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1. 发明申请

US20050228246A1 Method and apparatus for dynamically monitoring multiple in vivo tissue chromophores 有权
标题翻译：用于动态监测多个体内组织发色团的方法和装置
公开(公告)号：US20050228246A1
公开(公告)日：2005-10-13
申请号：US11103963
申请日：2005-04-12
申请人： Jangwoen Lee , Bruce Tromberg , Albert Cerussi , Matthew Brenner
发明人： Jangwoen Lee , Bruce Tromberg , Albert Cerussi , Matthew Brenner
IPC分类号： A61B5/00 , G01J3/28 , G01N21/31 , G01N21/35 , G01N21/49
CPC分类号： A61B5/14551 , A61B5/14552 , A61B5/412 , G01N21/31 , G01N21/359 , G01N21/49 , G01N2201/08
摘要： A device and method utilizes a broadband diffuse optical spectroscopy (DOS) system to dynamically calculate the concentrations of multiple chromophores in vivo using a non-invasive probe. The device and method permit dynamic monitoring of multiple in vivo tissue chromophores non-invasively with sensitivities necessary for effective therapeutic monitoring. The device includes a probe containing first and second source optical fibers as well as first and second detector optical fibers. The probe is placed adjacent to a sample of interest and detects reflected light which is passed to a proximally located detector and spectrometer. The concentrations of multiple chromophores are determined in real time. In a preferred embodiment, the multiple tissue chromophores include at least two of methemoglobin (MetHb), deoxyhemoglobin (Hb-R), oxyhemoglobin (Hb-O2), water (H2O), and methylene blue (MB). The device and method can be used quantify and monitor methemoglobin formation in subjects suffering from methemoglobinemia.
摘要翻译：一种使用宽带漫射光谱（DOS）系统的装置和方法使用非侵入性探针来动态地计算体内多个发色团的浓度。该装置和方法允许非侵入性地动态监测多个体内组织发色团，具有有效治疗监测所需的灵敏度。该装置包括包含第一和第二源光纤以及第一和第二检测器光纤的探针。将探针放置在感兴趣的样本附近，并检测反射光，其被传递到位于近端的检测器和光谱仪。多个发色团的浓度实时测定。在优选实施方案中，多组织发色团包括高铁血红蛋白（MetHb），脱氧血红蛋白（Hb-R），氧合血红蛋白（Hb-O 2 H），水（H 2 O 2） SUB）和亚甲基蓝（MB）。该装置和方法可用于定量和监测患有高铁血红蛋白血症的受试者中的高铁血红蛋白形成。

2. 发明授权

US07248909B2 Method and apparatus for dynamically monitoring multiple in vivo tissue chromophores 有权
标题翻译：用于动态监测多个体内组织发色团的方法和装置
公开(公告)号：US07248909B2
公开(公告)日：2007-07-24
申请号：US11103963
申请日：2005-04-12
申请人： Jangwoen Lee , Bruce J. Tromberg , Albert E. Cerussi , Matthew Brenner
发明人： Jangwoen Lee , Bruce J. Tromberg , Albert E. Cerussi , Matthew Brenner
IPC分类号： A61B5/00
CPC分类号： A61B5/14551 , A61B5/14552 , A61B5/412 , G01N21/31 , G01N21/359 , G01N21/49 , G01N2201/08
摘要： A device and method utilizes a broadband diffuse optical spectroscopy (DOS) system to dynamically calculate the concentrations of multiple chromophores in vivo using a non-invasive probe. The device and method permit dynamic monitoring of multiple in vivo tissue chromophores non-invasively with sensitivities necessary for effective therapeutic monitoring. The device includes a probe containing first and second source optical fibers as well as first and second detector optical fibers. The probe is placed adjacent to a sample of interest and detects reflected light which is passed to a proximally located detector and spectrometer. The concentrations of multiple chromophores are determined in real time. In a preferred embodiment, the multiple tissue chromophores include at least two of methemoglobin (MetHb), deoxyhemoglobin (Hb-R), oxyhemoglobin (Hb-O2), water (H2O), and methylene blue (MB). The device and method can be used quantify and monitor methemoglobin formation in subjects suffering from methemoglobinemia.
摘要翻译：一种使用宽带漫射光谱（DOS）系统的装置和方法使用非侵入性探针来动态地计算体内多个发色团的浓度。该装置和方法允许非侵入性地动态监测多个体内组织发色团，具有有效治疗监测所需的灵敏度。该装置包括包含第一和第二源光纤以及第一和第二检测器光纤的探针。将探针放置在感兴趣的样本附近，并检测反射光，其被传递到位于近端的检测器和光谱仪。多个发色团的浓度实时测定。在优选实施方案中，多组织发色团包括高铁血红蛋白（MetHb），脱氧血红蛋白（Hb-R），氧合血红蛋白（Hb-O 2 H），水（H 2 O 2） SUB）和亚甲基蓝（MB）。该装置和方法可用于定量和监测患有高铁血红蛋白血症的受试者中的高铁血红蛋白形成。

3. 发明申请

US20130005044A1 Rapid Method to Measure Cyanide in Biological Samples 有权
标题翻译：快速测定生物样品中氰化物的方法
公开(公告)号：US20130005044A1
公开(公告)日：2013-01-03
申请号：US13634703
申请日：2011-03-15
申请人： Gerry Boss , Vijay Sharma , Matthew Brenner , Pernendu K. Dasgupta , William Curt Blackledge
发明人： Gerry Boss , Vijay Sharma , Matthew Brenner , Pernendu K. Dasgupta , William Curt Blackledge
IPC分类号： G01N21/76 , C07F15/06
CPC分类号： G01N21/78 , G01N31/22 , G01N33/523 , G01N33/84 , G01N2201/0221
摘要： A method and devices analyze for the presence of cyanide in samples using colorimetric analysis of samples after contacting with cobinamide or monocyanocohinapmide.
摘要翻译：一种方法和装置用样品中的氰化物或单异氰尿酸药物接触后，使用比色分析来分析样品中氰化物的存在。

4. 发明申请

US20080134942A1 Carbon Nanotube-Fiber Reinforced Cement And Concrete 审中-公开
标题翻译：碳纳米管 - 纤维增强水泥和混凝土
公开(公告)号：US20080134942A1
公开(公告)日：2008-06-12
申请号：US11609620
申请日：2006-12-12
申请人： Matthew Brenner , Arjun Mariputtana Kavi , Michael Guan-Yu Li
发明人： Matthew Brenner , Arjun Mariputtana Kavi , Michael Guan-Yu Li
IPC分类号： C04B16/12 , C04B7/02
CPC分类号： C04B28/04 , C04B14/026 , C04B2103/30
摘要： Carbon nanotubes (CNTs) are combined with cement, aggregate and plasticizers to form composites with increased strength. CNT reinforced concretes comprising cement, plasticizer, aggregate, and nanotubes, hydrated with water are disclosed. A mixture of CNTs, cement, and plasticizer can be prepared for later admixture with aggregates and water to form composites having improved strength characteristics. A method for increasing the strength of concrete comprising the steps of admixing CNTs and plasticizer's with cement, aggregate, and water for hydration is also disclosed.
摘要翻译：碳纳米管（CNTs）与水泥，骨料和增塑剂结合形成复合材料，强度提高。公开了包含水合物的水泥，增塑剂，骨料和纳米管的CNT增强混凝土。可以制备CNT，水泥和增塑剂的混合物，用于随后与聚集体和水混合以形成具有改进的强度特性的复合材料。还公开了一种增加混凝土强度的方法，其包括将CNT和增塑剂与水泥，骨料和水混合以进行水合的步骤。

5. 发明授权

US08741658B2 Rapid method to measure cyanide in biological samples 有权
标题翻译：快速测定生物样品中氰化物的方法
公开(公告)号：US08741658B2
公开(公告)日：2014-06-03
申请号：US13634703
申请日：2011-03-15
申请人： Gerry Boss , Vijay Sharma , Matthew Brenner , Purnendu K. Dasgupta , William Curt Blackledge
发明人： Gerry Boss , Vijay Sharma , Matthew Brenner , Purnendu K. Dasgupta , William Curt Blackledge
IPC分类号： G01N21/78 , G01N21/77 , G01N33/52 , G01N33/48
CPC分类号： G01N21/78 , G01N31/22 , G01N33/523 , G01N33/84 , G01N2201/0221
摘要： A method and devices analyze for the presence of cyanide in samples using colorimetric analysis of samples after contacting with cobinamide or monocyanocohinapmide.
摘要翻译：一种方法和装置用样品中的氰化物或单异氰尿酸药物接触后，使用比色分析来分析样品中氰化物的存在。

6. 发明授权

US08285368B2 Endoscopic long range fourier domain optical coherence tomography (LR-FD-OCT) 有权
标题翻译：内窥镜远程傅立叶变换光学相干断层扫描（LR-FD-OCT）
公开(公告)号：US08285368B2
公开(公告)日：2012-10-09
申请号：US12833717
申请日：2010-07-09
申请人： Zhongping Chen , Jun Zhang , Matthew Brenner
发明人： Zhongping Chen , Jun Zhang , Matthew Brenner
IPC分类号： A61B6/00 , A61B1/00
CPC分类号： A61B5/0073 , A61B5/0066 , A61B5/6852 , A61B5/7257 , G01B9/02004 , G01B9/02007 , G01B9/02091 , G01B2290/45
摘要： An endoscopic swept-source Fourier Domain optical coherence tomographic system (FDOCT system) for imaging of tissue structure includes a Fourier Domain mode locked (FDML), high speed, narrow line-width, wavelength swept source, an OCT interferometer having a sample arm, a reference arm, a detection arm, and a source arm coupled to the swept source, an endoscopic probe coupled to the sample arm, and a data processing circuit coupled to the detection arm. The swept source includes a long optic fiber functioning as a cavity, a high optical gain lasing module, and a tunable narrow bandwidth bandpass filter for wavelength selection combined to form a unidirectional ring laser cavity, where the tunable narrow bandwidth bandpass filter is driven synchronously with the optical round-trip time of a propagating light wave in the cavity.
摘要翻译：用于组织结构成像的内窥镜扫描傅立叶域光学相干断层扫描系统（FDOCT系统）包括傅立叶域模式锁定（FDML），高速窄线宽波长扫描源，具有采样臂的OCT干涉仪，耦合到扫描源的参考臂，检测臂和源臂，耦合到采样臂的内窥镜探针以及耦合到检测臂的数据处理电路。扫频源包括用作空腔的长光纤，高光增益激光模块和用于波长选择的可调窄带宽带通滤波器，以组合形成单向环形激光腔，其中可调窄带宽带通滤波器与传播光波在空腔中的光学往返时间。

7. 发明申请

US20110009752A1 ENDOSCOPIC LONG RANGE FOURIER DOMAIN OPTICAL COHERENCE TOMOGRAPHY (LR-FD-OCT) 有权
标题翻译：内镜长距离光域相干光谱（LR-FD-OCT）
公开(公告)号：US20110009752A1
公开(公告)日：2011-01-13
申请号：US12833717
申请日：2010-07-09
申请人： Zhongping Chen , Jun Zhang , Matthew Brenner
发明人： Zhongping Chen , Jun Zhang , Matthew Brenner
IPC分类号： A61B1/267 , A61B6/00 , A61B1/07
CPC分类号： A61B5/0073 , A61B5/0066 , A61B5/6852 , A61B5/7257 , G01B9/02004 , G01B9/02007 , G01B9/02091 , G01B2290/45
摘要： An endoscopic swept-source Fourier Domain optical coherence tomographic system (FDOCT system) for imaging of tissue structure includes a Fourier Domain mode locked (FDML), high speed, narrow line-width, wavelength swept source, an OCT interferometer having a sample arm, a reference arm, a detection arm, and a source arm coupled to the swept source, an endoscopic probe coupled to the sample arm, and a data processing circuit coupled to the detection arm. The swept source includes a long optic fiber functioning as a cavity, a high optical gain lasing module, and a tunable narrow bandwidth bandpass filter for wavelength selection combined to form a unidirectional ring laser cavity, where the tunable narrow bandwidth bandpass filter is driven synchronously with the optical round-trip time of a propagating light wave in the cavity.
摘要翻译：用于组织结构成像的内窥镜扫描傅立叶域光学相干断层扫描系统（FDOCT系统）包括傅立叶域模式锁定（FDML），高速窄线宽波长扫描源，具有采样臂的OCT干涉仪，耦合到扫描源的参考臂，检测臂和源臂，耦合到采样臂的内窥镜探针以及耦合到检测臂的数据处理电路。扫频源包括用作空腔的长光纤，高光增益激光模块和用于波长选择的可调窄带宽带通滤波器，以组合形成单向环形激光腔，其中可调窄带宽带通滤波器与传播光波在空腔中的光学往返时间。

8. 发明授权

US07576865B2 Optical coherent tomographic (OCT) imaging apparatus and method using a fiber bundle 有权
标题翻译：光学相干断层扫描（OCT）成像设备和使用纤维束的方法
公开(公告)号：US07576865B2
公开(公告)日：2009-08-18
申请号：US11405812
申请日：2006-04-17
申请人： Zhongping Chen , Tuqiang Xie , David Mukai , Matthew Brenner
发明人： Zhongping Chen , Tuqiang Xie , David Mukai , Matthew Brenner
IPC分类号： G01B9/02
CPC分类号： A61B5/0073 , A61B5/0066 , A61B5/0068
摘要： A fiber-optic bundle based optical coherence tomography (OCT) probe method is demonstrated in a multimode optical fiber bundle based OCT system. The system can achieve a lateral resolution of 12 μm and an axial resolution of 10 μm using a super-luminescent diode source. This imaging approach eliminates any moving parts in the probe and has a primary advantage for use in extremely compact and safe OCT endoscopes to image internal organs and great potential to be combined with confocal endoscopic microscopy.
摘要翻译：基于光纤束的光学相干断层扫描（OCT）探针方法在基于多模光纤束的OCT系统中得到证明。该系统可以使用超发光二极管源实现12um的横向分辨率和10mum的轴向分辨率。该成像方法消除了探头中的任何移动部件，并且具有用于非常紧凑和安全的OCT内窥镜中用于成像内部器官和与共焦内窥镜显微镜组合的巨大潜力的主要优点。

9. 发明申请

US20070038119A1 Optical coherent tomographic (OCT) imaging apparatus and method using a fiber bundle 有权
标题翻译：光学相干断层扫描（OCT）成像设备和使用纤维束的方法
公开(公告)号：US20070038119A1
公开(公告)日：2007-02-15
申请号：US11405812
申请日：2006-04-17
申请人： Zhongping Chen , Tuqiang Xie , David Mukai , Matthew Brenner
发明人： Zhongping Chen , Tuqiang Xie , David Mukai , Matthew Brenner
IPC分类号： A61B6/00
CPC分类号： A61B5/0073 , A61B5/0066 , A61B5/0068
摘要： A fiber-optic bundle based optical coherence tomography (OCT) probe method is demonstrated in a multimode optical fiber bundle based OCT system. The system can achieve a lateral resolution of 12 μm and an axial resolution of 10 μm using a super-luminescent diode source. This imaging approach eliminates any moving parts in the probe and has a primary advantage for use in extremely compact and safe OCT endoscopes to image internal organs and great potential to be combined with confocal endoscopic microscopy.
摘要翻译：基于光纤束的光学相干断层扫描（OCT）探针方法在基于多模光纤束的OCT系统中得到证明。该系统可以使用超发光二极管源实现12um的横向分辨率和10mum的轴向分辨率。该成像方法消除了探头中的任何移动部件，并且具有用于非常紧凑和安全的OCT内窥镜中用于成像内部器官和与共焦内窥镜显微镜组合的巨大潜力的主要优点。

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