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    • 7. 发明授权
    • Anti-ischemic pharmaceutic compositions
    • 抗缺血药物组合物
    • US4407801A
    • 1983-10-04
    • US306224
    • 1981-09-28
    • Jean-Claude ArnaudMichelle Devissaguet
    • Jean-Claude ArnaudMichelle Devissaguet
    • A61K9/20A61K31/495A61K31/70
    • A61K9/2018A61K31/495A61K9/2059
    • The subject of the invention is a novel pharmaceutical composition, especially having an anti-ischaemic action, containing, in combination, a high dosage (within the range of from 20 to 80 mg) of the dihydrochloride (or another mineral or organic salt) of 1-(2,3,4-trimethoxybenzyl)piperazine and a disintegrating agent, such as mannitol or sodium carboxymethyl starch, that has the effect of liberating the salt of 1-(2,3,4-trimethoxybenzyl)piperazine virtually instantaneously in the organism, this composition being, furthermore, advantageously enclosed in a thin coating film or held together by a binder that is itself readily disintegrated in situ in the organism in such a manner that it makes possible a "flash" action, that is to say a virtually instantaneous action, of the above-mentioned salt in situ. This composition is administered to the patient at a dosage of from 20 to 80 mg/day.
    • 本发明的主题是特别是具有抗缺血作用的新型药物组合物,其组合含有二盐酸盐(或另一种矿物或有机盐)的高剂量(在20至80mg范围内) 1-(2,3,4-三甲氧基苄基)哌嗪和崩解剂,如甘露糖醇或羧甲基淀粉钠,其实际上可以瞬间释放1-(2,3,4-三甲氧基苄基)哌嗪的盐 此外,该组合物还有利地封闭在薄的涂膜中或通过粘合剂保持在一起,所述粘合剂本身容易在生物体中原位分解,使得可能发生“闪光”作用,也就是说 几乎瞬间作用,上述盐原位。 将该组合物以20至80mg /天的剂量施用于患者。