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    • 6. 发明申请
    • Pyran derivatives, process of preparation and use thereof in perfumery and flavouring
    • 吡喃衍生物,其制备方法及其在香料和调味剂中的应用
    • US20080138297A1
    • 2008-06-12
    • US11948176
    • 2007-11-30
    • Caroline PlessisJean Mane
    • Caroline PlessisJean Mane
    • A61K8/49C07D309/02A61Q9/02A61Q11/00C11D3/20A23L1/226A61Q13/00A61Q15/00A61Q5/00A61K31/351
    • C11B9/008A23L27/2052A61K8/498A61Q13/00C07D309/10C07D309/18C11D3/50
    • Pyran derivatives of general formula (I) wherein Y is a 5-, 6- or 7-membered ring, preferably a 5-membered ring, methyl or ethyl mono- or polysubstituted, and optionally unsaturated, and R1, R2, R3, R4 are, each independently, a hydrogen atom or a linear or branched C1-5 alkyl or C2-5 alkenyl group, and X is present or absent; when X is present, R5, R6, R7, R8, R9 are all present, and X is a hydrogen atom or an OZ group, wherein Z is a hydrogen atom or a R10 group or a C(O)R10 group; when X is absent, a double bond involving the carbon atom at the 4 position is present and R7, R8 and R9 are present, and one of R5 or R6 is present and the other one is absent, or R5, R6, and R7 are present, and one of R8 or R9 is present and the other one is absent, or R7 is a ═C(R11)(R12) group and R5, R6, R8, R9 are present; and when they are present, each of R5-R12 group is, independently, a hydrogen atom or a linear or branched C1-5 alkyl or C2-5 alkenyl group; and use of at least one pyran derivative of formula (I) as flavouring or fragrant agent.
    • 通式(I)的吡喃衍生物,其中Y是5-,6-或7-元环,优选五元环,甲基或乙基单或多取代且任选不饱和的,R 1,R 2,R 3,R 4 各自独立地为氢原子或直链或支链C 1-5烷基或C 2-5烯基,X存在或不存在; 当X存在时,R5,R6,R7,R8,R9全部存在,X为氢原子或OZ基团,其中Z为氢原子或R10基团或C(O)R10基团; 当X不存在时,存在涉及4位碳原子的双键并且存在R7,R8和R9,并且存在R5或R6中的一个,另一个不存在,或者R5,R6和R7是 存在,R8或R9之一存在,另一个不存在,或R7是-C(R11)(R12)基团,R5,R6,R8,R9存在; 并且当它们存在时,R 5 -R 12基团各自独立地为氢原子或直链或支链C 1-5烷基或C 2-5烯基 ; 并使用至少一种式(I)的吡喃衍生物作为调味剂或芳香剂。
    • 7. 发明授权
    • Pyran derivatives, process of preparation and use thereof in perfumery and flavouring
    • 吡喃衍生物,其制备方法及其在香料和调味剂中的应用
    • US07875737B2
    • 2011-01-25
    • US11948176
    • 2007-11-30
    • Caroline PlessisJean Mane
    • Caroline PlessisJean Mane
    • C07D309/00C07D315/00
    • C11B9/008A23L27/2052A61K8/498A61Q13/00C07D309/10C07D309/18C11D3/50
    • Pyran derivatives of general formula (I) wherein Y is a 5-, 6- or 7-membered ring, preferably a 5-membered ring, methyl or ethyl mono- or polysubstituted, and optionally unsaturated, and R1, R2, R3, R4 are, each independently, a hydrogen atom or a linear or branched C1-5 alkyl or C2-5 alkenyl group, and X is present or absent; when X is present, R5, R6, R7, R8, R9 are all present, and X is a hydrogen atom or an OZ group, wherein Z is a hydrogen atom or a R10 group or a C(O)R10 group; when X is absent, a double bond involving the carbon atom at the 4 position is present and R7, R8 and R9 are present, and one of R5 or R6 is present and the other one is absent, or R5, R6, and R7 are present, and one of R8 or R9 is present and the other one is absent, or R7 is a ═C(R11)(R12) group and R5, R6, R8, R9 are present; and when they are present, each of R5-R12 group is, independently, a hydrogen atom or a linear or branched C1-5 alkyl or C2-5 alkenyl group; and use of at least one pyran derivative of formula (I) as flavoring or fragrant agent.
    • 通式(I)的吡喃衍生物,其中Y是5-,6-或7-元环,优选五元环,甲基或乙基单或多取代且任选不饱和的,R 1,R 2,R 3,R 4 各自独立地为氢原子或直链或支链C 1-5烷基或C 2-5烯基,X存在或不存在; 当X存在时,R5,R6,R7,R8,R9全部存在,X为氢原子或OZ基团,其中Z为氢原子或R10基团或C(O)R10基团; 当X不存在时,存在涉及4位碳原子的双键并且存在R7,R8和R9,并且存在R5或R6中的一个,另一个不存在,或者R5,R6和R7是 存在,R8或R9之一存在,另一个不存在,或R7为≡C(R11)(R12)基团且R5,R6,R8,R9存在; 并且当它们存在时,R 5 -R 12基团各自独立地为氢原子或直链或支链C 1-5烷基或C 2-5烯基; 并使用至少一种式(I)的吡喃衍生物作为调味剂或芳香剂。
    • 8. 发明授权
    • Fragrance precursors
    • 香料前体
    • US06492563B2
    • 2002-12-10
    • US09829777
    • 2001-04-10
    • Markus GautschiCaroline PlessisSamuel Derrer
    • Markus GautschiCaroline PlessisSamuel Derrer
    • C07C49115
    • C11D3/507C07C45/64C07C45/673C07C45/71C07C49/84C07C49/83
    • The present invention is a fragrance precursor of formula I: for a fragrant ketone of formula II: and a fragrant ester of formula III: wherein, R1 to R5 represent independently H, —NO2, linear or branched C1-C6-alkyl, C1-C6-alkenyl, C1-C6-alkinyl or C1-C4-alkoxy, R1 and R2,R2 and R3, R3 and R4, and R4 and R5 may form together one or two aliphatic or aromatic rings, R6 and R7 are independently H, linear or branched C1-C6-alkyl-, C1-C6-alkenyl, C1-C6-alkinyl, and R8 and R9 are the residues of an acid R8-COOH and an alcohol R9OH respectively forming the fragrant ester of formula III. A method for providing an odor by admixing with a product a fragrance precursor as detailed above.
    • 本发明是式I的香料前体:对于式II的芳香酮和式III的芳香酯:其中R1至R5独立地表示H,-NO2,直链或支链C1-C6-烷基,C1- C 1 -C 6 - 烯基,C 1 -C 6 - 炔基或C 1 -C 4 - 烷氧基,R 1和R 2,R 2和R 3,R 3和R 4以及R 4和R 5可以一起形成一个或两个脂族或芳环,R 6和R 7独立地为H, 直链或支链C 1 -C 6 - 烷基 - ,C 1 -C 6 - 烯基,C 1 -C 6 - 炔基和R 8和R 9是分别形成式III芳香酯的酸性R8-COOH和醇R9OH的残基。 通过与产品混合来提供气味的方法,如上所述的香料前体。