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1. 发明申请

US20100322954A1 ENHANCED HIV-1 VACCINES AND METHODS FOR THEIR USE 审中-公开
标题翻译：增强HIV-1疫苗及其使用方法
公开(公告)号：US20100322954A1
公开(公告)日：2010-12-23
申请号：US12796614
申请日：2010-06-08
申请人： Jay A. Berzofsky , Takahiro Okazaki
发明人： Jay A. Berzofsky , Takahiro Okazaki
IPC分类号： A61K39/21 , A61P31/18 , C12N15/63 , C12Q1/70 , C12Q1/02
CPC分类号： C12N9/1276 , A61K39/00 , A61K39/12 , A61K39/21 , A61K39/385 , A61K2039/5158 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/55522 , A61K2039/55566 , A61K2039/57 , A61K2039/6018 , A61K2039/645 , C07K14/005 , C12N7/00 , C12N2740/16222 , C12N2740/16234
摘要： The present invention provides peptides and proteins for use in second generation HIV vaccines and as diagnostic tools in the treatment and control of HIV infection. The antiviral protection shown by compositions of the present invention has not been previously achieved with an HLA epitope-enhanced vaccine. These findings define a critical balance between MHC affinity and receptor crossreactivity required for effective epitope enhancement and also demonstrate construction and efficacy of such a component of a new generation vaccine.
摘要翻译：本发明提供用于第二代HIV疫苗的肽和蛋白质，以及用于治疗和控制HIV感染的诊断工具。本发明组合物显示的抗病毒保护尚未以HLA表位增强疫苗实现。这些发现定义了有效表位增强所需的MHC亲和力和受体交叉反应之间的关键平衡，并且还证明了新一代疫苗的这种组分的构建和功效。

2. 发明授权

US08877914B2 Compositions comprising nucleic acids encoding HIV-1 reverse transcriptase CTL epitopes 有权
标题翻译：包含编码HIV-1逆转录酶CTL表位的核酸的组合物
公开(公告)号：US08877914B2
公开(公告)日：2014-11-04
申请号：US12796614
申请日：2010-06-08
申请人： Jay A. Berzofsky , Takahiro Okazaki
发明人： Jay A. Berzofsky , Takahiro Okazaki
IPC分类号： C07H21/04 , A61K39/21 , A61K39/385 , C07K14/005 , A61K39/00
CPC分类号： C12N9/1276 , A61K39/00 , A61K39/12 , A61K39/21 , A61K39/385 , A61K2039/5158 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/55522 , A61K2039/55566 , A61K2039/57 , A61K2039/6018 , A61K2039/645 , C07K14/005 , C12N7/00 , C12N2740/16222 , C12N2740/16234
摘要： The present invention provides compositions comprising a vector including a nucleic acid comprising a nucleotide sequence encoding a peptide having the sequence X1LYQYMDDV, wherein X1 is any hydrophobic amino acid. The compositions are used to induce an immune response against human immunodeficiency virus (HIV).
摘要翻译：本发明提供包含载体的组合物，所述载体包含核酸，所述核酸包含编码具有序列X1LYQYMDDV的肽的核苷酸序列，其中X1是任何疏水性氨基酸。该组合物用于诱导针对人类免疫缺陷病毒（HIV）的免疫应答。

3. 发明授权

US07731971B2 Enhanced CTL epitope-containing HIV-1 reverse transcriptase polypeptides 失效
标题翻译：增强的含CTL表位的HIV-1逆转录酶多肽
公开(公告)号：US07731971B2
公开(公告)日：2010-06-08
申请号：US10551405
申请日：2004-03-29
申请人： Jay A. Berzofsky , Takahiro Okazaki
发明人： Jay A. Berzofsky , Takahiro Okazaki
IPC分类号： A61K39/21
CPC分类号： C12N9/1276 , A61K39/00 , A61K39/12 , A61K39/21 , A61K39/385 , A61K2039/5158 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/55522 , A61K2039/55566 , A61K2039/57 , A61K2039/6018 , A61K2039/645 , C07K14/005 , C12N7/00 , C12N2740/16222 , C12N2740/16234
摘要： The present invention provides peptides and proteins for use in second generation HIV vaccines and as diagnostic tools in the treatment and control of HIV infection. The antiviral protection shown by compositions of the present invention has not been previously achieved with an HLA epitope-enhanced vaccine. These findings define a critical balance between MHC affinity and receptor crossreactivity required for effective epitope enhancement and also demonstrate construction and efficacy of such a component of a new generation vaccine.
摘要翻译：本发明提供用于第二代HIV疫苗的肽和蛋白质，以及用于治疗和控制HIV感染的诊断工具。本发明组合物显示的抗病毒保护尚未以HLA表位增强疫苗实现。这些发现定义了有效表位增强所需的MHC亲和力和受体交叉反应之间的关键平衡，并且还证明了新一代疫苗的这种组分的构建和功效。

4. 发明申请

US20090317418A1 VACCINES AND METHODS FOR PREVENTION AND TREATMENT OF DRUG-RESISTANT HIV-1 AND HEPATITIS B VIRUS 有权
标题翻译：预防和治疗耐药性HIV-1和乙型肝炎病毒的疫苗和方法
公开(公告)号：US20090317418A1
公开(公告)日：2009-12-24
申请号：US11816704
申请日：2006-02-22
申请人： Andrew Catanzaro , Robert Yarchoan , Jay A. Berzofsky , Takahiro Okazaki , James T. Snyder, II , Samuel Broder
发明人： Andrew Catanzaro , Robert Yarchoan , Jay A. Berzofsky , Takahiro Okazaki , James T. Snyder, II , Samuel Broder
IPC分类号： A61K39/21 , A61K39/12 , A61K39/29 , C12N5/00 , C07K7/06 , C12N7/06 , A61P31/18 , A61P31/12 , A61P31/14
CPC分类号： A61K39/00 , A61K2039/57 , C07K14/005 , C12N2710/16722 , C12N2730/10122 , C12N2740/16222 , C12N2770/24222
摘要： The present invention provides methods for lowering a viral load of a virus resistant to an antiviral drug by inducing cytotoxic T lymphocytes (CTL) to recognize a predetermined mutated epitope within a viral protein of the drug-resistant virus. CTLs are induced by immunizing a host with a peptide comprising the predetermined mutation. The immunostimulating peptide may be further improved by epitope-enhancement for inducing specific CTLs. The antiviral protection against drug-resistant virus shown by compositions of the present invention and mediated by human HLA-restricted CTL has not been previously achieved.
摘要翻译：本发明提供了通过诱导细胞毒性T淋巴细胞（CTL）来识别抗药性病毒的病毒蛋白中的预定的突变表位来降低对抗病毒药物具有抗性的病毒的病毒载量的方法。通过用包含预定突变的肽免疫宿主诱导CTL。可以通过用于诱导特异性CTL的表位增强来进一步改善免疫刺激肽。由本发明组合物显示并由人HLA限制性CTL介导的抗药性病毒的抗病毒保护尚未获得。

5. 发明授权

US09474793B2 Vaccines and methods for prevention and treatment of drug-resistant HIV-1 and hepatitis B virus 有权
标题翻译：用于预防和治疗耐药性HIV-1和乙型肝炎病毒的疫苗和方法
公开(公告)号：US09474793B2
公开(公告)日：2016-10-25
申请号：US11816704
申请日：2006-02-22
申请人： Andrew Catanzaro , Robert Yarchoan , Jay A. Berzofsky , Takahiro Okazaki , James T. Snyder, II , Samuel Broder
发明人： Andrew Catanzaro , Robert Yarchoan , Jay A. Berzofsky , Takahiro Okazaki , James T. Snyder, II , Samuel Broder
IPC分类号： A61K38/08 , A61K39/21 , C07K7/06 , C07D239/04 , A61K39/00
CPC分类号： A61K39/00 , A61K2039/57 , C07K14/005 , C12N2710/16722 , C12N2730/10122 , C12N2740/16222 , C12N2770/24222
摘要： The present invention provides methods for lowering a viral load of a virus resistant to an antiviral drug by inducing cytotoxic T lymphocytes (CTL) to recognize a predetermined mutated epitope within a viral protein of the drug-resistant virus. CTLs are induced by immunizing a host with a peptide comprising the predetermined mutation. The immunostimulating peptide may be further improved by epitope-enhancement for inducing specific CTLs. The antiviral protection against drug-resistant virus shown by compositions of the present invention and mediated by human HLA-restricted CTL has not been previously achieved.
摘要翻译：本发明提供了通过诱导细胞毒性T淋巴细胞（CTL）来识别抗药性病毒的病毒蛋白中的预定的突变表位来降低对抗病毒药物具有抗性的病毒的病毒载量的方法。通过用包含预定突变的肽免疫宿主诱导CTL。可以通过用于诱导特异性CTL的表位增强来进一步改善免疫刺激肽。由本发明组合物显示并由人HLA限制性CTL介导的抗药性病毒的抗病毒保护尚未获得。

6. 发明申请

US20090214583A1 Epitope-enhancement of a human cd4 hiv epitope 审中-公开
标题翻译：人cd4 hiv表位的表位增强
公开(公告)号：US20090214583A1
公开(公告)日：2009-08-27
申请号：US11579230
申请日：2005-04-27
申请人： Jay A. Berzofsky , Takahiro Okazaki
发明人： Jay A. Berzofsky , Takahiro Okazaki
IPC分类号： A61K39/21 , C07K7/08 , C12Q1/02
CPC分类号： C07K14/005 , A61K2039/5154 , A61K2039/5158 , A61K2039/57 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322
摘要： Virus-specific CD4+T cell help and CD8+ cytotoxic T cell responses are critical for the maintenance of effective immunity in chronic viral infections. The importance of the CD4+T cells has been documented in HIV infection. A T1-specific CD4+T cell line from a healthy volunteer immunized with a canarypox vector expressing gp120 has been developed. The cell line was restricted to DR13, which is common in the U.S. in both Caucasians and African-Americans and is one of the major haplotypes in Africans. Amino acid substitutions in the T1 epitope were made to induce a stronger epitope-specific CD4+T cell response than the original epitope resulting in an improved CD4 epitope. A polypeptide comprising the enhanced CD4 epitope can be used as a component in compositions either alone or in combination with other adjuvants and other immunogenic compositions to induce a more effective immune response to HIV infection.
摘要翻译：病毒特异性CD4 + T细胞帮助和CD8 +细胞毒性T细胞反应对于维持慢性病毒感染的有效免疫是至关重要的。在HIV感染中已经记录了CD4 + T细胞的重要性。已经开发了用表达gp120的金丝细胞病毒载体免疫的健康志愿者的T1特异性CD4 + T细胞系。细胞系限于DR13，这是美国在高加索人和非洲裔美国人中常见的，是非洲人的主要单倍型之一。使T1表位中的氨基酸取代诱导比原始表位更强的表位特异性CD4 + T细胞应答，导致改善的CD4表位。包含增强的CD4表位的多肽可以单独使用或与其它佐剂和其它免疫原性组合物组合用作组合物，以诱导对HIV感染的更有效的免疫应答。

7. 发明申请

US20090226756A1 PISTON RING 有权
标题翻译：活塞环
公开(公告)号：US20090226756A1
公开(公告)日：2009-09-10
申请号：US12397027
申请日：2009-03-03
申请人： Junpei OGAWA , Takaaki Kondou , Tomonori Miyazawa , Toyoki Iguchi , Takuma Suzuki , Takeshi Makita , Katsuaki Ogawa , Takahiro Okazaki
发明人： Junpei OGAWA , Takaaki Kondou , Tomonori Miyazawa , Toyoki Iguchi , Takuma Suzuki , Takeshi Makita , Katsuaki Ogawa , Takahiro Okazaki
IPC分类号： B32B15/01 , C22C38/18 , C22C38/22 , C22C38/40 , B32B15/18 , B32B15/04
CPC分类号： F16J9/26 , C22C38/02 , C22C38/04 , C22C38/18 , C22C38/22 , C22C38/24 , C22C38/26 , C22C38/28 , C22C38/54 , Y10T428/12576 , Y10T428/12583 , Y10T428/1259 , Y10T428/12625 , Y10T428/12854 , Y10T428/12972 , Y10T428/12993 , Y10T428/31678
摘要： A piston ring includes: a refined steel including: carbon C in a range of 0.20% mass to 0.90% mass, silicon Si in a range of 0.10% mass to less than 0.60% mass, manganese Mn in a range of 0.20% mass to 1.50% mass, chromium Cr in a range of 0.30% mass to 2.00% mass, and a remnant including: iron Fe, and an unavoidable impurity. A parameter A calculated from the following expression (1) based on contents of the Si, Mn and Cr is 9.0 or less: parameter A=8.8 Si+1.6 Mn+1.7 Cr—expression (1). A parameter B calculated from the following expression (2) based on contents of the C, Si, Mn and Cr is 10.8 or more: parameter B=36 C+4.2 Si+3.8 Mn+4.5 Cr—expression (2).
摘要翻译：活塞环包括：精炼钢，其包括：碳C在0.20质量％至0.90质量％的范围内，硅Si在0.10质量％至小于0.60质量％的范围内，锰Mn在0.20质量％的范围内， 1.50质量％，铬Cr在0.30质量％至2.00质量％的范围内，残留物包括：铁Fe和不可避免的杂质。基于Si，Mn和Cr的含量由下式（1）算出的参数A为9.0以下：参数A = 8.8Si + 1.6Mn + 1.7Cr-表达式（1）。基于C，Si，Mn和Cr的含量，根据以下表达式（2）计算的参数B为10.8以上：参数B = 36℃+ 4.2Si + 3.8Mn + 4.5Cr-表达式（2）。

8. 发明申请

US20110242245A1 TRANSPORT APARATUS, RECORDING APPARATUS, AND METHOD OF LOADING A RECORDING MEDIUM 有权
标题翻译：运输APARATUS，记录装置和装载记录介质的方法
公开(公告)号：US20110242245A1
公开(公告)日：2011-10-06
申请号：US12998604
申请日：2009-09-30
申请人： Takahiro Okazaki
发明人： Takahiro Okazaki
IPC分类号： B41J2/01 , B65H23/10
CPC分类号： B65H23/32 , B41J11/0085 , B41J15/165 , B65H23/042 , B65H23/16 , B65H2301/522 , B65H2404/1526 , B65H2406/31 , B65H2801/12
摘要： Provided are a transport apparatus and a printer capable of transporting a recording medium with no slack even when a disturbance or the like has occurred, and maintaining horizontal attitudes of tension bars, as well as easy loading of the recording medium and easy placing of the tension bars after the recording medium is loaded. The tension bars apply tensions in a transport direction and in a direction perpendicular to the transport direction to the recording medium in a roll shape that is fed from a feeding roll and wound up onto a take-up roll. Accordingly, predetermined tensions are applied to the recording medium. Before the recording medium is loaded, the tension bars are supported at retrieval positions, respectively, and the respective tension bars are placed at predetermined positions after the recording medium is loaded, with the result that the recording medium may be loaded with ease.
摘要翻译：提供了即使发生干扰等也能够不间断地传送记录介质的传送装置和打印机，并且保持张力杆的水平姿态以及容易地装载记录介质并且容易地设置张力加载记录介质后的条。张力杆在从输送辊进给并卷绕到卷取辊上的卷状下沿输送方向和与输送方向垂直的方向施加张力。因此，对记录介质施加预定的张力。在装载记录介质之前，张力杆分别被支撑在检索位置，并且相应的张力杆被放置在记录介质装载之后的预定位置，结果可以容易地加载记录介质。

9. 发明授权

US08592050B2 Piston ring 有权
标题翻译：活塞环
公开(公告)号：US08592050B2
公开(公告)日：2013-11-26
申请号：US12397027
申请日：2009-03-03
申请人： Junpei Ogawa , Takaaki Kondou , Tomonori Miyazawa , Toyoki Iguchi , Takuma Suzuki , Takeshi Makita , Katsuaki Ogawa , Takahiro Okazaki
发明人： Junpei Ogawa , Takaaki Kondou , Tomonori Miyazawa , Toyoki Iguchi , Takuma Suzuki , Takeshi Makita , Katsuaki Ogawa , Takahiro Okazaki
IPC分类号： B32B15/04 , B32B15/18 , C22C38/22 , C22C38/44
CPC分类号： F16J9/26 , C22C38/02 , C22C38/04 , C22C38/18 , C22C38/22 , C22C38/24 , C22C38/26 , C22C38/28 , C22C38/54 , Y10T428/12576 , Y10T428/12583 , Y10T428/1259 , Y10T428/12625 , Y10T428/12854 , Y10T428/12972 , Y10T428/12993 , Y10T428/31678
摘要： A piston ring includes: a refined steel including: carbon C in a range of 0.20% mass to 0.90% mass, silicon Si in a range of 0.10% mass to less than 0.60% mass, manganese Mn in a range of 0.20% mass to 1.50% mass, chromium Cr in a range of 0.30% mass to 2.00% mass, and a remnant including: iron Fe, and an unavoidable impurity. A parameter A calculated from the following expression (1) based on contents of the Si, Mn and Cr is 9.0 or less: parameter A=8.8 Si+1.6 Mn+1.7 Cr—expression (1). A parameter B calculated from the following expression (2) based on contents of the C, Si, Mn and Cr is 10.8 or more: parameter B=36 C+4.2 Si+3.8 Mn+4.5 Cr—expression (2).
摘要翻译：活塞环包括：精炼钢，其包括：碳C在0.20质量％至0.90质量％的范围内，硅Si在0.10质量％至小于0.60质量％的范围内，锰Mn在0.20质量％的范围内， 1.50质量％，铬Cr在0.30质量％至2.00质量％的范围内，残留物包括：铁Fe和不可避免的杂质。基于Si，Mn和Cr的含量由下式（1）算出的参数A为9.0以下：参数A = 8.8Si + 1.6Mn + 1.7Cr-表达式（1）。基于C，Si，Mn和Cr的含量，根据以下表达式（2）计算的参数B为10.8以上：参数B = 36℃+ 4.2Si + 3.8Mn + 4.5Cr-表达式（2）。

10. 发明授权

US08474971B2 Transport apparatus, recording apparatus, and method of loading a recording medium 有权
标题翻译：运送装置，记录装置和装载记录介质的方法
公开(公告)号：US08474971B2
公开(公告)日：2013-07-02
申请号：US12998604
申请日：2009-09-30
申请人： Takahiro Okazaki
发明人： Takahiro Okazaki
IPC分类号： B41J2/01
CPC分类号： B65H23/32 , B41J11/0085 , B41J15/165 , B65H23/042 , B65H23/16 , B65H2301/522 , B65H2404/1526 , B65H2406/31 , B65H2801/12
摘要： A transport apparatus transports a recording medium fed from a feeding roll and wound up onto a take-up roll. A transport roller is arranged in a path between the feeding roll and the take-up roll. A first tension bar is arranged in a path between the transport roller and the take-up roll to apply tension to the recording medium in a first direction different from a transport direction of the recording medium. A second tension bar is arranged in a path between the first tension bar and the take-up roll to apply tension to the recording medium in a second direction different from the first direction. The first and second tension bars apply tension to the recording medium in the first and second directions so that the recording medium is tightened by the first and second tension bars and the tightened recording medium is wound up onto the take-up roll.
摘要翻译：输送装置输送从进料辊进料并记录到卷取辊上的记录介质。输送辊布置在进料辊和卷取辊之间的路径中。第一张力杆布置在传送辊和卷取辊之间的路径中，以沿与记录介质的传送方向不同的第一方向向记录介质施加张力。第二张力杆布置在第一张力杆和卷取辊之间的路径中，以沿与第一方向不同的第二方向向记录介质施加张力。第一和第二张力杆在第一和第二方向上向记录介质施加张力，使得记录介质被第一和第二张力杆紧固，并且紧固的记录介质被卷绕到卷取辊上。

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