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1. 发明申请

US20060286121A1 Adenoviral vector-based vaccines 审中-公开
标题翻译：基于腺病毒载体的疫苗
公开(公告)号：US20060286121A1
公开(公告)日：2006-12-21
申请号：US11337866
申请日：2006-01-23
申请人： Jason Gall , Thomas Wickham , William Enright , Douglas Brough , Mohammed Zuber , C. King , Gary Nabel , Cheng Cheng
发明人： Jason Gall , Thomas Wickham , William Enright , Douglas Brough , Mohammed Zuber , C. King , Gary Nabel , Cheng Cheng
IPC分类号： A61K39/12 , A61K39/395
CPC分类号： C12N15/86 , A61K48/00 , A61K2039/5256 , C07K2319/00 , C12N2710/10343 , C12N2710/10345
摘要： The invention provides a method of inducing an immune response in a mammal. The method comprises administering to the mammal a non-subgroup C adenoviral vector comprising an adenoviral fiber protein having an amino acid sequence comprising about 80% or more identity to an amino acid sequence encoding a subgroup C adenoviral fiber protein. The adenoviral vector further comprises a nucleic acid sequence encoding an antigen which is expressed in the mammal to induce an immune response. The invention further comprises a method of producing an adenoviral vector, and a composition comprising a serotype 41 or a serotype 35 adenoviral vector and a carrier. The invention also provides an adenoviral vector comprising a nucleic acid sequence encoding an adenoviral pIX protein operably linked to a heterologous expression control sequence, as well as a method of enhancing the stability and/or packaging capacity of an adenoviral vector.
摘要翻译：本发明提供在哺乳动物中诱导免疫应答的方法。该方法包括向哺乳动物施用非亚组C腺病毒载体，其包含具有与编码亚组C腺病毒纤维蛋白的氨基酸序列具有约80％或更高同一性的氨基酸序列的腺病毒纤维蛋白。腺病毒载体还包含编码在哺乳动物中表达以诱导免疫应答的抗原的核酸序列。本发明还包括产生腺病毒载体的方法和包含血清型41或血清型35腺病毒载体和载体的组合物。本发明还提供了一种腺病毒载体，其包含编码与异源表达控制序列可操作地连接的腺病毒pIX蛋白的核酸序列，以及增强腺病毒载体的稳定性和/或包装能力的方法。

2. 发明申请

US20080069836A1 METHOD OF USING ADENOVIRAL VECTORS WITH INCREASED IMMUNOGENICITY IN VIVO 审中-公开
标题翻译：使用腺病毒载体在体内具有增加的免疫原性的方法
公开(公告)号：US20080069836A1
公开(公告)日：2008-03-20
申请号：US11678947
申请日：2007-02-26
申请人： Gary Nabel , Cheng Cheng , Jason Gall , Thomas Wickham
发明人： Gary Nabel , Cheng Cheng , Jason Gall , Thomas Wickham
IPC分类号： A61K39/00 , A61P37/04 , C12N15/63
CPC分类号： C12N15/86 , A61K39/00 , C12N2710/10343 , Y02A50/412
摘要： The invention provides a method of inducing an immune response in a mammal. The method comprises administering to the mammal an adenoviral vector comprising (a) a subgroup C fiber protein wherein a native coxsackievirus and adenovirus receptor (CAR)-binding site is disrupted, (b) a subgroup C penton base protein wherein a native integrin-binding site is disrupted, and (c) a nucleic acid sequence encoding at least one antigen derived from an infectious agent other than an adenovirus which is expressed in the mammal to induce an immune response.
摘要翻译：本发明提供在哺乳动物中诱导免疫应答的方法。该方法包括向哺乳动物施用腺病毒载体，其包含（a）亚组C纤维蛋白，其中天然柯萨奇病毒和腺病毒受体（CAR）结合位点被破坏，（b）亚基C戊聚糖碱基蛋白，其中天然整联蛋白结合位点被破坏，和（c）编码至少一种来源于哺乳动物中表达的腺病毒以外的感染因子的抗原以诱导免疫应答的核酸序列。

3. 发明申请

US20080003236A1 ADENOVIRUS FIBER SHAFT COMPOSITION AND METHODS OF USE 审中-公开
标题翻译： ADENOVIRUS纤维轴组合物及其使用方法
公开(公告)号：US20080003236A1
公开(公告)日：2008-01-03
申请号：US11734851
申请日：2007-04-13
申请人： C. King , Jason Gall , Gary Nabel , Cheng Cheng
发明人： C. King , Jason Gall , Gary Nabel , Cheng Cheng
IPC分类号： A61K38/00 , A61K39/00 , A61K39/385 , A61P43/00 , C12N15/00 , C12P21/06
CPC分类号： A61K38/162 , A61K38/164 , C12N15/86 , C12N2710/10322 , C12N2710/10343 , C12N2750/14143 , Y02A50/386 , Y02A50/412
摘要： The invention provides a gene transfer vector and a conjugate comprising at least three contiguous amino acids of a shaft region of a subgroup C adenovirus fiber protein. The invention also provides methods of using the gene transfer vector and the conjugate to induce an immune response in a mammal, and to deliver a protein or a non-proteinaceous molecule to a specific cell type.
摘要翻译：本发明提供了一种基因转移载体和包含亚组C腺病毒纤维蛋白的轴区域的至少三个相邻氨基酸的缀合物。本发明还提供了使用基因转移载体和缀合物在哺乳动物中诱导免疫应答并将蛋白质或非蛋白质分子递送至特定细胞类型的方法。

4. 发明申请

US20070207166A1 Method of Using Adenoviral Vectors to Induce an Immune Response 审中-公开
标题翻译：使用腺病毒载体诱导免疫反应的方法
公开(公告)号：US20070207166A1
公开(公告)日：2007-09-06
申请号：US11578096
申请日：2005-04-12
申请人： Gary Nabel , Cheng Cheng , Wing-Pui Kong , Jason Gall , C. Richter King
发明人： Gary Nabel , Cheng Cheng , Wing-Pui Kong , Jason Gall , C. Richter King
IPC分类号： A61K39/12 , C12N15/861
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K2039/5256 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/57 , C12N7/00 , C12N15/86 , C12N2710/10343 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16234
摘要： The invention provides a method of inducing an immune response against a human immunodeficiency virus (HIV) in a mammal. The method comprises administering to the mammal an adenoviral vector composition comprising one or more adenoviral vectors encoding two or more different HIV antigens, the production of which induces an immune response against HIV in the mammal. The invention also provides an adenoviral vector composition comprising four adenoviral vectors encoding an HIV clade A Env protein, an HIV clade B Env protein, an HIV clade C Env protein, and a fusion protein comprising an HIV clade B Gag protein and Pol protein, respectively.
摘要翻译：本发明提供一种在哺乳动物中诱导针对人类免疫缺陷病毒（HIV）的免疫应答的方法。该方法包括向哺乳动物施用腺病毒载体组合物，其包含编码两种或更多种不同HIV抗原的一种或多种腺病毒载体，其产生在哺乳动物中诱导针对HIV的免疫应答。本发明还提供一种腺病毒载体组合物，其包含分别编码HIV进化枝A Env蛋白，HIV进化枝B Env蛋白，HIV进化枝C Env蛋白和包含HIV进化枝B Gag蛋白和Pol蛋白的融合蛋白的四种腺病毒载体。

5. 发明授权

US09133248B2 Methods of propagating monkey adenoviral vectors 有权
标题翻译：繁殖猴腺病毒载体的方法
公开(公告)号：US09133248B2
公开(公告)日：2015-09-15
申请号：US13508659
申请日：2010-11-09
申请人： Jason Gall , Douglas Brough , Christoph Kahl , Duncan McVey
发明人： Jason Gall , Douglas Brough , Christoph Kahl , Duncan McVey
IPC分类号： C07K14/005 , C12N7/00 , C12N15/86
CPC分类号： C07K14/005 , C12N7/00 , C12N15/86 , C12N2710/10322 , C12N2710/10332 , C12N2710/10343 , C12N2710/10352
摘要： The invention provides methods for propagating a monkey adenovirus in a cell including a human cell, comprising one or more gene products isolated from a human adenovirus. Also provided are methods for propagating wherein the monkey adenovirus comprises a nucleic acid sequence encoding a human adenovirus gene product. The invention further provides a monkey adenovirus. including a replication-deficient monkey adenovirus, obtained by such propagation methods.
摘要翻译：本发明提供了在包括人细胞的细胞中繁殖猴腺病毒的方法，其包含从人腺病毒分离的一种或多种基因产物。还提供了用于繁殖的方法，其中猴腺病毒包含编码人腺病毒基因产物的核酸序列。本发明进一步提供猴腺病毒。包括通过这种繁殖方法获得的复制缺陷型猴腺病毒。

6. 发明申请

US20120225470A1 METHODS OF PROPAGATING MONKEY ADENOVIRAL VECTORS 有权
标题翻译：传播猴子腺病毒载体的方法
公开(公告)号：US20120225470A1
公开(公告)日：2012-09-06
申请号：US13508659
申请日：2010-11-09
申请人： Jason Gall , Douglas Brough , Christoph Kahl , Duncan McVey
发明人： Jason Gall , Douglas Brough , Christoph Kahl , Duncan McVey
IPC分类号： C12N7/00
CPC分类号： C07K14/005 , C12N7/00 , C12N15/86 , C12N2710/10322 , C12N2710/10332 , C12N2710/10343 , C12N2710/10352
摘要： The invention provides methods for propagating a monkey adenovirus in a cell including a human cell, comprising one or more gene products isolated from a human adenovirus. Also provided are methods for propagating wherein the monkey adenovirus comprises a nucleic acid sequence encoding a human adenovirus gene product. The invention further provides a monkey adenovirus. including a replication-deficient monkey adenovirus, obtained by such propagation methods.
摘要翻译：本发明提供了在包括人细胞的细胞中繁殖猴腺病毒的方法，其包含从人腺病毒分离的一种或多种基因产物。还提供了用于繁殖的方法，其中猴腺病毒包含编码人腺病毒基因产物的核酸序列。本发明进一步提供猴腺病毒。包括通过这种繁殖方法获得的复制缺陷型猴腺病毒。

7. 发明申请

US20060140909A1 Method of using adenoviral vectors with increased persistence in vivo 审中-公开
标题翻译：使用体内持续性增加的腺病毒载体的方法
公开(公告)号：US20060140909A1
公开(公告)日：2006-06-29
申请号：US11208405
申请日：2005-08-19
申请人： Thomas Wickham , Masaki Akiyama , Jason Gall
发明人： Thomas Wickham , Masaki Akiyama , Jason Gall
IPC分类号： A61K48/00 , C12N15/861
CPC分类号： C12N15/86 , A61K48/00 , C12N2710/10322 , C12N2710/10343 , C12N2710/10345 , C12N2810/405 , C12N2810/50
摘要： The invention provides a method of expressing an exogenous nucleic acid in a mammal. The method comprises slowly releasing into the bloodstream a dose of replication-deficient or conditionally-replicating adenoviral vector having reduced ability to transduce mesothelial cells and hepatocytes. The normalized average bloodstream concentration of the adenovirus over 24 hours post-administration is at least about 1%. Alternatively, the normalized average bloodstream concentration over 24 hours post-administration is at least about 5-fold greater than the normalized average bloodstream concentration for an equivalent dose of a wild-type adenoviral vector. A method of destroying tumor cells in a mammal also is provided, as is a replication-deficient adenoviral vector comprising a serotype 5 or serotype 35 adenoviral genome with a serotype 41 fiber protein, wherein the replication-deficient adenoviral vector exhibits reduced native binding to integrins.
摘要翻译：本发明提供了在哺乳动物中表达外源核酸的方法。该方法包括缓慢释放一定剂量的复制缺陷型或条件复制型腺病毒载体，其具有降低转导间皮细胞和肝细胞的能力。给药后24小时内腺病毒的归一化平均血流浓度为至少约1％。或者，给药后24小时内的标准化平均血流浓度比相当剂量的野生型腺病毒载体的归一化平均血流浓度高至少约5倍。还提供了破坏哺乳动物肿瘤细胞的方法，以及包含血清型5或具有血清型41纤维蛋白的血清型35腺病毒基因组的复制缺陷型腺病毒载体，其中复制缺陷型腺病毒载体表现出降低的天然与整联蛋白结合。

8. 发明申请

US20050063953A1 Adenoviral vector with replication-dependent transgene expression 有权
标题翻译：具有复制依赖性转基因表达的腺病毒载体
公开(公告)号：US20050063953A1
公开(公告)日：2005-03-24
申请号：US10911957
申请日：2004-08-05
申请人： Erik Falck-Pedersen , Jason Gall
发明人： Erik Falck-Pedersen , Jason Gall
IPC分类号： A61K48/00 , C12N15/861
CPC分类号： C12N15/86 , A61K48/00 , C12N2710/10343 , C12N2840/44
摘要： The invention provides an adenoviral vector comprising (a) at least a portion of an adenoviral genome comprising a major late transcription unit containing a terminal exon, wherein the terminal exon comprises a 5′ splice acceptor DNA sequence element and a 3′ polyadenylation signal sequence, and (b) a non-native nucleic acid sequence encoding a protein that does not contribute to the adenoviral vector entry into a host cell, wherein the non-native nucleic acid sequence is positioned within the terminal exon, such that the non-native nucleic acid sequence is selectively expressed in cells within which the adenoviral vector can replicate. The invention further provides an adenoviral vector composition and a method for treating or preventing a pathologic state in a mammal, comprising administering to the mammal the adenoviral vector composition of the invention in an amount sufficient to treat or prevent the pathologic state in the mammal.
摘要翻译：本发明提供了一种腺病毒载体，其包含（a）至少一部分腺病毒基因组，其包含含有末端外显子的主要晚期转录单位，其中所述末端外显子包含5'剪接受体DNA序列元件和3'多腺苷酸化信号序列，和（b）编码不对腺病毒载体进入宿主细胞有贡献的蛋白质的非天然核酸序列，其中非天然核酸序列位于末端外显子内，使得非天然核酸酸序列在腺病毒载体可以复制的细胞中选择性表达。本发明进一步提供了一种用于治疗或预防哺乳动物病理状态的腺病毒载体组合物和方法，其包括以足以治疗或预防哺乳动物病理状态的量向哺乳动物施用本发明的腺病毒载体组合物。

9. 发明授权

US06576456B2 Chimeric adenovirus fiber protein 有权
标题翻译：嵌合腺病毒纤维蛋白
公开(公告)号：US06576456B2
公开(公告)日：2003-06-10
申请号：US09326447
申请日：1999-06-04
申请人： Thomas J. Wickham , Erik Falck-Pedersen , Petrus W. Roelvink , Joseph T. Bruder , Jason Gall , Imre Kovesdi
发明人： Thomas J. Wickham , Erik Falck-Pedersen , Petrus W. Roelvink , Joseph T. Bruder , Jason Gall , Imre Kovesdi
IPC分类号： C12N701
CPC分类号： C12N15/86 , A61K48/00 , C07K14/005 , C07K2319/00 , C12N2710/10322 , C12N2710/10343 , C12N2710/10345 , C12N2810/405 , C12N2810/6018 , C12N2830/00 , C12N2830/60
摘要： The invention provides a chimeric adenovirus fiber protein including a nonnative amino acid sequence, and a chimeric adenovirus fiber protein lacking a native amino acid receptor-binding sequence. The chimeric protein trimerizes when produced in a mammalian cell.
摘要翻译：本发明提供了包含非氨基酸序列的嵌合腺病毒纤维蛋白和缺乏天然氨基酸受体结合序列的嵌合腺病毒纤维蛋白。当在哺乳动物细胞中产生时，嵌合蛋白质三聚体。

10. 发明授权

US5770442A Chimeric adenoviral fiber protein and methods of using same 失效
标题翻译：嵌合腺病毒纤维蛋白及其使用方法
公开(公告)号：US5770442A
公开(公告)日：1998-06-23
申请号：US395381
申请日：1995-02-21
申请人： Thomas J. Wickham , Erik Falck-Pedersen , Petrus W. Roelvink , Joseph T. Bruder , Jason Gall , Imre Kovesdi
发明人： Thomas J. Wickham , Erik Falck-Pedersen , Petrus W. Roelvink , Joseph T. Bruder , Jason Gall , Imre Kovesdi
IPC分类号： C12N15/09 , A61K35/76 , A61K48/00 , C07K14/075 , C07K19/00 , C12N7/00 , C12N7/01 , C12N15/861 , C12N15/67 , C07H21/04 , C12N15/86 , C12P21/02
CPC分类号： C12N15/86 , C07K14/005 , A61K48/00 , C07K2319/00 , C12N2710/10322 , C12N2710/10343 , C12N2710/10345 , C12N2810/405 , C12N2810/6018 , C12N2830/00 , C12N2830/60
摘要： A recombinant adenovirus comprising a chimeric fiber protein and a therapeutic gene, a method of gene therapy involving the use of such an adenovirus, and an adenoviral transfer vector for the generation of such a recombinant adenovirus are provided.
摘要翻译：提供了包含嵌合纤维蛋白质和治疗基因的重组腺病毒，涉及使用这种腺病毒的基因治疗方法和用于产生这种重组腺病毒的腺病毒转移载体。

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