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2. 发明授权

US08735631B2 Method for manufacturing methylmercaptopropionaldehyde and methionine using renewable raw materials 有权
标题翻译：使用可再生原料制造甲基巯基丙醛和甲硫氨酸的方法
公开(公告)号：US08735631B2
公开(公告)日：2014-05-27
申请号：US13128927
申请日：2009-11-19
申请人： Jean-François Devaux , Jean-Luc Dubois
发明人： Jean-François Devaux , Jean-Luc Dubois
IPC分类号： C07C319/14 , C07C323/22 , C07C323/58 , A23K1/16
CPC分类号： C07C319/18 , A23K20/142 , A23K50/75 , C07C45/52 , C07C319/02 , C07C319/08 , C07C319/20 , C07C47/22 , C07C323/22 , C07C323/58 , C07C323/60 , C07C323/52 , C07C321/04
摘要： The present invention relates to a method for manufacturing methylmercaptopropionaldehyde (MMP) including at least the following steps: (a) dehydrating glycerol to acrolein from an aqueous solution of glycerol in the presence of an acid catalyst; (b) purifying the aqueous flux from step (a) to obtain a flux of acrolein containing at least 15 wt % of water relative to the acrolein; (c) causing a reaction of the acrolein flux obtained in step (b) with methylmercaptan in the presence of a catalyst; (d) optionally purifying the product obtained in step (c). The method of the invention can also include a reaction of the product obtained in step (c) or (d) with hydrocyanic acid, or sodium cyanide during a step (e) followed by a subsequent transformation to produce methionine or methionine hydroxyanalogue, which can then optionally be purified. The additional use of methylmercaptan and/or hydrocyanic acid derived from biomass as raw materials in the method according to the invention makes it possible to obtain MMP, methionine or methionine hydroxyanalogue made up of 100% organic carbon from renewable sources.
摘要翻译：本发明涉及至少包括以下步骤的甲基巯基丙醛（MMP）的制备方法：（a）在酸催化剂存在下，将甘油从甘油水溶液中脱水至丙烯醛; （b）纯化来自步骤（a）的水性助熔剂以获得相对于丙烯醛含有至少15重量％的水的丙烯醛流量; （c）在催化剂存在下使步骤（b）中得到的丙烯醛助熔剂与甲基硫醇反应; （d）任选地纯化步骤（c）中获得的产物。本发明的方法还可以包括步骤（c）或（d）中获得的产物与氢氰酸或氰化钠在步骤（e）中的反应，随后进行转化以产生甲硫氨酸或甲硫氨酸羟基对脯氨酸，其可以然后任选地被纯化。在根据本发明的方法中，以生物质为原料的甲基硫醇和/或氢氰酸的额外用途使得可以获得由可再生来源的100％有机碳组成的MMP，甲硫氨酸或甲硫氨酸羟基对映体。

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