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1. 发明申请

US20070048180A1 Nanoelectronic breath analyzer and asthma monitor 审中-公开
标题翻译：纳米电子呼吸分析仪和哮喘监测仪
公开(公告)号：US20070048180A1
公开(公告)日：2007-03-01
申请号：US11437275
申请日：2006-05-18
申请人： Jean-Christophe Gabriel , Vikram Joshi , Joseph Niemann , Alexander Star , David Thomas , Christian Valcke
发明人： Jean-Christophe Gabriel , Vikram Joshi , Joseph Niemann , Alexander Star , David Thomas , Christian Valcke
IPC分类号： G01N31/22
CPC分类号： G01N33/497 , B82Y15/00
摘要： Nanoelectronic sensors, including sensors for detecting analytes such as CO2, NO, anesthesia gases, and the like in human breath. An integrated multivalent monitor system is described which permits two or more analytes to be measured in breath, for example to monitor pulmonary conditions such as asthma. The monitor system may be configured to be compact, light weight, inexpensive, and to include a microprocessor capable of both analyzing measurements to determine patient status, and storing measurement history. Wireless embodiments provide such enhancements as remote monitoring.
摘要翻译：纳米电子传感器，包括用于在人呼吸中检测诸如CO 2，NO，麻醉气体等分析物的传感器。描述了一种综合多价监测系统，其允许在呼吸中测量两种或更多种分析物，例如监测肺部疾病如哮喘。监视器系统可以被配置为紧凑，重量轻，便宜，并且包括能够分析测量以确定患者状态并存储测量历史的微处理器。无线实施例提供诸如远程监视的增强。

2. 发明申请

US20070048181A1 Carbon dioxide nanosensor, and respiratory CO2 monitors 审中-公开
标题翻译：二氧化碳纳米传感器和呼吸二氧化碳监测仪
公开(公告)号：US20070048181A1
公开(公告)日：2007-03-01
申请号：US11488456
申请日：2006-07-18
申请人： Daniel Chang , Ying-Lan Chang , Jean-Christophe Gabriel , Vikram Joshi , William Mickelson , Joseph Niemann , John Passmore , Alexander Star , Christian Valcke
发明人： Daniel Chang , Ying-Lan Chang , Jean-Christophe Gabriel , Vikram Joshi , William Mickelson , Joseph Niemann , John Passmore , Alexander Star , Christian Valcke
IPC分类号： G01N31/22
CPC分类号： G01N27/4146 , B82Y15/00 , B82Y30/00 , G01N33/004 , G01N33/497
摘要： An electronic system and method for detecting analytes, such as carbon dioxide, is provided, using an improved nanostructure sensor (CO2 sensor). The CO2 sensor may comprise a substrate and a nanostructure, such as a one or more carbon nanotubes disposed over the substrate (e.g., as a network). One or more conductive elements may electrically communicate with the nanostructure. A counter or gate electrode may be positioned adjacent the nanostructure. A functionalization material reactive with carbon dioxide may be included, either disposed in contact with the nanostructure or isolated by a dielectric. The sensor may be connected to a circuit responsive to changes in CO2 concentration in the environment. Embodiments are described of medical sensing systems including one or more CO2 sensors. One embodiment comprises a breath sampling cannula which is connected to a sensor unit. In an alternative, the cannula permits supplemental oxygen to be administered, while recovering and measuring analytes in breath samples. The cannula may connect to a portable processor-display unit for monitoring one or more analytes, such as CO2. Another embodiment includes a cannula configured for the monitoring of sleep disorders, such as apnea, comprising one or more sensors disposed adjacent a breath sampling channel, optionally including flow rate or other sensors. The sensors may be connected by wired or wireless links for to a processor/input/display unit. Any of the embodiments may include filters, selectively permeable membranes, absorbents, and the like to precondition the breath sample, may be configured to include complementary chemistry measurements.
摘要翻译：提供了一种用于检测分析物（如二氧化碳）的电子系统和方法，使用改进的纳米结构传感器（CO2传感器）。 CO 2传感器可以包括衬底和纳米结构，例如设置在衬底上的一个或多个碳纳米管（例如，作为网络）。一个或多个导电元件可以与纳米结构电连通。计数器或栅电极可以邻近纳米结构定位。可以包括与二氧化碳反应的官能化材料，其被设置为与纳米结构接触或通过电介质隔离。传感器可以响应于环境中二氧化碳浓度的变化而连接到电路。描述了包括一个或多个CO 2传感器的医学感测系统的实施例。一个实施例包括连接到传感器单元的呼吸取样套管。在替代方案中，套管允许补充氧气，同时在呼吸样本中回收和测量分析物。套管可以连接到便携式处理器显示单元，用于监测一个或多个分析物，例如CO 2。另一个实施例包括配置用于监测睡眠障碍（例如呼吸暂停）的插管，其包括邻近呼吸采样通道设置的一个或多个传感器，可选地包括流速或其它传感器。传感器可以通过有线或无线链路连接到处理器/输入/显示单元。任何实施方案可以包括过滤器，选择性渗透膜，吸收剂等以预处理呼吸样品，可以被配置为包括互补的化学测量。

3. 发明授权

US07714398B2 Nanoelectronic measurement system for physiologic gases and improved nanosensor for carbon dioxide 有权
标题翻译：用于生理气体的纳米电子测量系统和改进的二氧化碳纳米传感器
公开(公告)号：US07714398B2
公开(公告)日：2010-05-11
申请号：US11390493
申请日：2006-03-27
申请人： Nadav Ben-Barak , Daniel M. Chang , Jean-Christophe P. Gabriel , Vikram Joshi , Joseph Niemann , Alexander Star , Christian Valcke
发明人： Nadav Ben-Barak , Daniel M. Chang , Jean-Christophe P. Gabriel , Vikram Joshi , Joseph Niemann , Alexander Star , Christian Valcke
IPC分类号： G01N27/414
CPC分类号： G01N33/5438 , A61B5/073 , A61B2562/0285 , B82Y10/00 , B82Y15/00 , B82Y20/00 , H01L51/0048 , H01L51/0052 , H01L51/0545
摘要： A system for measuring an analyte of interest, particularly carbon dioxide, dissolved in a fluid media of a patient including a nanoelectronic sensor and a measurement instrument in communication with the sensor and configured to receive at least a signal from the sensor indicative of a response of the sensor to at least the analyte of interest.
摘要翻译：一种用于测量感兴趣的分析物，特别是二氧化碳的系统，其溶解在患者的流体介质中，包括与所述传感器通信的纳米电子传感器和测量仪器，并且被配置为从所述传感器接收表示响应的信号传感器至少是所关注的分析物。

4. 发明申请

US20100056892A1 NANOELECTRONIC MEASUREMENT SYSTEM FOR PHYSIOLOGIC GASES AND IMPROVED NANOSENSOR FOR CARBON DIOXIDE 有权
标题翻译：用于生物气体的纳米电子测量系统和改进的二氧化碳纳米传感器
公开(公告)号：US20100056892A1
公开(公告)日：2010-03-04
申请号：US11390493
申请日：2006-03-27
申请人： Nadav Ben-Barak , Daniel M. Chang , Jean-Christophe P. Gabriel , Vikram Joshi , Joseph Niemann , Alexander Star , Christian Valcke
发明人： Nadav Ben-Barak , Daniel M. Chang , Jean-Christophe P. Gabriel , Vikram Joshi , Joseph Niemann , Alexander Star , Christian Valcke
IPC分类号： A61B5/05 , A61N1/36
CPC分类号： G01N33/5438 , A61B5/073 , A61B2562/0285 , B82Y10/00 , B82Y15/00 , B82Y20/00 , H01L51/0048 , H01L51/0052 , H01L51/0545
摘要： A system for measuring an analyte of interest, particularly carbon dioxide, dissolved in a fluid media of a patient including a nanoelectronic sensor and a measurement instrument in communication with the sensor and configured to receive at least a signal from the sensor indicative of a response of the sensor to at least the analyte of interest.
摘要翻译：一种用于测量感兴趣的分析物，特别是二氧化碳的系统，其溶解在患者的流体介质中，包括与所述传感器通信的纳米电子传感器和测量仪器，并且被配置为从所述传感器接收表示响应的信号传感器至少是所关注的分析物。

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