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1. 发明授权

US07618797B2 Infectious cDNA clone of North American porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof 有权
标题翻译：北美猪繁殖与呼吸综合征（PRRS）病毒的传染性cDNA克隆及其用途
公开(公告)号：US07618797B2
公开(公告)日：2009-11-17
申请号：US11586328
申请日：2006-10-25
申请人： Jay Gregory Calvert , Michael G. Sheppard , Siao-Kun W. Welch
发明人： Jay Gregory Calvert , Michael G. Sheppard , Siao-Kun W. Welch
IPC分类号： C12P19/34
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/525 , A61K2039/5254 , A61K2039/53 , A61K2039/552 , A61K2039/55544 , A61K2039/55566 , A61K2039/55577 , C07K2319/42 , C07K2319/60 , C12N7/00 , C12N15/86 , C12N2770/10021 , C12N2770/10022 , C12N2770/10034 , C12N2770/10043 , C12N2770/10061 , G01N33/56983 , G01N2333/08
摘要： The invention provides isolated polynucleotide molecules that comprise a DNA sequence encoding an infectious RNA sequence encoding a genetically-modified North American PRRS virus, wherein the polynucleotide molecule lacks at least one detectable antigenic epitope of North American PRRS virus. The invention also provides vaccines comprising genetically modified North American PRRS virus, RNA molecules, plasmids and viral vectors comprising the isolated polynucleotide molecules. Also provided are isolated polynucleotide molecules further comprising at least one nucleotide sequence that encodes a detectable heterologous antigenic epitope, and vaccines comprising North American PRRS virus, RNA molecules, plasmids and viral vectors comprising such isolated polynucleotide molecules.
摘要翻译：本发明提供了分离的多核苷酸分子，其包含编码编码经遗传修饰的北美PRRS病毒的感染性RNA序列的DNA序列，其中多核苷酸分子缺少至少一种可检测的北美PRRS病毒抗原表位。本发明还提供包含经遗传修饰的北美PRRS病毒，RNA分子，质粒和包含分离的多核苷酸分子的病毒载体的疫苗。还提供了进一步包含编码可检测的异源抗原表位的至少一个核苷酸序列的分离的多核苷酸分子，以及包含北美PRRS病毒，RNA分子，质粒和包含这种分离的多核苷酸分子的病毒载体的疫苗。

2. 发明授权

US08895025B2 Infectious cDNA of north american porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof 有权
标题翻译：北美猪繁殖与呼吸综合征（PRRS）病毒的感染性cDNA克隆及其用途
公开(公告)号：US08895025B2
公开(公告)日：2014-11-25
申请号：US12608305
申请日：2009-10-29
申请人： Jay Gregory Calvert , Michael G. Sheppard , Siao-Kun W. Welch , Raymond R. R. Rowland , Dal-Young Kim
发明人： Jay Gregory Calvert , Michael G. Sheppard , Siao-Kun W. Welch , Raymond R. R. Rowland , Dal-Young Kim
IPC分类号： A61K39/00 , C12N15/86 , C07K14/005 , C12N7/00
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/525 , A61K2039/5254 , A61K2039/53 , A61K2039/552 , A61K2039/55544 , A61K2039/55566 , A61K2039/55577 , C07K2319/42 , C07K2319/60 , C12N7/00 , C12N15/86 , C12N2770/10021 , C12N2770/10022 , C12N2770/10034 , C12N2770/10043 , C12N2770/10061 , G01N33/56983 , G01N2333/08
摘要： The invention provides isolated polynucleotide molecules that comprise a DNA sequence encoding an infectious RNA sequence encoding a genetically-modified North American PRRS virus, wherein the polynucleotide molecule lacks at least one detectable antigenic epitope of North American PRRS virus. The invention also provides vaccines comprising genetically modified North American PRRS virus, RNA molecules, plasmids and viral vectors comprising the isolated polynucleotide molecules. Also provided are isolated polynucleotide molecules further comprising at least one nucleotide sequence that encodes a detectable heterologous antigenic epitope, and vaccines comprising North American PRRS virus, RNA molecules, plasmids and viral vectors comprising such isolated polynucleotide molecules.
摘要翻译：本发明提供了分离的多核苷酸分子，其包含编码编码经遗传修饰的北美PRRS病毒的感染性RNA序列的DNA序列，其中多核苷酸分子缺少至少一种可检测的北美PRRS病毒抗原表位。本发明还提供包含经遗传修饰的北美PRRS病毒，RNA分子，质粒和包含分离的多核苷酸分子的病毒载体的疫苗。还提供了进一步包含编码可检测的异源抗原表位的至少一个核苷酸序列的分离的多核苷酸分子，以及包含北美PRRS病毒，RNA分子，质粒和包含这种分离的多核苷酸分子的病毒载体的疫苗。

3. 发明申请

US20110040080A1 Infectious cDNA Clone of North American Porcine Reproductive and Respiratory Syndrome (PRRS) Virus and Uses Thereof 有权
标题翻译：北美猪繁殖与呼吸综合征（PRRS）病毒及其用途的传染性cDNA克隆
公开(公告)号：US20110040080A1
公开(公告)日：2011-02-17
申请号：US12619880
申请日：2009-11-17
申请人： Jay Gregory Calvert , Michael G. Sheppard , Siao-Kun W. Welch , Raymond R.R. Rowland , Dal-Young Kim
发明人： Jay Gregory Calvert , Michael G. Sheppard , Siao-Kun W. Welch , Raymond R.R. Rowland , Dal-Young Kim
IPC分类号： C07H21/04
CPC分类号： C07K14/005 , A61K2039/525 , A61K2039/53 , C12N15/86 , C12N2770/10022 , C12N2770/10043
摘要： The invention provides isolated polynucleotide molecules, including plasmids; viral vectors; and transfected host cells that comprise a DNA sequence encoding an infectious RNA sequence encoding a North American PRRS virus; and also North American PRRS viruses encoded thereby. The invention further provides isolated infectious RNA molecules encoding a North American PRRS virus. The invention also provides isolated polynucleotide molecules, infectious RNA molecules, viral vectors, and transfected host cells encoding genetically-modified North American PRRS viruses; and genetically-modified North American PRRS viruses encoded thereby. The invention also provides vaccines comprising such plasmids, RNA molecules, viral vectors, and North American PRRS viruses, and methods of using these vaccines in swine and in other animals. Also provided are isolated polynucleotide molecules, viral vectors, and transfected host cells that comprise a nucleotide sequence encoding a peptide of a North American PRRS virus. These viral vectors and transfected host cell lines are useful in providing peptides to compensate for mutated peptide coding sequences of DNA sequences encoding genetically-modified North American PRRS viruses so that functional virions can be generated.
摘要翻译：本发明提供分离的多核苷酸分子，包括质粒; 病毒载体; 和包含编码编码北美PRRS病毒的感染性RNA序列的DNA序列的转染宿主细胞; 以及由此编码的北美PRRS病毒。本发明还提供编码北美PRRS病毒的分离的感染性RNA分子。本发明还提供分离的多核苷酸分子，感染性RNA分子，病毒载体和编码经遗传修饰的北美PRRS病毒的转染宿主细胞; 和由此编码的转基因北美PRRS病毒。本发明还提供包含这样的质粒，RNA分子，病毒载体和北美PRRS病毒的疫苗，以及在猪和其他动物中使用这些疫苗的方法。还提供了分离的多核苷酸分子，病毒载体和包含编码北美PRRS病毒的肽的核苷酸序列的转染宿主细胞。这些病毒载体和转染的宿主细胞系可用于提供肽以补偿编码经遗传修饰的北美PRRS病毒的DNA序列的突变的肽编码序列，从而可以产生功能性病毒体。

4. 发明授权

US08492533B2 Infectious cDNA clone of North American porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof 有权
公开(公告)号：US08492533B2
公开(公告)日：2013-07-23
申请号：US12615504
申请日：2009-11-10
申请人： Jay Gregory Calvert , Michael G. Sheppard , Siao-Kun W. Welch , Raymond R. R. Rowland , Dal-Young Kim
发明人： Jay Gregory Calvert , Michael G. Sheppard , Siao-Kun W. Welch , Raymond R. R. Rowland , Dal-Young Kim
IPC分类号： C07H21/04
摘要： The invention provides isolated polynucleotide molecules that comprise a DNA sequence encoding an infectious RNA sequence encoding a genetically-modified North American PRRS virus, wherein the polynucleotide molecule lacks at least one detectable antigenic epitope of North American PRRS virus. The invention also provides vaccines comprising genetically modified North American PRRS virus, RNA molecules, plasmids and viral vectors comprising the isolated polynucleotide molecules. Also provided are isolated polynucleotide molecules further comprising at least one nucleotide sequence that encodes a detectable heterologous antigenic epitope, and vaccines comprising North American PRRS virus, RNA molecules, plasmids and viral vectors comprising such isolated polynucleotide molecules.

5. 发明授权

US08481705B2 Infectious cDNA clone of North American porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof 有权
公开(公告)号：US08481705B2
公开(公告)日：2013-07-09
申请号：US12619880
申请日：2009-11-17
申请人： Jay Gregory Calvert , Michael G. Sheppard , Siao-Kun W. Welch , Raymond R. R. Rowland , Dal-Young Kim
发明人： Jay Gregory Calvert , Michael G. Sheppard , Siao-Kun W. Welch , Raymond R. R. Rowland , Dal-Young Kim
IPC分类号： C07H21/04
CPC分类号： C07K14/005 , A61K2039/525 , A61K2039/53 , C12N15/86 , C12N2770/10022 , C12N2770/10043
摘要： The invention provides isolated polynucleotide molecules, including plasmids; viral vectors; and transfected host cells that comprise a DNA sequence encoding an infectious RNA sequence encoding a North American PRRS virus; and also North American PRRS viruses encoded thereby. The invention further provides isolated infectious RNA molecules encoding a North American PRRS virus. The invention also provides isolated polynucleotide molecules, infectious RNA molecules, viral vectors, and transfected host cells encoding genetically-modified North American PRRS viruses; and genetically-modified North American PRRS viruses encoded thereby. The invention also provides vaccines comprising such plasmids, RNA molecules, viral vectors, and North American PRRS viruses, and methods of using these vaccines in swine and in other animals. Also provided are isolated polynucleotide molecules, viral vectors, and transfected host cells that comprise a nucleotide sequence encoding a peptide of a North American PRRS virus. These viral vectors and transfected host cell lines are useful in providing peptides to compensate for mutated peptide coding sequences of DNA sequences encoding genetically-modified North American PRRS viruses so that functional virions can be generated.

6. 发明申请

US20100136659A1 Infectious cDNA Clone of North American Porcine Reproductive and Respiratory Syndrome (PPRS) Virus and Uses Thereof 有权
标题翻译：北美猪繁殖与呼吸综合征（PPRS）病毒的传染性cDNA克隆及其用途
公开(公告)号：US20100136659A1
公开(公告)日：2010-06-03
申请号：US12607358
申请日：2009-10-28
申请人： Jay Gregory Calvert , Michael G. Sheppard , Siao-Kun W. Welch , Raymond R. R. Rowland , Dal-Young Kim
发明人： Jay Gregory Calvert , Michael G. Sheppard , Siao-Kun W. Welch , Raymond R. R. Rowland , Dal-Young Kim
IPC分类号： C12N7/01 , C07H21/04 , C12N15/63
CPC分类号： C07K14/005 , A61K2039/525 , A61K2039/53 , C12N15/86 , C12N2770/10022 , C12N2770/10043
摘要： The invention provides isolated polynucleotide molecules, including plasmids; viral vectors; and transfected host cells that comprise a DNA sequence encoding an infectious RNA sequence encoding a North American PRRS virus; and also North American PRRS viruses encoded thereby. The invention further provides isolated infectious RNA molecules encoding a North American PRRS virus. The invention also provides isolated polynucleotide molecules, infectious RNA molecules, viral vectors, and transfected host cells encoding genetically-modified North American PRRS viruses; and genetically-modified North American PRRS viruses encoded thereby. The invention also provides vaccines comprising such plasmids, RNA molecules, viral vectors, and North American PRRS viruses, and methods of using these vaccines in swine and in other animals. Also provided are isolated polynucleotide molecules, viral vectors, and transfected host cells that comprise a nucleotide sequence encoding a peptide of a North American PRRS virus. These viral vectors and transfected host cell lines are useful in providing peptides to compensate for mutated peptide coding sequences of DNA sequences encoding genetically-modified North American PRRS viruses so that functional virions can be generated.
摘要翻译：本发明提供分离的多核苷酸分子，包括质粒; 病毒载体; 和包含编码编码北美PRRS病毒的感染性RNA序列的DNA序列的转染宿主细胞; 以及由此编码的北美PRRS病毒。本发明还提供编码北美PRRS病毒的分离的感染性RNA分子。本发明还提供分离的多核苷酸分子，感染性RNA分子，病毒载体和编码经遗传修饰的北美PRRS病毒的转染宿主细胞; 和由此编码的转基因北美PRRS病毒。本发明还提供包含这样的质粒，RNA分子，病毒载体和北美PRRS病毒的疫苗，以及在猪和其他动物中使用这些疫苗的方法。还提供了分离的多核苷酸分子，病毒载体和包含编码北美PRRS病毒的肽的核苷酸序列的转染宿主细胞。这些病毒载体和转染的宿主细胞系可用于提供肽以补偿编码经遗传修饰的北美PRRS病毒的DNA序列的突变的肽编码序列，从而可以产生功能性病毒体。

7. 发明授权

US08609827B2 Infectious cDNA clone of North American porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof 有权
公开(公告)号：US08609827B2
公开(公告)日：2013-12-17
申请号：US12615504
申请日：2009-11-10
申请人： Jay Gregory Calvert , Michael G. Sheppard , Siao-Kun W. Welch , Raymond R. R. Rowland , Dal-Young Kim
发明人： Jay Gregory Calvert , Michael G. Sheppard , Siao-Kun W. Welch , Raymond R. R. Rowland , Dal-Young Kim
IPC分类号： C07H21/04
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/525 , A61K2039/5254 , A61K2039/53 , A61K2039/552 , A61K2039/55544 , A61K2039/55566 , A61K2039/55577 , C07K2319/42 , C07K2319/60 , C12N7/00 , C12N15/86 , C12N2770/10021 , C12N2770/10022 , C12N2770/10034 , C12N2770/10043 , C12N2770/10061 , G01N33/56983 , G01N2333/08
摘要： The invention provides isolated polynucleotide molecules that comprise a DNA sequence encoding an infectious RNA sequence encoding a genetically-modified North American PRRS virus, wherein the polynucleotide molecule lacks at least one detectable antigenic epitope of North American PRRS virus. The invention also provides vaccines comprising genetically modified North American PRRS virus, RNA molecules, plasmids and viral vectors comprising the isolated polynucleotide molecules. Also provided are isolated polynucleotide molecules further comprising at least one nucleotide sequence that encodes a detectable heterologous antigenic epitope, and vaccines comprising North American PRRS virus, RNA molecules, plasmids and viral vectors comprising such isolated polynucleotide molecules.

8. 发明授权

US07691389B2 Infectious cDNA clone of north american porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof 有权
标题翻译：北美猪繁殖与呼吸综合征（PRRS）病毒的传染性cDNA克隆及其用途
公开(公告)号：US07691389B2
公开(公告)日：2010-04-06
申请号：US11366851
申请日：2006-03-01
申请人： Jay Gregory Calvert , Michael G Sheppard , Siao-Kun W. Welch
发明人： Jay Gregory Calvert , Michael G Sheppard , Siao-Kun W. Welch
IPC分类号： A61K39/12
CPC分类号： C07K14/005 , A61K2039/525 , A61K2039/53 , C12N15/86 , C12N2770/10022 , C12N2770/10043
摘要： The invention provides isolated polynucleotide molecules, including plasmids; viral vectors; and transfected host cells that comprise a DNA sequence encoding an infectious RNA sequence encoding a North American PRRS virus; and also North American PRRS viruses encoded thereby. The invention further provides isolated infectious RNA molecules encoding a North American PRRS virus. The invention also provides isolated polynucleotide molecules, infectious RNA molecules, viral vectors, and transfected host cells encoding genetically-modified North American PRRS viruses; and genetically-modified North American PRRS viruses encoded thereby. The invention also provides vaccines comprising such plasmids, RNA molecules, viral vectors, and North American PRRS viruses, and methods of using these vaccines in swine and in other animals. Also provided are isolated polynucleotide molecules, viral vectors, and transfected host cells that comprise a nucleotide sequence encoding a peptide of a North American PRRS virus. These viral vectors and transfected host cell lines are useful in providing peptides to compensate for mutated peptide coding sequences of DNA sequences encoding genetically-modified North American PRRS viruses so that functional virions can be generated.
摘要翻译：本发明提供分离的多核苷酸分子，包括质粒; 病毒载体; 和包含编码编码北美PRRS病毒的感染性RNA序列的DNA序列的转染宿主细胞; 以及由此编码的北美PRRS病毒。本发明还提供编码北美PRRS病毒的分离的感染性RNA分子。本发明还提供分离的多核苷酸分子，感染性RNA分子，病毒载体和编码经遗传修饰的北美PRRS病毒的转染宿主细胞; 和由此编码的转基因北美PRRS病毒。本发明还提供包含这样的质粒，RNA分子，病毒载体和北美PRRS病毒的疫苗，以及在猪和其他动物中使用这些疫苗的方法。还提供了分离的多核苷酸分子，病毒载体和包含编码北美PRRS病毒的肽的核苷酸序列的转染宿主细胞。这些病毒载体和转染的宿主细胞系可用于提供肽以补偿编码经遗传修饰的北美PRRS病毒的DNA序列的突变的肽编码序列，从而可以产生功能性病毒体。

9. 发明授权

US09566324B2 North American porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof 有权
标题翻译：北美猪繁殖与呼吸综合征（PRRS）病毒及其用途
公开(公告)号：US09566324B2
公开(公告)日：2017-02-14
申请号：US13884077
申请日：2011-11-09
申请人： Jay Gregory Calvert , David Ewell Slade , Siao-Kun W. Welch
发明人： Jay Gregory Calvert , David Ewell Slade , Siao-Kun W. Welch
IPC分类号： A61K39/12 , C07K16/08 , C07K14/005 , C12N7/00 , A61K39/00
CPC分类号： A61K39/12 , A61K2039/5254 , A61K2039/552 , A61K2039/57 , C07K14/005 , C07K16/08 , C12N7/00 , C12N15/86 , C12N2770/10022 , C12N2770/10034 , C12N2770/10043 , C12N2770/10051 , C12N2770/10062 , C12N2770/10064 , C12N2770/10071
摘要： The invention provides isolated polynucleotide molecules that comprise a DNA sequence encoding an infectious RNA sequence encoding a genetically-modified North American PRRS virus, methods to make it and related polypeptides, polynucleotides, and various components. Vaccines comprising the genetically modified virus and polynucleotides and a diagnostic kit to distinguish between naturally infected and vaccinated animals are also provided.
摘要翻译：本发明提供了分离的多核苷酸分子，其包含编码编码经遗传修饰的北美PRRS病毒的感染性RNA序列的DNA序列，其制备方法和相关多肽，多核苷酸和各种成分。还提供了包含经遗传修饰的病毒和多核苷酸的疫苗和用于区分天然感染和接种疫苗的动物的诊断试剂盒。

10. 发明申请

US20140072589A1 North American Porcine Reproductive and Respiratory Syndrome (PRRS) Virus and Uses Thereof 有权
标题翻译：北美猪繁殖与呼吸综合征（PRRS）病毒及其用途
公开(公告)号：US20140072589A1
公开(公告)日：2014-03-13
申请号：US13884077
申请日：2011-11-09
申请人： Jay Gregory Calvert , David Ewell Slade , Siao-Kun W. Welch
发明人： Jay Gregory Calvert , David Ewell Slade , Siao-Kun W. Welch
IPC分类号： A61K39/12 , C07K16/08
CPC分类号： A61K39/12 , A61K2039/5254 , A61K2039/552 , A61K2039/57 , C07K14/005 , C07K16/08 , C12N7/00 , C12N15/86 , C12N2770/10022 , C12N2770/10034 , C12N2770/10043 , C12N2770/10051 , C12N2770/10062 , C12N2770/10064 , C12N2770/10071
摘要： The invention provides isolated polynucleotide molecules that comprise a DNA sequence encoding an infectious RNA sequence encoding a genetically-modified North American PRRS virus, methods to make it and related polypeptides, polynucleotides, and various components. Vaccines comprising the genetically modified virus and polynucleotides and a diagnostic kit to distinguish between naturally infected and vaccinated animals are also provided.
摘要翻译：本发明提供了分离的多核苷酸分子，其包含编码编码经遗传修饰的北美PRRS病毒的感染性RNA序列的DNA序列，其制备方法和相关多肽，多核苷酸和各种成分。还提供了包含经遗传修饰的病毒和多核苷酸的疫苗和用于区分天然感染和接种疫苗的动物的诊断试剂盒。

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