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1. 发明授权

US5635375A Method of increasing the yield and heme saturation of cystathione .beta.-synthase 失效
标题翻译：增加胱硫醚β - 硫酸钠的产量和血红素饱和度的方法
公开(公告)号：US5635375A
公开(公告)日：1997-06-03
申请号：US370036
申请日：1995-01-09
申请人： Jan P. Kraus , Vladimir Kery
发明人： Jan P. Kraus , Vladimir Kery
IPC分类号： C12N1/38 , C12N9/88 , C12P21/04 , C12P1/02
CPC分类号： C12N9/88 , C12N1/38 , C07K2319/00
摘要： A method of increasing the yield and heme saturation of hemoproteins in microorganisms. In this method, an effective amount of a heme precursor is added to a culture of hemoprotein producing microorganisms.
摘要翻译：提高微生物中血蛋白的产量和血红素饱和度的方法。在该方法中，将有效量的血红素前体加入产生血液蛋白的微生物的培养物中。

2. 发明授权

US5523225A DNA sequence encoding human cystathionine .beta.-synthase 失效
标题翻译：编码人胱硫醚β - 酶的DNA序列
公开(公告)号：US5523225A
公开(公告)日：1996-06-04
申请号：US120960
申请日：1993-09-13
申请人： Jan P. Kraus
发明人： Jan P. Kraus
IPC分类号： A61K38/00 , C12N9/88 , C12N15/60 , C12N5/10 , C12N1/19 , C12N1/21 , C12N15/63
CPC分类号： C12N9/88 , A61K38/00
摘要： Disclosed is a purified and isolated DNA sequence encoding human cystathionine .beta.-synthase. Also disclosed is a purified and isolated human cystathionine .beta.-synthase encoded by this DNA sequence. Included is a composition of human cystathionine .beta.-synthase in a pharmacologically acceptable carrier for treating a human suffering from homocystinuria. Also provided are methods of screening human patients to detect mutations in the cystathionine .beta.-synthase gene.
摘要翻译：公开了一种纯化和分离的编码人胱硫醚β - 酶的DNA序列。还公开了由该DNA序列编码的纯化和分离的人胱硫醚β-硫蛋白酶。包括在用于治疗患有同类胱氨酸尿症的人的药理学上可接受的载体中的人胱硫醚β - 硫辛酸的组合物。还提供了筛选人类患者以检测胱硫醚β-Synthase基因突变的方法。

3. 发明申请

US20120263700A1 HUMAN CYSTATHIONINE BETA-SYNTHASE VARIANTS AND METHODS OF PRODUCTION THEREOF 有权
标题翻译：人CYSTATHIONINE BETA-SYNTHASE变种及其生产方法
公开(公告)号：US20120263700A1
公开(公告)日：2012-10-18
申请号：US13221379
申请日：2011-08-30
申请人： Jan P. Kraus , Jana Oliveriusova
发明人： Jan P. Kraus , Jana Oliveriusova
IPC分类号： A61K38/51 , A61P3/00 , C12N9/10 , C12N9/88 , C12N9/96
CPC分类号： C12N9/88 , A61K38/00 , C12Y402/01022
摘要： Human cystathionine β-synthase variants are disclosed, as well as a method to produce recombinant human cystathionine β-synthase and variants thereof. More particularly, the role of both the N-terminal and C-terminal regions of human CBS has been studied, and a variety of truncation mutants and modified CBS homologues are described. In addition, a method to express and purify recombinant human cystathionine β-synthase (CBS) and variants thereof which have only one or two additional amino acid residues at the N-terminus are described.
摘要翻译：公开了人胱硫醚和bgr- -Synthase变体，以及一种产生重组人胱硫醚及其变体的方法。更具体地，已经研究了人CBS的N-末端和C-末端区域的作用，并且描述了各种截短突变体和修饰的CBS同源物。另外，描述了在N末端仅具有一个或两个另外的氨基酸残基的重组人胱硫醚和bgr.Synthase（CBS）及其变体的表达和纯化方法。

4. 发明授权

US07485307B2 Human cystathionine β-synthase variants and methods of production thereof 有权
标题翻译：人胱硫醚β-合酶变体及其生产方法
公开(公告)号：US07485307B2
公开(公告)日：2009-02-03
申请号：US10464811
申请日：2003-06-17
申请人： Jan P. Kraus , Jana Oliveriusova
发明人： Jan P. Kraus , Jana Oliveriusova
IPC分类号： A61K39/00 , C12Q1/68 , C12Q1/70 , C12N1/20 , C12N15/00 , C07H21/04
CPC分类号： C12N9/88 , A61K38/00 , C12Y402/01022
摘要： Human cystathionine β-synthase variants are disclosed, as well as a method to produce recombinant human cystathionine β-synthase and variants thereof. More particularly, the role of both the N-terminal and C-terminal regions of human CBS has been studied, and a variety of truncation mutants and modified CBS homologues are described. In addition, a method to express and purify recombinant human cystathionine β-synthase (CBS) and variants thereof which have only one or two additional amino acid residues at the N-terminus are described.
摘要翻译：公开了人胱硫醚β-合酶变体，以及产生重组人胱硫醚β-合酶及其变体的方法。更具体地，已经研究了人CBS的N-末端和C-末端区域的作用，并且描述了各种截短突变体和修饰的CBS同源物。此外，描述了在N末端仅具有一个或两个另外的氨基酸残基的重组人胱硫醚β-合酶（CBS）及其变体的表达和纯化方法。

5. 发明授权

US5656425A Screening for mutations by expressing cDNA segments 失效
标题翻译：通过表达cDNA片段筛选突变
公开(公告)号：US5656425A
公开(公告)日：1997-08-12
申请号：US108216
申请日：1993-08-17
申请人： Jan P. Kraus
发明人： Jan P. Kraus
IPC分类号： C12N9/88 , C12N15/10 , C12Q1/68 , C12P21/00
CPC分类号： C12Q1/6827 , C12N15/102 , C12N9/88 , C07K2319/00
摘要： A rapid screening method is described for detecting, localizing, and expressing pathogenic mutations in patients suffering from diseases which can include genetically inherited diseases. The screening method allows simultaneous localization and expression of the mutation. By identifying the types and locations of the mutations causing a disease, the method can aid in determining the course of treatment for the disease. The method involves making an expression vector containing a sequence encoding an inactive enzyme by deleting a segment of the coding sequence of the enzyme in the vector, replacing the deleted segment with a corresponding segment from a patient's enzyme coding sequence to make a hybrid enzyme, expressing the hybrid enzyme and assaying the hybrid enzyme for activity to determine whether the Patient's enzyme cDNA contains a pathogenic mutation.
摘要翻译：描述了用于检测，定位和表达患有可能包括遗传性遗传疾病的疾病的患者的致病突变的快速筛选方法。筛选方法允许同时定位和表达突变。通过鉴定导致疾病的突变的类型和位置，该方法可以帮助确定疾病的治疗过程。该方法包括通过缺失载体中酶的编码序列的片段来制备含有编码无活性酶的序列的表达载体，用来自患者的酶编码序列的相应片段代替缺失的片段以制备杂交酶，表达杂交酶并测定杂交酶的活性以确定患者的酶cDNA是否含有致病突变。

6. 发明授权

US08007787B2 Human cystathionine β-synthase variants and methods of production thereof 有权
标题翻译：人类胱硫醚和硫酸盐变体及其生产方法
公开(公告)号：US08007787B2
公开(公告)日：2011-08-30
申请号：US12359287
申请日：2009-01-24
申请人： Jan P. Kraus
发明人： Jan P. Kraus
IPC分类号： A61K38/51 , C12Q1/527
CPC分类号： C12N9/88 , A61K38/00 , C12Y402/01022
摘要： Human cystathionine β-synthase variants are disclosed, as well as a method to produce recombinant human cystathionine β-synthase and variants thereof. More particularly, the role of both the N-terminal and C-terminal regions of human CBS has been studied, and a variety of truncation mutants and modified CBS homologues are described. In addition, a method to express and purify recombinant human cystathionine β-synthase (CBS) and variants thereof which have only one or two additional amino acid residues at the N-terminus are described.
摘要翻译：公开了人胱硫醚和bgr- -Synthase变体，以及一种产生重组人胱硫醚及其变体的方法。更具体地，已经研究了人CBS的N-末端和C-末端区域的作用，并且描述了各种截短突变体和修饰的CBS同源物。另外，描述了在N末端仅具有一个或两个另外的氨基酸残基的重组人胱硫醚和bgr.Synthase（CBS）及其变体的表达和纯化方法。

7. 发明申请

US20100166725A1 Human Cystathionine beta-Synthase Variants and Methods of Production Thereof 有权
标题翻译：人类胱硫醚β-合酶变体及其生产方法
公开(公告)号：US20100166725A1
公开(公告)日：2010-07-01
申请号：US12359287
申请日：2009-01-24
申请人： Jan P. Kraus , Jana Oliveriusova
发明人： Jan P. Kraus , Jana Oliveriusova
IPC分类号： A61K38/45 , C12N9/10 , C12P21/00 , A61P43/00
CPC分类号： C12N9/88 , A61K38/00 , C12Y402/01022
摘要： Human cystathionine β-synthase variants are disclosed, as well as a method to produce recombinant human cystathionine β-synthase and variants thereof. More particularly, the role of both the N-terminal and C-terminal regions of human CBS has been studied, and a variety of truncation mutants and modified CBS homologues are described. In addition, a method to express and purify recombinant human cystathionine β-synthase (CBS) and variants thereof which have only one or two additional amino acid residues at the N-terminus are described.
摘要翻译：公开了人胱硫醚和bgr- -Synthase变体，以及一种产生重组人胱硫醚及其变体的方法。更具体地，已经研究了人CBS的N-末端和C-末端区域的作用，并且描述了各种截短突变体和修饰的CBS同源物。另外，描述了在N末端仅具有一个或两个另外的氨基酸残基的重组人胱硫醚和bgr.Synthase（CBS）及其变体的表达和纯化方法。

8. 发明授权

US08398989B2 Human cystathionine β-synthase variants and methods of production thereof 有权
标题翻译：人类胱硫醚和硫酸盐变体及其生产方法
公开(公告)号：US08398989B2
公开(公告)日：2013-03-19
申请号：US13221379
申请日：2011-08-30
申请人： Jan P. Kraus , Jana Oliveriusova
发明人： Jan P. Kraus , Jana Oliveriusova
IPC分类号： A61K39/00 , C12Q1/68 , C12Q1/70 , C12N1/20 , C12N15/00 , C07H21/04
CPC分类号： C12N9/88 , A61K38/00 , C12Y402/01022
摘要： Human cystathionine β-synthase variants are disclosed, as well as a method to produce recombinant human cystathionine β-synthase and variants thereof. More particularly, the role of both the N-terminal and C-terminal regions of human CBS has been studied, and a variety of truncation mutants and modified CBS homologues are described. In addition, a method to express and purify recombinant human cystathionine β-synthase (CBS) and variants thereof which have only one or two additional amino acid residues at the N-terminus are described.
摘要翻译：公开了人胱硫醚和bgr- -Synthase变体，以及一种产生重组人胱硫醚及其变体的方法。更具体地，已经研究了人CBS的N-末端和C-末端区域的作用，并且描述了各种截短突变体和修饰的CBS同源物。另外，描述了在N末端仅具有一个或两个另外的氨基酸残基的重组人胱硫醚和bgr.Synthase（CBS）及其变体的表达和纯化方法。

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