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1. 发明授权

US08603502B2 Compositions comprising jasmonic acid derivatives and use of these derivatives 有权
标题翻译：包含茉莉酸衍生物的组合物和这些衍生物的用途
公开(公告)号：US08603502B2
公开(公告)日：2013-12-10
申请号：US10356551
申请日：2003-02-03
申请人： Christophe Boulle , Maria Dalko , Jean-Luc Leveque , Lucie Simonetti
发明人： Christophe Boulle , Maria Dalko , Jean-Luc Leveque , Lucie Simonetti
IPC分类号： A61K31/557
CPC分类号： C07C69/732 , A61K8/345 , A61K8/365 , A61K8/44 , A61Q1/02 , A61Q5/00 , A61Q19/00 , A61Q19/08 , C07C35/06 , C07C59/11 , C07C59/46 , C07C69/675 , C07C2601/08
摘要： Cosmetic or pharmaceutical compositions comprising compounds of formula (I) and the corresponding salts thereof: wherein: R1 is a radical chosen from —COOR′, —CONR′R″, —CH2OR′, —COR′, —CH2R′, —SO2OR′, —PO3R′R″ and —NHR′, wherein R′ and R″, which may be identical or different, are defined herein; R2 is chosen from saturated and unsaturated, linear, branched and cyclic hydrocarbon radicals comprising from 1 to 18 carbon atoms which are optionally substituted by from 1 to 5 identical or different entities chosen from —OR′″, —OCOR′″, —SR′″, —SCOR′″, NR′″R″″, —NHCOR′″, halogen, —CN, —COOR′″ and —COR′″, wherein R′″ and R″″, which may be identical or different, are defined herein, as well as the use of these compounds, for example, to promote skin desquamation, to stimulate epidermal renewal and/or to combat the signs of skin ageing.
摘要翻译：包含式（I）化合物及其相应盐的化妆品或药物组合物：其中：R1为选自-COOR'，-CONR'R“，-CHOOR'，-COR'，-CH2R'，-SO2OR的基团 '，-PO 3 R'R“和-NHR'，其中R'和R”可以相同或不同，在本文中定义; R 2选自包含1至18个碳原子的饱和和不饱和的，直链的，支链的和环状的烃基，其任选被1-5个相同或不同的选自-OR“，-OCOR” - ， - SR“'，-SCOR''，NR”'R“'， - NHCOR''，卤素，-CN，-COOR”和-COR“，其中R”'和 R“”可以相同或不同，并且这些化合物的用途，例如促进皮肤脱屑，刺激表皮更新和/或抵抗皮肤老化的迹象。

2. 发明申请

US20100179222A1 COMPOSITIONS COMPRISING JASMONIC ACID DERIVATIVES AND USE OF THESE DERIVATIVES 有权
标题翻译：包含苹果酸衍生物的组合物和这些衍生物的使用
公开(公告)号：US20100179222A1
公开(公告)日：2010-07-15
申请号：US12728580
申请日：2010-03-22
申请人： Christophe Boulle , Maria Dalko , Jean-Luc Leveque , Lucie Simonetti
发明人： Christophe Boulle , Maria Dalko , Jean-Luc Leveque , Lucie Simonetti
IPC分类号： A61K8/36 , A61K8/34 , A61Q19/08 , A61Q19/00
CPC分类号： C07C69/732 , A61K8/345 , A61K8/365 , A61K8/44 , A61Q1/02 , A61Q5/00 , A61Q19/00 , A61Q19/08 , C07C35/06 , C07C59/11 , C07C59/46 , C07C69/675 , C07C2601/08
摘要： Cosmetic or pharmaceutical compositions comprising compounds of formula (I) and the corresponding salts thereof: wherein: R1 is a radical chosen from —COOR′, —CONR′R″, —CH2OR′, —COR′, —CH2R′, —SO2OR′, —PO3R′R″ and —NHR′, wherein R′ and R″, which may be identical or different, are defined herein; R2 is chosen from saturated and unsaturated, linear, branched and cyclic hydrocarbon radicals comprising from 1 to 18 carbon atoms which are optionally substituted by from 1 to 5 identical or different entities chosen from —OR′″, —OCOR′″, —SR′″, —SCOR′″, NR′″R″″, —NHCOR′″, halogen, —CN, —COOR′″ and —COR′″, wherein R′″ and R″″, which may be identical or different, are defined herein; as well as the use of these compounds, for example, to promote skin desquamation, to stimulate epidermal renewal and/or to combat the signs of skin ageing.
摘要翻译：包含式（I）化合物及其相应盐的化妆品或药物组合物：其中：R1是选自-COOR'，-CONR'R“，-CHOOR'，-COR'， - CH 2 R'， - SO 2 OR' ，-PO3R'R“和-NHR'，其中R'和R”可以相同或不同，在本文中定义; R2选自包含1至18个碳原子的饱和和不饱和，直链，支链和环状烃基，其任选被1至5个选自-OR'，-OCOR'“，-SR'的相同或不同的实体取代， “，-SCOR'”，NR“R”“，-NHCOR”，卤素，-CN，-COOR'和-COR'“，其中R'”和R“”可以相同或不同，在本文中定义; 以及这些化合物的使用，例如，促进皮肤脱屑，刺激表皮更新和/或抵抗皮肤老化的迹象。

3. 发明授权

US08609117B2 Compositions comprising jasmonic acid derivatives and use of the derivatives 有权
标题翻译：包含茉莉酸衍生物的组合物和衍生物的用途
公开(公告)号：US08609117B2
公开(公告)日：2013-12-17
申请号：US12728580
申请日：2010-03-22
申请人： Christophe Boulle , Maria Dalko , Jean-Luc Leveque , Lucie Simonetti
发明人： Christophe Boulle , Maria Dalko , Jean-Luc Leveque , Lucie Simonetti
IPC分类号： A61K31/557
CPC分类号： C07C69/732 , A61K8/345 , A61K8/365 , A61K8/44 , A61Q1/02 , A61Q5/00 , A61Q19/00 , A61Q19/08 , C07C35/06 , C07C59/11 , C07C59/46 , C07C69/675 , C07C2601/08
摘要： Cosmetic or pharmaceutical compositions comprising compounds of formula (I) and the corresponding salts thereof: wherein: R1 is a radical chosen from —COOR′, —CONR′R″, —CH2OR′, —COR′, —CH2R′, —SO2OR′, —PO3R′R″ and —NHR′, wherein R′ and R″, which may be identical or different, are defined herein; —R2 is chosen from saturated and unsaturated, linear, branched and cyclic hydrocarbon radicals comprising from 1 to 18 carbon atoms which are optionally substituted by from 1 to 5 identical or different entities chosen from —OR′″, —OCOR′″, —SR′″, —SCOR′″, NR′″R″″, —NHCOR′″, halogen, —CN, —COOR′″ and —COR′″, wherein R′″ and R″″, which may be identical or different, are defined herein; as well as the use of these compounds, for example, to promote skin desquamation, to stimulate epidermal renewal and/or to combat the signs of skin ageing.
摘要翻译：包含式（I）化合物及其相应盐的化妆品或药物组合物：其中：R1是选自-COOR'，-CONR'R“，-CHOOR'，-COR'，-CH2R'，-SO2OR的基团 '，-PO 3 R'R“和-NHR'，其中R'和R”可以相同或不同，在本文中定义; -R2选自包含1至18个碳原子的饱和和不饱和，直链，支链和环状烃基，其任选被1至5个选自-OR“，-OCOR”，“ -SR“'，-SCOR”，NR“'R”'， - NHCOR''，卤素，-CN，-COOR“和-COR”'，其中R“ 和R“'可以相同或不同，在本文中定义; 以及这些化合物的使用，例如，促进皮肤脱屑，刺激表皮更新和/或抵抗皮肤老化的迹象。

4. 发明授权

US08481594B2 Compositions comprising jasmonic acid derivatives and use of these derivatives 有权
标题翻译：包含茉莉酸衍生物的组合物和这些衍生物的用途
公开(公告)号：US08481594B2
公开(公告)日：2013-07-09
申请号：US12406570
申请日：2009-03-18
申请人： Christophe Boulle , Maria Dalko , Jean-Luc Leveque , Lucie Simonetti
发明人： Christophe Boulle , Maria Dalko , Jean-Luc Leveque , Lucie Simonetti
IPC分类号： A61K31/122 , A61K31/60
CPC分类号： C07C69/732 , A61K8/345 , A61K8/365 , A61K8/44 , A61Q1/02 , A61Q5/00 , A61Q19/00 , A61Q19/08 , C07C35/06 , C07C59/11 , C07C59/46 , C07C69/675 , C07C2601/08
摘要： Cosmetic or pharmaceutical compositions comprising compounds of formula (I) and the corresponding salts thereof: wherein: R1 is a radical chosen from —COOR′, —CONR′R″, —CH2OR′, —COR′, —CH2R′, —SO2OR′, —PO3R′R″ and —NHR′, wherein R′ and R″, which may be identical or different, are defined herein;R2 is chosen from saturated and unsaturated, linear, branched and cyclic hydrocarbon radicals comprising from 1 to 18 carbon atoms which are optionally substituted by from 1 to 5 identical or different entities chosen from —OR′″, —OCOR′″, —SCOR′″, NR′″R″″, —NHCOR′″, halogen, —CN, —COOR′″ and —COR′″, wherein R′″ and R″″, which may be identical or different, are defined herein;as well as the use of these compounds, for example, to promote skin desquamation, to stimulate epidermal renewal and/or to combat the signs of skin ageing.
摘要翻译：包含式（I）化合物及其相应盐的化妆品或药物组合物：其中：R1为选自-COOR'，-CONR'R“，-CHOOR'，-COR'，-CH2R'，-SO2OR的基团 '，-PO 3 R'R“和-NHR'，其中R'和R”可以相同或不同，在本文中定义; R 2选自包含1至18个碳原子的饱和和不饱和的，直链的，支链的和环状的烃基，其任选被1-5个相同或不同的选自-OR“，-OCOR” - ， - ，“NR”，“R”“，”-NHCOR“，卤素，-CN，-COOR”和-COR“，其中R”'和R“ 其可以相同或不同，在本文中定义; 以及这些化合物的使用，例如，促进皮肤脱屑，刺激表皮更新和/或抵抗皮肤老化的迹象。

5. 发明申请

US20060167102A1 Compositions comprising cyclopentane derivatives and their use 审中-公开
标题翻译：包含环戊烷衍生物的组合物及其用途
公开(公告)号：US20060167102A1
公开(公告)日：2006-07-27
申请号：US11389166
申请日：2006-03-27
申请人： Jean-Luc Leveque , Maria Dalko , Christophe Boulle
发明人： Jean-Luc Leveque , Maria Dalko , Christophe Boulle
IPC分类号： A61K31/557
CPC分类号： A61K8/36 , A61K8/35 , A61K8/37 , A61K2800/28 , A61Q19/00 , A61Q19/08
摘要： Cosmetic or pharmaceutical compositions comprising compounds of formula (I) and the corresponding salts thereof: in which: R1 is a radical chosen from —COOR′, —CONR′R″, —CH2OR′, —COR′, —CH2R′, —SO2OR′, —PO3R′R″ and —NHR′, wherein R′ and R,″ which may be identical or different, are chosen from a hydrogen atom and saturated and unsaturated, linear, branched and cyclic hydrocarbon radicals comprising from 1 to 18 carbon atoms, which are optionally substituted by from 1 to 5 identical or different entities chosen from —OR′″, —OCOR′″, —SR′″, —SCOR′″, NR′″R″″, —NHCOR′″, halogen atoms, —CN, —COOR′″ and —COR′″, wherein R′″ and R″″, which may be identical or different, are chosen from a hydrogen atom, aryl radicals and saturated and unsaturated, linear and branched hydrocarbon radicals comprising from 1 to 4 carbon atoms; R2 is a radical chosen from linear, branched and cyclic hydrocarbon radicals comprising at least one unsaturation and comprising from 2 to 18 carbon atoms, which are optionally substituted by from 1 to 5 identical or different entities chosen from —OR′″, —OCOR′″, —SR′″, —SCOR′″, NR′″R″″, —NHCOR′″, halogen atoms, —CN, —COOR′″ and —COR′″, wherein R′″ and R″″, which may be identical or different, are chosen from a hydrogen atom, aryl radicals and saturated and unsaturated, linear and branched hydrocarbon radicals comprising from 1 to 4 carbon atoms as well as the use of these compounds, for example, to promote skin desquamation, to stimulate epidermal renewal and/or to combat the signs of skin ageing.
摘要翻译：包含式（I）化合物及其相应盐的化妆品或药物组合物：其中：R 1是选自-COOR'，-CONR'R“，-CH” 2 OR'，-COR'，-CH 2 R'，-SO 2 OR'，-PO 3 R' R“和-NHR'，其中可以相同或不同的R'和R”选自氢原子和包含1至18个碳原子的饱和和不饱和，直链，支链和环状烃基，其中任选地被1至5个相同或不同的选自-OR“，-OCOR”'，-SR“'，-SCOR”，NR“'R”'，-NHCOR “，卤素原子，-CN，-COOR”和-COR“，其中R”'和R“'可以相同或不同，选自氢原子，芳基和包含1至4个碳原子的饱和和不饱和的直链和支链烃基; R 2是选自包含至少一个不饱和键并包含2至18个碳原子的直链，支链和环状烃基的基团，其任选被1至5个相同或不同的实体取代，所述实体选自 -OR''，-OCOR''，-SR“'，-SCOR''，NR”'R“'， - NHCOR''，卤素原子，-CN，-COOR” '和-COR''，其中可以相同或不同的R“'和R”'选自氢原子，芳基和饱和和不饱和的直链和支链烃基，其包含1至 4个碳原子以及这些化合物的使用，例如促进皮肤脱屑，刺激表皮更新和/或抵抗皮肤老化的迹象。

6. 发明授权

US08679513B2 Cosmetic use of a jasmonic acid derivative for treating the hair and the scalp 有权
标题翻译：化妆品使用茉莉酸衍生物治疗头发和头皮
公开(公告)号：US08679513B2
公开(公告)日：2014-03-25
申请号：US13382114
申请日：2010-07-01
申请人： Christophe Boulle , Maria Dalko
发明人： Christophe Boulle , Maria Dalko
IPC分类号： A61K8/02
CPC分类号： A61K8/365 , A61Q1/10 , A61Q7/00
摘要： The present invention relates to the cosmetic use of jasmonic acid derivatives of formula (I) in which: R1 represents a radical COOR3, R3 denoting a hydrogen atom or a C1-C4 alkyl radical, optionally substituted with one or more hydroxyl groups; R2 represents a linear saturated or unsaturated hydrocarbon-based radical containing from 1 to 18 carbon atoms, or a branched or cyclic saturated or unsaturated hydrocarbon-based radical containing from 3 to 18 carbon atoms; and also an optical isomer thereof and/or a corresponding salt thereof, in a composition for caring for and/or making up keratin fibers, in particular human keratin fibers, for the purpose of inducing and/or stimulating the growth of the keratin fibers and/or of halting their loss and/or increasing their density.
摘要翻译：本发明涉及式（I）茉莉酸衍生物的化妆品用途，其中：R1代表氢原子或C1-C4烷基的基团COOR3，R3表示任选被一个或多个羟基取代; R2表示含有1至18个碳原子的直链饱和或不饱和烃基，或含有3至18个碳原子的支链或环状饱和或不饱和烃基; 以及用于照顾和/或制备角蛋白纤维，特别是人角蛋白纤维的组合物中的旋光异构体和/或其相应的盐，用于诱导和/或刺激角蛋白纤维的生长，以及 /或停止其损失和/或增加其密度。

7. 发明授权

US07294641B2 Heterocyclic compound for stimulating or inducing the growth of the hair or eyelashes and/or slowing down their loss, composition comprising it and its uses 失效
标题翻译：用于刺激或诱导毛发或睫毛生长和/或减缓其损失的杂环化合物，包含其的组合物及其用途
公开(公告)号：US07294641B2
公开(公告)日：2007-11-13
申请号：US10671508
申请日：2003-09-29
申请人： Christophe Boulle , Roger Rozot , Maria Dalko
发明人： Christophe Boulle , Roger Rozot , Maria Dalko
IPC分类号： A61Q7/00 , A61K8/49 , A61K31/4178 , A61K31/422 , A61K31/427
CPC分类号： C07D417/06 , A61K8/49 , A61K8/4913 , A61K8/4986 , A61K31/427 , A61K35/36 , A61K2800/782 , A61Q7/00 , A61K2300/00
摘要： Heterocyclic compounds useful for stimulating/inducing the growth of keratinous fibers, notably human hair/eyelashes, and/or slowing the loss of same, have the following structural formula (I) or salt thereof: in which Hy is a heterocycle of 4 to 7 atoms, optionally comprising carbonyl/thiocarbonyl functional groups, and G is O, S or NH.
摘要翻译：可用于刺激/诱导角质纤维（特别是人发/睫毛）生长和/或减缓其损失的杂环化合物具有以下结构式（I）或其盐：其中Hy是4至7的杂环原子，任选地包含羰基/硫代羰基官能团，G是O，S或NH。

8. 发明申请

US20070065472A1 Benzyl-1,3-thiazolidine-2,4-dione compounds for stimulating or inducing the growth and/or for reducing the loss of keratin fibers 审中-公开
标题翻译：用于刺激或诱导生长和/或减少角蛋白纤维损失的苄基-1,3-噻唑烷-2,4-二酮化合物
公开(公告)号：US20070065472A1
公开(公告)日：2007-03-22
申请号：US11476053
申请日：2006-06-28
申请人： Christophe Boulle , Maria Dalko
发明人： Christophe Boulle , Maria Dalko
IPC分类号： A61K8/49 , A61K31/426
CPC分类号： A61Q7/00 , A61K8/49 , A61K31/426 , A61Q1/10
摘要： The benzyl-1,3-thiazolidine-2,4-dione compounds having the structural formula (I), or salt and/or solvate thereof; are useful active agents for inducing and/or stimulating the growth of mammalian keratin fibers and/or reducing the loss and/or increasing the density thereof, particularly of human head hair, beard hair, moustache hair, eyelashes and eyebrows, and advantageously are active agents for caring for or making up the hair or the eyelashes.
摘要翻译：具有结构式（I）的苄基-1,3-噻唑烷-2,4-二酮化合物或其盐和/或溶剂合物; 是用于诱导和/或刺激哺乳动物角蛋白纤维生长和/或降低其特别是人头发，胡须毛，胡子毛，睫毛和眉毛的损失和/或增加其密度的有用的活性剂，并且有利地是活性的照顾或弥补头发或睫毛的代理人。

9. 发明授权

US09421157B2 Use of C-glycoside derivatives as pro-desquamating active agents 有权
标题翻译： C-糖苷衍生物作为脱去脱屑活性剂的用途
公开(公告)号：US09421157B2
公开(公告)日：2016-08-23
申请号：US12306565
申请日：2007-06-29
申请人： Maria Dalko , Christophe Boulle , Dominique Bernard
发明人： Maria Dalko , Christophe Boulle , Dominique Bernard
IPC分类号： C12Q1/68 , A61K31/74 , A61K8/60 , A61Q5/00 , A61Q19/00
CPC分类号： A61K8/602 , A61K2800/28 , A61K2800/88 , A61Q5/006 , A61Q19/00 , A61Q19/008
摘要： A cosmetic use of at least one C-glycoside derivative in a composition comprising a physiologically acceptable medium, as a cosmetic agent for promoting the desquamation of the skin and/or the scalp and/or for stimulating epidermal renewal.
摘要翻译：至少一种C-糖苷衍生物在包含生理学上可接受的培养基的组合物中的化妆用途，作为用于促进皮肤脱皮和/或头皮的化妆品和/或用于刺激表皮更新。

10. 发明申请

US20100105741A1 ADMINISTRATION OF PYRIDINEDICARBOXYLIC ACID COMPOUNDS FOR STIMULATING OR INDUCING THE GROWTH OF HUMAN KERATINOUS FIBERS AND/OR ARRESTING THEIR LOSS 审中-公开
标题翻译：吡啶二羧酸化合物的施用用于刺激或诱导人类激素纤维的生长和/或损害它们的损失
公开(公告)号：US20100105741A1
公开(公告)日：2010-04-29
申请号：US12650777
申请日：2009-12-31
申请人： Maria Dalko , Geneviève Loussouarn , Charles El Rawadi , Christophe Boulle , Bruno Bernard
发明人： Maria Dalko , Geneviève Loussouarn , Charles El Rawadi , Christophe Boulle , Bruno Bernard
IPC分类号： A61K31/44
CPC分类号： A61K8/4926 , A61K8/37 , A61K8/494 , A61K8/4953 , A61Q1/10 , A61Q7/00
摘要： The invention relates to the use in a composition for caring for human hair or eyelashes of an effective amount of a pyridinedicarboxylic acid derivative of general formula (I) or of one of its salts, in which R1 and R2 represent, independently of one another, OH, OR′, —NH2, —NHR′ or —NR′R″, and R′ and R″ represent, independently of one another, a saturated or unsaturated and linear or branched C1-C18 alkyl radical or an aryl radical, this alkyl or aryl radical optionally being substituted by at least one OH, alkoxy, acyloxy, amino or alkylamino group, or R′ and R″ together represent a heterocycle, the composition being intended to induce and/or stimulate the growth of human keratinous fibers, such as the hair and eyelashes, and/or slow down their loss; the invention also relates to a cosmetic treatment intended to stimulate the growth of human keratinous fibers, such as the hair and eyelashes, and/or slow down their loss.
摘要翻译：本发明涉及用于照护人发或睫毛的组合物中有效量的通式（I）的吡啶二羧酸衍生物或其盐之一，其中R 1和R 2彼此独立地表示， OH，OR'，-NH 2，-NHR'或-NR'R“，R'和R”彼此独立地表示饱和或不饱和和直链或支链的C 1 -C 18烷基或芳基，任选被至少一个OH，烷氧基，酰氧基，氨基或烷基氨基取代的烷基或芳基，或R'和R“一起表示杂环，该组合物旨在诱导和/或刺激人角质纤维的生长，如头发和睫毛，和/或减慢他们的损失; 本发明还涉及旨在刺激人角质纤维如头发和睫毛的生长和/或减缓其损失的美容治疗。

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