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1. 发明申请

US20120142979A1 PRODUCTION OF FATTY ACIDS & DERIVATIVES THEREOF 审中-公开
标题翻译：生产脂肪酸及其衍生物
公开(公告)号：US20120142979A1
公开(公告)日：2012-06-07
申请号：US13302957
申请日：2011-11-22
申请人： Jay D. KEASLING , Zhihao Hu , Chris Somerville , George Church , David Berry , Lisa Friedman , Andreas Schirmer , Shane Brubaker , Stephen B. Del Cardayre
发明人： Jay D. KEASLING , Zhihao Hu , Chris Somerville , George Church , David Berry , Lisa Friedman , Andreas Schirmer , Shane Brubaker , Stephen B. Del Cardayre
IPC分类号： C12P7/04 , C12N1/19 , C12N1/21 , C07C33/025 , C07C31/125
CPC分类号： C12P7/04 , C07C31/125 , C07C33/02 , C10L1/026 , C10L1/328 , C12P7/6436 , C12P7/6463 , C12P7/649 , Y02E50/13
摘要： Compositions and methods for production of fatty alcohols using recombinant microorganisms are provided as well as fatty alcohol compositions produced by such methods.
摘要翻译：提供了使用重组微生物生产脂肪醇的组合物和方法以及通过这些方法生产的脂肪醇组合物。

2. 发明申请

US20100242345A1 PRODUCTION OF FATTY ACIDS & DERIVATIVES THEREOF 审中-公开
标题翻译：生产脂肪酸及其衍生物
公开(公告)号：US20100242345A1
公开(公告)日：2010-09-30
申请号：US12278957
申请日：2007-05-18
申请人： Jay D. Keasling , Zhihao Hu , Chris Sommerville , George Church , David Berry , Lisa Friedman , Andreas Schirmer , Shane Brubaker , Stephen B. del Cardayre
发明人： Jay D. Keasling , Zhihao Hu , Chris Sommerville , George Church , David Berry , Lisa Friedman , Andreas Schirmer , Shane Brubaker , Stephen B. del Cardayre
IPC分类号： C12N1/00 , C12N1/36 , C07C57/03 , C12N1/21 , C12P7/64 , C10L1/19 , C12N1/19
CPC分类号： C12P7/04 , C07C31/125 , C07C33/02 , C10L1/026 , C10L1/328 , C12P7/6436 , C12P7/6463 , C12P7/649 , Y02E50/13
摘要： Genetically engineered microorganisms are provided that produce products from the fatty acid biosynthetic pathway (fatty acid derivatives), as well as methods of their use.
摘要翻译：提供从脂肪酸生物合成途径（脂肪酸衍生物）产生产物的基因工程微生物以及其使用方法。

3. 发明申请

US20080293060A1 Methods and Compositions for Identification of Hydrocarbon Response, Transport and Biosynthesis Genes 审中-公开
标题翻译：用于鉴定烃反应，运输和生物合成基因的方法和组合物
公开(公告)号：US20080293060A1
公开(公告)日：2008-11-27
申请号：US12108278
申请日：2008-04-23
申请人： Andreas Schirmer , Zhihao Hu , Bernardo da Costa
发明人： Andreas Schirmer , Zhihao Hu , Bernardo da Costa
IPC分类号： C12Q1/68 , C12N1/21
CPC分类号： C12Q1/6897 , C12N15/1086
摘要： Disclosed is a method using an alkane response element (ARE) from, e.g., Acinetobacter spp. to (i) identify and clone hydrocarbon biosynthesis genes, (ii) identify and clone hydrocarbon transporter genes (iii) identify and clone hydrocarbon response genes. Screening cells were developed that expressed a transcriptional activator, e.g., alkR, and included a reporter gene, e.g., GFP operatively linked to an ARE promoter, e.g., the alkM promoter. The cells were transformed with libraries from organisms capable of hydrocarbon biosynthesis. Transformed cells that expressed the reporter gene harbored library-derived genes involved in one or more of the above-mentioned processes; and these genes were isolated from the cells using standard molecular biology techniques. Additional systems were designed wherein screening cells also expressed a gene identified in the original screen, e.g., an additional hydrocarbon pathway gene, e.g., an enhancer.
摘要翻译：公开了一种使用来自例如不动杆菌属（Acinetobacter spp）的烷烃应答元件（ARE）的方法。（i）识别和克隆烃类生物合成基因，（ii）鉴定和克隆烃转运蛋白基因（iii）鉴定和克隆烃类反应基因。开发了表达转录激活物例如alkR的筛选细胞，并且包括报告基因，例如可操作地连接到ARE启动子的例如alkM启动子的GFP。用能够进行烃生物合成的生物体的文库转化细胞。表达报告基因的转化细胞携带参与一个或多个上述过程的文库衍生基因; 并使用标准分子生物学技术从细胞中分离出这些基因。设计另外的系统，其中筛选细胞还表达在原始筛选中鉴定的基因，例如另外的烃途径基因，例如增强子。

4. 发明授权

US07671190B2 Recombinant polynucleotides encoding pro-geldanamycin producing polyketide synthases and accessory proteins, and uses thereof 有权
标题翻译：编码前格尔氏霉素的聚酮化合物合酶和辅助蛋白质的重组多核苷酸及其用途
公开(公告)号：US07671190B2
公开(公告)日：2010-03-02
申请号：US11654485
申请日：2007-01-16
申请人： Richard C. Hutchinson , Ralph C. Reid , Zhihao Hu , Andreas Rascher , Andreas Schirmer , Robert McDaniel
发明人： Richard C. Hutchinson , Ralph C. Reid , Zhihao Hu , Andreas Rascher , Andreas Schirmer , Robert McDaniel
IPC分类号： C12N15/53 , C12N15/74 , C12N15/76 , C12N15/31 , C12N9/06
CPC分类号： C07D491/08 , C07D225/06 , C12N15/52 , C12Q1/689 , C12Q1/6895
摘要： The invention relates to recombinant polyketide synthase enzymes, polyketide modifying proteins, and other proteins involved in polyketide biosynthesis or function. The invention provides domains of geldanamycin and herbimycin polyketide synthases, polynucleotides that encode such enzymes, and to host cells in which such encoding polynucleotides can be advantageously expressed.
摘要翻译：本发明涉及重组聚酮化合物合成酶，聚酮化合物修饰蛋白和涉及聚酮化合物生物合成或功能的其它蛋白质。本发明提供了格尔德霉素和草甘膦聚酮化合物合酶的结构域，编码这种酶的多核苷酸，以及可以有利地表达这种编码多核苷酸的宿主细胞。

5. 发明申请

US20070269855A1 Recombinant polynucleotides encoding pro-geldanamycin producing polyketide synthases and accessory proteins, and uses thereof 有权
标题翻译：编码前格尔氏霉素的聚酮化合物合酶和辅助蛋白质的重组多核苷酸及其用途
公开(公告)号：US20070269855A1
公开(公告)日：2007-11-22
申请号：US11654485
申请日：2007-01-16
申请人： Richard Hutchinson , Ralph Reid , Zhihao Hu , Andreas Rascher , Andreas Schirmer , Robert McDaniel
发明人： Richard Hutchinson , Ralph Reid , Zhihao Hu , Andreas Rascher , Andreas Schirmer , Robert McDaniel
IPC分类号： C12P1/00 , C07H21/00 , C12N1/20 , C12N15/00
CPC分类号： C07D491/08 , C07D225/06 , C12N15/52 , C12Q1/689 , C12Q1/6895
摘要： The invention relates to recombinant polyketide synthase enzymes, polyketide modifying proteins, and other proteins involved in polyketide biosynthesis or function. The invention provides domains of geldanamycin and herbimycin polyketide synthases, polynucleotides that encode such enzymes, and to host cells in which such encoding polynucleotides can be advantageously expressed.
摘要翻译：本发明涉及重组聚酮化合物合成酶，聚酮化合物修饰蛋白和涉及聚酮化合物生物合成或功能的其它蛋白质。本发明提供了格尔德霉素和草甘膦聚酮化合物合酶的结构域，编码这种酶的多核苷酸，以及可以有利地表达这种编码多核苷酸的宿主细胞。

6. 发明授权

US07189549B2 Recombinant polynucleotides encoding pro-geldanamycin producing polyketide synthase and accessory proteins, and uses thereof 有权
标题翻译：编码前格尔氏霉素的聚酮化合物合酶和辅助蛋白质的重组多核苷酸及其用途
公开(公告)号：US07189549B2
公开(公告)日：2007-03-13
申请号：US10461194
申请日：2003-06-13
申请人： Richard C. Hutchinson , Ralph C. Reid , Zhihao Hu , Andreas Rascher , Andreas Schirmer , Robert McDaniel
发明人： Richard C. Hutchinson , Ralph C. Reid , Zhihao Hu , Andreas Rascher , Andreas Schirmer , Robert McDaniel
IPC分类号： C12N9/02 , C12N9/10 , C12N15/53 , C12N15/54 , C12N15/74
CPC分类号： C07D491/08 , C07D225/06 , C12N15/52 , C12Q1/689 , C12Q1/6895
摘要： The invention relates to recombinant polyketide synthase enzymes, polyketide modifying proteins, and other proteins involved in polyketide biosynthesis or function. The invention provides domains of geldanamycin and herbimycin polyketide synthases, polynucleotides that encode such enzymes, and to host cells in which such encoding polynucleotides can be advantageously expressed.
摘要翻译：本发明涉及重组聚酮化合物合成酶，聚酮化合物修饰蛋白和涉及聚酮化合物生物合成或功能的其它蛋白质。本发明提供了格尔德霉素和草甘膦聚酮化合物合酶的结构域，编码这种酶的多核苷酸，以及可以有利地表达这种编码多核苷酸的宿主细胞。

7. 发明授权

US08530221B2 Production of branched chain fatty acids and derivatives thereof in recombinant microbial cells 有权
标题翻译：在重组微生物细胞中生产支链脂肪酸及其衍生物
公开(公告)号：US08530221B2
公开(公告)日：2013-09-10
申请号：US13104819
申请日：2011-05-10
申请人： Zhihao Hu , Grace J. Lee , Andreas W. Schirmer , Kseniya Zakharyevich , Derek L. Greenfield , Tarah S. Baron , Kevin Holden
发明人： Zhihao Hu , Grace J. Lee , Andreas W. Schirmer , Kseniya Zakharyevich , Derek L. Greenfield , Tarah S. Baron , Kevin Holden
IPC分类号： C12N1/00 , C12N1/20 , C12P1/00
CPC分类号： C12P7/6436 , C12N15/52 , C12P7/6409
摘要： Recombinant microbial cells are provided which have been engineered to produce branched chain products such as branched fatty acid derivatives by the fatty acid biosynthetic pathway, and methods of making branched fatty acid derivatives using the recombinant microbial cells.
摘要翻译：提供已经通过脂肪酸生物合成途径工程改造成产生支链产物如支链脂肪酸衍生物的重组微生物细胞，以及使用重组微生物细胞制备支链脂肪酸衍生物的方法。

8. 发明授权

US08372610B2 Production of odd chain fatty acid derivatives in recombinant microbial cells 有权
标题翻译：在重组微生物细胞中生产奇链脂肪酸衍生物
公开(公告)号：US08372610B2
公开(公告)日：2013-02-12
申请号：US13232927
申请日：2011-09-14
申请人： Grace J. Lee , John R. Haliburton , Zhihao Hu , Andreas W. Schirmer
发明人： Grace J. Lee , John R. Haliburton , Zhihao Hu , Andreas W. Schirmer
IPC分类号： C12P7/64 , C12N1/20 , C12N15/74
CPC分类号： C12P7/6409 , C07C53/126 , C07C57/03 , C12N9/0006 , C12N9/1018 , C12N9/1029 , C12N9/1217 , C12N9/16 , C12N9/18 , C12N9/88 , C12N9/90 , C12Y101/01003 , C12Y101/01085 , C12Y201/03001 , C12Y203/01041 , C12Y207/02004 , C12Y301/02001 , C12Y401/01041 , C12Y401/03022 , C12Y402/01033 , C12Y402/03001 , C12Y403/01019 , C12Y504/99002
摘要： Recombinant microbial cells are provided which have been engineered to produce fatty acid derivatives having linear chains containing an odd number of carbon atoms by the fatty acid biosynthetic pathway. Also provided are methods of making odd chain fatty acid derivatives using the recombinant microbial cells, and compositions comprising odd chain fatty acid derivatives produced by such methods.
摘要翻译：提供了重组微生物细胞，其已被工程化以通过脂肪酸生物合成途径产生具有含有奇数个碳原子的直链的脂肪酸衍生物。还提供了使用重组微生物细胞制备奇数链脂肪酸衍生物的方法，以及包含通过这些方法产生的奇数链脂肪酸衍生物的组合物。

9. 发明申请

US20080233618A1 Biosynthetic gene cluster for leptomycins 有权
标题翻译： leptomycins的生物合成基因簇
公开(公告)号：US20080233618A1
公开(公告)日：2008-09-25
申请号：US11895327
申请日：2007-08-24
申请人： Zhihao Hu , Ralph Reid
发明人： Zhihao Hu , Ralph Reid
IPC分类号： C12P17/06 , C12N9/10 , C12N1/00 , C12N15/54 , C12N1/21
CPC分类号： C12N15/52 , C07K2319/00
摘要： Polypeptides and domains of leptomycin polyketide synthase and the nucleic acids encoding them are provided. Methods to prepare leptomycin, leptomycin analogs, and leptomycin derivatives are described, as are methods to prepare other polyketides using the nucleic acids encoding leptomycin polyketide synthase domains or modifying enzymes.
摘要翻译：提供了多肽和克隆霉素聚酮合成酶的结构域和编码它们的核酸。还描述了制备雷霉霉素，曲霉素类似物和曲霉素衍生物的方法，以及使用编码雷霉霉素聚酮合成酶结构域或修饰酶的核酸制备其它聚酮化合物的方法。

10. 发明申请

US20050208629A1 Plasmids for polyketide production 审中-公开
标题翻译：用于聚酮化合物生产的质粒
公开(公告)号：US20050208629A1
公开(公告)日：2005-09-22
申请号：US11050937
申请日：2005-02-04
申请人： Zhihao Hu , C. Hutchinson
发明人： Zhihao Hu , C. Hutchinson
IPC分类号： C12N1/21 , C12N9/00 , C12N15/52 , C12N15/74 , C12P19/62
CPC分类号： C12N15/52 , C12P19/62
摘要： Streptomyces plasmids comprising a SCP2*-derived vector, lacking a specific 45 base pair sequence, have a higher copy number and can be used to increase gene expression in host cells. Such plasmids, encoding polyketide synthase genes, are useful for polyketide production in host cells.
摘要翻译：包含SCP2 *衍生载体（缺乏特异性45碱基对序列）的链霉菌质粒具有较高的拷贝数，可用于增加宿主细胞中的基因表达。编码聚酮化合物合酶基因的这种质粒可用于宿主细胞中聚酮化合物的产生。

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