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1. 发明申请

US20120184498A1 DERMASEPTIN B2 USED AS AN INHIBITOR OF THE GROWTH OF A TUMOR 审中-公开
标题翻译：用作肿瘤生长抑制剂的DERMASEPTIN B2
公开(公告)号：US20120184498A1
公开(公告)日：2012-07-19
申请号：US13381477
申请日：2010-06-29
申请人： Jean Delbe , Mohamed Amiche , Ali Ladram , Cécile Galanth , Pierre Nicolas , Yamina Hamma , Johanna Allegonda Anna Van Zoggel , José Courty
发明人： Jean Delbe , Mohamed Amiche , Ali Ladram , Cécile Galanth , Pierre Nicolas , Yamina Hamma , Johanna Allegonda Anna Van Zoggel , José Courty
IPC分类号： A61K38/17 , C12N15/63 , A61K31/7088 , A61P19/02 , C07H21/04 , A61P35/00 , A61P35/02 , A61P35/04 , C12N9/96 , C07K14/435
CPC分类号： C07K14/463 , A61K38/1703 , A61K38/4886 , A61K45/06 , C07K2319/00
摘要： The invention relates to the use of peptides corresponding to dermaseptin B2 or fragments thereof for treating proliferative diseases such as cancer or ocular lesions, and to pharmaceutical compositions containing such peptides.
摘要翻译：本发明涉及对应于皮肤抑素B2或其片段的肽用于治疗增殖性疾病如癌症或眼部病变的用途，以及含有这些肽的药物组合物的用途。

2. 发明授权

US09522942B2 Analogs of temporin-SHa and uses thereof 有权
标题翻译：临床SHA的类似物及其用途
公开(公告)号：US09522942B2
公开(公告)日：2016-12-20
申请号：US13257018
申请日：2010-03-18
申请人： Ali Ladram , Denis Sereno , Feten Abbassi , Bruno Oury , Mohamed Amiche , Pierre Nicolas
发明人： Ali Ladram , Denis Sereno , Feten Abbassi , Bruno Oury , Mohamed Amiche , Pierre Nicolas
IPC分类号： C07K14/46 , C12N15/82
CPC分类号： C07K14/463 , C12N15/8282 , C12N15/8283
摘要： The present invention relates to novel antimicrobial peptides, to pharmaceutical compositions comprising said peptides, and to the uses thereof, in particular as antimicrobial drugs, disinfectants, pesticides or preservatives. The present invention also relates to a transgenic plant expressing said novel peptides.
摘要翻译：本发明涉及新型抗微生物肽，包含所述肽的药物组合物及其用途，特别是抗微生物药物，消毒剂，杀虫剂或防腐剂。本发明还涉及表达所述新肽的转基因植物。

3. 发明申请

US20120005790A1 ANALOGS OF TEMPORIN-SHA AND USES THEREOF 有权
标题翻译：。。。。。。。。。。。
公开(公告)号：US20120005790A1
公开(公告)日：2012-01-05
申请号：US13257018
申请日：2010-03-18
申请人： Ali Ladram , Denis Sereno , Feten Abassi , Bruno Oury , Mohamed Amiche , Pierre Nicolas
发明人： Ali Ladram , Denis Sereno , Feten Abassi , Bruno Oury , Mohamed Amiche , Pierre Nicolas
IPC分类号： A01N37/18 , C12N15/63 , C12N5/10 , A61K38/10 , A61K38/17 , A01N25/34 , A01H5/00 , C07K14/435 , C07K7/08 , C12N1/19 , C12N1/21 , A01P1/00 , A01P3/00 , A61P31/04 , A61P31/10 , A61P31/00 , A61P31/12 , A61P33/00 , A61P33/02 , C12N15/12
CPC分类号： C07K14/463 , C12N15/8282 , C12N15/8283
摘要： The present invention relates to novel antimicrobial peptides, to pharmaceutical compositions comprising said peptides, and to the uses thereof, in particular as antimicrobial drugs, disinfectants, pesticides or preservatives. The present invention also relates to a transgenic plant expressing said novel peptides.
摘要翻译：本发明涉及新型抗微生物肽，包含所述肽的药物组合物及其用途，特别是抗微生物药物，消毒剂，杀虫剂或防腐剂。本发明还涉及表达所述新肽的转基因植物。

4. 发明授权

US06440690B1 Peptides for the activation of the immune system in humans and animals 失效
标题翻译：用于激活人和动物免疫系统的肽
公开(公告)号：US06440690B1
公开(公告)日：2002-08-27
申请号：US09181941
申请日：1998-10-28
申请人： Amram Mor , Ioannis Vouldoukis , Pierre Nicolas
发明人： Amram Mor , Ioannis Vouldoukis , Pierre Nicolas
IPC分类号： C12Q118
CPC分类号： C07K7/08 , A61K38/1703 , A61K39/00 , C07K14/43563 , C07K14/43572 , C07K14/46 , C07K14/463 , C07K14/47 , C07K14/472 , C07K14/4723 , C07K14/4742 , C07K14/575 , C07K14/57545 , C07K14/595 , C07K14/79 , Y02A50/41 , Y02A50/412 , Y02A50/423 , Y02A50/466 , Y02A50/472 , Y02A50/487
摘要： The present invention is directed to compositions and methods for the treatment of diseases comprising the administration of compositions comprising one or more peptide(s) having a stimulatory effect on the afflicted host's immune system. Specifically, the invention relates to methods comprising the use of cationic amphipathic peptides having an &agr;-helical structure and effecting activation of macrophages when administered in a therapeutically sufficient amount. The methods of the present invention are useful for the treatment of, for example, infectious diseases or cancer.
摘要翻译：本发明涉及用于治疗疾病的组合物和方法，包括施用包含对受影响的宿主的免疫系统具有刺激作用的一种或多种肽的组合物。具体而言，本发明涉及包含使用具有α-螺旋结构的阳离子两亲肽的方法，并且当以治疗上足够的量给药时，其可促进巨噬细胞的活化。本发明的方法可用于治疗例如感染性疾病或癌症。

5. 发明申请

US20060057270A1 Flour based food product comprising thermostable alpha-amylase 审中-公开
标题翻译：含有热稳定性α-淀粉酶的基于面粉的食品
公开(公告)号：US20060057270A1
公开(公告)日：2006-03-16
申请号：US10532267
申请日：2003-10-30
申请人： Pierre Nicolas , Carl Hansen
发明人： Pierre Nicolas , Carl Hansen
IPC分类号： A21D10/00
CPC分类号： A21D13/062 , A21D8/042
摘要： The invention relates to a flour based food product comprising a thermostable α-amylase and in-situ modified starch, as well as to a process comprising the steps of making a batter by mixing at least flour, water and a thermo-resistant α-amylase and cooking the batter on at least one hot surface, to the use of thermostable α-amylase to manipulate textural attributes of flour based food products, and to a method for modifying starch in a wafer without increasing batter viscosity. Preferred flour based food products are wafers, biscuits and crackers.
摘要翻译：本发明涉及包含热稳定性α-淀粉酶和原位改性淀粉的面粉基食品，以及包括以下步骤的方法：至少混合面粉，水和耐热α-淀粉酶并且在至少一个热表面上烹饪面糊，使用热稳定性α-淀粉酶来操作面粉基食品的纹理特性，以及用于在不增加面糊粘度的情况下对晶片中的淀粉进行改性的方法。优选的基于面粉的食品是晶片，饼干和饼干。

6. 发明授权

US5929433A Reading device for a mosaic of electromagnetic detectors and detection system equipped with such a device 失效
标题翻译：用于装配有这种装置的电磁检测器和检测系统的马赛克的读取装置
公开(公告)号：US5929433A
公开(公告)日：1999-07-27
申请号：US880287
申请日：1997-06-24
申请人： Jacques Cluzel , Pierre Nicolas
发明人： Jacques Cluzel , Pierre Nicolas
IPC分类号： G01J1/44 , G01T1/17 , G01T1/24 , H04N5/374 , G01J1/00 , H01J40/14
CPC分类号： H04N5/3743 , H04N3/155 , H04N3/1562 , H04N3/1587
摘要： Reading device for an array of radiation detectors arranged as a mosaic of detectors and having a plurality of capacitors (222), each connected to a reading circuit (224, 225). According to the invention, each capacitor (222) is associated with a subarray of several detectors of the mosaic, the reading device also having a plurality of controllable switches (231, 232, 233, 224) for successively connecting each detector of each subarray respectively to the associated integrating capacitor (222) and the reading device having means (226) for controlling the closing and opening of the switches in an order excluding the simultaneous reading of the signal of closer neighbouring detectors.
摘要翻译：布置成检测器马赛克的辐射检测器阵列的读取装置，并具有多个电容器（222），每个电容器连接到读取电路（224,225）。根据本发明，每个电容器（222）与马赛克的几个检测器的子阵列相关联，读取装置还具有多个可控开关（231,232,233,224），用于分别连续地连接每个子阵列的每个检测器到相关联的积分电容器（222）和读取装置具有用于以不同于更靠近的相邻检测器的信号的同时读取的顺序来控制开关的闭合和打开的装置（226）。

7. 发明授权

US5008544A System for the detection of information in the form of electromagnetic radiation and reading the detected information 失效
标题翻译：用于以电磁辐射的形式检测信息并读取检测到的信息的系统
公开(公告)号：US5008544A
公开(公告)日：1991-04-16
申请号：US382427
申请日：1989-07-19
申请人： Pierre Nicolas , Philippe Pantigny
发明人： Pierre Nicolas , Philippe Pantigny
IPC分类号： H01L27/148 , H04N5/217 , H04N5/359
CPC分类号： H04N5/33 , H01L27/14881 , H04N5/359
摘要： It comprises information photodetection means (2), which have N photodetectors (6), each photodetector being able to supply a current having an information-carrying component and a non-information carrying component, N being an integer at least equal to 1, reading means (4) for the thus detected information and which use for this purpose the current supplied by each photodetector, and N other regulatable means (22) respectively associated with the N photodetectors each other regulatable means being able to extract a regulatable intensity current from the current supplied by the associated photodetector prior to the use of said latter current by the reading means.
摘要翻译：它包括具有N个光电检测器（6）的信息光检测装置（2），每个光电检测器能够提供具有信息携带部件和非信息传送部件的电流，N是至少等于1的整数，读数用于这样检测到的信息的装置（4），以及为此目的使用由每个光电检测器提供的电流，以及N个分别与N个光电检测器相关联的可调节装置（22），其中可调节装置能够提取可调节的强度电流在由所述读取装置使用所述后一电流之前由相关联的光电检测器提供的电流。

8. 发明授权

US07280088B2 Method and device for controlling a matrix electron source, with regulation by the emitted charge 失效
标题翻译：用于控制矩阵电子源的方法和装置，通过发射电荷进行调节
公开(公告)号：US07280088B2
公开(公告)日：2007-10-09
申请号：US10332883
申请日：2001-07-12
申请人： Pierre Nicolas , Denis Sarrasin
发明人： Pierre Nicolas , Denis Sarrasin
IPC分类号： G09G3/22
CPC分类号： G09G3/22 , G09G3/2007 , G09G3/2014 , G09G2310/027 , G09G2310/0275 , G09G2320/0209
摘要： Process and device for control of an electron source with matrix structure, regulated by the emitted charge.The invention is applicable to an electron source comprising addressing rows and columns which intersect to define emission areas, the electrons being supplied by the columns. According to this invention, the emission of electrons is triggered by increasing the potential of the columns to a value that will enable preferential emission of unaddressed rows. Then, throughout the emission duration, the potential of columns will be kept equal to this value, while simultaneously making measurements in the columns of the quantity of charges emitted by the pixels in the said columns. Secondly, when the quantity of charges measured on a column reaches a required charge quantity, the potential of this column is switched to a value that will block the emission of electrons.The invention is particularly applicable to flat field emission displays.
摘要翻译：用于控制具有矩阵结构的电子源的过程和装置，由发射电荷调节。本发明可应用于电子源，包括寻址行和列，其相交以限定发射区域，电子由列提供。根据本发明，通过将色谱柱的电位增加到能够优先排放未经处理的行的值来触发电子的发射。然后，在整个发射持续时间期间，列的电位将保持等于该值，同时在由所述列中的像素发射的电荷量的列中进行测量。其次，当在列上测量的电荷量达到所需的电荷量时，该列的电位被切换到将阻止电子发射的值。本发明特别适用于平场发射显示器。

9. 发明申请

US20070080647A1 Divergence-controlled hybrid multiple electron beam-emitting device 失效
标题翻译：发散控制的混合多电子束发射装置
公开(公告)号：US20070080647A1
公开(公告)日：2007-04-12
申请号：US10585073
申请日：2004-12-29
申请人： Yohan Desieres , Pierre Nicolas , Charlotte Gillot , Serge Gidon , Jean-Luc Martin
发明人： Yohan Desieres , Pierre Nicolas , Charlotte Gillot , Serge Gidon , Jean-Luc Martin
IPC分类号： G09G3/10
CPC分类号： H01J3/021 , B82Y10/00 , B82Y40/00 , H01J9/185 , H01J37/073 , H01J37/243 , H01J37/3177 , H01J2237/0635 , H01J2237/3175 , H01J2237/31774
摘要： An electronic emission device including plural electron beams including a first structure having a plurality of emission sources of electron beam, hybridized with a second structure including a plurality of diaphragm openings.
摘要翻译：一种电子发射装置，包括多个电子束，其包括具有多个电子束发射源的第一结构，与包括多个隔膜开口的第二结构杂交。

10. 发明授权

US06876344B2 Flat thermionic emission screen and with integrated anode control device 失效
标题翻译：平面热电子发射屏和集成阳极控制装置
公开(公告)号：US06876344B2
公开(公告)日：2005-04-05
申请号：US10076454
申请日：2002-02-19
申请人： Pierre Nicolas
发明人： Pierre Nicolas
IPC分类号： H01J31/12 , G09G3/20 , G09G3/22 , H01J3/02 , H01J21/10
CPC分类号： B82Y10/00 , G09G3/22 , H01J3/022 , H01J21/105
摘要： A flat thermionic emission screen (1) has a first substrate (2) on which are arranged an emission cathode (4) and an electron extraction grid (8), a second substrate (12) facing the first substrate (2) on which is arranged an anode (14) designed to collect the electrons emitted by the cathode (4), and an electronic control circuit of the anode (14) voltage having at least one commutation component (18, 20). The commutation component (18,20) is built into the first substrate (2) and in the second substrate (12) of the screen (1).
摘要翻译：平坦的热离子发射屏（1）具有第一衬底（2），排列有发射阴极（4）和电子提取栅极（8），面对第一衬底（2）的第二衬底（12）布置了设计成收集由阴极（4）发射的电子的阳极（14）和具有至少一个换向组件（18,20）的阳极（14）电压的电子控制电路。整流部件（18,20）被内置在屏幕（1）的第一基板（2）和第二基板（12）中。

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