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1. 发明授权

US08476409B2 Bispecific anti-IGF-1R and anti-ErbB3 antibodies 有权
标题翻译：双特异性抗IGF-1R和抗ErbB3抗体
公开(公告)号：US08476409B2
公开(公告)日：2013-07-02
申请号：US13451135
申请日：2012-04-19
申请人： Jason Baum , Bryan Johnson , Alexey Alexandrovich Lugovskoy , Lihui Xu , Neeraj Kohli , Jonathan Basil Fitzgerald , Sharlene Adams
发明人： Jason Baum , Bryan Johnson , Alexey Alexandrovich Lugovskoy , Lihui Xu , Neeraj Kohli , Jonathan Basil Fitzgerald , Sharlene Adams
IPC分类号： C07K16/30 , C07H21/04 , A61K39/00
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/2869 , C07K16/30 , C07K16/32 , C07K16/40 , C07K16/468 , C07K2317/31 , C07K2317/33 , C07K2317/35 , C07K2317/52 , C07K2317/565 , C07K2317/60 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： Provided are bispecific antibodies that are useful as anti-neoplastic agents and that bind specifically to human IGF-1R and human ErbB3. Exemplary antibodies inhibit signal transduction through either or both of IGF-1R and ErbB3.
摘要翻译：提供可用作抗肿瘤剂并且特异性结合人IGF-1R和人ErbB3的双特异性抗体。示例性的抗体通过IGF-1R和ErbB3之一或两者抑制信号转导。

2. 发明授权

US10780241B2 Devices and methods for minimizing and treating high-altitude sickness 有权
公开(公告)号：US10780241B2
公开(公告)日：2020-09-22
申请号：US12541144
申请日：2009-08-13
申请人： David Fine , Gregory Vasquez , Bryan Johnson
发明人： David Fine , Gregory Vasquez , Bryan Johnson
IPC分类号： A61M16/10 , A61K33/00 , A61K31/198 , A61M16/00 , A61M16/06
摘要： A device and method for treating high-altitude sickness can include a handheld device, and can deliver a therapeutic amount of nitric oxide to an individual's lungs in order to minimize or treat high-altitude sickness. The device is self-contained and portable, which allows an individual to carry and use the device in high-altitude or other low-oxygen environments.

3. 发明授权

US08715577B2 Conversion of nitrogen dioxide (NO2) to nitric oxide (NO) 有权
标题翻译：二氧化氮（NO2）转化为一氧化氮（NO）
公开(公告)号：US08715577B2
公开(公告)日：2014-05-06
申请号：US13436018
申请日：2012-03-30
申请人： David H. Fine , David P. Rounbehler , Gregory Vasquez , Bryan Johnson
发明人： David H. Fine , David P. Rounbehler , Gregory Vasquez , Bryan Johnson
IPC分类号： A62B7/08 , G05B1/00 , G05D16/00 , B01J19/00 , A61M15/00 , A61M16/00 , A61M16/10 , A62B7/10 , A62B23/02
CPC分类号： B01J12/007 , A61K33/00 , A61M16/10 , A61M16/122 , A61M2016/1025 , A61M2202/0007 , A61M2202/0078 , A61M2202/0275 , A61M2205/07 , A61M2205/12 , A62B7/08 , C01B21/24
摘要： A nitric oxide delivery system, which includes a gas bottle having nitrogen dioxide in air, converts nitrogen dioxide to nitric oxide and employs a surface-active material, such as silica gel, coated with an aqueous solution of antioxidant, such as ascorbic acid. A nitric oxide delivery system may be used to generate therapeutic gas including nitric oxide for use in delivering the therapeutic gas to a mammal.
摘要翻译：包括在空气中具有二氧化氮的气瓶的一氧化氮输送系统将二氧化氮转化为一氧化氮，并使用涂覆有抗氧化剂水溶液如抗坏血酸的表面活性物质如硅胶。一氧化氮递送系统可用于产生治疗气体，包括用于将治疗气体递送至哺乳动物的一氧化氮。

4. 发明授权

US08173072B2 Conversation of nitrogen dioxide (NO2) to nitric oxide (NO) 有权
公开(公告)号：US08173072B2
公开(公告)日：2012-05-08
申请号：US12563662
申请日：2009-09-21
申请人： David H. Fine , David P. Rounbehler , Gregory Vasquez , Bryan Johnson
发明人： David H. Fine , David P. Rounbehler , Gregory Vasquez , Bryan Johnson
IPC分类号： B01J19/00 , A61M15/00 , A61M16/10 , A61M16/00 , A62B7/10 , A62B23/02
CPC分类号： B01J12/007 , A61K33/00 , A61M16/10 , A61M16/122 , A61M2016/1025 , A61M2202/0007 , A61M2202/0078 , A61M2202/0275 , A61M2205/07 , A61M2205/12 , A62B7/08 , C01B21/24
摘要： A nitric oxide delivery system, which includes a gas bottle having nitrogen dioxide in air, converts nitrogen dioxide to nitric oxide and employs a surface-active material, such as silica gel, coated with an aqueous solution of antioxidant, such as ascorbic acid. A nitric oxide delivery system may be used to generate therapeutic gas including nitric oxide for use in delivering the therapeutic gas to a mammal.

5. 发明申请

US20100043787A1 SYSTEMS AND DEVICES FOR GENERATING NITRIC OXIDE 有权
标题翻译：用于生成氮氧化物的系统和装置
公开(公告)号：US20100043787A1
公开(公告)日：2010-02-25
申请号：US12541137
申请日：2009-08-13
申请人： David H. Fine , Bryan Johnson , Gregory Vasquez
发明人： David H. Fine , Bryan Johnson , Gregory Vasquez
IPC分类号： A61M16/10 , B01J19/00
CPC分类号： A61M16/12 , A61M16/10 , A61M16/104 , A61M16/105 , A61M16/107 , A61M16/1075 , A61M16/109 , A61M16/16 , A61M2202/0275 , A62B7/08 , A62B21/00 , C01B21/24
摘要： Various systems and devices for generating nitric oxide are disclosed herein. According to one embodiment, the device includes a body having an inlet, an outlet, and a porous solid matrix positioned with the body. The porous solid matrix is coated with an aqueous solution of an antioxidant, wherein the inlet is configured to receive a gas flow and fluidly communicate the gas flow to the outlet through the solid matrix to convert nitrogen dioxide in the gas flow into nitric oxide. The porous solid matrix allows the device to be used in any orientation. Additionally, the porous solid matrix provides a rigid structure suitable to withstand vibrations and abuse without compromising device functionality.
摘要翻译：本文公开了用于产生一氧化氮的各种系统和装置。根据一个实施例，该装置包括具有与主体定位的入口，出口和多孔固体基体的主体。多孔固体基质涂覆有抗氧化剂的水溶液，其中入口被配置为接收气流并将气流流体连通到通过固体基质的出口，以将气流中的二氧化氮转化成一氧化氮。多孔固体基质允许该装置以任何取向使用。此外，多孔固体基质提供了适合于抵抗振动和滥用的刚性结构，而不会影响装置的功能。

6. 发明申请

US20060258193A1 Lead terminal multi-tool 失效
标题翻译：领导终端多工具
公开(公告)号：US20060258193A1
公开(公告)日：2006-11-16
申请号：US11127886
申请日：2005-05-12
申请人： Kyle Hoecke , Gregory Sundberg , Michelle Fangmeier , Bryan Johnson
发明人： Kyle Hoecke , Gregory Sundberg , Michelle Fangmeier , Bryan Johnson
IPC分类号： H01R4/66
CPC分类号： A61N1/3752 , A61B5/0422 , A61N1/05 , A61N1/056 , H01R43/22 , H01R2201/12
摘要： The document discusses, among other things, apparatuses, assemblies, and methods for facilitating the installation of an implantable lead into a subject. In one example, the apparatus includes a housing having a lead terminal passageway on a first end and having an introductory opening on a second end. The lead terminal passageway is adapted to be inserted over a lead terminal end. The introductory opening is adapted to accept a stylet and guide it into a pin lumen. In another example, the apparatus includes one or both of at least one protective terminal contact device and a securing contact device allowing electrical contact to be made with a lead terminal ring or a lead terminal pin without damaging or bridging between such elements of the lead terminal end. The securing contact device is also adapted to mechanically engage the lead terminal pin thereto for facilitating actuation of fixation devices.
摘要翻译：该文件尤其涉及便于将可植入引线安装到受试者中的装置，组件和方法。在一个示例中，该装置包括壳体，该壳体具有在第一端上的引线端子通道，并且在第二端上具有引导开口。引线端子通道适于插入引线端子端。介绍性开口适于接纳探针并将其引导到针管腔中。在另一示例中，该装置包括至少一个保护端子接触装置和固定接触装置中的一个或两个，其允许用引线端子环或引线端子引脚进行电接触，而不会在引线端子的这些元件之间损坏或桥接结束。固定接触装置还适于将引线端子销机械地接合到其上，以促进固定装置的致动。

7. 发明申请

US20060037459A1 Apparatus and method for self-tuning stringed musical instruments with an accompanying vibrato mechanism 有权
标题翻译：具有伴随颤音机构的自调弦乐器的装置和方法
公开(公告)号：US20060037459A1
公开(公告)日：2006-02-23
申请号：US11207187
申请日：2005-08-18
申请人： Neil Skinn , Frank Strazzabosco , Steve Kith , Bryan Johnson , Sharon Stanberg
发明人： Neil Skinn , Frank Strazzabosco , Steve Kith , Bryan Johnson , Sharon Stanberg
IPC分类号： G10D3/14 , G10D3/04 , G10D1/08
CPC分类号： G10D3/143 , G10D3/146 , G10G7/02
摘要： An automatic tuning system for a stringed instrument is provided having a string adjustment assembly comprising a motor and gear assembly, wherein the motor and gear assembly is pivotable on a housing for the tuning system. The system can also include a vibrato arm in contact with the motor and gear assembly, and a vibrato return spring in contact with both the motor and gear assembly and the instrument, which is capable of reversibly changing the position of a string contact surface in the string adjustment assembly with respect to the string, thereby lowering the pitch of the string and then raising it to its original pitch. The system can also include an option board for wireless communication with remote components such as a remote footswitch or other type of control panel. Other remote devices may also be wirelessly connected to the tuning system, including other instruments, audio devices for receiving sound, and the like. The system comprises a processor that can be preprogrammed with generic instructions for motor movement to achieve specific pitch changes and can also be programmed to store the motor instructions required to achieve specific pitch changes each time the system performs an automatic tuning correction, and to utilize these instructions the next time the system is tuned. The system is capable of performing fine tuning corrections as well as of prompting a user to perform coarse-tuning corrections. It also allows a user to change tunings while playing.
摘要翻译：提供了一种用于弦乐器的自动调谐系统，其具有包括马达和齿轮组件的弦调节组件，其中马达和齿轮组件可在用于调谐系统的壳体上枢转。该系统还可以包括与马达和齿轮组件接触的颤音臂，以及与马达和齿轮组件和仪器接触的颤音复位弹簧，其能够可逆地改变弦接触表面的位置弦调整组件，从而降低弦的音调，然后将其提高到原来的音高。该系统还可以包括用于与诸如远程脚踏开关或其他类型的控制面板的远程组件进行无线通信的选件板。其他远程设备也可以无线地连接到调谐系统，包括其他仪器，用于接收声音的音频设备等。该系统包括处理器，其可以用用于电动机运动的通用指令进行预编程以实现特定的间距变化，并且还可以被编程为在每次系统执行自动调谐校正时存储实现特定间距变化所需的电机指令，并利用这些指令下次系统调整时的指示。该系统能够执行微调校正以及提示用户执行粗调校正。它还允许用户在播放时更改调谐。

8. 发明申请

US20150374949A1 DELIVERY OF ULTRA PURE NITRIC OXIDE (NO) 审中-公开
标题翻译：超纯氧化氮（NO）
公开(公告)号：US20150374949A1
公开(公告)日：2015-12-31
申请号：US14546373
申请日：2014-11-18
申请人： David H. Fine , Gregory Vasquez , Bryan Johnson , Ryan Denton , Lucas G. Gamero
发明人： David H. Fine , Gregory Vasquez , Bryan Johnson , Ryan Denton , Lucas G. Gamero
IPC分类号： A61M16/12
CPC分类号： A61M16/122 , A61M16/0666 , A61M16/10 , A61M16/105 , A61M16/1055 , A61M16/107 , A61M16/1075 , A61M16/12 , A61M2016/0027 , A61M2016/102 , A61M2202/0266 , A61M2202/0275 , A61M2202/03 , A61M2205/0238 , A61M2205/18 , A61M2205/3368 , A61M2205/3653 , A61M2205/7518 , A61M2205/8206 , A61M2207/10 , A61M2209/088 , C01B21/24
摘要： A system for delivering a therapeutic amount of nitric oxide can include a reservoir assembly, a gas supply, and a delivery conduit including a first cartridge, wherein the first cartridge can include a surface-activated material saturated with an aqueous solution of a reducing agent.
摘要翻译：用于递送治疗量的一氧化氮的系统可以包括储存器组件，气体供应和包括第一药筒的输送导管，其中第一药筒可以包含饱和还原剂水溶液的表面活化物质。

9. 发明申请

US20110259325A1 Delivery of ultra pure nitric oxide (NO) 有权
标题翻译：超纯氧化氮（NO）
公开(公告)号：US20110259325A1
公开(公告)日：2011-10-27
申请号：US13094535
申请日：2011-04-26
申请人： David H. Fine , Gregory Vasquez , Bryan Johnson , Ryan Denton , Lucas G. Gamero
发明人： David H. Fine , Gregory Vasquez , Bryan Johnson , Ryan Denton , Lucas G. Gamero
IPC分类号： A61M16/10 , B65D8/04 , B65D85/00 , B65B1/04
CPC分类号： A61M16/122 , A61M16/0666 , A61M16/10 , A61M16/105 , A61M16/1055 , A61M16/107 , A61M16/1075 , A61M16/12 , A61M2016/0027 , A61M2016/102 , A61M2202/0266 , A61M2202/0275 , A61M2202/03 , A61M2205/0238 , A61M2205/18 , A61M2205/3368 , A61M2205/3653 , A61M2205/7518 , A61M2205/8206 , A61M2207/10 , A61M2209/088 , C01B21/24
摘要： A system for deliverying a therapeutic amount of nitric oxide can include a reservoir assembly, a gas supply, and a delivery conduit including a first cartridge, wherein the first cartridge can include a surface-activated material saturated with an aqueous solution of a reducing agent.
摘要翻译：用于递送治疗量的一氧化氮的系统可以包括储存器组件，气体供应和包括第一盒的输送导管，其中第一盒可包括饱和还原剂的水溶液的表面活化材料。

10. 发明申请

US20110220103A1 NITRIC OXIDE DELIVERY SYSTEM 有权
标题翻译：氮氧化物输送系统
公开(公告)号：US20110220103A1
公开(公告)日：2011-09-15
申请号：US12951811
申请日：2010-11-22
申请人： David H. Fine , Gregory Vasquez , Bryan Johnson , Jody Fuller , Ryan Denton
发明人： David H. Fine , Gregory Vasquez , Bryan Johnson , Jody Fuller , Ryan Denton
IPC分类号： A61M16/12
CPC分类号： A61M16/104 , A61K33/00 , A61M16/0057 , A61M16/0066 , A61M16/1075 , A61M16/12 , A61M2016/102 , A61M2202/0208 , A61M2202/0275 , A61M2205/8206
摘要： An ambulatory or stationary device for delivery of a therapeutic amount of nitric oxide to an individual's lungs.
摘要翻译：用于将治疗量的一氧化氮递送至个体肺的移动或固定装置。

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