thomas R. Belliotti , Suzanne R. Kesten , Thomas A. Pugsley , David J. Wustrow
IPC分类号： C07D213/74 , C07D235/30 , C07D239/42 , C07D239/46 , C07D239/94 , C07D241/20 , C07D277/38 , C07D277/42 , C07D277/82 , C07D401/12 , C07D403/12 , C07D417/12 , A61K31/505 , A61K31/495 , C07D403/02 , C07D403/14 , C07D417/02 , C07D417/14
CPC分类号： C07D213/74 , C07D235/30 , C07D239/42 , C07D239/47 , C07D239/94 , C07D241/20 , C07D277/42 , C07D277/82 , C07D401/12 , C07D403/12 , C07D417/12
摘要： Substituted cyclohexylamines and derivatives thereof are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful as dopaminergic, serotonergic, antipsychotic, and anxiolytic agents.
摘要翻译： PCT No.PCT / US96 / 13687第 371日期：1998年3月20日 102（e）1998年3月20日PCT PCT 1996年8月23日PCT公布。出版物WO97 / 11070 日期1997年3月27日描述了取代的环己胺及其衍生物，以及其制备方法及其药物组合物，其可用作中枢神经系统试剂，并且特别可用作多巴胺能，5-羟色胺能，抗精神病药和抗焦虑剂。

9. 发明授权

US5444069A Imidazo-pyridine angiotensin II antagonists used to treat memory loss 失效
标题翻译：咪唑吡啶血管紧张素II拮抗剂用于治疗记忆丧失
公开(公告)号：US5444069A
公开(公告)日：1995-08-22
申请号：US227223
申请日：1994-04-13
申请人： David T. Dudley , John C. Hodges , Thomas A. Pugsley , Michael D. Taylor
发明人： David T. Dudley , John C. Hodges , Thomas A. Pugsley , Michael D. Taylor
IPC分类号： A61K31/435 , A61K31/437 , A61K31/44 , A61K45/00 , A61K51/00 , A61K51/04 , A61P13/12 , A61P25/00 , A61P25/22 , A61P25/24 , A61P43/00 , C07D471/04 , A61K31/415 , A61K31/34
CPC分类号： A61K31/44 , A61K51/0455 , A61K2121/00 , Y10S514/841
摘要： The present invention relates to the use of 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acids and analogs thereof in antagonizing the binding of angiotensin II to AT.sub.2 receptors to treat memory loss.
摘要翻译：本发明涉及4,5,6,7-四氢-1H-咪唑并[4,5-c]吡啶-6-羧酸及其类似物在拮抗血管紧张素II与AT2受体结合治疗记忆中的用途失利。

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