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1. 发明授权

US5616733A Preparation method for 2-coumaranone 失效
标题翻译： 2-香豆素的制备方法
公开(公告)号：US5616733A
公开(公告)日：1997-04-01
申请号：US472400
申请日：1995-06-07
申请人： Jean-Claude Vallejos , Alain Perrard , Yani Christidis , Pierre Gallezot
发明人： Jean-Claude Vallejos , Alain Perrard , Yani Christidis , Pierre Gallezot
IPC分类号： B01J23/42 , B01J23/44 , C07B61/00 , C07D307/83 , C07D307/78
CPC分类号： C07D307/83 , Y02P20/582
摘要： Preparation process for 2-coumaranone in which glyoxylic acid, in vapor phase, is reacted with cyclohexanone, in the presence of a dehydrogenation catalyst.
摘要翻译：其中在脱氢催化剂存在下，气相中的乙醛酸与环己酮反应的2-香豆素的制备方法。

2. 发明授权

US5223621A Transvinylation of carboxylic acids 失效
标题翻译：羧酸的转化
公开(公告)号：US5223621A
公开(公告)日：1993-06-29
申请号：US817194
申请日：1992-01-06
申请人： Jean-Claude Vallejos , Yani Christidis
发明人： Jean-Claude Vallejos , Yani Christidis
IPC分类号： C07C67/10
CPC分类号： C07C67/10
摘要： Transvinylation process between vinyl acetate or vinyl propionate and a carboxylic acid of general formula (I),RCOOH (I)in which R represents a substituted or non-substituted alkyl, cycloalkyl, aralkyl or aromatic radical, in the presence of a palladium catalyst, in which the catalyst is obtained in situ, by reacting, in the reaction medium, a derivative of palladium chosen from the group constituted by palladium II acetate, nitrate or hydroxide and palladium deposited on charcoal, with a tertiary amine chosen from the group constituted by 2,2'-bipyridyl, orthophenanthroline or tetramethylethylenediamine, that the quantity of palladium used, expressed in gram-atom of palladium II per 100 moles of carboxylic acid of general formula (I) is between 0.005 and 1 and that the quantity of amine is greater than 1 and less than 10 moles per gram-atom of palladium II used and use for the preparation of certain products.
摘要翻译：乙酸乙烯酯或丙酸乙烯酯与通式（I）的羧酸，其中R表示取代或未取代的烷基，环烷基，芳烷基或芳族基团的RCOOH（I）在钯催化剂存在下的反应，其中通过在反应介质中使选自由钯II乙酸酯，硝酸盐或氢氧化物构成的组的钯衍生物和沉积在活性炭上的钯与选自以下组成的组中的叔胺反应获得催化剂： 2,2'-联吡啶基，邻菲咯啉或四甲基乙二胺，使用的钯的量（以每100摩尔通式（I）的羧酸计）钯II的克原子数为0.005〜1，胺的量为大于1且小于10摩尔/克原子的钯II，并用于制备某些产品。

3. 发明授权

US5053527A Process for the manufacture of alkyl pyruvates 失效
标题翻译：制备亚苄基吡咯烷酮的方法
公开(公告)号：US5053527A
公开(公告)日：1991-10-01
申请号：US525209
申请日：1990-05-18
申请人： Yani Christidis , Jean-Claude Vallejos
发明人： Yani Christidis , Jean-Claude Vallejos
IPC分类号： B01J27/06 , C07B61/00 , C07C67/313 , C07C69/716
CPC分类号： C07C67/313 , C07C69/716
摘要： The invention provides an improved process for the manufacture of alkyl pyruvates having general formula (I):CH.sub.3 --CO--COOR (I)where R represents a C.sub.1 to C.sub.8 alkyl radical, by controlled oxidation of the corresponding alkyl lactate.The process is characterized in that the controlled oxidation is carried out using an aqueous hydrogen peroxide solution in the presence of catalytic quantities of bromium.
摘要翻译：本发明提供了制备具有通式（I）的烷基丙酮酸盐的改进方法：其中R表示C1至C8烷基的CH3-CO-COOR（Ⅰ）通过相应的乳酸烷基酯的受控氧化。该方法的特征在于，在催化量的溴的存在下，使用过氧化氢水溶液进行受控氧化。

4. 发明授权

US4384137A Process for preparation of hydroxyarylglyoxylic acids and their alkaline salts, and application thereof to preparation of sodium parahydroxyphenylglyoxylate 失效
标题翻译：羟基芳基乙醛酸及其碱式盐的制备方法及其在制备对羟基苯基乙醛酸钠
公开(公告)号：US4384137A
公开(公告)日：1983-05-17
申请号：US375124
申请日：1982-04-20
申请人： Alain Schouteeten , Yani Christidis , Jean-Claude Vallejos
发明人： Alain Schouteeten , Yani Christidis , Jean-Claude Vallejos
IPC分类号： C07C59/90 , B01J27/00 , B01J31/04 , C07C45/39 , C07C47/575 , C07C51/00 , C07C51/235 , C07C51/373 , C07C51/41 , C07C51/487 , C07C67/00 , C07C65/40
CPC分类号： C07C51/412 , C07C45/39 , C07C47/575 , C07C51/373 , C07C51/487
摘要： The invention relates to a process for preparation of hydroxyarylglyoxylic acids starting from hydroxyarylglycolic acids, by catalytic oxidation in an aqueous alkaline medium to pH higher than, or equal to, 11.5, through oxygen or oxygen-containing gas, characterized in that it is carried out in homogeneous phase at a temperature lower than, or equal to, 30.degree. C., and in the presence of cupric ions, and in that at the end of the reaction, the desired acid is isolated from the reactional medium through acidification to pH of about 0.5.The sodium parahydroxyphenylglyoxylate is obtained when acidification is stopped at pH=5, at the end of the reaction.
摘要翻译： PCT No.PCT / FR81 / 00108 Sec。 1982年4月20日 102（e）1982年4月20日PCT PCT日期：1981年8月27日PCT公布。公开号WO82 / 00821 1982年3月18日。本发明涉及由羟基芳基乙醇酸制备羟基芳基乙醛酸的方法，通过在含水碱性介质中通过氧或含氧气体在含水碱性介质中的催化氧化至pH高于或等于11.5，其特征在于其在低于或等于30℃的温度下并且在铜离子存在下在均相中进行，并且在反应结束时，将所需的酸从反应介质通过酸化至约0.5的pH。在反应结束时酸化停止pH = 5时得到对羟基苯基乙醛酸钠。

5. 发明授权

US3983114A Method of preparation of 6-aza uracile and its O-disilyl derivative 失效
标题翻译： 6-氮杂尿嘧啶及其O-二甲硅烷基衍生物的制备方法
公开(公告)号：US3983114A
公开(公告)日：1976-09-28
申请号：US625839
申请日：1975-10-24
申请人： Yani Christidis , Jean-Claude Vallejos
发明人： Yani Christidis , Jean-Claude Vallejos
IPC分类号： C07D253/06 , C07F7/18
CPC分类号： C07F7/1856 , C07D253/06
摘要： A method of preparation of 6-aza uracile, comprising the steps of:A. Cyclization of semi-carbazone of glyoxylic acid by heating this latter with an excess of a trialkyl-silylation agent taken as a solvent and isolating the resulting product, namely the O-disilylated derivative of 6-aza uracile (or di-3,5 (trialkylsiloxy)1,2,4 triazine) andB. subjection of the product resulting from step a) to an acid hydrolysis.
摘要翻译：一种制备6-氮杂尿嘧啶的方法，包括以下步骤：

6. 发明授权

US5395964A Preparation process for hydroxyphenylacetic acids 失效
标题翻译：羟基苯乙酸的制备方法
公开(公告)号：US5395964A
公开(公告)日：1995-03-07
申请号：US245898
申请日：1994-05-19
申请人： Jean-Claude Vallejos , Yani Christidis
发明人： Jean-Claude Vallejos , Yani Christidis
IPC分类号： C07B61/00 , C07C51/377 , C07C59/52 , C07C59/56 , C07C59/64 , C07C65/01
CPC分类号： C07C51/377
摘要： Preparation process for a hydroxyphenylacetic acid of formula (I): ##STR1## where R.dbd.H, alkyl or alkoxyl as well as its salts, in which the corresponding free or salified hydroxymandelic acid of formula (II): ##STR2## in which R has the meaning given previously and M.dbd.H, K or an ammonium group is reacted in an aqueous medium, at a temperature greater than or equal to 50.degree. C., with formic acid in the presence of catalytic quantities of an oxygenated derivative of sulphur having a degree of oxidation from 2 to 4, in order to obtain the hydroxyphenylacetic acid of formula (I) which is isolated or, if desired, is salified according to the usual methods and the hydroxyphenylacetic acid thus obtained.
摘要翻译：式（I）的羟基苯基乙酸的制备方法：其中R = H，烷基或烷氧基及其盐，其中相应的式（II）的游离或盐化的羟基扁桃酸：（II）其中R具有先前给出的含义，M = H，K或铵基在水性介质中，在大于或等于50℃的温度下，与甲酸在催化量存在下反应的氧化度为2至4的硫的氧化衍生物，以获得分离的或如果需要，根据常规方法成盐的式（I）的羟基苯基乙酸和由此获得的羟基苯基乙酸。

7. 发明授权

US4515970A Process for preparation of alkanoic acids 失效
标题翻译：链烷酸的制备方法
公开(公告)号：US4515970A
公开(公告)日：1985-05-07
申请号：US601221
申请日：1984-04-17
申请人： Yani Christidis , Jean-Claude Vallejos
发明人： Yani Christidis , Jean-Claude Vallejos
IPC分类号： B01J27/00 , B01J27/06 , C07B61/00 , C07C51/00 , C07C51/347 , C07C51/353 , C07C59/52 , C07C59/56 , C07C59/64 , C07C67/00 , C07D317/60 , C07D333/24 , C07C63/36
CPC分类号： C07D333/24 , C07C51/347 , C07D317/60
摘要： A process for preparation of substituted acetic acids having the general formula I:Ar--CHR--COOH Iin which R is selected from the group consisting in one hydrogen atom and C.sub.1 -C.sub.4 -alkyl radicals, and Ar is selected from the group consisting in radicals of aromatic nature selected from the following radicals: 2-thienyl, 2-methoxy-1-naphthyl, 3,4-methylenedioxy-phenyl, and the substituted phenyls of the general formula II: ##STR1## where R.sub.1 is selected from the group consisting in hydrogen and C.sub.1 -C.sub.4 -alkyl groups, and R.sub.2 is selected from the group consisting in hydrogen, halogen, alkyl, alkoxy and hydroxy-groups, such process comprising the step of reacting under heat in an acid medium, in the presence of red phosphorus and catalytic quantities of iodine or hydriodic acid, an alpha carbonylated carboxylic acid having the general formula III:R--CO--COOH IIIin which R has the same meaning as above with an unsaturated derivative of aromatic nature selected from the group consisting in thiophene, 2-methoxynaphthalene, 1,2-methylenedioxy-benzene, and the substituted aromatic hydrocarbons having the general formula IV: ##STR2## in which R.sub.1, R.sub.2 have the same meanings as above, possibly within a compatible organic solvent.
摘要翻译：制备具有通式I的取代乙酸的方法：其中R选自一个氢原子和C 1 -C 4 - 烷基，Ar选自自由基的芳族性质选自以下基团：2-噻吩基，2-甲氧基-1-萘基，3,4-亚甲二氧基 - 苯基和通式II的取代的苯基：其中R 1选自由氢和C 1 -C 4烷基组成，R 2选自氢，卤素，烷基，烷氧基和羟基，该方法包括在酸性介质中在加热下，在存在红磷和催化量的碘或氢碘酸，具有通式III的α羰基化羧酸：R-CO-COOHIII，其中R具有与上述相同的含义的芳族自由基的不饱和衍生物，选自噻吩 e，2-甲氧基萘，1,2-亚甲二氧基苯和具有通式IV的取代芳烃：其中R 1，R 2具有与上述相同的含义，可能在相容的有机溶剂中。

8. 发明授权

US5306833A Preparation process for arylacetic acids and their alkali metal salts 失效
标题翻译：芳基乙酸及其碱金属盐的制备方法
公开(公告)号：US5306833A
公开(公告)日：1994-04-26
申请号：US12632
申请日：1993-02-03
申请人： Jean-Claude Vallejos , Yani Christidis
发明人： Jean-Claude Vallejos , Yani Christidis
IPC分类号： C07D317/60 , C07C51/377 , C07C57/32 , C07C57/40 , C07C59/52 , C07C59/64 , C07D333/24 , C07C67/297
CPC分类号： C07C51/377
摘要： Process for obtaining an arylacetic acid of general formula (I):Ar--CHR--COOH (I)in which R=H, C.sub.1 -C.sub.4 alk, Ar=2-thienyl, 3-thienyl, 1-naphthyl, 2-naphthyl, 1-(2-methoxy naphthyl), 3,4-methylenedioxy phenyl or phenyl of general formula (II): ##STR1## in which R.sub.1 =H, OH or C.sub.1 -C.sub.4 alkoxy, R.sub.2 =H, C.sub.1 -C.sub.4 alk, C.sub.1 -C.sub.4 alkoxy or OH, as well as their alkali metal salts, by reaction in a solvent of the corresponding arylglycolic acid of general formula (III):Ar-CR(OH)--COOH (III)or one of its alkali metal salts with a hydrogen donor agent chosen from the group constituted by: formic acid, or one of its alkali metal salts, phosphonic acid, phosphinic acid, or one of their alkali metal salts, in the presence of a hydrogen transfer catalyst, which if desired is isolated or salified, and use for the preparation of certain acids of formula (I).
摘要翻译：获得通式（I）的芳基乙酸的方法：其中R = H，C 1 -C 4烷基，Ar = 2-噻吩基，3-噻吩基，1-萘基，2-萘基， 1-（2-甲氧基萘基），3,4-亚甲二氧基苯基或通式（II）的苯基：（*化学结构*）（II）其中R1 = H，OH或C1-C4烷氧基，R2 = 通过在相应的通式（III）的芳基乙酸的溶剂中反应：Ar-CR（OH）-COOH（III）或一个或多个其中之一的C 1 -C 4烷基，C 1 -C 4烷氧基或OH，以及它们的碱金属盐的碱金属盐与选自下组的氢供体试剂：甲酸或其碱金属盐，膦酸，次膦酸或其一种碱金属盐之一在氢转移催化剂存在下，如果需要，其分离或成盐，并用于制备式（I）的某些酸。

9. 发明授权

US4481374A Process for the preparation of hydroxybenzaldehydes 失效
标题翻译：制备羟基苯甲醛的方法
公开(公告)号：US4481374A
公开(公告)日：1984-11-06
申请号：US414243
申请日：1982-08-26
申请人： Yani Christidis , Jean-Claude Vallejos
发明人： Yani Christidis , Jean-Claude Vallejos
IPC分类号： C07C47/565 , C07C45/00 , C07C45/29 , C07C45/38 , C07C67/00
CPC分类号： C07C45/38
摘要： The invention relates to a process for the preparation of hydroxybenzaldehydes by oxidation of hydroxybenzylic alcohols through oxygen or oxygen-containing gas, said process being carried out in aqueous alkaline medium in the absence of any catalyst whatsoever, at a temperature comprised between 25.degree. and 50.degree. C. and in the presence of an alkaline hydroxide in such a quantity that the molar ratio of alkaline hydroxide to hydroxybenzylic alcohol used is comprised between 2.25 and 10.
摘要翻译： PCT No.PCT / FR82 / 00007 Sec。 371日期1982年8月26日 102（e）日期1982年8月26日PCT提交1982年1月14日PCT公布。第WO82 / 02549号公报日本1982年8月5日。本发明涉及通过羟基苄基醇通过氧或含氧气体的氧化制备羟基苯甲醛的方法，所述方法在不存在任何催化剂的情况下在碱性介质中进行，温度在25℃至50℃之间，并且在碱性氢氧化物存在下使碱性氢氧化物与羟基苄基醇的摩尔比在2.25至10之间。

10. 发明授权

US5773632A Process for the preparation of the enol lactone of 2-oxocyclohexlidene acetic acid and application to the preparation of 2-cuomaranone 失效
标题翻译：制备2-氧代环己烯乙酸的烯醇内酯的方法，用于制备2-叔丙酮
公开(公告)号：US5773632A
公开(公告)日：1998-06-30
申请号：US883594
申请日：1997-06-26
申请人： Nathalie Carmona , Laurent Carmona , Alain Perrard , Jean-Claude Vallejos
发明人： Nathalie Carmona , Laurent Carmona , Alain Perrard , Jean-Claude Vallejos
IPC分类号： B01J23/44 , B01J27/10 , B01J31/02 , B01J31/10 , C07B61/00 , C07D307/83
CPC分类号： C07D307/83
摘要： A process for the preparation of the enol lactone of 2-oxocyclohexylidene acetic acid wherein (i) glyoxylic acid is allowed to react with cyclohexanone in the presence of a halogen acid in order to obtain a crude reaction product B1, then (ii) said crude reaction product B1 is allowed to react, after solubilisation in an organic solvent, in the presence of a strong acid soluble in said organic solvent or of strongly acid resins, in order to obtain the enol lactone of 2-oxocyclohexylidene acetic acid which is isolated if desired, and application to the preparation of 2-coumaranone.
摘要翻译：制备2-氧代亚环己基乙酸的烯醇内酯的方法，其中使（ⅰ）乙醛酸在卤酸存在下与环己酮反应，得到粗反应产物B1，然后将所述粗品反应产物B1在有机溶剂溶解后，在可溶于所述有机溶剂或强酸树脂的强酸存在下反应，以获得2-氧代亚环己基乙酸的烯醇内酯，如果期望和应用于2-香豆素的制备。

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