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1. 发明申请

US20050202426A1 Whole cell engineering using real-time metabolic flux analysis 审中-公开
标题翻译：全细胞工程使用实时代谢通量分析
公开(公告)号：US20050202426A1
公开(公告)日：2005-09-15
申请号：US10491358
申请日：2002-10-01
申请人： Jay Short , Martin Latterich , Michael Levin , Jing Wei , Pengcheng Fu
发明人： Jay Short , Martin Latterich , Michael Levin , Jing Wei , Pengcheng Fu
IPC分类号： G01N27/62 , A61K48/00 , B01J20/281 , B01J20/285 , C07K1/16 , C12N1/15 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/85 , C12Q1/00 , C12Q1/02 , C12Q1/68 , G01N27/64 , G01N30/04 , G01N30/06 , G01N30/26 , G01N30/34 , G01N30/46 , G01N30/60 , G01N30/72 , G01N30/84 , G01N30/86 , G01N30/88 , G01N31/00 , G01N31/22 , G01N33/48 , G01N33/50 , G01N33/569 , G01N33/58 , G01N33/68 , G06F19/00
CPC分类号： G01N33/56911 , G01N33/5091
摘要： The invention provides methods for whole cell engineering of new and modified phenotypes by using “on-line” or “real-time” metabolic flux analysis. The invention provides a method for whole cell engineering of new or modified phenotypes by using real-time metabolic flux analysis by making a modified cell by modifying the genetic composition of a cell and culturing the modified cell to generate a plurality of modified cells and measuring at least one metabolic parameter of the cell by monitoring the cell culture of in real time. The invention also provides articles comprising machine-readable medium including machine-executable instructions and systems, e.g., computer systems, to practice the methods of the invention.
摘要翻译：本发明通过使用“在线”或“实时”代谢通量分析提供新的和修饰的表型的全细胞工程的方法。本发明提供了一种通过使用实时代谢通量分析通过改变细胞的遗传组成并培养修饰的细胞以产生多个修饰的细胞并通过在通过实时监测细胞培养物，细胞的至少一种代谢参数。本发明还提供包括机器可读介质的文章，其包括机器可执行指令和系统，例如计算机系统，以实施本发明的方法。

2. 发明申请

US20050124010A1 Whole cell engineering by mutagenizing a substantial portion of a starting genome combining mutations and optionally repeating 审中-公开
标题翻译：通过诱变大部分起始基因组合突变和任选地重复的整个细胞工程
公开(公告)号：US20050124010A1
公开(公告)日：2005-06-09
申请号：US10398271
申请日：2001-10-01
申请人： Jay Short , Pengcheng Fu , Jing Wei , Michael Levin , Martin Latterich
发明人： Jay Short , Pengcheng Fu , Jing Wei , Michael Levin , Martin Latterich
IPC分类号： A01H1/00 , A01K67/027 , C12N20060101 , C12N15/00 , C12N15/09 , C12N15/10 , C12N15/82 , C12Q1/02 , C12Q1/68 , G01N27/447 , G01N27/62 , G01N30/88 , G01N33/483 , G01N33/53 , G01N33/534 , G01N33/566 , G01N33/58 , G01N33/68 , G01N37/00 , G01N33/574 , G01N33/48 , G01N33/50 , G06F19/00
CPC分类号： C12N15/102 , C12N15/1027 , C12N15/1058 , C12N15/8241 , G01N33/534 , G01N33/6848 , G01N2800/52
摘要： This invention relates to the field of cellular and whole organism engineering. Specifically, this invention relates to a cellular transformation, directed evolution, and screening method for creating novel transgenic organisms having desirable properties. Thus in one aspect, this invention relates to a method of generating a transgenic organism, such as a microbe or a plant, having a plurality of traits that are diffenentially activatable.
摘要翻译：本发明涉及细胞和整体生物工程领域。具体地，本发明涉及用于产生具有期望性质的新型转基因生物的细胞转化，定向进化和筛选方法。因此，在一个方面，本发明涉及产生具有多个难以发生活性的性状的转基因生物体如微生物或植物的方法。

3. 发明授权

US08661785B2 System and method for liquid reductant injection 有权
标题翻译：液体还原剂注入系统和方法
公开(公告)号：US08661785B2
公开(公告)日：2014-03-04
申请号：US13419830
申请日：2012-03-14
申请人： Michael Levin , Furqan Zafar Shaikh , Thomas A. McCarthy , Bret Alan Zimmerman
发明人： Michael Levin , Furqan Zafar Shaikh , Thomas A. McCarthy , Bret Alan Zimmerman
IPC分类号： F01N3/20
CPC分类号： F01N3/208 , F01N9/00 , F01N2610/02 , F01N2610/1473 , Y02T10/24 , Y02T10/47
摘要： A method for operating a liquid reductant injection system is provided. The method includes storing a reductant mixture of ethanol, water, and urea; drawing the stored mixture into an electrically heated pick-up tube for delivery via a delivery line to the exhaust by operating a pump in a first direction; and, clearing a return line that returns the stored mixture or the delivery line by operating the pump in a second, reverse, direction. In this way, by including ethanol in the reductant solution, a freezing point temperature of the liquid reductant may be reduced.
摘要翻译：提供了一种操作液体还原剂注入系统的方法。该方法包括储存乙醇，水和尿素的还原剂混合物; 将所储存的混合物通过在第一方向上操作泵将所述储存的混合物经由输送管线输送到电加热的拾取管中以进行排放; 并且通过以第二反向的方向操作泵来清除返回存储的混合物或输送管线的返回管线。以这种方式，通过在还原剂溶液中包含乙醇，可以降低液体还原剂的凝固点温度。

4. 发明申请

US20130186076A1 METHOD TO PROTECT THE EXHAUST MANIFOLD FROM OVERHEATING USING HEAT PIPE 有权
标题翻译：使用热管过热保护排气管的方法
公开(公告)号：US20130186076A1
公开(公告)日：2013-07-25
申请号：US13354209
申请日：2012-01-19
申请人： Shiguang (Steven) Zhou , Michael Levin , Furqan Zafar Shaikh , Jeffrey Scott Hepburn , Donald S. Masch , Zhaoyang Zeng , James Patrick O'Neill , Danrich Henry Demitroff
发明人： Shiguang (Steven) Zhou , Michael Levin , Furqan Zafar Shaikh , Jeffrey Scott Hepburn , Donald S. Masch , Zhaoyang Zeng , James Patrick O'Neill , Danrich Henry Demitroff
IPC分类号： F01N3/02
CPC分类号： F01N3/043 , F01N3/046 , F01N3/055 , F01N13/102 , F01N2240/02 , F02B37/00 , Y02T10/20
摘要： An exhaust system for an engine is disclosed herein. The exhaust system includes a catalytic converter, an exhaust manifold upstream from the catalytic converter, and a heat pipe in thermal contact with the exhaust manifold and atmosphere. The system further includes a phase changing material that passively absorbs heat after catalytic light-off.
摘要翻译：这里公开了用于发动机的排气系统。排气系统包括催化转化器，催化转化器上游的排气歧管和与排气歧管和气氛热接触的热管。该系统还包括在催化熄灭后被动吸收热量的相变材料。

5. 发明授权

US08386021B2 Energy transfer amplification for intrabody devices 有权
公开(公告)号：US08386021B2
公开(公告)日：2013-02-26
申请号：US12574374
申请日：2009-10-06
申请人： Assaf Govari , Michael Levin
发明人： Assaf Govari , Michael Levin
IPC分类号： A61B5/05
CPC分类号： A61B5/6846 , A61B5/06 , A61B5/4528 , A61B2090/3975 , A61B2560/0219 , A61F2/32 , A61F2/36 , A61F2/38 , A61F2/4657 , A61F2002/3067 , A61F2002/3429 , A61F2002/3611 , A61F2002/4658 , A61F2002/4668 , A61F2250/0002 , A61N1/3787
摘要： Apparatus for driving current in a power circuit of a medical device inserted into a body of a subject includes a power transmitter, which is adapted to generate, in a vicinity of the body, an electromagnetic field having a predetermined frequency capable of inductively driving the current in the power circuit. A passive energy transfer amplifier, having a resonant response at the frequency of the electromagnetic field is placed in proximity to the medical device so as to enhance the current driven in the power circuit by the electromagnetic field.

6. 发明授权

US08191356B2 Liquid injector assembly with a flanged connector connection 有权
公开(公告)号：US08191356B2
公开(公告)日：2012-06-05
申请号：US12575803
申请日：2009-10-08
申请人： Dwayne Pollitt , Furqan Zafar Shaikh , Scott Donald Cooper , Michael Levin , John Paul Bogema , Bret Alan Zimmerman , Gary Scott Nichols
发明人： Dwayne Pollitt , Furqan Zafar Shaikh , Scott Donald Cooper , Michael Levin , John Paul Bogema , Bret Alan Zimmerman , Gary Scott Nichols
IPC分类号： F01N3/00 , F01N3/10 , B05B1/24 , B05B7/16 , B05B15/00 , B05C1/00
CPC分类号： F01N3/2066 , F01N3/36 , F01N2610/02 , F01N2610/03 , F01N2610/1453 , Y02T10/24
摘要： A system for injecting from an injector into a duct of an engine system is provided. The system may include a first flange on a duct connection side, a second flange on an injector connection side, a stand-off separating the first flange from the second flange to form an air gap therebetween, and a seal offset from at least one of the first and the second flanges and located within the airgap and between the first flange and the second flange.

7. 发明授权

US07930878B2 Method and apparatus for rapidly thawing frozen NOx reductant 有权
标题翻译：快速解冻冷冻NOx还原剂的方法和装置
公开(公告)号：US07930878B2
公开(公告)日：2011-04-26
申请号：US11679206
申请日：2007-02-27
申请人： David Cook , Furqan Zafar Shaikh , Michael Levin , David Furedy , Evan Kent Dawson , Daniel Kabat , Jeremy Keller
发明人： David Cook , Furqan Zafar Shaikh , Michael Levin , David Furedy , Evan Kent Dawson , Daniel Kabat , Jeremy Keller
IPC分类号： F01N3/00 , F01N3/10
CPC分类号： F01N3/2066 , B01D2251/2067 , F01N2610/02 , F01N2610/10 , F01N2610/14 , F01N2610/1406 , Y02A50/2325 , Y02T10/24
摘要： According to one aspect of the present invention, a liquid reductant tank for supplying liquid reductant to a selective catalytic reduction system is disclosed. The tank includes a tank cavity for holding a liquid reductant and being at least partially defined by one or more side walls; a liquid reductant supply line at least partially situated within the tank cavity and for communicating liquid reductant from the tank cavity to outside of the tank cavity; and a heating element situated at least partially within the liquid reductant supply line and for thawing frozen reductant situated within the supply line during cold start conditions to obtain liquid reductant for use in a selective catalytic reduction system.
摘要翻译：根据本发明的一个方面，公开了一种用于向选择性催化还原系统供应液体还原剂的液体还原剂罐。该罐包括用于保持液体还原剂并且至少部分地由一个或多个侧壁限定的罐腔; 液体还原剂供应管线至少部分地位于罐腔内并用于将液体还原剂从罐腔连通到罐腔外部; 以及加热元件，其至少部分地位于液体还原剂供应管线内，并用于在冷启动条件期间解冻位于供应管线内的冷冻还原剂，以获得用于选择性催化还原系统的液体还原剂。

8. 发明申请

US20110067381A1 Method for NOx Reduction 有权
标题翻译：降低NOx的方法
公开(公告)号：US20110067381A1
公开(公告)日：2011-03-24
申请号：US12564746
申请日：2009-09-22
申请人： Bret Alan Zimmerman , Michael Levin , John Paul Bogema , Furqan Zafar Shaikh
发明人： Bret Alan Zimmerman , Michael Levin , John Paul Bogema , Furqan Zafar Shaikh
IPC分类号： F01N3/20
CPC分类号： F01N3/2066 , F01N2240/20 , F01N2610/02 , F01N2610/1453 , Y02A50/2325 , Y02T10/24
摘要： The present application relates to mitigating NOx emissions, and more particularly, to vehicles including a selective catalytic reduction (SCR) system in the exhaust of a diesel or gasoline engine. In one example a method includes temporarily increasing a liquid reductant dosing value injected by an injector from a first dosing value to a second dosing value, the temporary increase in response to a change from injecting liquid reductant onto a first impact location on a disperser device to injecting onto a second impact location on the disperser device.
摘要翻译：本申请涉及减轻NOx排放，更具体地涉及包括在柴油或汽油发动机的排气中的选择性催化还原（SCR）系统的车辆。在一个实例中，一种方法包括将喷射器注入的液体还原剂计量值从第一计量值暂时增加到第二计量值，响应于将液体还原剂注入到分散器装置上的第一冲击位置上的变化而临时增加到喷射到分散器装置上的第二冲击位置上。

9. 发明申请

US20110024937A1 Tablet Formation System for Fully-Loaded Presses 审中-公开
标题翻译：全压机压片机组成系统
公开(公告)号：US20110024937A1
公开(公告)日：2011-02-03
申请号：US12512718
申请日：2009-07-30
申请人： Semen Dukler , Lev Tsygan , Michael Levin
发明人： Semen Dukler , Lev Tsygan , Michael Levin
IPC分类号： B29C43/34 , B29C43/58
CPC分类号： B30B11/08 , B29C43/08 , B29C43/58 , B29C2043/3283 , B29C2043/3618 , B29C2043/5833 , B29C2043/5883
摘要： Rotary press machine including dies, pairs of upper and lower punches with a part of each lower punch being movable in a respective die to selectively enable formation of a cavity in the die, a feeding system for feeding powder material into the cavities, when present, in a feeding stage, a pressing system for pressing the upper and lower punches together in a pressing stage and a tablet ejection system for ejecting formed tablets from the dies in a tablet ejection stage. The upper and lower punches are rotated sequentially through the feeding stage, the pressing stage, and the tablet ejection stage to thereby enable formation of tablets if powder material is feed into the cavities in the dies. To enable selective formation of tablets and thereby optimize production thereof, an adjustment mechanism is provided and enables selective formation of the cavities in the dies. The adjustment mechanism may comprise removeable rings attached to at least one, or to a plurality of lower punches, which rings are selectively engaged by the adjustment mechanism.
摘要翻译：包括模具的旋转压力机成对的上下冲头，每个下冲头的一部分可在相应的模具中移动，以选择性地在模具中形成空腔，用于将粉料输送到空腔中的进料系统，在进料阶段，用于在压制阶段中将上冲头和下冲头压在一起的压制系统和用于在片剂喷射阶段从模具中排出成形片剂的片剂排出系统。上冲头和下冲头依次通过进料阶段，加压阶段和片剂喷射阶段旋转，从而如果将粉末材料进料到模具中的空腔中，则能够形成片剂。为了能够选择性地形成片剂并由此优化其生产，提供了调节机构，并且能够选择性地形成模具中的空腔。调节机构可以包括附接到至少一个或多个下冲头的可移除环，该多个下冲头通过调节机构选择性地接合该环。

10. 发明授权

US07613497B2 Energy transfer amplification for intrabody devices 有权
标题翻译：能量转移扩增用于体内器件
公开(公告)号：US07613497B2
公开(公告)日：2009-11-03
申请号：US10629660
申请日：2003-07-29
申请人： Assaf Govari , Michael Levin
发明人： Assaf Govari , Michael Levin
IPC分类号： A61B5/05
CPC分类号： A61B5/6846 , A61B5/06 , A61B5/4528 , A61B2090/3975 , A61B2560/0219 , A61F2/32 , A61F2/36 , A61F2/38 , A61F2/4657 , A61F2002/3067 , A61F2002/3429 , A61F2002/3611 , A61F2002/4658 , A61F2002/4668 , A61F2250/0002 , A61N1/3787
摘要： Apparatus for driving current in a power circuit of a medical device inserted into a body of a subject includes a power transmitter, which is adapted to generate, in a vicinity of the body, an electromagnetic field having a predetermined frequency capable of inductively driving the current in the power circuit. A passive energy transfer amplifier, having a resonant response at the frequency of the electromagnetic field is placed in proximity to the medical device so as to enhance the current driven in the power circuit by the electromagnetic field.
摘要翻译：用于驱动插入到被检体内的医疗装置的电源电路中的电流的装置包括：功率发射器，其适于在身体附近产生具有能够感应地驱动电流的预定频率的电磁场在电源电路中。在电磁场的频率处具有谐振响应的无源能量传递放大器放置在靠近医疗装置的位置，以便通过电磁场增强在电力电路中驱动的电流。

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